Heat stress has an enormous economic impact on the global dairy industry, but the mechanisms by which hyperthermia negatively affect systemic physiology and milk synthesis are not clear. Study ...objectives were to evaluate production parameters and metabolic variables in lactating dairy cows during short-term heat stress or pair-fed conditions coupled with bST administration. Twenty-two multiparous Holstein cows were subjected to 3 experimental periods: 1) thermoneutral conditions with ad libitum intake for 7 d (P1); 2) heat stress (HS) with ad libitum intake (n=10) or pair-fed (PF) in thermoneutral conditions (n=12) for 7 d (P2), and 3) 7 d of HS or PF in conditions as described in P2 with recombinant bovine somatotropin administered on d 1 (P3). All cows received an intravenous glucose tolerance test (GTT) on d 5 of each period. Heat stress conditions were cyclical and temperatures ranged from 29.4 to 38.9°C. Rectal temperatures and respiration rates increased during heat stress (38.6–40.4°C and 44–89 breaths/min, respectively). Heat stress reduced dry matter intake by 30% and by design PF cows had similar intake reductions (28%). During heat stress and pair-feeding, milk yield decreased by 27.6% (9.6kg) and 13.9% (4.8kg), respectively, indicating that reduced feed intake accounted for only 50% of the decreased milk production. Milk yield increased with recombinant bovine somatotropin in both HS (9.7%) and PF (16.1%) cows. Cows in both groups were in positive energy balance (3.95 Mcal/d) during P1 but entered negative energy balance during P2 and P3 (−5.65 Mcal/d). Heat stress and pair-feeding treatments decreased (9.3%) basal glucose concentrations. Heat stress conditions had no effect on basal NEFA levels during P2; however, PF cows (despite a similar calculated energy balance) had a 2-fold increase in basal NEFA concentrations. Both groups had increased plasma urea nitrogen levels during P2 and P3 compared with P1. Basal insulin levels increased (37%) during P2 and P3 in HS cows but did not differ between periods in PF cows. During P2 and compared with P1, PF cows had a decreased rate of glucose disposal, whereas HS cows had a similar disposal rate following the GTT. During P2 and compared with P1, PF cows had a reduced insulin response whereas HS cows had a similar insulin response to the GTT. In summary, reduced nutrient intake accounted for only 50% of heat stress-induced decreases in milk yield, and feed intake-independent shifts in postabsorptive glucose and lipid homeostasis may contribute to the additional reduction in milk yield.
We present a new technique for choosing spatial regions for X-ray spectroscopy, called ‘contour binning’. The method chooses regions by following contours on a smoothed image of the object. In ...addition, we re-explore a simple method for adaptively smoothing X-ray images according to the local count rate, we term ‘accumulative smoothing’, which is a generalization of the method used by fadapt. The algorithms are tested by applying them to a simulated cluster data set. We illustrate the techniques by using them on a 50 ks Chandra observation of the Cassiopeia A supernova remnant. Generated maps of the object showing abundances in eight different elements, absorbing column density, temperature, ionization time-scale and velocity are presented. Tests show that contour binning reproduces surface brightness considerably better than other methods. It is particularly suited to objects with detailed spatial structure such as supernova remnants and the cores of galaxy clusters, producing aesthetically pleasing results.
This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the ...prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy, should be performed on a gluten-containing diet. The diagnosis of CD is based on a combination of clinical, serological and histopathological data. In a group of children the diagnosis may be made without biopsy if strict criteria are available. The treatment for CD is primarily a gluten-free diet (GFD), which requires significant patient education, motivation and follow-up. Slow-responsiveness occurs frequently, particularly in those diagnosed in adulthood. Persistent or recurring symptoms necessitate a review of the original diagnosis, exclude alternative diagnoses, confirm dietary adherence (dietary review and serology) and follow-up biopsy. In addition, evaluation to exclude complications of CD, such as refractory CD or lymphoma, should be performed. The guideline also deals with other gluten-related disorders, such as dermatitis herpetiformis, which is a cutaneous manifestation of CD characterized by granular IgA deposits in the dermal papillae. The skin lesions clear with gluten withdrawal. Also, less well-defined conditions such as non-coeliac gluten sensitivity (NCGS) and gluten-sensitive neurological manifestations, such as ataxia, have been addressed. Newer therapeutic modalities for CD are being studied in clinical trials but are not yet approved for use in practice.
We examine the velocity width of cool X-ray emitting material using XMM-Newton Reflection Grating Spectrometer (RGS) spectra of a sample of clusters and group of galaxies and elliptical galaxies. ...Improving on our previous analyses, we apply a spectral model which accounts for broadening due to the spatial extent of the source. With both conventional and Markov Chain Monte Carlo approaches we obtain limits, or in a few cases measurements, of the velocity broadening of the coolest X-ray material. In our sample, we include new observations targeting objects with compact, bright, line-rich cores. One of these, MACS J2229.7−2755, gives a velocity limit of
at the 90 per cent confidence level. Other systems with limits close to
include A 1835, NGC 4261 and NGC 4472. For more than a third of the targets we find limits better than
. HCG 62, NGC 1399 and A 3112 show evidence for
velocity broadening. For a smaller sample of objects, we use continuum-subtracted emission line surface brightness profiles to account for the spatial broadening. Although there are significant systematic errors associated with the technique (
), we find broadening at the level of 280 to
in A 3112, NGC 1399 and NGC 4636.
A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac ...disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating great confusion among health care professionals. The number of individuals embracing a gluten-free diet (GFD) appears much higher than the projected number of celiac disease patients, fueling a global market of gluten-free products approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along with celiac disease, other conditions related to the ingestion of gluten have emerged as health care concerns. This review will summarize our current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.
A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and ...management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterology. Areas of controversies were explored through phone meetings and web surveys. Nine working groups examined the following areas of CD diagnosis and management: classification of CD; genetics and immunology; diagnostics; serology and endoscopy; follow-up; gluten-free diet; refractory CD and malignancies; quality of life; novel treatments; patient support; and screening for CD.
We present the results from extensive, new observations of the Perseus Cluster of galaxies, obtained as a Suzaku Key Project. The 85 pointings analysed span eight azimuthal directions out to 2° = 2.6 ...Mpc, to and beyond the virial radius r
200 ∼ 1.8 Mpc, offering the most detailed X-ray measurements of the intracluster medium (ICM) at large radii in any cluster to date. The azimuthally averaged density profile for r > 0.4r
200 is relatively flat, with a best-fitting power-law index δ = 1.69 ± 0.13, significantly smaller than expected from numerical simulations. The entropy profile in the outskirts lies systematically below the power-law behaviour expected from large-scale structure formation models which include only the heating associated with gravitational collapse. Conversely, the pressure profile beyond ∼0.6r
200 shows an excess with respect to the best-fitting model describing the SZ measurements for a sample of clusters observed with the Planck satellite. The differences between the expected and measured density, entropy and pressure profiles can be explained by a systematic overestimation of the ICM density at large radii caused by homogeneous modelling of inhomogeneous gas distributions (i.e. gas clumping), with the density overestimates ranging from factors of ∼1.2 to 2 or more at r
200 along different directions. We find no evidence for a bias in the temperature measurements within the virial radius. Along the cluster minor axis, we find a flattening of the entropy profiles outside ∼0.6r
200, while along the major axis, the entropy rises all the way to the outskirts.
We make a further study of the very deep Chandra observation of the X‐ray brightest galaxy cluster, A 426 in Perseus. We examine the radial distribution of energy flux inferred by the ...quasi‐concentric ripples in surface brightness, assuming they are due to sound waves, and show that it is a significant fraction of the energy lost by radiative cooling within the inner 75–100 kpc, where the cooling time is 4–5 Gyr, respectively. The wave flux decreases outward with radius, consistent with energy being dissipated. Some newly discovered large ripples beyond 100 kpc, and a possible intact bubble at 170 kpc radius, may indicate a larger level of activity by the nucleus a few 100 Myr ago. The distribution of metals in the intracluster gas peaks at a radius of about 40 kpc and is significantly clumpy on scales of 5 kpc. The temperature distribution of the soft X‐ray filaments and the hard X‐ray emission component found within the inner 50 kpc are analysed in detail. The pressure due to the non‐thermal electrons, responsible for a spectral component interpreted as inverse Compton emission, is high within 40 kpc of the centre and boosts the power in sound waves there; it drops steeply beyond 40 kpc. We find no thermal emission from the radio bubbles; in order for any thermal gas to have a filling factor within the bubbles exceeding 50 per cent, the temperature of that gas has to exceed 50 keV.
We present the first results of our study of a sample of 101 X-ray galaxy groups and clusters, which is volume-limited in each of three X-ray luminosity bins. The aim of this work is to study the ...properties of the innermost ICM in the cores of our groups and clusters, and to determine the effect of non-gravitational processes, such as active galactic nucleus (AGN) feedback, on the ICM. The entropy of the ICM is of special interest, as it bears the imprint of the thermal history of a cluster, and it also determines a cluster's global properties. Entropy profiles can therefore be used to examine any deviations from cluster self-similarity, as well as the effects of feedback on the ICM. We find that the entropy profiles are well-fitted by a simple power-law model, of the form K(r) = α × (r/100 kpc)β, where α and β are constants. We do not find evidence for the existence of an 'entropy floor', i.e. our entropy profiles do not flatten out at small radii, as suggested by some previous studies.
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