A
bstract
The Compact Linear Collider (CLIC) is a proposed future high-luminosity linear electron-positron collider operating at three energy stages, with nominal centre-of-mass energies
s
= 380 GeV, ...1
.
5 TeV, and 3 TeV. Its aim is to explore the energy frontier, providing sensitivity to physics beyond the Standard Model (BSM) and precision measurements of Standard Model processes with an emphasis on Higgs boson and top-quark physics. The opportunities for top-quark physics at CLIC are discussed in this paper. The initial stage of operation focuses on top-quark pair production measurements, as well as the search for rare flavour-changing neutral current (FCNC) top-quark decays. It also includes a top-quark pair production threshold scan around 350 GeV which provides a precise measurement of the top-quark mass in a well-defined theoretical framework. At the higher-energy stages, studies are made of top-quark pairs produced in association with other particles. A study of t
̄
tH production including the extraction of the top Yukawa coupling is presented as well as a study of vector boson fusion (VBF) production, which gives direct access to high-energy electroweak interactions. Operation above 1 TeV leads to more highly collimated jet environments where dedicated methods are used to analyse the jet constituents. These techniques enable studies of the top-quark pair production, and hence the sensitivity to BSM physics, to be extended to higher energies. This paper also includes phenomenological interpretations that may be performed using the results from the extensive top-quark physics programme at CLIC.
The shared HPC cluster NEMO at the University of Freiburg has been made available to local ATLAS users through the provisioning of virtual machines incorporating the ATLAS software environment ...analogously to a WLCG center. This concept allows to run both data analysis and production on the HPC host system which is connected to the existing Tier2/Tier3 infrastructure. Schedulers of the two clusters were integrated in a dynamic, on-demand way. An automatically generated, fully functional virtual machine image provides access to the local user environment. The performance in the virtualized environment is evaluated for typical High-Energy Physics applications.
A 61-year-old woman was admitted with a suspected diagnosis of atypical pneumonia. Extended diagnostic measures revealed interstitial lung disease (ILD), polyserositis, polyarthritis and myopathy. ...With detection of an antibody against PL-7 (anti-threonyl-transfer-RNA synthetase) the diagnosis of anti-synthetase syndrome (ASS) was established. ASS are rare inflammatory myopathies which frequently present as multisystemic diseases with severe organ involvement. An immunosuppressive regimen with steroids and cyclophosphamide led to successful induction of disease remission. Maintenance therapy will be conducted with azathioprine. ASS should always be considered in the differential diagnosis of myopathies and ILDs.
Zusammenfassung
Eine 61-jährige Patientin wurde mit Verdacht auf eine atypische Pneumonie eingewiesen. Die weiterführende Diagnostik zeigte eine interstitielle Lungenerkrankung (ILD), Polyserositis, ...Polyarthritis sowie Myopathie. Durch Nachweis eines Anti-Threonyl-Transfer-RNA-Synthetase(PL-7)-Antikörpers konnte die Diagnose eines Antisynthetasesyndroms (ASS) gestellt werden. ASS sind seltene autoimmune Myopathien, die sich häufig als Multisystemerkrankung mit schwerer Beteiligung innerer Organe präsentieren. Unter einer Therapie mit Steroiden und Cyclophosphamid kam es zu einer erfolgreichen Remissionsinduktion. Eine Erhaltungstherapie mit Azathioprin ist geplant. ASS sollten in der Differenzialdiagnose von myopathischen Beschwerden und ILD stets bedacht werden.
The potential for detecting DM at the Compact Linear Collider (CLIC) is
investigated at \mbox{$\sqrt{s}=$ 3 TeV}. The sensitivity of the search is
estimated by computing the 95\% confidence level ...upper limit cross section as a
function of the dark matter mass. Left-handed (right-handed) polarised \Pem
beams increase (decrease) respectively the Standard Model backgrounds and are
essential to characterize the WIMPs properties and control the systematic
errors. Using right-handed polarised \Pem beams is decreasing significantly the
95\% confidence level cross section. Using the ratio of the energy
distributions for left-handed and right-handed polarised \Pem beams, systematic
errors cancel out. Computing the 95\% confidence level upper limit cross
section using the ratio requires a model assumption to compute the expected
number of signal events. Exclusion limits for dark matter are derived using
dark matter Simplified Models for two values of the e-e-mediator vertex
coupling, a mediator width of 10 GeV and for a fixed value of the
mediator-DM-DM coupling. For a mediator mass of 3.5 TeV, the measurement of the
differential distribution of the significance as a function of the photon
energy for the process \mbox{\Pem \Pep $\to$ X X \PGg} allows the
discrimination between different dark matter mediators and the measurement of
the WIMP mass to nearly half the centre-of-mass energy. For a \mbox{1 TeV}
WIMP, the mass is determined with a 1\% accuracy.
The Compact Linear Collider, CLIC, is a proposed e\(^+\)e\(^-\) collider at the TeV scale whose physics potential ranges from high-precision measurements to extensive direct sensitivity to physics ...beyond the Standard Model. This document summarises the physics potential of CLIC, obtained in detailed studies, many based on full simulation of the CLIC detector. CLIC covers one order of magnitude of centre-of-mass energies from 350 GeV to 3 TeV, giving access to large event samples for a variety of SM processes, many of them for the first time in e\(^+\)e\(^-\) collisions or for the first time at all. The high collision energy combined with the large luminosity and clean environment of the e\(^+\)e\(^-\) collisions enables the measurement of the properties of Standard Model particles, such as the Higgs boson and the top quark, with unparalleled precision. CLIC might also discover indirect effects of very heavy new physics by probing the parameters of the Standard Model Effective Field Theory with an unprecedented level of precision. The direct and indirect reach of CLIC to physics beyond the Standard Model significantly exceeds that of the HL-LHC. This includes new particles detected in challenging non-standard signatures. With this physics programme, CLIC will decisively advance our knowledge relating to the open questions of particle physics.
Early reperfusion treatment in acute myocardial infarction (AMI) preserves ventricular function and saves lives. After onset of AMI symptoms, patients often delay for hours until the decision to seek ...medical help.
Of the MI-heart (Myocardial Infarction--HElp seeking And ReacTions) study was to identify factors determining patient decision delay.
739 consecutive patients with confirmed AMI (median age 65.3 years, 30.2% females) were studied after transfer from the intensive care unit. A standardized interview covered AMI symptoms, attitudes toward symptoms, coping strategies, and clinical and sociodemographic variables.
Of patients, 93.3% knew an AMI could be deadly. 43.9% of the patients who suspected an AMI, and knew it could be deadly, decided late (> 1 hour) to seek medical help. In univariate analyses, attitudes toward symptoms and coping strategies had the highest impact on a late decision. Stepwise logistic regression identified the following independent contributors to a late decision to seek medical help (relative risk, 95% confidence interval): wanting to wait and see (3.53; 2.32-5.39), not taking symptoms seriously (2.47; 1.64-3.72), not wanting to bother anybody (2.14; 1.29-3.57), symptoms improving at first (2.33; 1.52-3.56), asking others for advice (0.46; 0.30-0.71), taking pain medication (2.01; 1.01-4.03), age > 65 years (1.69; 1.17-2.44), very strong intensity of angina (0.60; 0.42-0.87).
Emotional attitudes to AMI symptoms and inadequate coping strategies are the major determinants of patient decision delay. They should be considered as a key factor in patient and public education. Modification of these emotional factors might best be achieved by an individualized approach.
The potential for detecting DM at the Compact Linear Collider (CLIC) is investigated at \mbox{\(\sqrt{s}=\) 3 TeV}. The sensitivity of the search is estimated by computing the 95\% confidence level ...upper limit cross section as a function of the dark matter mass. Left-handed (right-handed) polarised \Pem beams increase (decrease) respectively the Standard Model backgrounds and are essential to characterize the WIMPs properties and control the systematic errors. Using right-handed polarised \Pem beams is decreasing significantly the 95\% confidence level cross section. Using the ratio of the energy distributions for left-handed and right-handed polarised \Pem beams, systematic errors cancel out. Computing the 95\% confidence level upper limit cross section using the ratio requires a model assumption to compute the expected number of signal events. Exclusion limits for dark matter are derived using dark matter Simplified Models for two values of the e-e-mediator vertex coupling, a mediator width of 10 GeV and for a fixed value of the mediator-DM-DM coupling. For a mediator mass of 3.5 TeV, the measurement of the differential distribution of the significance as a function of the photon energy for the process \mbox{\Pem \Pep \(\to\) X X \PGg} allows the discrimination between different dark matter mediators and the measurement of the WIMP mass to nearly half the centre-of-mass energy. For a \mbox{1 TeV} WIMP, the mass is determined with a 1\% accuracy.
A case is made for growth of a new metadiscipline of sustainability science and engineering. This new field integrates industrial, social, and environmental processes in a global context. The skills ...required for this higher level discipline represent a metadisciplinary endeavor, combining information and insights across multiple disciplines and perspectives with the common goal of achieving a desired balance among economic, environmental, and societal objectives. Skills and capabilities that are required to support the new metadiscipline are summarized. Examples of integrative projects are discussed in the areas of sustainability metrics and integration of industrial, societal, and environmental impacts. It is clear that a focus on green engineering that employs pollution prevention and industrial ecology alone are not sufficient to achieve sustainability, because even systems with efficient material and energy use can overwhelm the carrying capacity of a region or lead to other socially unacceptable outcomes. To meet the educational and human resource needs required for this new discipline, the technological and environmental awareness of society must be elevated and a sufficient and diverse pool of human talent must be attracted to this discipline.
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