Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse origins. This critical review offers a compilation on the main ...results achieved by the use of ionic-liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid-liquid extractions, IL-based liquid-liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to the field are discussed, with particular emphasis on the major lacunas found within the IL community dedicated to separation processes and by suggesting some steps to overcome the current limitations.
Plastic pollution is generated by the unsustainable use and disposal of plastic products in modern society, threatening economies, ecosystems, and human health. Current clean-up strategies have ...attempted to mitigate the negative effects of plastic pollution but are unable to compete with increasing quantities of plastic entering the environment. Thus, reducing inputs of plastic to the environment must be prioritized through a global multidisciplinary approach. Mismanaged waste is a major land-based source of plastic pollution that can be reduced through improvements in the life-cycle of plastics, especially in production, consumption, and disposal, through an Integrated Waste Management System. In this review paper, we discuss current practices to improve life cycle and waste management of plastics that can be implemented to reduce health and environmental impacts of plastics and reduce plastics pollution. Ten recommendations for stakeholders to reduce plastic pollution include (1) regulation of production and consumption; (2) eco-design; (3) increasing the demand for recycled plastics; (4) reducing the use of plastics; (5) use of renewable energy for recycling; (6) extended producer responsibility over waste; (7) improvements in waste collection systems; (8) prioritization of recycling; (9) use of bio-based and biodegradable plastics; and (10) improvement in recyclability of e-waste.
Microplastics can be present in the environment as manufactured microplastics (known as primary microplastics) or resulting from the continuous weathering of plastic litter, which yields ...progressively smaller plastic fragments (known as secondary microplastics). Herein, we discuss the numerous issues associated with the analysis of microplastics, and to a less extent of nanoplastics, in environmental samples (water, sediments, and biological tissues), from their sampling and sample handling to their identification and quantification. The analytical quality control and quality assurance associated with the validation of analytical methods and use of reference materials for the quantification of microplastics are also discussed, as well as the current challenges within this field of research and possible routes to overcome such limitations.
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•Microplastics have been identified as environmental pollutants.•The sampling, sample handling, identification and quantification of microplastics were discussed.•The validation of analytical methods and use of reference materials for the microplastics quantification were highlighted.•The current challenges in these issues are identified.
The basis invariant flavor puzzle Bento, Miguel P.; Silva, João P.; Trautner, Andreas
The journal of high energy physics,
01/2024, Letnik:
2024, Številka:
1
Journal Article
Recenzirano
Odprti dostop
A
bstract
The flavor puzzle of the Standard Model quark sector is formulated in a non-perturbative way, using basis invariants that are independent of the choice of quark field basis. To achieve ...this, we first derive the algebraic ring of 10 CP even (primary) and 1 CP odd (secondary) basis invariants, using the Hilbert series and plethystic logarithm. An orthogonal basis in the ring of basis invariants is explicitly constructed, using hermitian projection operators derived via birdtrack diagrams. The thereby constructed invariants have well defined CP transformation behavior and give the most direct access to the flavor symmetric alignments of basis covariants. We firstly “measure” the orthogonal basis invariants from experimental data and characterize their location in the available parameter space. The experimentally observed orthogonal basis invariants take very close to maximal values and are highly correlated. Explaining the location of the invariants at close to maximal points, including the associated miniscule and highly correlated deviations, corresponds to solving the flavor puzzle in the invariant language. Once properly normalized, the orthogonal basis invariants are close to scale (RGE) invariant, hence, provide exquisite targets for fits of both, low- and high-scale (bottom-up and top-down) flavor models. Our result provides an entirely new angle on the flavor puzzle, and opens up ample opportunities for its ultimate exploration.
Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, has recently joined HIV/AIDS as the world's deadliest infectious disease, affecting around 9.6 million people ...worldwide in 2014. Of those, about 1.2 million died from the disease. Resistance acquisition to existing antibiotics, with the subsequent emergence of Multi-Drug Resistant mycobacteria strains, together with an increasing economic burden, has urged the development of new anti-TB drugs. In this scope, antimicrobial peptides (AMPs), which are small, cationic and amphipathic peptides that make part of the innate immune system, now arise as promising candidates for TB treatment. In this review, we analyze the potential of AMPs for this application. We address the mechanisms of action, advantages and disadvantages over conventional antibiotics and how problems associated with its use may be overcome to boost their therapeutic potential. Additionally, we address the challenges of translational development from benchside to bedside, evaluate the current development pipeline and analyze the expected global impact from a socio-economic standpoint. The quest for more efficient and more compliant anti-TB drugs, associated with the great therapeutic potential of emerging AMPs and the rising peptide market, provide an optimal environment for the emergence of AMPs as promising therapies. Still, their pharmacological properties need to be enhanced and manufacturing-associated issues need to be addressed.
•H2 and CH4 production was assessed in a two-stage acidogenesis-methanogenesis system.•Addition of glycerol to food waste and sewage sludge increased H2 and CH4 yields.•Stable H2 and CH4 production ...and higher energy yield were obtained at 1% glycerol.•The use of 3% glycerol led to process instabilities in the methanogenic phase.•Co-digestion of food waste, sewage sludge and glycerol maximizes energy production.
In this study, hydrogen and methane production from co-digestion of food waste (FW), sewage sludge (SS) and raw glycerol (GL) was evaluated in a two-stage acidogenesis-methanogenesis anaerobic system under mesophilic conditions (35 °C). The effect of glycerol addition (1 and 3% v/v) as co-substrate was assessed in ternary mixtures (FW + SS + GL), with the concentration of all substrates kept at 10 g VS/L. Besides contributing to reduce the lag phase of the acidogenic bacterial culture, the presence of GL increased the hydrogen production in all tested conditions and the maximum hydrogen yield was obtained for the FW + SS + 3%GL mixture (179.3 mL H2/g VS). On the other hand, the highest methane production (342 mL CH4/g VS) was achieved in the test supplemented with 1% GL. At 3% GL, abrupt reductions in the biogas CH4 content and pH values resulting from instability in methanogenesis process were noticed over the experiment. By taking into account the hydrogen and methane production stages, the highest energy yield (i.e., 15.5 kJ/g VS) was obtained with the ternary mixture containing 1% GL. Overall, the results of this study demonstrate the feasibility of using glycerol as co-substrate to increase the H2 and CH4 production efficiency in a two-stage anaerobic co-digestion process, allowing simultaneous treatment of three residues (FW, SS and GL) and energy production.
Adenosine A2A receptors (A2AR) overfunction causes synaptic and memory dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ1-42)-based model of early AD, we now unraveled that this ...involves an increased synaptic release of ATP coupled to an increased density and activity of ecto-5′-nucleotidase (CD73)-mediated formation of adenosine selectively activating A2AR. Thus, CD73 inhibition with α,β-methylene-ADP impaired long-term potentiation (LTP) in mouse hippocampal slices, which is occluded upon previous superfusion with the A2AR antagonist SCH58261. Furthermore, α,β-methylene-ADP did not alter LTP amplitude in global A2AR knockout (KO) and in forebrain neuron-selective A2AR-KO mice, but inhibited LTP amplitude in astrocyte-selective A2AR-KO mice; this shows that CD73-derived adenosine solely acts on neuronal A2AR. In agreement with the concept that ATP is a danger signal in the brain, ATP release from nerve terminals is increased after intracerebroventricular Aβ1-42 administration, together with CD73 and A2AR upregulation in hippocampal synapses. Importantly, this increased CD73 activity is critically required for Aβ1-42 to impair synaptic plasticity and memory since Aβ1-42-induced synaptic and memory deficits were eliminated in CD73-KO mice. These observations establish a key regulatory role of CD73 activity over neuronal A2AR and imply CD73 as a novel target for modulation of early AD.
•A2AR-mediated control of LTP requires CD73-mediated catabolism into adenosine.•β-amyloid caused synaptic and memory dysfunction involving CD73/A2AR upregulation.•A2AR overfunction needs increased ATP release and CD73-convertion to adenosine.•CD73 is a key controller of A2AR and a novel target to interfere with AD.
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