A variety of terminal alkynes are facilely convertible into cis-boryl(stannyl)alkenes with inverse regioselectivity to those of the previous borylstannylation by the copper-catalyzed three-component ...reaction using a masked diboron. The synthetic utility of the resulting boryl(stannyl)alkenes has been demonstrated by chemoselective coupling reactions.
Abstract
We report on a search for electron antineutrinos (
ν
¯
e
) from astrophysical sources in the neutrino energy range 8.3–30.8 MeV with the KamLAND detector. In an exposure of 6.72 kton-year of ...the liquid scintillator, we observe 18 candidate events via the inverse beta decay reaction. Although there is a large background uncertainty from neutral current atmospheric neutrino interactions, we find no significant excess over background model predictions. Assuming several supernova relic neutrino spectra, we give upper flux limits of 60–110 cm
−2
s
−1
(90% confidence level, CL) in the analysis range and present a model-independent flux. We also set limits on the annihilation rates for light dark matter pairs to neutrino pairs. These data improve on the upper probability limit of
8
B solar neutrinos converting into
ν
¯
e
,
P
ν
e
→
ν
¯
e
<
3.5
×
10
−
5
(90% CL) assuming an undistorted
ν
¯
e
shape. This corresponds to a solar
ν
¯
e
flux of 60 cm
−2
s
−1
(90% CL) in the analysis energy range.
Abstract
We present the results of a search for MeV-scale electron antineutrino events in KamLAND coincident with the 60 gravitational wave events/candidates reported by the LIGO/Virgo collaboration ...during their second and third observing runs. We find no significant coincident signals within a ±500 s timing window from each gravitational wave and present 90% C.L. upper limits on the electron antineutrino fluence between 10
8
and 10
13
cm
−2
for neutrino energies in the energy range of 1.8–111 MeV.
Widely-used
Streptomyces
-derived antibacterial aminoglycosides have encountered challenges because of antibiotic resistance and toxicity. Today, they are largely relegated to medicinal topical ...applications. However, chemical modification to amphiphilic aminoglycosides can revive their efficacy against bacterial pathogens and expand their targets to other pathogenic microbes and disorders associated with hyperactive connexin hemichannels. For example, amphiphilic versions of neomycin and neamine are not subject to resistance and have expanded antibacterial spectra, and amphiphilic kanamycins are effective antifungals and have promising therapeutic uses as connexin hemichannel inhibitors. With further research and discoveries aimed at improved formulations and delivery, amphiphilic aminoglycosides may achieve new horizons in pharmacopeia and agriculture for
Streptomyces
aminoglycosides beyond just serving as topical antibacterials.
A novel aminoglycoside, FG08, that differs from kanamycin B only by a C8 alkyl chain at the 4″-O position, was previously reported. Unlike kanamycin B, FG08 shows broad-spectrum fungicidal but not ...anti-bacterial activities. To understand its specificity for fungi, the mechanism of action of FG08 was studied using intact cells of the yeast Saccharomyces cerevisiae and small unilamellar membrane vesicles. With exposure to FG08 (30 µg mL(-1)), 8-fold more cells were stained with fluorescein isothiocyanate, cells had 4 to 6-fold higher K(+) efflux rates, and 18-fold more cells were stained with SYTOX Green in comparison to exposure to kanamycin B (30 µg mL(-1)). Yeast mutants with aberrant membrane sphingolipids (no sphingoid base C4 hydroxyl group, truncated very long fatty acid chain, or lacking the terminal phosphorylinositol group of mannosyl-diinositolphosphorylphytoceramide were 4 to 8-fold less susceptible to growth inhibition with FG08 and showed 2 to 10-fold lower SYTOX Green dye uptake rates than did the isogenic wild-type strain. FG08 caused leakage of pre-loaded calcein from 50% of small unilamellar vesicles with glycerophospholipid and sterol compositions that mimic the compositions of fungal plasma membranes. Less than 5 and 10% of vesicles with glycerophospholipid and sterol compositions that mimic bacterial and mammalian cell plasma membranes, respectively, showed calcein leakage. In tetrazolium dye cytotoxicity tests, mammalian cell lines NIH3T3 and C8161.9 showed FG08 toxicity at concentrations that were 10 to 20-fold higher than fungicidal minimal inhibitory concentrations. It is concluded that FG08's growth inhibitory specificity for fungi lie in plasma membrane permeability changes involving mechanisms that are modulated by membrane lipid composition.
We present the results of a search for extraterrestrial electron antineutrinos (v sub(e)'s) in the energy range 8.3 MeV < Ev sub(e) < 31.8 MeV using the KamLAND detector. In an exposure of 4.53 ...kton-year, we identify 25 candidate events. All of the candidate events can be attributed to background, most importantly neutral current atmospheric neutrino interactions, setting an upper limit on the probability of super(8)B solar converting into v sub(e)'s at 5.3 x 10 super(-5) (90% CL), if we assume an undistorted v sub(e) shape. This limit corresponds to a solar v sub(e) flux of 93 cm super(-2) s super(-1) or an event rate of 1.6 events (kton - year) super(-1) above the energy threshold Ev sub(e) > or =, slanted 8.3 MeV. The present data also allows us to set more stringent limits on the diffuse supernova neutrino flux and on the annihilation rates for light dark matter particles.
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