We present the calculation of the full next-to-leading order (NLO) QCD corrections to Higgs boson pair production via gluon fusion at the LHC, including the exact top-mass dependence in the two-loop ...virtual and one-loop real corrections. This is the first independent cross-check of the NLO QCD corrections presented in the literature before. Our calculation relies on numerical integrations of Feynman integrals, stabilised with integration-by-parts and a Richardson extrapolation to the narrow width approximation. We present results for the total cross section as well as for the invariant Higgs-pair-mass distribution at the LHC, including for the first time a study of the uncertainty due to the scheme and scale choice for the top mass in the loops.
A
bstract
New Physics that becomes relevant at some high scale Λ beyond the experimental reach, can be described in the effective theory approach by adding higher-dimensional operators to the ...Standard Model (SM) Lagrangian. In Higgs pair production through gluon fusion, which gives access to the trilinear Higgs self-coupling, this leads not only to modifications of the SM couplings but also induces novel couplings not present in the SM. For a proper prediction of the cross section, higher order QCD corrections that are important for this process, have to be taken into account. The various higher-dimensional contributions are affected differently by the QCD corrections. In this paper, we provide the next-to-leading order (NLO) QCD corrections to Higgs pair production including dimension-6 operators in the limit of large top quark masses. Depending on the dimension-6 coefficients entering the Lagrangian, the new operators affect the relative NLO QCD corrections by several per cent, while modifying the cross section by up to an order of magnitude.
We present the program package NMSSMCALC for the calculation of the loop-corrected NMSSM Higgs boson masses and decay widths in the CP-conserving and CP-violating NMSSM. The full one-loop corrections ...to the Higgs boson masses are evaluated in a mixed renormalisation scheme of on-shell and DR¯ conditions. The Higgs decay widths include the dominant higher order QCD corrections, and the decays into bottom quarks, strange quarks and τ leptons are supplemented by higher order SUSY corrections through effective couplings. All relevant off-shell decays into two massive gauge bosons, gauge and Higgs boson and Higgs pair final states as well as into heavy quark pairs are computed. The input and output files feature the SUSY Les Houches Accord so that the program can easily be linked with existing computer tools.
Program title: NMSSMCALC
Catalogue identifier: AEUE_v1_0
Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEUE_v1_0.html
Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland
Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html
No. of lines in distributed program, including test data, etc.: 53070
No. of bytes in distributed program, including test data, etc.: 329132
Distribution format: tar.gz
Programming language: Fortran77.
Computer: Any with a Fortran77 system.
Operating system: Linux, Unix.
RAM: 0.5MB
Classification: 11.1.
Nature of problem:
Computation of the NMSSM Higgs mass spectrum including higher order corrections in a mixed renormalisation scheme of on-shell and DRbar conditions, and numerical calculation of the decay widths and branching ratios, both in the CP-conserving and in the CP-violating NMSSM. The decay widths include the dominant higher order QCD corrections and, for the neutral Higgs boson decays into a bottom quark pair, the higher order SUSY–QCD and the approximate SUSY–electroweak (elw) corrections up to one-loop accuracy. The decays into a strange quark pair include the dominant resummed SUSY–QCD corrections and the one into a τ pair the dominant resummed SUSY–elw corrections. Analogously for the charged Higgs boson the higher order SUSY corrections have been implemented for the decays into fermion pairs. In the real NMSSM, the decays into stop and sbottom pairs, respectively, contain the SUSY–QCD corrections. All relevant off-shell decays into massive gauge bosons, into gauge and Higgs bosons, into Higgs pairs and into heavy quark pairs have been taken into account. The input and output files feature the SUSY Les Houches Accord (SLHA).
Solution method:
The necessary input values are set in the two input files inp.dat (in the SLHA format) and bhdecay.in. The file inp.dat, where the choice between the real and the complex NMSSM can be made, is read in by CalcMasses.F, which calculates the one-loop corrected NMSSM Higgs mass spectrum. CalcMasses.F writes out all necessary parameters, masses and mixing angles in an SLHA format file slha.in, which is read in by bhdecay.f (by bhdecay c.f in the complex case). This Fortran routine then computes the decay widths and branching ratios and writes them out in an SLHA format file slha decay.out. Furthermore it writes out all parameters and mixing angles.
Restrictions:
At present the NMSSM Higgs spectrum is calculated at one-loop accuracy, the Higgs self-couplings at leading order, and no renormalisation group running of the input parameters is included. However, we are about to implement the two-loop corrections to the NMSSM Higgs boson masses and the Higgs self-couplings. Furthermore, the renormalisation group equations for the input parameters shall be provided in the near future. The program does not provide any distributions.
Running time:
Less than one second per point
The monitoring of water colour parameters can provide an important diagnostic tool for the assessment of aquatic ecosystem condition. Remote sensing has long been used to effectively monitor ...chlorophyll concentrations in open ocean systems; however, operational monitoring in coastal and estuarine areas has been limited because of the inherent complexities of coastal systems, and the coarse spectral and spatial resolutions of available satellite systems. Data were collected using the National Aeronautics and Space Administration (NASA) Advanced Visible-Infrared Imaging Spectrometer (AVIRIS) flown at an altitude of approximately 20 000 m to provide hyperspectral imagery and simulate both MEdium Resolution Imaging Spectrometer (MERIS) and Moderate Resolution Imaging Spectrometer (MODIS) data. AVIRIS data were atmospherically corrected using a radiative transfer modelling approach and analysed using band ratio and linear regression models. Regression analysis was performed with simultaneous field measurements data in the Neuse River Estuary (NRE) and Pamlico Sound on 15 May 2002. Chlorophyll a (Chl a) concentrations were optimally estimated using AVIRIS bands (9.5 nm) centred at 673.6 and 692.7 nm, resulting in a coefficient of determination (R
2
) of 0.98. Concentrations of Chromophoric Dissolved Organic Matter (CDOM), Total Suspended Solids (TSS) and Fixed Suspended Solids (FSS) were also estimated, resulting in coefficients of determination of R
2
= 0.90, 0.59 and 0.64, respectively. Ratios of AVIRIS bands centred at or near those corresponding to the MERIS and MODIS sensors indicated that relatively good satellite-based estimates could potentially be derived for water colour constituents at a spatial resolution of 300 and 500 m, respectively.
**Current address: University of Minnesota, Department of Forest Resources, St Paul, MN 55108, USA.
A
bstract
Higgs-pair production via gluon fusion is the dominant production mechanism of Higgs-boson pairs at hadron colliders. In this work, we present details of our numerical determination of the ...full next-to-leading-order (NLO) QCD corrections to the leading top-quark loops. Since gluon fusion is a loop-induced process at leading order, the NLO calculation requires the calculation of massive two-loop diagrams with up to four different mass/energy scales involved. With the current methods, this can only be done numerically, if no approximations are used. We discuss the setup and details of our numerical integration. This will be followed by a phenomenological analysis of the NLO corrections and their impact on the total cross section and the invariant Higgs-pair mass distribution. The last part of our work will be devoted to the determination of the residual theoretical uncertainties with special emphasis on the uncertainties originating from the scheme and scale dependence of the (virtual) top mass. The impact of the trilinear Higgs-coupling variation on the total cross section will be discussed.
Female cynomolgus monkeys exhibit different degrees of reproductive dysfunction with moderate metabolic and psychosocial stress. In this study, the expression of four genes pivotal to serotonin ...neural function was assessed in monkeys previously categorized as highly stress resistant (
n=3; normal menstrual cyclicity through two stress cycles), medium stress resistant (
n=5; ovulatory in the first stress cycle but anovulatory in the second stress cycle), or low stress resistant (i.e. stress-sensitive;
n=4; anovulatory as soon as stress is initiated).
In situ hybridization and quantitative image analysis was used to measure mRNAs coding for SERT (serotonin transporter), 5HT1A autoreceptor, MAO-A and MAO-B (monoamine oxidases) at six levels of the dorsal raphe nucleus (DRN). Optical density (OD) and positive pixel area were measured with NIH Image software. In addition, serotonin neurons were immunostained and counted at three levels of the DRN. Finally, each animal was genotyped for the serotonin transporter long polymorphic region (5HTTLPR). Stress sensitive animals had lower expression of SERT mRNA in the caudal region of the DRN (
P<0.04). SERT mRNA OD in the caudal DRN was positively correlated with serum progesterone during a pre-stress control cycle (
P<0.0007). 5HT1A mRNA OD signal tended to decline in the stress-sensitive group, but statistical difference between averages was lacking in analysis of variance. However, 5HT1A mRNA signal was positively correlated with control cycle progesterone (
P<0.009). There was significantly less MAO-A mRNA signal in the stress-sensitive group (
P<0.007) and MAO-A OD was positively correlated with progesterone from a pre-stress control cycle (
P<0.007). MAO-B mRNA exhibited a similar downward trend in the stress-sensitive group. MAO-B OD also correlated with control cycle progesterone (
P<0.003). There were significantly fewer serotonin neurons in the stress-sensitive group. All animals contained only the long form of the 5HTTLPR. Thus, all serotonin-related mRNAs examined in the dorsal raphe to date were lower (SERT, MAO-A) or exhibited a lower trend (5HT1A, MAO-B) in the stress sensitive animals, which probably reflects the lower number of serotonin neurons present.
The role of COX-2 in heart pathology Streicher, J M; Wang, Y
Cardiovascular & hematological agents in medicinal chemistry
6, Številka:
1
Journal Article
Recenzirano
Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins, and an important anti-inflammation drug target. Recent focus has been placed on the role of COX-2 in heart function and ...pathology, due to the finding that specific COX-2 inhibitors significantly increased the risk of heart disease in chronic users. However, the exact role of COX-2 in cardiac physiology and disease remains controversial due to the conflicting data reported. Roughly equal numbers of reports have shown either a detrimental role or a protective role for COX-2 in heart in experimental models. Here we attempt to provide a background on the more general roles of COX-2 in pathophysiology, as well as molecular mechanisms employed to control COX-2 expression. This background provides a basis for better understanding the functional role of COX-2 in human heart pathologies, based on the results of COX-2 pharmacological inhibitor studies in humans as well as COX-2 expression in human heart disease. Furthermore, we will explore the experimental evidence implicating different intracellular molecular signaling cascades that regulate COX-2 expression in cardiomyocytes. All of this data permits a more mechanistic understanding of the published studies using pharmacological inhibitors of COX-2 in experimental models of heart pathology. Lastly, we will examine the use of genetic manipulation of COX-2 in mice as one of the future avenues in an attempt to resolve the role of COX-2 in cardiac physiology and pathology.
All of the serotonin-producing neurons of the mammalian brain are located in 10 nuclei in the mid- and hindbrain regions. The cells of the rostal nuclei project to almost every area of the forebrain ...and regulate diverse neural processes from higher order functions in the prefrontal cortex such as integrative cognition and memory, to limbic system control of arousal and mood, to diencephalic functions such as pituitary hormone secretion, satiety, and sexual behavior. The more caudal serotonin neurons project to the spinal cord and interact with numerous autonomic and sensory systems. All of these neural functions are sensitive to the presence or absence of the ovarian hormones, estrogen and progesterone. We have shown that serotonin neurons in nonhuman primates contain estrogen receptor β and progestin receptors. Thus, they are targets for ovarian steroids which in turn modify gene expression. Any change in serotoninergic neural function could be manifested by a change in any of the projection target systems and in this manner, serotonin neurons integrate steroid hormone information and partially transduce their action in the CNS. This article reviews the work conducted in this laboratory on the actions of estrogens and progestins in the serotonin neural system of nonhuman primates. Comparisons to results obtained in other laboratory animal models are made when available and limited clinical data are referenced. The ability of estrogens and progestins to alter the function of the serotonin neural system at various levels provides a cellular mechanism whereby ovarian hormones can impact cognition, mood or arousal, hormone secretion, pain, and other neural circuits.
Supersymmetric theories provide elegant extensions of the Standard Model. Among these the NMSSM is a model which in addition to the content of the MSSM includes a new singlet to solve the mu problem. ...We present here the basic features of the NMSSM Higgs sector and a new Fortran implementation of the decays of the Higgs bosons in the NMSSM, both with real and complex parameters.
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