Genetic factors are known to be of importance in determining the rate of biotransformation of foreign compounds in the liver. Adverse reactions to drugs are increased and pharmacokinetic parameters ...altered with age. In the present study, the effect of age on plasma paroxonase activity is studied. Paroxonase is a hepatically synthesized enzyme whose activity is almost entirely determined by genetic factors. It therefore serves as a model to determine whether changes in the frequency or expression of genes could explain the altered responses to drugs observed with age. The frequency distribution for paroxonase activity for 186 elderly people is closely similar to that obtained from 190 blood transfusion volunteers and 189 family members. Paroxonase activity, as with all other previously investigated pharmacogenetic polymorphisms, is unchanged with age. The hypothesis is put forward that genetic determinants of drug metabolism remain unchanged with age.
New data on diagnosis, drug therapy, surgery and psychosocial concerns have emerged since the publication of the 1998 Guidelines for the Management of Parkinson's Disease. This article reviews new ...data and addresses issues left unanswered in the previous guidelines.
We review recent experimental results on B meson decays. These include
measurements of the inclusive production of charmed and non-charmed mesons and
baryons, the reconstruction of a large number of ...exclusive hadronic final
states with charmed mesons, the search for exclusive hadronic final states
without charmed mesons, and the first observation of the decay B-> K* gamma
which is described by an electromagnetic penguin diagram. The theoretical
implications of these results will be considered. The figures can be obtained
in postscript format EMAIL from kh@ohstpy.mps.ohio-state.edu.
We review recent experimental results on B meson decays. These include measurements of the inclusive production of charmed and non-charmed mesons and baryons, the reconstruction of a large number of ...exclusive hadronic final states with charmed mesons, the search for exclusive hadronic final states without charmed mesons, and the first observation of the decay B-> K* gamma which is described by an electromagnetic penguin diagram. The theoretical implications of these results will be considered. The figures can be obtained in postscript format EMAIL from kh@ohstpy.mps.ohio-state.edu.
Parkinson's disease is a chronic and disabling illness and there is currently wide variation in its management. This article presents the first UK-specific guidelines for the management of ...Parkinson's disease and it contains a treatment decision free to aid the physician in deciding when and how to treat patients. We hope this document will prove useful to all those involved in the planning and delivery of care to patients with Parkinson's disease.
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