We report on modeling, development, and optical characterization of fused silica photonic crystal fiber with germanium doped microinclusion placed in the middle of the core. The fiber is designed to ...efficiently couple and guide LP
mode. It offers high optical density in the center region, large mode separation, low losses, and small dispersion with relatively flat profile for both LP
and LP
modes in 1-1.6 µm wavelength range. We demonstrate that by changing geometrical and material parameters of the inclusion partially independent tuning of propagation constants of individual modes is possible, what might be found is a variety of potential applications, e.g., in nonlinear optics. We also show that diffraction-limited propagation of LP
mode in free space can be exploited in microscopy or lab-on-a-chip systems, where the proposed fiber can be used for light delivery.
Integration of optically-active nanodiamonds with glass fibers is a powerful method of scaling of diamond magnetic sensing functionality. We propose a novel approach for integration of nanodiamonds ...containing nitrogen-vacancy centers directly into the fiber core. The core is fabricated using nanostructurization, that is by stacking the preform from 790 soft glass canes, drawn from a single rod dip-coated with nanodiamonds suspended in isopropyl alcohol. This enables manual control over distribution of nanoscale features, here - the nanodiamonds across and along the fiber core. We verify this by mapping the nanodiamond distribution in the core using confocal microscopy. The nanodiamonds are separated longitudinally either by 15 microns or 24 microns, while in the transverse plane separation of approximately 1 micron is observed, corresponding to the individual cane diameter in the final fiber, without significant agglomeration. Filtered, red fluorescence is observed with naked eye uniformly along the fiber. Its magnetic sensitivity is confirmed by in optically detected magnetic resonance recorded with a coiled, 60-cm-long fiber sample with readout contrast limited mainly by microwave antenna coverage. NV fluorescence intensity in 0 to 35 mT magnetic field is also demonstrated, allowing magnetometry applications with a large B-field dynamic range in absence of microwaves.
We report a silica glass nested capillary anti-resonant nodeless fiber with transmission and low bending sensitivity in the mid-infrared around 4000 nm. The fiber is characterized in terms of ...transmission over 1700-4200 nm wavelengths, revealing a mid-infrared 3500-4200 nm transmission window, clearly observable for a 12 m long fiber. Bending loss around 4000 nm is 0.5 dB/m measured over 3 full turns with 40 mm radius, going up to 5 dB/m for full turns with 15 mm radius. Our results provide experimental evidence of hollow-core silica fibers in which nested, anti-resonant capillaries provide high bend resistance in the mid-infrared. This is obtained for a fiber with large core diameter of over 60 um relative to around 30 um-capillaries in the cladding, which motivates its application in gas fiber lasers or fiber-based mid-infrared spectroscopy of COx or NxO analytes.
Determined polarization state of light is required in nonlinear optics applications related to ultrashort and single-cycle light pulse generation. Such short time scales require up to full octave of ...spectral width of light. Fiber-based, pulse-preserving and linearly polarized supercontinuum can meet these requirements. We report on the development - from linear simulations of the fiber structure, through fabrication of physical fibers to their versatile characterization - of polarization maintaining, highly nonlinear photonic crystal fibers, intended for femtosecond pumping at a wavelength of 1560 nm. Full octave of linearly polarized light around this wavelength would enable to cover amplification bandwidths of the three major fiber amplifiers from ytterbium doped systems up to thulium and holmium doped fiber amplifiers, with a coherent, linearly polarized seed signal. At the same time, an all-normal chromatic dispersion profile over an entire transmission window, and small dispersion of nonlinearity in the developed fibers, would facilitate use of commercially available femtosecond fiber lasers as pump sources for the developed fibers.
We report on designing, fabrication and experimental characterization of highly nonlinear, tellurite glass photonic crystal fibers with engineered normal dispersion characteristics for coherent ...supercontinuum generation. Effectively single mode, air-hole lattice fibers, with measured, all-normal dispersion profiles as flat as -10 to -50 ps/mn/km over 1500-2400 nm wavelengths are developed and investigated. Supercontinuum spectra are measured for these fibers, with a spectral width covering 1100-2600 nm wavelengths under pumping with a robust, fixed-wavelength erbium fiber-based femtosecond laser, delivering 90 fs pulses, centered at 1560 nm with peak power below 40 kW. To the best of our knowledge, this is the first engineered microstructured fiber, which due to its high nonlinearity, enables a self-phase modulation and optical wave breaking-based supercontinuum pumped with a turn-key, 40 kW femtosecond laser at spectral widths obtainable with previous all-normal dispersion fiber designs only under pumping with systems delivering peak power in the MW range.
Ultrasound-assisted, catheter-directed, low-dose thrombolysis (USAT) at an average alteplase dose of 20 mg infused over 12 to 24 hours reversed right ventricular disfunction and improved pulmonary ...hemodynamics in intermediate–high-risk pulmonary embolism patients. As bleeding risk increases with the thrombolytic dose, establishing a minimal effective USAT dosing regimen is of clinical importance. We aimed to investigate hemodynamic effects and safety of a very low-alteplase-dose USAT of 10 mg administered within 5 hours. We included 12 consecutive intermediate–high-risk pulmonary embolism patients with symptoms duration of <14 days and proximal thrombi location in pulmonary arteries. Pulmonary Embolism Response Team decision-based fixed, bilateral ultrasound-assisted alteplase infusions at the rate of 1mg/hour/catheter for 5 hours through EKOS system catheters were made. The primary efficacy measure was the change in invasive systolic and mean pulmonary arteries pressure, and in cardiac index from USAT start to termination. Safety measures were 180-day all-cause death or cardiopulmonary decompensation and bleeding complications. The systolic pulmonary arteries pressure and mean pulmonary arteries pressure decreased from 53 (45.5 to 59) to 37.5 (27.5 to 40.5) mm Hg (p = 0.02) and from 29.5 (27.5 to 32) to 21.5 (15.5 to 25) mm Hg (p = 0.02), respectively. The cardiac index increased from 1.6 (1.5 to 1.8) to 2.2 (1.9 to 2.4) l/min/m2, (p = 0.02). No deaths, decompensations, or need for therapy intensification occurred. There was 1 episode of access-site bleeding, which subsided after conservative management. No intracranial hemorrhages appeared. In conclusion, reduced dose and duration USAT improved pulmonary hemodynamics and cardiac function leading to cardiopulmonary stabilization in intermediate-high risk pulmonary embolism patients at a low periprocedural risk.
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