To observe the efficacy and safety of pelvic floor magnetic stimulation (PFMS) combined with mirabegron in female patients with refractory overactive bladder (OAB) symptoms.
A total of 160 female ...patients with refractory OAB symptoms were prospectively randomized into two groups. Eighty cases in the combination group accepted PFMS and mirabegron therapy and 80 cases as control only accepted mirabegron therapy (The clinical trial registry number: ChiCTR2200070171). The lower urinary tract symptoms, OAB questionnaire (OAB-q) health-related quality of life (HRQol), symptom bother score and OABSS between two groups were compared at the 1st, 2nd and 4th week ends.
All of 160 patients were randomly assigned to two groups, of which 80 patients were included in the combination group and 80 in the mirabegron group. The incidences of LUTS, including urgency, frequent urination, and incontinence episodes, in the 2nd week and the 4th week after combination treatment were significantly lower than those in the mirabegron group (
< 0.05). The incidence of drug-related adverse events between two groups was similar, and there was no statistically significant difference (
> 0.05). With respect to secondary variables, the OAB-q HRQol score in the combination group was statistically superior in comparison with that in the mirabegron group between the 2nd week and the 4th week (
< 0.05). This was consistent with the primary outcome. Meanwhile, from the second to fourth week, the OAB-q symptom bother score and OABSS in the combination group were both lower than in the mirabegron group (
< 0.05).
Combination therapy of PFMS and mirabegron demonstrated significant improvements over mirabegron monotherapy in reducing refractory OAB symptoms for female patients, and providing a higher quality of life without increasing bothersome adverse effects.
https://www.chictr.org.cn/, ChiCTR-INR-22013524.
The electronic structures and photocatalytic properties of bismuth oxyhalide bilayers (BiOX1/BiOX2, X1 and X2 are Cl, Br, I) are studied by density functional theory. Briefly, their compositionally ...tunable bandgaps range from 1.85 to 3.41 eV, suitable for sun-light absorption, and all bilayers have band-alignments good for photocatalytic water-splitting. Among them, heterogeneous BiOBr/BiOI bilayer is the best as it has the smallest bandgap. More importantly, photo-excitation of BiOBr/BiOI leads to electron supply to the conduction band minimum with localized states belonging mainly to bismuth of BiOBr where the H(+)/H2 half-reaction of water-splitting can be sustained. Meanwhile, holes generated by such photo-excitation are mainly derived from the iodine states of BiOI in the valence band maximum; thus, the O2/H2O half-reaction of water splitting is facilitated on BiOI. Detailed band-structure analysis also indicates that this intriguing spatial separation of photo-generated electron-hole pairs and the two half-reactions of water splitting are good for a wide photo-excitation spectrum from 2-5 eV; as such, BiOBr/BiOI bilayer can be an efficient photocatalyst for water-splitting, particularly with further optimization of its optical absorptivity.
Dysregulation of long non-coding RNAs has been found in many human cancers, including colorectal cancer that is still the third most prevalent cancer worldwide and related to poor prognosis; along ...with this, robust testimony has identified that long non-coding RNAs can take charge of tumor suppressor genes or oncogenes. This review summarizes nowadays research achievements on the character of long non-coding RNAs in the prognosis and diagnosis of colorectal cancer. On the basis of the results acquired in the last decade, some long non-coding RNAs are rising as biomarkers of colorectal cancer for prognosis, diagnosis, even prediction of therapeutic result, and have crucial effects in the regulation of colorectal cancer cell functions such as proliferation, invasion, apoptosis, metastasis, and drug resistant ability. Also, long non-coding RNAs, circulating in body fluids, could act as novel, affordable, lightly accessible, non-invasive detection tools for the personal health management of patients with colorectal cancer. Especially, circulating long non-coding RNA profiles may be demonstrating preferable prognostic and diagnostic capability and better accuracy than respective long non-coding RNAs in colorectal cancer.
The objective was to investigate the safety and efficacy of the nutrition protocol in enhanced recovery after surgery (ERAS) of hypopharyngeal cancer. Protocol focus was patient consumption of ...nutritional supplements perioperatively. In this retrospective study, a total of 78 patients with hypopharyngeal cancer were divided into the ERAS group (n = 39) and the control group (n = 39). The data were collected from two groups of three time points: 1 day before surgery, 1 day after surgery, and 7 days after surgery. The difference between two groups of the nutritional and immune status, postoperative exhaust time, hospitalization expense and hospitalization time were compared. The nutritional and immune status in the ERAS group were better than that in the control group at 7 days after surgery (P < .05); The hospitalization expense and hospitalization time in the ERAS group were lower comparing with the control group (P < .05). Our nutrition protocol is effective and safe in ERAS of patients with hypopharyngeal cancer. It's significant to implement ERAS of hypopharyngeal cancer patients with nutritional protocol during peroperative period, which will improve immune system, maintain health metabolic functions, and reduce the hospitalization time as well as the hospitalization expense.
A novel Gram-stain-positive, aerobic, cocci-shaped actinobacterium, designated YIM 75000
T
, was isolated from a soil sample collected from a dry-hot river valley in Yunnan Province, P.R. China. ...Growth was observed at 10–45 °C (optimal 37 °C), 0–8% (w/v) NaCl (optimal at 0–3% NaCl) and pH 6.0–8.0 (optimal at pH 7.3). The peptidoglycan contained LL-diaminopimelic acid, glycine, glutamic acid as well as alanine and its type was A3
γ
with an LL-Dpm-Gly interpeptide bridge. The major cellular fatty acids (> 10%) were C
16:0
, Summed In Feature 3 (C
16:1
ω6c
/C
16:1
ω7c
) and C
17:1
ω8c
. The predominant menaquinone was MK-9(H
4
). The major whole-cell sugars contained rhamnose, ribose, arabinose and mannose. The DNA G+C content was 77.0 mol%. The 16S rRNA gene sequence similarities of strain YIM 75000
T
with other species were less than 94%. Phylogenetic analyses based on 16S rRNA gene sequences and genome data, revealed that strain YIM 75000
T
together with the genus
Motilibacter
formed a distinct phylogenetic lineage within the phylum Actinobacteria, separating them from members of all orders. Strain YIM 75000
T
showed 73.4–73.7% average nucleotide identity and 19.5–19.7% digital DNA–DNA hybridization identity with the closely related genus
Motilibacter
. Based on the phenotypic, phylogenetic and chemotaxonomic data, it is proposed that the new isolate represents the nomenclature type of the novel species
Vallicoccus soli
gen. nov., sp. nov. (YIM 75000
T
= DSM 45377
T
= KCTC 49228
T
= CGMCC 1.13844
T
) which is the nomenclature type of the novel genus
Vallicoccus
gen. nov. within
Vallicoccaceae
fam. nov and
Motilibacterales
ord. nov in the phylum Actinobacteria. The family
Vallicoccaceae
fam. nov. and the order
Motilibacterales
(contains
Vallicoccaceae
fam. nov. and
Motilibacteraceae
Lee
2013
) ord. nov. are formally proposed.
Androgynous tendencies and persistently low fertility rates have been observed in many countries, causing major social concerns. The theory of sexual selection suggests a possible mechanism between ...androgyny and decreased sexual activeness, as masculinity and femininity constitute an important aspect of reproductive strategies. This theory has also been proven by evolutionary and societal evidence. Therefore, we investigate the association between masculinity and femininity with sexual activeness, as well as the influence of gender-role conformity on the frequency of sexual intercourse through sexually selected traits among 42,492 Chinese youths. Sexual activeness was measured using sexual attitudes, experience, behaviors, and pleasure. Mediation analysis was employed to investigate the effects of sexually selected traits on the association between masculinity and femininity with sexual activeness, and gender-role conformity with the frequency of sexual intercourse. Low sexual activeness was found to be associated with low gender-role conformity. Our findings also suggest that physical attractiveness, sexual motivation, and interpersonal relationships may mediate the association between sexual activeness and gender-role conformity, supporting the males-compete/females-choose model.
With the goal of supporting close-range observation tasks of a spherical amphibious robot, such as ecological observations and intelligent surveillance, a moving target detection and tracking system ...was designed and implemented in this study. Given the restrictions presented by the amphibious environment and the small-sized spherical amphibious robot, an industrial camera and vision algorithms using adaptive appearance models were adopted to construct the proposed system. To handle the problem of light scattering and absorption in the underwater environment, the multi-scale retinex with color restoration algorithm was used for image enhancement. Given the environmental disturbances in practical amphibious scenarios, the Gaussian mixture model was used to detect moving targets entering the field of view of the robot. A fast compressive tracker with a Kalman prediction mechanism was used to track the specified target. Considering the limited load space and the unique mechanical structure of the robot, the proposed vision system was fabricated with a low power system-on-chip using an asymmetric and heterogeneous computing architecture. Experimental results confirmed the validity and high efficiency of the proposed system. The design presented in this paper is able to meet future demands of spherical amphibious robots in biological monitoring and multi-robot cooperation.
Abstract
Background
Little is known about the access to measures of sexual and reproductive health (SRH) services among sexual minority communities in China, where sexuality-related stigma and ...discrimination remains high. The aim of this study is to investigate access to measures of SRH services among Chinese sexual minority youths (SMY) aged 17 to 24 years old.
Methods
This cross-sectional study utilizes data on 54,580 youths from the 2019–2020 National College Student Survey on Sexual and Reproductive Health, conducted across 31 provinces in mainland China. Multivariable logistic regression modelling was utilized to assess the access to SRH services among Chinese youth with different self-reported sexual orientation.
Results
The majority of respondents identified as heterosexual (77.6%). The remaining respondents identified as bisexual (9.0%), lesbian or gay (2.8%), others (3.02%), or unknown (7.51%). Gay men reported greater access to free contraceptives at health centers (OR 1.62, 95% CI: 1.32–1.99) and were more likely to have receive medical treatment for sexual and reproductive issues (OR 1.83, 95% CI: 1.26–2.63) compared to heterosexual men. Gay and bisexual men were also more likely to use condom at first sexual intercourse compared to heterosexual men (gay men: OR 1.38, 95% CI: 1.13–1.68; bisexual men: OR 1.33, 95% CI: 1.03–1.71). However, the associations were reversed among women (lesbians: OR 0.05, 95% CI: 0.03 to 0.08; bisexuals: 0.75, 95% CI: 0.65 to 0.86).
Conclusions
Although SMY reported higher utilization of SRH services compared to their heterosexual counterparts, access to SRH services remains low among Chinese youths. Greater focus should be placed on improving access to SMY-friendly SRH services among Chinese youths.
The current decolonizing global health movement is calling us to take a post-colonial perspective at the research and practice of global health, an area that has been re-defined by contemporary ...scholars and advocates with the purpose of promoting equity and justice. In this article, we summarize the main points of discussion from the Symposium organized by the editorial board of Global Health Research and Policy, convened in July 2021 in Wuhan, China. Experts participating in the symposium discussed what decolonizing global health means, how to decolonize it, and what criteria to apply in measuring its completion. Through the meeting, a consensus was reached that the current status quo of global health is still replete with various forms of colonial vestiges-ideologies and practices-, and to fully decolonize global health, systemic reforms must be taken that target the fundamental assumptions of global health: does investment in global health bring socioeconomic development, or is it the other way around? Three levels of colonial vestiges in global health were raised and one guiding principle was proposed when thinking of solutions for them. More theoretical discussion needs to be explored to guide practices to decolonize global health.
A Gram-stain-positive, aerobic, nonmotile actinobacterium, designated strain YIM 93776
T
, was isolated from a saline sediment sample collected from Aiding Lake in Xinjiang Uygur Autonomous Region, ...Northwest China. Phylogenetic analysis based on the 16S rRNA gene sequences showed that strain YIM 93776
T
was affiliated to the genus
Glycomyces
and was closely related to
Glycomyces albus
TRM 49136
T
(97.6% sequence similarity),
Glycomyces lacisalsi
XHU 5089
T
(97.0%) and
Glycomyces anabasis
EGI 6500139
T
(96.2%). The cell wall contained
meso
-diaminopimelic acid and the whole-cell hydrolysates sugars were galactose, mannose, arabinase, glucose and ribose. The predominant menaquinones were MK-9 (H
4
) and MK-10 (H
4
). Diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol, two phosphatidylglyceride, two unidentified phospholipids and two unidentified polar lipids were detected in the polar lipid extracts. Major fatty acids were anteiso-C
17:0
, iso-C
15:0
, iso-C
16:0
, anteiso-C
15:0
and anteiso C
17:1
A. The draft genome sequence of strain YIM 93776
T
was 5.37 Mbp in size with 69.5% DNA G + C content. The dDDH and ANI values between strain YIM 93776
T
and related neighbours were 25.0–34.3% and 77.3–79.8%, respectively. On the basis of morphological, chemotaxonomic and phylogenetic evidence, strain YIM 93776
T
; therefore, represents a novel species, for which the name
Glycomyces salinus
sp. nov. is proposed. The type strain is YIM 93776
T
(= KCTC 49430
T
= CGMCC 4.7685
T
).
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