The possibility has been proposed that the vicious cycle which consists of basal diseases, bacterial metabolites and host persistent inflammation affected on intractability of chronic respiratory ...tract infections (CRTI) . To elucidate the contribution of host inflammation to the intractability of CRTI, we investigated the effect of repeated inhalations of sterilized Escherichia colisuspension on cellular and biochemical parameters in bronchoalveolar lavage fluid (BALF) and lung tissue using rats. An influx of neutrophils, a leakage of albumin and an increase of neutrophil elastase activity in airways were maintained during the repeated inhalations, which confirmed that there arose a chronic pulmonary inflammation. In histological studies, the lung tissue of inhaled rats showed chronic inflammatory features which resembled in diffuse panbronchiolitis. In the model, erythromycin reduced the number of neutrophils, the concentration of albumin, and the elastase activity in BALF. Furthermore, no or weak histological changes were observed in the lung tissue of rats treated with erythromycin, and the deterioration of pulmonary mechanics was suppressed. These results suggest that host persistent and excessive inflammation contributes markedly to the exacerbation of basal disease caused by CRTI, and that the suppression of such inflammation is promising to its medical care.
In a series of twenty-five children (0-14 years) born of diabetic mothers, the congenital abnormalities, the bone development, the neuropsychological development and the glucose tolerance were ...studied. The results are summarized as follows. (1) Eighteen of the 25 children showed normal weight andheight of their age, 4 overweight with normal height, 2 normal weight with low height, and one underweight and low height. (2) No congenital major abnormalities were observed, however minor ones were observed in eleven children (44%) (3) Nineteen of twenty-two children showed normal development of the bones, and three delayed. (4) None showed mental retardation. (5) Fifteen of twenty-one children showed normal findings of EEGs, 4 borderline ones, and 2 abnormal ones. (6) One-hundred gram-OGTT was examined in thirteen children. Eleven of them showed normal blood glucose patterns, and two borderline ones. Four of them showed low insulin responses, one delayed response, 2 hyperresponses, and 6 normal responses.
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