Magnesium is the fourth most common mineral in the human body and the second richest intracellular cation. This element is necessary for many physiological reactions, especially in the cardiovascular ...and respiratory systems. COVID-19 is an infectious disease caused by SARS-CoV-2. The majority of people who become ill as a result of COVID-19 have mild-to-moderate symptoms and recover without specific treatment. Moreover, there are people who develop severe forms of COVID-19, which require highly specialized medical assistance. Magnesium deficiency may play a role in the pathophysiology of infection with SARS-CoV-2. The primary manifestation of COVID-19 remains respiratory, but the virus can spread to other organs and tissues, complicating the clinical picture and culminating in multiorgan failure. The key mechanisms involved in the disease include direct viral cytotoxicity, endothelial dysfunction, and exaggerated release of inflammatory cytokines. The aim of this review was to summarize the available data regarding the role of magnesium in COVID-19 patients and its particularities in different clinical settings.
Irritable bowel syndrome (IBS) is one of the most common diseases of gastro-enterology, associating abdominal pain, transit disorders and changes in the consistency of the stools. Material and ...method. The study included 200 patients suffering from IBS, selected from a total of 2,300 patients of a family medicine practice in urban area. For diagnosis and classification, Rome III criteria and Bristol scale were used. For a subgroup was applied a questionnaire for the evaluation of quality of life, QoL. Treatment was initiated on three levels. Results. The incidence of the disease during the 3 years of study (2013-2016) was 2.9%. The type of IBS most often encountered was the one with dominance of constipation (IBS-C 32.5%), followed by the alternating form (IBS-A 26%), mixed (IBS-M-24%) and the dominance of diarrhea (IBS-D 18.5%). Form with more severe impact on the quality of life is IBS-C – 52.24 score, and most easily tolerated IBS-A – 69 score. Treatment was initiated at the on level I at 33% of the patients at the on level II to 36 %, and on level III to 31% of the patients. Maximum efficiency of treatment scores were obtained from patients on treatment level III. Complete remission of symptoms is obtained only in 9.5% of total patients. Conclusions. SII is a common condition in family medicine practice, due to changes in the modern diet. The diagnosis can be facilitated by the application of questionnaires, and treatment is based on changes in lifestyle and on pharmacological agents.
The aim of this paper is to describe the temporal progression and clinical picture of a 2-year-old child with infantile Refsum disease, as well as the diagnostic procedures performed; this case ...presented multiple hematologic, metabolic, and developmental complications and progressive disabilities. Genetic testing revealed a mutation of the
(Peroxisomal Biogenesis Factor 6) gene, and the metabolic profile was consistent with the diagnosis. Particularly, the child also presented altered coagulation factors and developed a spontaneous brain hemorrhage. The clinical picture includes several neurological, ophthalmological, digestive, cutaneous, and endocrine disorders as a result of the very long chain fatty acid accumulation as well as secondary oxidative anomalies. The study of metabolic disorders occurring because of genetic mutations is a subject of core importance in the pathology of children today. The PEX mutations, difficult to identify antepartum, are linked to an array of cell anomalies with severe consequences on the patient's status, afflicting multiple organs and systems. This is the reason for which our case history may be relevant, including a vast number of symptoms, as well as modified biological parameters.
Type 1 diabetes is one of the most common chronic diseases in children and adolescents, with an increasing incidence globally. Major variations in serum glucose cause severe ketoacidosis and ...hypoglycemia, acute metabolic complications of the disease. We performed a retrospective study on a group of 119 children and adolescents with type 1 diabetes in whom only the cases with ketoacidosis and severe hypoglycemia that required emergency hospitalization were quantified. At the same time, we identified the causes and determinants of these acute complications. According to the case study, 28.6% of patients (34 cases) presented severe hypoglycemia, the most common causes of hypoglycemia being intense physical activity without additional carbohydrate intake, delayed carbohydrate intake, and excess insulin. 15.3% of patients (18 cases) had ketoacidosis, of which 55.55% were recurrent ketoacidosis. Ketoacidosis has been detected in patients with poor glycemic balance and poor treatment compliance by not following a diet and skipping insulin doses. Among the additional risk fac-tors, we identified age over 13 years and the age of diabetes greater than 5 years, for both acute complications.
Classic polyarteritis nodosa (PAN) is a vasculitis with systemic manifestations that is characterized by inflammatory and necrotizing lesions affecting medium and small muscular arteries, most ...frequently at the bifurcation of the vessels. These lesions lead to the formation of microaneurysms, hemorrhaging ruptured aneurysms, thrombosis, and, consequently, ischemia or organ infarction.
: We present a complex clinical case of a patient with a late diagnosis of polyarteritis nodosa with multiorgan involvement.
: The 44-year-old patient, in an urban environment, presented on her own in the emergency room for acute ischemia phenomena and forearm and right-hand compartment syndrome, requiring surgical decompression in the Plastic Surgery Clinic.
: Significant inflammatory syndrome is noted, alongside severe normocytic hypochromic iron deficiency anemia, nitrogen retention syndrome, hyperkalemia, hepatic syndrome, and immunological disturbances: absence of cANCA, pANCA, anti Scl 70 Ac, antinuclear Ac, and anti dDNA Ac, as well as a low C3 fraction of the plasmatic complement system. The morphological aspect described in the right-hand skin biopsy correlated with the clinical data supports the diagnosis of PAN.
: The viral form of PAN seems to be individualized as a distinct entity, requiring early, aggressive medication.
Postpartum depression (PPD) is a major health problem, and in recent years its prevalencehas been increasing. The physiological changes and mood disorders associated withpregnancy and the postnatal ...period are mainly due to a hormonal imbalance. Destabilizingthe mother's hypothalamic pituitary adrenal (HPA) axis increases the susceptibility todepression, probably by significantly increasing plasma cortisol. Stress and inflammation playa key role in postpartum. Also, lactogenic hormones have antidepressant and anxiolyticeffects, the low concentration of oxytocin in the perinatal period being a triggering factor ofPPD.Natural nutrition, ideal for every newborn and infant, positively influences the mother'smental health and may reduce the risk of developing PPD, possibly by attenuating cortisolresponse to stress. The link between breastfeeding and PPD has not been thoroughlyapproached. PPD is associated with early termination of breastfeeding, while long-termbreastfeeding reduced the risk of PPD. The mother's willingness to breastfeed, her confidencein the ability to breastfeed, her mental health during pregnancy, her family's support, andtrained medical staff are some of the mediators that can contribute to the maintenance ofnatural nutrition in PPD.
Introduction: Considering the generalized Internet access as well as the electronic communication, teens and young adults are at risk for a new type of dependency, the Internet addiction, with a high ...impact on the personal and professional life, as well as on the school performance. Objective: The current paper aims to introduce in the clinical practice a validated diagnosis tool for this new condition, allowing the proper identification of the problem cases for counselling and specific approach by the Family Physician and the Child Psychiatrist. Method: The IAT (Internet Addiction Test), created by Kimberly Young, was selected and applied on two small groups of patients from a Family Medicine practice (Group A) and a Child Psychiatry practice (Group B) from an urban setting, city of Iași. Results: Accordingly to the test standard interpretation, the patients have been divided in: average user (20 49p) 28 cases (70%), occasional or frequent problem presenting user (50 79p) 11 cases (27,5%), significant problem presenting user (80 100p) 1 case (2,5%). The group of patients presenting to the Child Psychiatry practice for other issues had a higher incidence of Internet addiction problems. Conclusions: The Family Physician must screen for Internetassociated problems to discover early stage excessive users. The validated screening tools are useful in the current practice and the specialty counselling is extremely important for this specific population.
The bulk of the subject population was made of 211 (39%) prisoners of the 20-29 age group, 148 prisoners of the 30-39 age group (27%), with a precarious marital status and having a low level of ...education. The frequency of the subjects who administer drugs by injection shots was significantly higher at the VHB/C group (10,2%), as compared to the witness group (2,4%), a frequency which is statistically significant (p=0,001). The intake of cocaine as crack was small in both investigated groups (7,4% vs 4,2%), as the frequency differences were statistically insignificant (p=0,264). Based on the type of aggression, by drawing the ROC curve it is confirmed that self-aggression is an important risk factor. Physical aggression was present with 57,1% of the subjects (57,1% vs 42,9%) with previous criminal records, sexual aggression with 73% (73% vs 27%), whereas self-aggression with (58,5% vs 41,5%,). Incarcerated individuals suffer from a consistent psychiatrically and somatically pathology, as compared to the general population. It needs specific, multi-disciplinary measures. The psychotherapy component plays an important part in preventing the spread of the disease.
The role of vitamin D in depression Petroaie, Antoneta Dacia; Bolos, Alexandra; Coman, Adorata Elena ...
Buletin de psihiatrie integrativa,
2019, Letnik:
80, Številka:
1
Journal Article
PDF
