The energy spectrum of the cosmic microwave background (CMB) allows us to constrain episodes of energy release in the early Universe. In this paper, we revisit and refine computations of the ...cosmological thermalization problem. For this purpose a new code, called CosmoTherm, was developed that allows us to solve the coupled photon-electron Boltzmann equation in the expanding, isotropic Universe for a small spectral distortion in the CMB. We explicitly compute the shape of the spectral distortions caused by energy release due to (i) annihilating dark matter; (ii) decaying relict particles; (iii) dissipation of acoustic waves; and (iv) quasi-instantaneous heating. We also demonstrate that (v) the continuous interaction of CMB photons with adiabatically cooling non-relativistic electrons and baryons causes a negativeμ-type CMB spectral distortion of ΔI
ν/I
ν∼ 10−8 in the GHz spectral band. We solve the thermalization problem including improved approximations for the double Compton and Bremsstrahlung emissivities, as well as the latest treatment of the cosmological recombination process. At redshifts z≲ 103, the matter starts to cool significantly below the temperature of the CMB so that at very low frequencies, free-free absorption alters the shape of primordial distortions significantly. In addition, the cooling electrons down-scatter CMB photons, introducing a small late negative y-type distortion at high frequencies. We also discuss our results in the light of the recently proposed CMB experiment PIXIE, for which CosmoTherm should allow detailed forecasting. Our current computations show that for energy injection because of points (ii) and (iv), PIXIE should allow us to improve existing limits, while the CMB distortions caused by the other processes seem to remain unobservable with the currently proposed sensitivities and spectral bands of PIXIE.
Abstract
Silk damping of primordial small-scale perturbations in the photon-baryon fluid due to diffusion of photons inevitably creates spectral distortions in the cosmic microwave background (CMB). ...With the proposed CMB experiment PIXIE it might become possible to measure these distortions and thereby constrain the primordial power spectrum at comoving wavenumbers 50 ≲ k ≲ 104 Mpc−1. Since primordial fluctuations in the CMB on these scales are completely erased by Silk damping, these distortions may provide the only way to shed light on otherwise unobservable aspects of inflationary physics. A consistent treatment of the primordial dissipation problem requires going to the second order in perturbation theory, while thermalization of these distortions necessitates the consideration of the second order in Compton scattering energy transfer. Here we give a full 2 × 2 treatment for the creation and evolution of spectral distortions due to the acoustic dissipation process, consistently including the effect of polarization and photon mixing in the free-streaming regime. We show that 1/3 of the total energy (9/4 larger than previous estimates) stored in small-scale temperature perturbations imprints observable spectral distortions, while the remaining 2/3 only raises the average CMB temperature, an effect that is unobservable. At high redshift dissipation is mainly mediated through the quadrupole anisotropies, while after recombination peculiar motions are most important. During recombination the damping of the higher multipoles is also significant. We compute the average distortion for several examples using CosmoTherm, analysing their dependence on parameters of the primordial power spectrum. For one of the best-fitting 7-year Wilkinson Microwave Anisotropy Probe cosmologies, with n
S = 1.027 and n
run = −0.034, the cooling of baryonic matter practically compensates the heating from acoustic dissipation in the μ-era. We also derive the evolution equations for anisotropic spectral distortions in the first order perturbation theory. We furthermore argue that the first order anisotropies of spectral distortions may dominate over the corresponding second order contributions from recombination if an average fractional distortion ≃10−5 is already present before recombination.
Based on a homogeneous set of X-ray, infrared and ultraviolet observations from Chandra, Spitzer, GALEX and 2MASS archives, we study populations of high-mass X-ray binaries (HMXBs) in a sample of 29 ...nearby star-forming galaxies and their relation to the star-formation rate (SFR). In agreement with previous results, we find that HMXBs are a good tracer of the recent star-formation activity in the host galaxy and their collective luminosity and number scale with the SFR: in particular,
. However, the scaling relations still bear a rather large dispersion of rms ∼ 0.4 dex, which we believe is of a physical origin.
We present the catalogue of 1055 X-ray sources detected within the D25 ellipse for galaxies of our sample and construct the average X-ray luminosity function (XLF) of HMXBs with substantially improved statistical accuracy and better control of systematic effects than achieved in previous studies. The XLF follows a power law with a slope of 1.6 in the log (L
X) ∼ 35-40 luminosity range with moderately significant evidence for a break or cut-off at L
X∼ 1040 erg s−1. As before, we did not find any features at the Eddington limit for a neutron star or a stellar-mass black hole.
We discuss the implications of our results for the theory of binary evolution. In particular we estimate the fraction of compact objects that once in their lifetime experienced an X-ray active phase powered by accretion from a high-mass companion and obtain a rather large number, f
X∼ 0.2 × (0.1 Myr/τX), where τX is the lifetime of the X-ray active phase. This is ∼4 orders of magnitude more frequent than in low-mass X-ray binaries (LMXBs). We also derive constraints on the mass distribution of the secondary star in HMXBs.
We calculate the one-point probability density distribution functions (PDF) and the power spectra of the thermal and kinetic Sunyaev-Zeldovich (tSZ and kSZ) effects and the mean Compton Y parameter ...using the Magneticum Pathfinder simulations, state-of-the-art cosmological hydrodynamical simulations of a large cosmological volume of (896 Mpc h super( -1)) super( 3). These simulations follow in detail the thermal and chemical evolution of the intracluster medium as well as the evolution of supermassive black holes and their associated feedback processes. We construct full-sky maps of tSZ and kSZ from the light-cones out to z = 0.17, and one realization of 8 ...8 x 8 ...8 deep light-cone out to z = 5.2. The local universe at z < 0.027 is simulated by a constrained realization. The tail of the one-point PDF of tSZ from the deep light-cone follows a power-law shape with an index of -3.2. Once convolved with the effective beam of Planck, it agrees with the PDF measured by Planck. The predicted tSZ power spectrum agrees with that of the Planck data at all multipoles up to l ... 1000, once the calculations are scaled to the Planck 2015 cosmological parameters with ... = 0.308 and ... = 0.8149. Consistent with the results in the literature, however, we continue to find the tSZ power spectrum at l = 3000 that is significantly larger than that estimated from the high-resolution ground-based data. The simulation predicts the mean fluctuating Compton Y value of Y = 1.18 x 10 super( -6) for ... = 0.272 and ... = 0.809. Nearly half (...5 x 10 super( -7)) of the signal comes from haloes below a virial mass of 10 super( 13) M... h super( -1). Scaling this to the Planck 2015 parameters, we find Y = 1.57 x 10 super( -6). (ProQuest: ... denotes formulae/symbols omitted.)
Abstract
We study the emission from the hot interstellar medium (ISM) in a sample of nearby late-type galaxies defined in Paper I. Our sample covers a broad range of star formation rates (SFRs) from ...∼0.1 to ∼17 M⊙ yr−1 and stellar masses from ∼3 × 108 to ∼6 × 1010 M⊙. We take special care of systematic effects and contamination from bright and faint compact sources. We find that in all galaxies at least one optically thin thermal emission component is present in the unresolved emission, with the average temperature of 〈kT〉 = 0.24 keV. In about ∼1/3 of galaxies, a second, higher temperature component is required, with 〈kT〉 = 0.71 keV. Although statistically significant variations in temperature between galaxies are present, we do not find any meaningful trends with the stellar mass or SFR of the host galaxy. The apparent luminosity of the diffuse emission in the 0.5-2 keV band linearly correlates with the SFR with the scale factor of L
x
/SFR≈8.3×1038ergs−1(M⊙yr−1)−1, of which in average ∼30-40 per cent is likely produced by faint compact sources of various types. We attempt to estimate the bolometric luminosity of the gas and obtain results differing by an order of magnitude, log(L
bol/SFR) ∼ 39−40, depending on whether intrinsic absorption in star-forming galaxies is allowed or not. Our theoretically most accurate, but in practice the most model-dependent result for the intrinsic bolometric luminosity of the ISM is L
bol/SFR ∼ 1.5×1040erg s−1(M⊙yr−1)−1. Assuming that core-collapse supernovae are the main source of energy, it is implied that ϵSN ∼ 5×10−2(ESN/1051)−1 of mechanical energy of supernovae is converted into thermal energy of the ISM.
Human genetics has been haunted by the mystery of "missing heritability" of common traits. Although studies have discovered >1,200 variants associated with common diseases and traits, these variants ...typically appear to explain only a minority of the heritability. The proportion of heritability explained by a set of variants is the ratio of (i) the heritability due to these variants (numerator), estimated directly from their observed effects, to (ii) the total heritability (denominator), inferred indirectly from population data. The prevailing view has been that the explanation for missing heritability lies in the numerator—that is, in as-yet undiscovered variants. While many variants surely remain to be found, we show here that a substantial portion of missing heritability could arise from overestimation of the denominator, creating "phantom heritability." Specifically, (i) estimates of total heritability implicitly assume the trait involves no genetic interactions (epistasis) among loci; (ii) this assumption is not justified, because models with interactions are also consistent with observable data; and (iii) under such models, the total heritability may be much smaller and thus the proportion of heritability explained much larger. For example, 80% of the currently missing heritability for Crohn's disease could be due to genetic interactions, if the disease involves interaction among three pathways. In short, missing heritability need not directly correspond to missing variants, because current estimates of total heritability may be significantly inflated by genetic interactions. Finally, we describe a method for estimating heritability from isolated populations that is not inflated by genetic interactions.
Genetic predictions of height differ among human populations and these differences have been interpreted as evidence of polygenic adaptation. These differences were first detected using SNPs ...genome-wide significantly associated with height, and shown to grow stronger when large numbers of sub-significant SNPs were included, leading to excitement about the prospect of analyzing large fractions of the genome to detect polygenic adaptation for multiple traits. Previous studies of height have been based on SNP effect size measurements in the GIANT Consortium meta-analysis. Here we repeat the analyses in the UK Biobank, a much more homogeneously designed study. We show that polygenic adaptation signals based on large numbers of SNPs below genome-wide significance are extremely sensitive to biases due to uncorrected population stratification. More generally, our results imply that typical constructions of polygenic scores are sensitive to population stratification and that population-level differences should be interpreted with caution.
This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
PolyPhen-2 (Polymorphism Phenotyping v2), available as software and via a Web server, predicts the possible impact of amino acid substitutions on the stability and function of human proteins using ...structural and comparative evolutionary considerations. It performs functional annotation of single-nucleotide polymorphisms (SNPs), maps coding SNPs to gene transcripts, extracts protein sequence annotations and structural attributes, and builds conservation profiles. It then estimates the probability of the missense mutation being damaging based on a combination of all these properties. PolyPhen-2 features include a high-quality multiple protein sequence alignment pipeline and a prediction method employing machine-learning classification. The software also integrates the UCSC Genome Browser's human genome annotations and MultiZ multiple alignments of vertebrate genomes with the human genome. PolyPhen-2 is capable of analyzing large volumes of data produced by next-generation sequencing projects, thanks to built-in support for high-performance computing environments like Grid Engine and Platform LSF.
Human genetic variation is distributed nonrandomly across the genome, though the principles governing its distribution are only partially known. DNA replication creates opportunities for mutation, ...and the timing of DNA replication correlates with the density of SNPs across the human genome. To enable deeper investigation of how DNA replication timing relates to human mutation and variation, we generated a high-resolution map of the human genome’s replication timing program and analyzed its relationship to point mutations, copy number variations, and the meiotic recombination hotspots utilized by males and females. DNA replication timing associated with point mutations far more strongly than predicted from earlier analyses and showed a stronger relationship to transversion than transition mutations. Structural mutations arising from recombination-based mechanisms and recombination hotspots used more extensively by females were enriched in early-replicating parts of the genome, though these relationships appeared to relate more strongly to the genomic distribution of causative sequence features. These results indicate differential and sex-specific relationship of DNA replication timing to different forms of mutation and recombination.
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