In the history of astronomy, major advances in our understanding of the Universe have come from dramatic improvements in our ability to accurately measure astronomical quantities. Aided by rapid ...progress in information technology, current sky surveys are changing the way we view and study the Universe. Next- generation surveys will maintain this revolutionary progress. We focus here on the most ambitious survey currently planned in the visible band, the Large Synoptic Survey Telescope (LSST). LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: constraining dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. It will be a large, wide-field ground-based system designed to obtain multiple images covering the sky that is visible from Cerro Pachon in Northern Chile. The current baseline design, with an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg2 field of view, and a 3,200 Megapixel camera, will allow about 10,000 square degrees of sky to be covered using pairs of 15-second exposures in two photometric bands every three nights on average. The system is designed to yield high image quality, as well as superb astrometric and photometric accuracy. The survey area will include 30,000 deg2 with ? < +34.5? , and will be imaged multiple times in six bands, ugrizy, covering the wavelength range 320-1050 nm. About 90% of the observing time will be devoted to a deep- wide-fast survey mode which will observe a 20,000 deg2 region about 1000 times in the six bands during the anticipated 10 years of operation. These data will result in databases including 10 billion galaxies and a similar number of stars, and will serve the majority of science programs. The remaining 10% of the observing time will be allocated to special programs such as Very Deep and Very Fast time domain surveys. We describe how the LSST science drivers led to these choices of system parameters.
U istoriji astronomije, veliki pomaci u nasem razumevanju Vasione cesto su proizilazili iz dramaticnog napretka u mogucnostima preciznog merenja astronomskih velicina. Zahvaljuju i brzom razvoju informacionih tehnologija, savremeni pregledi neba menjaju nacin na koji posmatramo i proucavamo Vasionu. Pregledi neba sledece generacije nastavice ovim putem revolucionarnog napretka. U ovom radu usredsredjujemo se na najambiciozniji planirani projekat pregleda neba u vidljivom delu spektra, Veliki sinopticki teleskop za pregled neba (skr. LSST, od eng. Large Synoptic Survey Telescope). LSST ce imati jedinstvene mogucnosti pregleda u kratkim vremenskim intervalima. Dizajn LSST odredjuju cetiri primarna naucna zadatka: ogranicavanje na parametre vezane za tamnu energiju i tamnu materiju, pravljenje inventara objekata Suncevog sistema, istrazivace kratkotrajnih pojava na nebu u vidljivom delu spektra i mapiranje Mlecnog puta. Teleskop ce predstavljati veliki, zemaljski, sirokougaoni sistem dizajniran za dobijanje visestrukih snimaka koji bi u potpunosti pokrili nebo vidljivo iz mesta Cerro Pachon u severnom Cileu. Aktuelni osnovni dizajn predvidja primarno ogledalo precnika 8.4 m (efektivno 6.5 m), vidno polje od 9.6 kvadratnih stepeni i kameru sa 3200 megapiksela, sto ce omoguciti da se u dve ekspozicije od po 15 sekundi, u dva fotometrijska filtera, za tri noci u proseku, pokrije ukupno 10 000 kvadratnih stepeni neba. Sistem je dizajniran tako da obezbedi visok kvalitet snimaka, kao i izuzetnu astrometrijsku i fotometrijsku tacnost. Pregled ce pokriti ukupnu povrsinu od 30 000 kvadratnih stepeni, u oblasti deklinacija ? < +34.5? , snimaju i vise puta u sest filtera, ugrizy, koji pokrivaju oblasti talasnih duzina od 320-1050 nm. Oko 90% posmatrackog vremena bice iskorisceno za rad u tzv. dubokom-sirokom-brzom modu, pri cemu ce se, tokom predvidjenih 10 godina rada teleskopa, otprilike 1000 puta u sest filtera posmatrati oblast od 20 000 kvadratnih stepeni. Prikupljeni podaci ce biti pohranjeni u bazu koja ce ukljucivati oko 10 milijardi galaksija i priblizno isti broj zvezda, i koja ce sluziti vecini naucnih programa. Preostalih 10% posmatrackog vremena predvidjeno je za posebne programe kao sto su Vrlo Duboki i Vrlo Brzi pregledi. Ovde opisujemo kako se od naucnih zadataka programa LSST doslo do ovih izbora parametara sistema.
Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidrug ...resistant bacteria, especially Gram-negative bacteria for which the situation is particularly critical. Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a promising strategy able to considerably increase the efficacy of drugs. Such a Trojan horse strategy can also extend activity of specific Gram-positive antibiotics to Gram-negative bacteria.
In the management of gastric outlet obstruction (GOO), EUS-guided gastroenterostomy (EUS-GE) seems to be safe and more effective than enteral stent placement. However, comparisons with laparoscopic ...GE (L-GE) are scarce. Our aim was to perform a propensity score–matched comparison between EUS-GE and L-GE.
An international, multicenter, retrospective analysis was performed of consecutive EUS-GE and L-GE procedures in 3 academic centers (January 2015 to May 2020) using propensity score matching to minimize selection bias. A standard maximum propensity score difference of .1 was applied, also considering underlying disease and oncologic staging.
Overall, 77 patients were treated with EUS-GE and 48 patients with L-GE. By means of propensity score matching, 37 patients were allocated to both groups, resulting in 74 (1:1) matched patients. Technical success was achieved in 35 of 37 EUS-GE–treated patients (94.6%) versus 100% in the L-GE group (P = .493). Clinical success, defined as eating without vomiting or GOO Scoring System ≥2, was achieved in 97.1% and 89.2%, respectively (P = .358). Median time to oral intake (1 interquartile range {IQR}, .3-1.0 vs 3 IQR, 1.0-5.0 days, P < .001) and median hospital stay (4 IQR, 2-8 vs 8 IQR, 5.5-20 days, P < .001) were significantly shorter in the EUS-GE group. Overall (2.7% vs 27.0%, P = .007) and severe (.0% vs 16.2%, P = .025) adverse events were identified more frequently in the L-GE group.
For patients with GOO, EUS-GE and L-GE showed almost identical technical and clinical success. However, reduced time to oral intake, shorter median hospital stay, and lower rate of adverse events suggest that the EUS-guided approach might be preferable.
The COVID-19 pandemic has disproportionately affected persons in long-term care, who often experience health disparities. To delineate the COVID-19 disease burden among persons with intellectual ...disabilities, we prospectively collected data from 36 care facilities for 3 pandemic waves during March 2020-May 2021. We included outcomes for 2,586 clients with PCR-confirmed SARS-CoV-2 infection, among whom 161 had severe illness and 99 died. During the first 2 pandemic waves, infection among persons with intellectual disabilities reflected patterns observed in the general population, but case-fatality rates for persons with intellectual disabilities were 3.5 times higher and were elevated among those >40 years of age. Severe outcomes were associated with older age, having Down syndrome, and having >1 concurrent condition. Our study highlights the disproportionate COVID-19 disease burden among persons with intellectual disabilities and the need for disability-inclusive research and policymaking to inform disease surveillance and public health policies for this population.
Bacteria use small molecules called siderophores to scavenge iron. Siderophore-Fe
complexes are recognised by outer-membrane transporters and imported into the periplasm in a process dependent on the ...inner-membrane protein TonB. The siderophore enterobactin is secreted by members of the family Enterobacteriaceae, but many other bacteria including Pseudomonas species can use it. Here, we show that the Pseudomonas transporter PfeA recognises enterobactin using extracellular loops distant from the pore. The relevance of this site is supported by in vivo and in vitro analyses. We suggest there is a second binding site deeper inside the structure and propose that correlated changes in hydrogen bonds link binding-induced structural re-arrangements to the structural adjustment of the periplasmic TonB-binding motif.
1: ESGE recommends the use of endoscopic ultrasound-guided biliary drainage (EUS-BD) over percutaneous transhepatic biliary drainage (PTBD) after failed endoscopic retrograde cholangiopancreatography ...(ERCP) in malignant distal biliary obstruction when local expertise is available.Strong recommendation, moderate quality evidence. 2: ESGE suggests EUS-BD with hepaticogastrostomy only for malignant inoperable hilar biliary obstruction with a dilated left hepatic duct when inadequately drained by ERCP and/or PTBD in high volume expert centers.Weak recommendation, moderate quality evidence. 3: ESGE recommends that EUS-guided pancreatic duct (PD) drainage should only be considered in symptomatic patients with an obstructed PD when retrograde endoscopic intervention fails or is not possible.Strong recommendation, low quality evidence. 4: ESGE recommends rendezvous EUS techniques over transmural PD drainage in patients with favorable anatomy owing to its lower rate of adverse events.Strong recommendation, low quality evidence. 5: ESGE recommends that, in patients at high surgical risk, EUS-guided gallbladder drainage (GBD) should be favored over percutaneous gallbladder drainage where both techniques are available, owing to the lower rates of adverse events and need for re-interventions in EUS-GBD.Strong recommendation, high quality of evidence. 6: ESGE recommends EUS-guided gastroenterostomy (EUS-GE), in an expert setting, for malignant gastric outlet obstruction, as an alternative to enteral stenting or surgery.Strong recommendation, low quality evidence. 7: ESGE recommends that EUS-GE may be considered in the management of afferent loop syndrome, especially in the setting of malignancy or in poor surgical candidates. Strong recommendation, low quality evidence. 8: ESGE suggests that endoscopic ultrasound-directed transgastric ERCP (EDGE) can be offered, in expert centers, to patients with a Roux-en-Y gastric bypass following multidisciplinary decision-making, with the aim of overcoming the invasiveness of laparoscopy-assisted ERCP and the limitations of enteroscopy-assisted ERCP.Weak recommendation, low quality evidence.
The purpose of this systematic review of 107 papers is to address the conceptual confusion about what inclusive leadership (IL) behavior entails and understand the theoretical development of IL. ...Synthesizing the divergent conceptualizations of inclusive leader behaviors, we propose a multi-level (i.e., employee, team, organizational) model of IL behavior consisting of four dimensions namely, fostering employee's uniqueness (e.g., promoting diversity); strengthening belongingness within a team (e.g., building relationships); showing appreciation (e.g., recognizing efforts and contributions); and supporting organizational efforts (e.g., promoting organizational mission on inclusion). Further, we provide a summary of studied variables as a nomological network in relation to inclusive leadership and an overview of the different theories (e.g., social exchange, intrinsic motivation) supporting the respective relationships and explaining the underlying mechanisms (e.g., reciprocity, motivation). We propose future research to empirically test the multi-level model of IL and examine the predictive value in terms of employee and organizational outcomes.
•Systematic review of 107 academic articles on inclusive leadership•Inclusive leadership goes beyond fostering uniqueness and strengthening belongingness•Inclusive leadership is a multi-level concept (i.e., employee, team, organizational)•More focus on antecedents of inclusive leadership is needed to understand how to facilitate inclusive leadership•Multiple theoretical lenses should be considered in concert to understand inclusive leadership thoroughly
Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we ...developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of α-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products.
► Engineering of the yeast central carbon metabolism to develop a platform cell factory. ► More efficient provision of the precursor metabolite acetyl-CoA. ► The platform cell factory can be used for improving α-santalene production by four-fold.
Background
Concerns have been raised about access to cancer screening and the timely receipt of cancer care for people with an intellectual disability (ID). However, knowledge about cancer mortality ...as a potential consequence of these disparities is still limited. This study, therefore, compared cancer‐related mortality patterns between people with and without ID.
Methods
A historical cohort study (2015‐2019) linked the Dutch adult population (approximately 12 million people with an ID prevalence of 1.45%) and mortality registries. Cancer‐related mortality was identified by the underlying cause of death (according to the chapter on neoplasms in the International Classification of Diseases, Tenth Revision). Observed mortality and calculated age‐ and sex‐standardized mortality ratios (SMRs) with 95% confidence intervals (CIs) were reported.
Results
There were 11,102 deaths in the ID population (21.7% cancer‐related; n = 2408) and 730,405 deaths in the general population (31.2%; n = 228,120) available for analysis. Cancer was noted as the cause of death more often among people with ID in comparison with the general population (SMR, 1.48; 95% CI, 1.42‐1.54), particularly in the young age groups. High‐mortality cancers included cancers within the national screening program (SMRs, 1.43‐1.94), digestive cancers (SMRs, 1.24‐2.56), bladder cancer (SMR, 2.07; 95% CI, 1.61‐2.54), and cancers of unknown primary (SMR, 2.48; 95% CI, 2.06‐2.89).
Conclusions
Cancer was reported as the cause of death approximately 1.5 times more often in people with ID compared with the general population. This mortality disparity may indicate adverse effects from inequalities in screening and cancer care experienced by people with ID.
Lay Summary
People with an intellectual disability (ID) may find it challenging to participate in cancer screening or to receive timely cancer care.
To understand potential consequences in terms of mortality, this study compared cancer‐related mortality between people with and without ID in the Netherlands.
Cancer was reported as the cause of death approximately 1.5 times more often among people with ID than others.
Because large differences were found that were related to screening cancers and cancers for which the primary tumor was unknown, this study's results raise concerns about equality in screening practices and cancer care for people with ID.
Cancer is reported as the cause of death approximately 1.5 times more often in people with an intellectual disability compared with those without one. Differences are particularly noted for deaths related to cancers within the national screening program and cancers of unknown primary.
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