Interaction between the solar wind and objects in the solar system varies largely according to the settings, such as the existence of a global intrinsic magnetic field and/or thick atmosphere. The ...Moon's case is characterized by the absence of both of them. Low energy ion measurements on the lunar orbit is realized more than 30 years after the Apollo period by low energy charged particle analyzers MAP‐PACE on board SELENE(KAGUYA). MAP‐PACE ion sensors have found that 0.1%∼1% of the solar wind protons are reflected back from the Moon instead of being absorbed by the lunar surface. Some of the reflected ions are accelerated above solar wind energy as they are picked‐up by the solar wind convection electric field. The proton reflection that we have newly discovered around the Moon should be a universal process that characterizes the environment of an airless body.
Tongue squamous cell carcinoma (TSCC) is highly diverse, even in its early stages. This cancer is classified into three subtypes (superficial, exophytic, and endophytic) based on macroscopic ...appearance. Of these subtypes, the endophytic tumours have the worst prognosis because of their invasiveness and higher frequency of metastasis.
To understand the molecular mechanism underlying the endophytic subtype and to identify biomarkers, we performed a comprehensive gene expression microarray analysis of clinical biopsy samples and also confirmed the clinical relevance of differential gene expression.
Expression of the parvin-beta (PARVB) gene and its encoded protein was significantly upregulated in endophytic-type TSCC. PARVB is known to play a critical role in actin reorganization and focal adhesions. Knockdown of PARVB expression in vitro caused apparent decreases in cell migration and wound healing, implying that PARVB has a crucial role in cell motility. Moreover, metastasis-free survival was significantly lower in patients with higher tumour expression of PARVB.
These findings suggest that PARVB overexpression is a candidate biomarker for endophytic tumours and metastasis. This protein may be a clinically useful target for adjuvant TSCC therapy.
We report the clinical outcome and findings at second-look arthroscopy of 216 patients (mean age 25 years (11 to 58)) who underwent anterior cruciate ligament (ACL) reconstruction or augmentation. ...There were 73 single-bundle ACL augmentations (44 female, 29 male), 82 double-bundle ACL reconstructions (35 female, 47 male), and 61 single-bundle ACL reconstructions (34 female, 27 male). In 94 of the 216 patients, proprioceptive function of the knee was evaluated before and 12 months after surgery using the threshold to detect passive motion test. Second-look arthroscopy showed significantly better synovial coverage of the graft in the augmentation group (good: 60 (82%), fair: 10 (14%), poor: 3 (4%)) than in the other groups (p = 0.039). The mean side-to-side difference measured with a KT-2000 arthrometer was 0.4 mm (-3.3 to 2.9) in the augmentation group, 0.9 mm (-3.2 to 3.5) in the double-bundle group, and 1.3 mm (-2.7 to 3.9) in the single-bundle group: the result differed significantly between the augmentation and single-bundle groups (p = 0 .013). No significant difference in the Lysholm score or pivot-shift test was seen between the three groups (p = 0.09 and 0.65, respectively). In patients with good synovial coverage, three of the four measurements used revealed significant improvement in proprioceptive function (p = 0.177, 0.020, 0.034, and 0.026). We conclude that ACL augmentation is a reasonable treatment option for patients with favourable ACL remnants.
Objective. miRNAs, which are non-coding RNAs, play a role in the pathogenesis of disease including OA. miRNA (miR)-34a is induced by p53, subsequently leading to cell apoptosis, which is one of the ...major factors in the pathogenesis of OA. The purpose of this study is to investigate the effect of silencing miR-34a on IL-1β-induced chondrocyte apoptosis in a rat OA model in vitro. Methods. Locked nucleotide analogue (LNA)-modified miR-34a-specific anti-sense was transfected into rat chondrocyte monolayer culture. After that, IL-1β was added to the chondrocytes to create an OA model in vitro. The effect of silencing miR-34a on the prevention of chondrocyte apoptosis was analysed by assessment of the expression levels of Col2a1 and iNOS, also through assessment of cell viability and TUNEL staining. Results. The expression of miR-34a was significantly up-regulated by IL-1β. Silencing of miR-34a significantly prevented IL-1β-induced down-regulation of Col2a1, as well as IL-1β-induced up-regulation of iNOS. Finally, MiR-34a inhibitor could also reduce TUNEL-positive cells. Conclusion. Silencing of miR-34a by LNA-modified anti-sense could effectively reduce rat chondrocyte apoptosis induced by IL-1β. This present study revealed that silencing of miR-34a might develop a novel intervention for OA treatment through the prevention of cartilage degradation.
Highlights ► Thrombin activates MAPK and primary-cultured rat microglia. ► Sesamin suppresses the activation of p44/42 MAPK and cultured microglia. ► Hemorrhagic neuron injury is involved in ...activated p44/42 MAPK and microglia. ► Sesamin suppresses the activation of p44/42 MAPK and microglia in vivo . ► Sesamin confers neuroprotection.
The fluxgate magnetometer MGF on board the Mio spacecraft of the BepiColombo mission is introduced with its science targets, instrument design, calibration report, and scientific expectations. The ...MGF instrument consists of two tri-axial fluxgate magnetometers. Both sensors are mounted on a 4.8-m long mast to measure the magnetic field around Mercury at distances from near surface (initial peri-center altitude is 590 km) to 6 planetary radii (11640 km). The two sensors of MGF are operated in a fully redundant way, each with its own electronics, data processing and power supply units. The MGF instrument samples the magnetic field at a rate of up to 128 Hz to reveal rapidly-evolving magnetospheric dynamics, among them magnetic reconnection causing substorm-like disturbances, field-aligned currents, and ultra-low-frequency waves. The high time resolution of MGF is also helpful to study solar wind processes (through measurements of the interplanetary magnetic field) in the inner heliosphere. The MGF instrument firmly corroborates measurements of its companion, the MPO magnetometer, by performing multi-point observations to determine the planetary internal field at higher multi-pole orders and to separate temporal fluctuations from spatial variations.
The result of curative treatment for very elderly patients with tongue carcinoma has not been reported to date. We retrospectively reviewed the results of brachytherapy in 125 the patients aged over ...75 years.
The results of brachytherapy in 125 patients, 75 years old or older, with Stage I or II squamous cell carcinoma of the oral tongue were reviewed. The 125 cases consisted of 31 Stage I and 94 Stage II cases; 67 patients were under 80 years old and 58 were over 80 years old. All patients were treated using low-dose-rate brachytherapy ((198)Au/(222)Rn: 59 cases; (192)Ir: 38 cases; (226)Ra/(137)Cs: 28 cases).
None of the patients stopped treatment during the course of brachytherapy. The 3 year and 5 year control rates of the primary lesions were both 86%. Post-brachytherapy neck node metastasis was diagnosed in 43 cases and radical neck dissection was performed for 24 cases (21 of the 24 cases were under 80 years old). As a result, the 7 year disease-specific survival (DSS) rate for patients aged under 80 years old was 70% and 41% for those over 80 years old (p = 0.03).
The brachytherapy for elderly patients with tongue cancer was safe, and the control of the primary lesion was almost the same as in younger patients. However, modalities available to treat neck node metastasis are limited. More conservative surgical approaches combined with post-operative irradiation may be advocated for neck node metastasis for elderly patients with tongue cancer.
It is known that the Hawaiian 1960 lava sometimes yields higher palaeointensities than the IGRF (36.2 μT). In order to clarify the causes, we have performed a comprehensive investigation of ...palaeointensity measurements on 19 cores from the lava. According to various rock magnetic analyses, they are classified into three groups with degrees of the deuteric oxidation. In Coe's version of the Thellier method, a significantly larger mean palaeointensity of 49.0 ± 9.6 μT (N= 17) was observed similar to previous studies. These palaeointensities showed a dependence on the oxidation indices, which can be explained by thermochemical remanent magnetization (TCRM) acquisition during the natural cooling stage of the lava. Although it is generally difficult to distinguish the TCRM from thermoremanent magnetization (TRM), a low-temperature demagnetization (LTD) treatment on NRM and TRM in the Thellier experiment seems to allow us to detect the influence of the TCRM on NRM. Another possible tool for TCRM detection is the double-heating technique (DHT) of the Shaw method combined with LTD (LTD–DHT Shaw method). It gave a better average of 39.4 ± 7.9 μT (N= 9), though the success rate was much lower. Most of the inappropriate results were screened by a combination of the double-heating test, the ARM correction and the LTD treatment. If two outliers are further excluded, the average is improved to be 35.7 ± 3.3 μT (N= 7), which agrees well with the expected intensity. The results of both methods emphasize the importance of taking and measuring samples from the parts of various oxidation degrees in a lava flow.
The SHiP-charm project was proposed to measure the associated charm production induced by 400 GeV/c protons in a thick target, including the contribution from cascade production. An optimisation run ...was performed in July 2018 at CERN SPS using a hybrid setup. The high resolution of nuclear emulsions acting as vertex detector was complemented by electronic detectors for kinematic measurements and muon identification. Here we present first results on the analysis of nuclear emulsions exposed in the 2018 run, which prove the capability of reconstructing proton interaction vertices in a harsh environment, where the signal is largely dominated by secondary particles produced in hadronic and electromagnetic showers within the lead target.
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