We present a summary of recent tests and measurements of hadronic interaction properties with air showers. This report has a special focus on muon density measurements. Several experiments reported ...deviations between simulated and recorded muon densities in extensive air showers, while others reported no discrepancies. We combine data from eight leading air shower experiments to cover shower energies from PeV to tens of EeV. Data are combined using the
z
-scale, a unified reference scale based on simulated air showers. Energy-scales of experiments are cross-calibrated. Above 10 PeV, we find a muon deficit in simulated air showers for each of the six considered hadronic interaction models. The deficit is increasing with shower energy. For the models EPOS-LHC and QGSJet-II.04, the slope is found significant at 8 sigma.
Seasonal variations of atmospheric muons are traditionally interpreted in terms of an effective temperature that relates the atmospheric temperature profile at a given time to the dependence of muon ...production on atmospheric depth. This paper aims to review and generalize the treatment of muon production and effective temperature that has been used to interpret seasonal variations of atmospheric muons by many experiments. The formalism is developed both in integral form – for application to compact detectors at a fixed depth that record all muons with Eμ>Eμmin – and in differential form — for application to extended detectors like IceCube, KM3NeT, and Baikal-GVD, where the rates are proportional to energy-dependent effective areas.
Cosmic-ray physics at the South Pole Soldin, D.; Evenson, P.A.; Kolanoski, H. ...
Astroparticle physics,
September 2024, 2024-09-00, Letnik:
161
Journal Article
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The geographic South Pole provides unique opportunities to study cosmic particles in the Southern Hemisphere. It represents an optimal location to deploy large-scale neutrino telescopes in the deep ...Antarctic ice, such as AMANDA or IceCube. In both cases, the presence of an array, constructed to observe extensive air showers, enables hybrid measurements of cosmic rays. While additional neutron monitors can provide information on solar cosmic rays, large detector arrays, like SPASE or IceTop, allow for precise measurements of cosmic rays with energies above several 100TeV. In coincidence with the signals recorded in the deep ice, which are mostly due to the high-energy muons produced in air showers, this hybrid detector setup provides important information about the nature of cosmic rays.
In this review, we will discuss the historical motivation and developments towards measurements of cosmic rays at the geographic South Pole and highlight recent results reported by the IceCube Collaboration. We will emphasize the important contributions by Thomas K. Gaisser and his colleagues that ultimately led to the rich Antarctic research program which today provides crucial insights into cosmic-ray physics.
ABSTRACT The IceCube Collaboration has previously discovered a high-energy astrophysical neutrino flux using neutrino events with interaction vertices contained within the instrumented volume of the ...IceCube detector. We present a complementary measurement using charged current muon neutrino events where the interaction vertex can be outside this volume. As a consequence of the large muon range the effective area is significantly larger but the field of view is restricted to the Northern Hemisphere. IceCube data from 2009 through 2015 have been analyzed using a likelihood approach based on the reconstructed muon energy and zenith angle. At the highest neutrino energies between and a significant astrophysical contribution is observed, excluding a purely atmospheric origin of these events at significance. The data are well described by an isotropic, unbroken power-law flux with a normalization at neutrino energy of and a hard spectral index of . The observed spectrum is harder in comparison to previous IceCube analyses with lower energy thresholds which may indicate a break in the astrophysical neutrino spectrum of unknown origin. The highest-energy event observed has a reconstructed muon energy of which implies a probability of less than for this event to be of atmospheric origin. Analyzing the arrival directions of all events with reconstructed muon energies above no correlation with known γ-ray sources was found. Using the high statistics of atmospheric neutrinos we report the current best constraints on a prompt atmospheric muon neutrino flux originating from charmed meson decays which is below 1.06 in units of the flux normalization of the model in Enberg et al.
A search for point-like and extended sources of cosmic neutrinos using data collected by the ANTARES and IceCube neutrino telescopes is presented. The data set consists of all the track-like and ...shower-like events pointing in the direction of the Southern Sky included in the nine-year ANTARES point-source analysis, combined with the throughgoing track-like events used in the seven-year IceCube point-source search. The advantageous field of view of ANTARES and the large size of IceCube are exploited to improve the sensitivity in the Southern Sky by a factor of ∼2 compared to both individual analyses. In this work, the Southern Sky is scanned for possible excesses of spatial clustering, and the positions of preselected candidate sources are investigated. In addition, special focus is given to the region around the Galactic Center, whereby a dedicated search at the location of SgrA* is performed, and to the location of the supernova remnant RXJ 1713.7-3946. No significant evidence for cosmic neutrino sources is found, and upper limits on the flux from the various searches are presented.
Tacrolimus is one of the commonly used immunosuppressive drugs for pediatric heart transplants. Large variation exists in pharmacokinetics during the direct post-transplant period, resulting in an ...increased risk of adverse events. Limited data are available on the interaction of age, CYP3A5 and ABCB1 genotype, and disease severity on the variation in disposition and outcome in pediatric heart transplant recipients.
We studied the relationship between age and CYP3A5 and ABCB1 genotype and the Pediatric Risk of Mortality (PRISM) score on tacrolimus dose (mg/kg), steady-state trough concentrations, and concentration/dose ratio, as well as rejection and renal function for 14 days after heart transplant in children.
Tacrolimus was administered to 39 children (median age, 6.0 years) after transplant. A correlation was found between the age at the time of transplant and the tacrolimus dosing requirements (r(s) = -0.447, p = 0.004) and the concentration/dose ratio (r(s) = 0.351, p = 0.029). CYP3A5 expressors required median (interquartile range) higher doses of tacrolimus (0.14 0.09 vs 0.06 0.04 mg/kg/12 hours, p = 0.001), and had lower concentration/dose ratios (45.34 44.54 vs 177.78 145.38 ng/ml per mg/kg/12 hours, p < 0.0001). This relationship was not seen with the ABCB1 genotype. Age and CYP3A5 genotype predicted the tacrolimus dosing requirements as well as the concentration/dose ratio (R(2) = 0.351, p = 0.001 and R(2) = 0.521, p < 0.001). No relationship was found between any of the CYP3A5 or ABCB1 genotypes and the estimated glomerular filtration rate.
Younger age and CYP3A5 expressor genotype were independently associated with higher dosing requirements and lower tacrolimus concentration/dose ratios.
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