Abstract
Bolometric luminosities and Eddington ratios of both X-ray selected broad-line (Type-1) and narrow-line (Type-2) active galactic nuclei (AGN) from the XMM-Newton survey in the Cosmic ...Evolution Survey field are presented. The sample is composed of 929 AGN (382 Type-1 AGN and 547 Type-2 AGN) and it covers a wide range of redshifts, X-ray luminosities and absorbing column densities. About 65 per cent of the sources are spectroscopically identified as either Type-1 or Type-2 AGN (83 and 52 per cent, respectively), while accurate photometric redshifts are available for the rest of the sample. The study of such a large sample of X-ray selected AGN with a high-quality multiwavelength coverage from the far-infrared (now with the inclusion of Herschel data at 100 and 160 μm) to the optical-ultraviolet allows us to obtain accurate estimates of bolometric luminosities, bolometric corrections and Eddington ratios. The k
bol - L
bol relations derived in this work are calibrated for the first time against a sizable AGN sample, and rely on observed redshifts, X-ray luminosities and column density distributions. We find that k
bol is significantly lower at high L
bol with respect to previous estimates by Marconi et al. and Hopkins et al. Black hole (BH) masses and Eddington ratios are available for 170 Type-1 AGN, while BH masses for Type-2 AGN are computed for 481 objects using the BH mass-stellar mass relation and the morphological information. We confirm a trend between k
bol and λEdd, with lower hard X-ray bolometric corrections at lower Eddington ratios for both Type-1 and Type-2 AGN. We find that, on average, the Eddington ratio increases with redshift for all types of AGN at any given M
BH, while no clear evolution with redshift is seen at any given L
bol.
To search for a transmissible agent involved in lupus pathogenesis, we investigated the faecal microbiota of patients with systemic lupus erythematosus (SLE) for candidate pathobiont(s) and evaluated ...them for special relationships with host immunity.
In a cross-sectional discovery cohort, matched blood and faecal samples from 61 female patients with SLE were obtained. Faecal 16 S rRNA analyses were performed, and sera profiled for antibacterial and autoantibody responses, with findings validated in two independent lupus cohorts.
Compared with controls, the microbiome in patients with SLE showed decreased species richness diversity, with reductions in taxonomic complexity most pronounced in those with high SLE disease activity index (SLEDAI). Notably, patients with SLE had an overall 5-fold greater representation of
(
) of the
family, and individual communities also displayed reciprocal contractions of a species with putative protective properties. Gut
abundance correlated with serum antibodies to only 1/8
strains tested. Anti-RG antibodies correlated directly with SLEDAI score and antinative DNA levels, but inversely with C3 and C4. These antibodies were primarily against antigen(s) in an
strain-restricted pool of cell wall lipoglycans. Novel structural features of these purified lipoglycans were characterised by mass spectrometry and NMR. Highest levels of serum anti-
strain-restricted antibodies were detected in those with active nephritis (including Class III and IV) in the discovery cohort, with findings validated in two independent cohorts.
These findings suggest a novel paradigm in which specific strains of a gut commensal may contribute to the immune pathogenesis of lupus nephritis.
Using a compilation of 25 studies from the literature, we investigate the evolution of the star-forming galaxy (SFG) main sequence (MS) in stellar mass and star formation rate (SFR) out to z ~ 6. ...After converting all observations to a common set of calibrations, we find a remarkable consensus among MS observations (~0.1 dex 1sigma interpublication scatter). By fitting for time evolution of the MS in bins of constant mass, we deconvolve the observed scatter about the MS within each observed redshift bin. After accounting for observed scatter between different SFR indicators, we find the width of the MS distribution is ~0.2 dex and remains constant over cosmic time. Our best fits indicate the slope of the MS is likely time-dependent, with our best-fit log SFR(Mlow *,t) = (0.84 + or - 0.02 - 0.026 + or - 0.003 x t) log Mlow *-(6.51 + or - 0.24 - 0.11 + or - 0.03 x t), where t is the age of the universe in Gyr. We use our fits to create empirical evolutionary tracks in order to constrain MS galaxy star formation histories (SFHs), finding that (1) the most accurate representations of MS SFHs are given by delayed-Tau models, (2) the decline in fractional stellar mass growth for a "typical" MS galaxy today is approximately linear for most of its lifetime, and (3) scatter about the MS can be generated by galaxies evolving along identical evolutionary tracks assuming an initial 1Sigma spread in formation times of ~1.4 Gyr.
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•Methanotrophs can use renewable methane as a carbon source.•Potential to generate multiple products from a single strain.•Multiple products can enhance process economics and decrease ...organic waste.•Growth rates and cell density strongly affect gas use and reactor volume.
Methane, a carbon source for methanotrophic bacteria, is the principal component of natural gas and is produced during anaerobic digestion of organic matter (biogas). Methanotrophs are a viable source of single cell protein (feed supplement) and can produce various products, since they accumulate osmolytes (e.g. ectoine, sucrose), phospholipids (potential biofuels) and biopolymers (polyhydroxybutyrate, glycogen), among others. Other cell components, such as surface layers, metal chelating proteins (methanobactin), enzymes (methane monooxygenase) or heterologous proteins hold promise as future products. Here, scenarios are presented where ectoine, polyhydroxybutyrate or protein G are synthesised as the primary product, in conjunction with a variety of ancillary products that could enhance process viability. Single or dual-stage processes and volumetric requirements for bioreactors are discussed, in terms of an annual biomass output of 1000 tonnesyear−1. Product yields are discussed in relation to methane and oxygen consumption and organic waste generation.
Natural IgM are highly represented in the circulation at birth, and these often autoreactive antibodies have been postulated to have innate-like properties and play crucial roles in apoptotic cell ...clearance, tissue homeostasis, and immune modulation. This review summarizes the known properties of these IgM autoantibodies, and the evidence that these anti-apoptotic cell IgM natural antibodies can regulate inflammatory responses through ancient pathways of the innate immune system that first arose long before the initial emergence of the adaptive immune system. While the regulatory contributions of these natural IgM autoantibodies are certainly not an essential and fundamental component of host defenses, these provide an additional layer to further protect the host. More importantly, these IgM antibody responses are highly inducible and their up-regulation can be a powerful means for the host to survive in a setting of chronic inflammation. The observed beneficial clinical associations for cardiovascular disease and autoimmunity, as well as opportunities for potential therapeutic implications are discussed.
ABSTRACT We investigate the physical conditions of ionized gas in high-z star-forming galaxies using diagnostic diagrams based on the rest-frame optical emission lines. The sample consists of 701 ...galaxies with an H detection at , from the Fiber Multi-Object Spectrograph (FMOS)-COSMOS survey, that represent the normal star-forming population over the stellar mass range , with those at being well sampled. We confirm an offset of the average location of star-forming galaxies in the Baldwin-Phillips-Terlevich (BPT) diagram ( versus ), primarily toward higher , compared with local galaxies. Based on the S ii ratio, we measure an electron density ( ), which is higher than that of local galaxies. Based on comparisons to theoretical models, we argue that changes in emission-line ratios, including the offset in the BPT diagram, are caused by a higher ionization parameter both at fixed stellar mass and at fixed metallicity, with additional contributions from a higher gas density and possibly a hardening of the ionizing radiation field. Ionization due to active galactic nuclei is ruled out as assessed with Chandra. As a consequence, we revisit the mass-metallicity relation using and a new calibration including as recently introduced by Dopita et al. Consistent with our previous results, the most massive galaxies ( ) are fully enriched, while those at lower masses have metallicities lower than local galaxies. Finally, we demonstrate that the stellar masses, metallicities, and star formation rates of the FMOS sample are well fit with a physically motivated model for the chemical evolution of star-forming galaxies.
Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-tuning of the recognition and response to foreign threats. However, in health there are some types of ...antibodies that instead recognize self-antigens and these contribute to the enhancement of primitive innate functions. This repertoire of natural IgM antibodies is postulated to have been selected during immune evolution for their contributions to critical immunoregulatory and housekeeping properties. The clearance of dying cells is one of the most essential responsibilities of the immune system, which is required to prevent uncontrolled inflammation and autoimmunity. In the murine immune system, natural IgM antibodies that recognize apoptotic cells have been shown to enhance the phagocytic clearance of dead and dying cells and to suppress innate immune signaling pathways. In the mouse, natural IgM are often the products of B-1 cell clones that arise during immune development without an absolute requirement for exogenous antigenic stimulation. In patients with systemic lupus erythematosus, IgM autoantibodies, which bind to neo-epitopes on apoptotic cells, have been demonstrated to be present at significantly higher levels in patients with lower disease activity and with less severe organ damage. While certain specificities of IgM autoantibodies correlate with protection from lupus renal disease, others may convey protective properties from lupus-associated atherosclerotic cardiovascular disease. New and unexpected insights into the functional roles of IgM antibodies are still emerging, especially regarding the functions of natural antibodies. Herein, we review recent progress in our understanding of the potential roles of natural IgM autoantibodies in the regulation of immune homeostasis and for protection from autoimmune and inflammatory diseases.
ABSTRACT We present 0 4 resolution extinction-independent distributions of star formation and dust in 11 star-forming galaxies (SFGs) at z = 1.3-3.0. These galaxies are selected from sensitive ...blank-field surveys of the 2′ × 2′ Hubble Ultra-Deep Field at λ = 5 cm and 1.3 mm using the Karl G. Jansky Very Large Array and Atacama Large Millimeter/submillimeter Array. They have star formation rates (SFRs), stellar masses, and dust properties representative of massive main-sequence SFGs at z ∼ 2. Morphological classification performed on spatially resolved stellar mass maps indicates a mixture of disk and morphologically disturbed systems; half of the sample harbor X-ray active galactic nuclei (AGNs), thereby representing a diversity of z ∼ 2 SFGs undergoing vigorous mass assembly. We find that their intense star formation most frequently occurs at the location of stellar-mass concentration and extends over an area comparable to their stellar-mass distribution, with a median diameter of 4.2 1.8 kpc. This provides direct evidence of galaxy-wide star formation in distant blank-field-selected main-sequence SFGs. The typical galactic-average SFR surface density is 2.5 M yr−1 kpc−2, sufficiently high to drive outflows. In X-ray-selected AGN where radio emission is enhanced over the level associated with star formation, the radio excess pinpoints the AGNs, which are found to be cospatial with star formation. The median extinction-independent size of main-sequence SFGs is two times larger than those of bright submillimeter galaxies, whose SFRs are 3-8 times larger, providing a constraint on the characteristic SFR (∼300 M yr−1) above which a significant population of more compact SFGs appears to emerge.
ABSTRACT We present a sample of accreting supermassive black holes (SMBHs) in dwarf galaxies at . We identify dwarf galaxies in the NEWFIRM Medium Band Survey with stellar masses of that have ...spectroscopic redshifts from the DEEP2 survey and lie within the region covered by deep (flux limit of ) archival Chandra X-ray data. From our sample of 605 dwarf galaxies, 10 exhibit X-ray emission consistent with that arising from active galactic nucleus (AGN) activity. If black-hole mass scales roughly with stellar mass, then we expect that these AGNs are powered by SMBHs with masses of and typical Eddington ratios of . Furthermore, we find an AGN fraction consistent with extrapolations of other searches of for and . Our AGN fraction is in good agreement with a semi-analytic model, suggesting that, as we search larger volumes, we may use comparisons between observed AGN fractions and models to understand seeding mechanisms in the early universe.
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