Abstract
We report on long-term multiwavelength monitoring of blazar Mrk 421 by the GLAST-AGILE Support Program of the Whole Earth Blazar Telescope (GASP-WEBT) collaboration and Steward Observatory, ...and by the Swift and Fermi satellites. We study the source behaviour in the period 2007–2015, characterized by several extreme flares. The ratio between the optical, X-ray and γ-ray fluxes is very variable. The γ-ray flux variations show a fair correlation with the optical ones starting from 2012. We analyse spectropolarimetric data and find wavelength-dependence of the polarization degree (P), which is compatible with the presence of the host galaxy, and no wavelength dependence of the electric vector polarization angle (EVPA). Optical polarimetry shows a lack of simple correlation between P and flux and wide rotations of the EVPA. We build broad-band spectral energy distributions with simultaneous near-infrared and optical data from the GASP-WEBT and ultraviolet and X-ray data from the Swift satellite. They show strong variability in both flux and X-ray spectral shape and suggest a shift of the synchrotron peak up to a factor of ∼50 in frequency. The interpretation of the flux and spectral variability is compatible with jet models including at least two emitting regions that can change their orientation with respect to the line of sight.
ABSTRACT
Here we report on the results of the Whole Earth Blazar Telescope photo-polarimetric campaign targeting the blazar S5 0716+71, organized in 2014 March to monitor the source simultaneously in
...BVRI
and near-IR filters. The campaign resulted in an unprecedented data set spanning ∼110 hr of nearly continuous, multiband observations, including two sets of densely sampled polarimetric data mainly in the
R
filter. During the campaign, the source displayed pronounced variability with peak-to-peak variations of about 30% and “bluer-when-brighter” spectral evolution, consisting of a day-timescale modulation with superimposed hour-long microflares characterized by ∼0.1 mag flux changes. We performed an in-depth search for quasi-periodicities in the source light curve; hints for the presence of oscillations on timescales of ∼3 and ∼5 hr do not represent highly significant departures from a pure red-noise power spectrum. We observed that, at a certain configuration of the optical polarization angle (PA) relative to the PA of the innermost radio jet in the source, changes in the polarization degree (PD) led the total flux variability by about 2 hr; meanwhile, when the relative configuration of the polarization and jet angles altered, no such lag could be noted. The microflaring events, when analyzed as separate pulse emission components, were found to be characterized by a very high PD (>30%) and PAs that differed substantially from the PA of the underlying background component, or from the radio jet positional angle. We discuss the results in the general context of blazar emission and energy dissipation models.
Clinical evaluation of floaters lacks quantitative assessment of vitreous structure. This study used quantitative ultrasound (QUS) to measure vitreous opacities. Since floaters reduce contrast ...sensitivity (CS) and quality of life (Visual Function Questionnaire VFQ), it is hypothesized that QUS will correlate with CS and VFQ in patients with floaters.
Twenty-two eyes (22 subjects; age = 57 ± 19 years) with floaters were evaluated with Freiburg acuity contrast testing (FrACT; %Weber) and VFQ. Ultrasonography used a customized probe (15-MHz center frequency, 20-mm focal length, 7-mm aperture) with longitudinal and transverse scans taken in primary gaze and a horizontal longitudinal scan through premacular vitreous in temporal gaze. Each scan set had 100 frames of log-compressed envelope data. Within each frame, two regions of interest (ROIs) were analyzed (whole-central and posterior vitreous) to yield three parameters (energy, E; mean amplitude, M; and percentage of vitreous filled by echodensities, P50) averaged over the entire 100-frame dataset. Statistical analyses evaluated E, M, and P50 correlations with CS and VFQ.
Contrast sensitivity ranged from 1.19%W (normal) to 5.59%W. All QUS parameters in two scan positions within the whole-central ROI correlated with CS (R > 0.67, P < 0.001). P50 in the nasal longitudinal position had R = 0.867 (P < 0.001). Correlations with VFQ ranged from R = 0.52 (P < 0.013) to R = 0.65 (P < 0.001).
Quantitative ultrasound provides quantitative measures of vitreous echodensity that correlate with CS and VFQ, providing objective assessment of vitreous structure underlying the functional disturbances induced by floaters, useful to quantify vitreous disease severity and the response to therapy.
Abstract
In 2015 July 29–September 1, the satellite XMM–Newton pointed at the BL Lac object PG 1553+133 six times, collecting data for 218 h. During one of these epochs, simultaneous observations by ...the Swift satellite were requested to compare the results of the X-ray and optical–UV instruments. Optical, near-infrared and radio monitoring was carried out by the Whole Earth Blazar Telescope (WEBT) collaboration for the whole observing season. We here present the results of the analysis of all these data, together with an investigation of the source photometric and polarimetric behaviour over the last 3 yr. The 2015 EPIC spectra show slight curvature and the corresponding light curves display fast X-ray variability with a time-scale of the order of 1 h. In contrast to previous results, during the brightest X-ray states detected in 2015 the simple log-parabolic model that best fits the XMM–Newton data also reproduces reasonably well the whole synchrotron bump, suggesting a peak in the near-UV band. We found evidence of a wide rotation of the polarization angle in 2014, when the polarization degree was variable, but the flux remained almost constant. This is difficult to interpret with deterministic jet emission models, while it can be easily reproduced by assuming some turbulence of the magnetic field.
Alzheimer's disease (AD) pathology precedes symptoms and its detection can identify at-risk individuals who may benefit from early treatment. Since the retinal nerve fiber layer (RNFL) is depleted in ...established AD, we tested whether its thickness can predict whether cognitively healthy (CH) individuals have a normal or pathological cerebrospinal fluid (CSF) Aß42 (A) and tau (T) ratio.
As part of an ongoing longitudinal study, we enrolled CH individuals, excluding those with cognitive impairment and significant ocular pathology. We classified the CH group into two sub-groups, normal (CH-NAT, n = 16) or pathological (CH-PAT, n = 27), using a logistic regression model from the CSF AT ratio that identified >85% of patients with a clinically probable AD diagnosis. Spectral-domain optical coherence tomography (OCT) was acquired for RNFL, ganglion cell-inner plexiform layer (GC-IPL), and macular thickness. Group differences were tested using mixed model repeated measures and a classification model derived using multiple logistic regression.
Mean age (± standard deviation) in the CH-PAT group (n = 27; 75.2 ± 8.4 years) was similar (p = 0.50) to the CH-NAT group (n = 16; 74.1 ± 7.9 years). Mean RNFL (standard error) was thinner in the CH-PAT group by 9.8 (2.7) μm; p < 0.001. RNFL thickness classified CH-NAT vs. CH-PAT with 87% sensitivity and 56.3% specificity.
Our retinal data predict which individuals have CSF biomarkers of AD pathology before cognitive deficits are detectable with 87% sensitivity. Such results from easy-to-acquire, objective and non-invasive measurements of the RNFL merit further study of OCT technology to monitor or screen for early AD pathology.
The occurrence of low-amplitude flux variations in blazars on hourly timescales, commonly known as microvariability, is still a widely debated subject in high-energy astrophysics. Several competing ...scenarios have been proposed to explain such occurrences, including various jet plasma instabilities leading to the formation of shocks, magnetic reconnection sites, and turbulence. In this Letter, we present the results of our detailed investigation of a prominent, five-hour-long optical microflare detected during the recent WEBT campaign on 2014 March 2-6 targeting the blazar 0716+714. After separating the flaring component from the underlying base emission continuum of the blazar, we find that the microflare is highly polarized, with the polarization degree ~(40-60)% + or - (2-10)% and the electric vector position angle ~(10-20)degrees + or - (1-8)degrees slightly misaligned with respect to the position angle of the radio jet. The microflare evolution in the (Q,U) Stokes parameter space exhibits a looping behavior with a counterclockwise rotation, meaning the polarization degree decreases with the flux (but is higher in the flux decaying phase), and an approximately stable polarization angle. The overall very high polarization degree of the flare, its symmetric flux rise and decay profiles, and also its structured evolution in the Q-U plane all imply that the observed flux variation corresponds to a single emission region characterized by a highly ordered magnetic field. As discussed in the paper, a small-scale but strong shock propagating within the outflow, and compressing a disordered magnetic field component, provides a natural, though not unique, interpretation of our findings.
Melanopsin-expressing retinal ganglion cells (mRGCs), intrinsically photosensitive RGCs, mediate the light-based pupil response and the light entrainment of the body's circadian rhythms through their ...connection to the pretectal nucleus and hypothalamus, respectively. Increased awareness of circadian rhythm dysfunction in neurological conditions including Alzheimer's disease (AD), has led to a wave of research focusing on the role of mRGCs in these diseases. Postmortem retinal analyses in AD patients demonstrated a significant loss of mRGCs, and in vivo measurements of mRGC function with chromatic pupillometry may be a potential biomarker for early diagnosis and progression of AD.
We performed a prospective case-control study in 20 cognitively healthy study participants: 10 individuals with pre-symptomatic AD pathology (pre-AD), identified by the presence of abnormal levels of amyloid β42 and total Tau proteins in the cerebrospinal fluid, and 10 age-matched controls with normal CSF amyloid β42 and Tau levels. To evaluate mRGC function, we used a standardized protocol of chromatic pupillometry on a Ganzfeld system using red (640 nm) and blue (450 nm) light stimuli and measured the pupillary light response (PLR). Non-invasive wrist actigraphy and standardized sleep questionnaires were also completed to evaluate rest-activity circadian rhythm.
Our results did not demonstrate a significant difference of the PLR between pre-AD and controls but showed a variability of the PLR in the pre-AD group compared with controls on chromatic pupillometry. Wrist actigraphy showed variable sleep-wake patterns and irregular circadian rhythms in the pre-AD group compared with controls.
The variability seen in measurements of mRGC function and sleep-wake cycle in the pre-AD group suggests that mRGC dysfunction occurs in the pre-symptomatic AD stages, preceding cognitive decline. Future longitudinal studies following progression of these participants can help in elucidating the relationship between mRGCs and circadian rhythm dysfunction in AD.
PDF
