Gastric cancer Van Cutsem, Eric, Prof; Sagaert, Xavier, MD; Topal, Baki, Prof ...
The Lancet (British edition),
11/2016, Letnik:
388, Številka:
10060
Journal Article
Recenzirano
Summary Gastric cancer is one of the leading causes of cancer-related death worldwide. Many patients have inoperable disease at diagnosis or have recurrent disease after resection with curative ...intent. Gastric cancer is separated anatomically into true gastric adenocarcinomas and gastro-oesophageal-junction adenocarcinomas, and histologically into diffuse and intestinal types. Gastric cancer should be treated by teams of experts from different disciplines. Surgery is the only curative treatment. For locally advanced disease, adjuvant or neoadjuvant therapy is usually implemented in combination with surgery. In metastatic disease, outcomes are poor, with median survival being around 1 year. Targeted therapies, such as trastuzumab, an antibody against HER2 (also known as ERBB2), and the VEGFR-2 antibody ramucirumab, have been introduced. In this Seminar, we present an update of the causes, classification, diagnosis, and treatment of gastric cancer.
... the concentration of vernix caseosa in amniotic fluid might have a role because difficult labours are associated with higher concentrations of spillage as a result of increased manipulation.4 ...Immunological hypersensitivity to vernix caseosa has been dismissed as a possible mechanism, since most patients are primiparous and have not had enough time to become sensitised;2 nevertheless, the good response to steroids suggests an immunological component in addition to the inflammation.3 It has also been suggested that VCP can be initiated by antenatal or intrapartum leakage of amniotic fluid via reflux through the fallopian tubes, or an unrecognised uterine perforation.5 VCP usually presents in women with low parity. The symptoms, which resemble an acute abdomen, usually start 3 to 35 days after caesarean section.1 It is important to rule out more common causes of acute abdomen -eg, appendicitis, cholecystitis, or intestinal perforation-when VCP is suspected.
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