Highlights • Substance P signaling contributed to spinal glial activation and nociceptive sensitization. • C-fiber afferent signaling induced spinal glial activation and hypersensitivity. • ...Neuroglial activation contributed to the maintenance of chronic post fracture hypersensitivity.
Background and purpose
The effect of the triglyceride (TG) to high‐density lipoprotein cholesterol (HDL‐C) ratio (TG/HDL‐C) on clinical outcomes of acute ischaemic stroke (AIS) patients is unclear. ...This study sought to determine whether the TG/HDL‐C ratio in AIS patients is associated with worse outcomes at 3 months.
Methods
Acute ischaemic stroke patients who were admitted from 2011 to 2014 were enrolled in this study. TG, total cholesterol (TC), HDL‐C and low‐density lipoprotein cholesterol (LDL‐C) were collected on admission. Three end‐points were defined according to the modified Rankin scale (mRS) score at 3 months after symptom onset (excellent outcome, mRS 0–1; good outcome, mRS 0–2; and death, mRS 6).
Results
In all, 1006 patients were included (median age 68.5 years; 58.2% male). Higher TG, non‐HDL‐C and TG/HDL‐C were strongly associated with the three end‐points after adjustments: excellent odds ratio (OR) = 1.39, OR 1.89 and OR 2.34, respectively and good (OR 1.48, OR 2.90 and OR 4.12) outcomes, and death (OR 0.59, OR 0.29 and OR 0.26). According to receiver operating characteristic (ROC) analysis, the best discriminating factor was a TG/HDL‐C ≥ 0.87 for excellent outcomes area under the ROC curve (AUC) 0.596; sensitivity 73.3%; specificity 42.7% and non‐death (AUC 0.674; sensitivity 67.8%; specificity 60.6%) as well as a TG/HDL‐C ≥ 1.01 for a good outcome (AUC 0.652; sensitivity 61.6%; specificity 63.2%). Patients with a TG/HDL‐C < 0.87 had a 2.94‐fold increased risk of death (95% confidence interval 1.89–4.55) compared with patients with a TG/HDL‐C ≥ 0.87.
Conclusions
A lower TG/HDL‐C was independently associated with death and worse outcome at 3 months in AIS.
Performance of the BL03U beamline at SSRF Sun, Z. P.; Liu, Z. H.; Liu, Z. T. ...
Journal of synchrotron radiation,
September 2020, Letnik:
27, Številka:
5
Journal Article
Recenzirano
The vacuum ultraviolet beamline BL03U with a photon energy range from 7 eV upwards has been constructed at the 3.5 GeV Shanghai Synchrotron Radiation Facility. Equipped with an APPLE‐Knot undulator, ...this beamline is dedicated to angle‐resolved photoemission spectroscopy. An energy‐resolving power of higher than 4.6 × 104 has been achieved in the photon energy range 21.6–48 eV, which is almost the same as the theoretical estimation.
The design and performance test of the vacuum ultraviolet beamline BL03U at SSRF are described.
Transparent flexible thin‐film transistors (see Figure) have been made using single‐walled carbon nanotube networks of high and moderate coverages as the conducting and semiconducting layers. ...Electrical (e.g., good performance on plastic), optical (e.g. transparency to visible wavelengths), and mechanical (e.g. extreme flexibility) characteristics that would be difficult, or impossible, to achieve with conventional materials are reported.
The Carnian Humid Episode (CHE), also known as the Carnian Pluvial Event, and associated biotic changes are major enigmas of the Mesozoic record in western Tethys. We show that the CHE also occurred ...in eastern Tethys (South China), suggestive of a much more widespread and probably global climate perturbation. Oxygen isotope records from conodont apatite indicate a double-pulse warming event. The CHE coincided with an initial warming of 4 °C. This was followed by a transient cooling period and then a prolonged ∼7 °C warming in the later Carnian (Tuvalian 2). Carbon isotope perturbations associated with the CHE of western Tethys occurred contemporaneously in South China, and mark the start of a prolonged period of carbon cycle instability that persisted until the late Carnian. The dry-wet transition during the CHE coincides with the negative carbon isotope excursion and the temperature rise, pointing to an intensification of hydrologic cycle activities due to climatic warming. While carbonate platform shutdown in western Tethys is associated with an influx of siliciclastic sediment, the eastern Tethyan carbonate platforms are overlain by deep-water anoxic facies. The transition from oxygenated to euxinic facies was via a condensed, manganiferous carbonate (MnO content up to 15.1 wt%), that records an intense Mn shuttle operating in the basin. Significant siliciclastic influx in South China only occurred after the CHE climatic changes and was probably due to foreland basin development at the onset of the Indosinian Orogeny. The mid-Carnian biotic crisis thus coincided with several phenomena associated with major extinction events: a carbonate production crisis, climate warming, δ13C oscillations, marine anoxia, biotic turnover and flood basalt eruptions (of the Wrangellia Large Igneous Province).
•Carnian Pluvial Event manifested in South China, confirming a true global change.•The Carnian environmental perturbations were much longer than previously known.•Warming, δ13C oscillations, and intense euxinia are seen in the eastern Tethys.•Carbonate production crisis in South China predates Indosinian Orogeny activities.
Abstract
Boron (B), as a low-Z material, is widely employed for wall conditioning to enhance plasma performance in fusion devices. In the Experimental Advanced Superconducting Tokamak, a series of ...experiments involving real-time B powder injection has been conducted to investigate fuel particle behavior. It was observed that fuel particle recycling decreased with an increase in the amount of B powder injected, resulting in an increase in short-term fuel retention. The fuel recycling decreased by up to 80%, as indicated by divertor neutral pressure and D
α
line emission. Furthermore, each B atom exhibited a trapping capacity of 0.3 D particles during B powder injection at a typical flow rate. The real-time B injection had no wall hysteresis effect on D retention, implying that cumulative B injection and deposited film did not affect long-term D retention. The possible mechanism for D retention is the formation of B-C-O-D compounds and co-deposition between B and D particles during discharges. This investigation would be valuable for evaluating T retention when B is used as wall conditioning material in future fusion reactor devices.
Soil classification systems are not consistent between countries or organizations thereby hindering the communication and organizational functions they are intended to promote. World Reference Base ...for soil resources (WRB) was endorsed and adopted by the International Union of Soil Sciences (IUSS) as the standard for soil correlation and international communication. As a widely used classification system in China, Genetic Soil Classification of China (GSCC) differs from WRB in its underlying understanding about the genetic process. The differences limit communication between Chinese and international soil scientists because there is no standard cross-reference between GSCC and WRB. This paper describes a cross-reference of GSCC to WRB at different scales. The basic soil data set used in the study includes 7292 soil profile data (representative of soil series) collected throughout China. First, a brief history of soil classification in China is provided to familiarize readers with GSCC and its origins. Second, cross-reference at the pedon scale is addressed based on data compiled from 51 monoliths acquired in China by the International Soil Reference and Information Centre (ISRIC) in the 1980s and 1990s. Each of GSCC's 7292 soil series is classified into their equivalent reference soil groups according to the WRB soil reference key. Pedon scale cross referencing is discussed using the database from the Second National Soil Survey of China. Third, the concept and calculation of referencibility is introduced and the process for cross-referencing soil classification systems at national scale is addressed. GIS based analysis generates 60 reference results between GSCC soil great groups and WRB reference group. Results demonstrate that there is great variability in the maximum referencibility between soil great groups of GSCC and WRB soil groups, which ranged from 29.4% to 100%. In terms of the maximum referencibility, it can be divided into three categories: high (80%–100%), intermediate (50%–80%), and low (<
50%). Among the 60 soil great groups of GSCC, 12 could be labeled as high maximum referencibility, 27 categorized as medium maximum referencibility and the remaining 21 are associated with low maximum referencibility. Finally, the main cause of low maximum referencibility is explored and the potential solution to improve cross reference accuracy was proposed.
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