Quercetagetin and patuletin were extracted by the same method from two different
species that have multiple uses in folk medicine in Mexico and around the globe, one of which is as an anticancer ...agent. Their biological activity (IC
and necrotic, apoptotic and selective activities of these flavonols) was evaluated and compared to that of quercetin, examining specifically the effects of C6 substitution among quercetin, quercetagetin and patuletin. We find that the presence of a methoxyl group in C6 enhances their potency.
We use about two decades of geodetic measurements to characterize interseismic strain build up along the Central Andes subduction zone from Lima, Peru, to Antofagasta, Chile. These measurements are ...modeled assuming a 3‐plate model (Nazca, Andean sliver and South America Craton) and spatially varying interseismic coupling (ISC) on the Nazca megathrust interface. We also determine slip models of the 1996 Mw = 7.7 Nazca, the 2001 Mw = 8.4 Arequipa, the 2007 Mw = 8.0 Pisco and the Mw = 7.7 Tocopilla earthquakes. We find that the data require a highly heterogeneous ISC pattern and that, overall, areas with large seismic slip coincide with areas which remain locked in the interseismic period (with high ISC). Offshore Lima where the ISC is high, a Mw∼8.6–8.8 earthquake occurred in 1746. This area ruptured again in a sequence of four Mw∼8.0 earthquakes in 1940, 1966, 1974 and 2007 but these events released only a small fraction of the elastic strain which has built up since 1746 so that enough elastic strain might be available there to generate a Mw > 8.5 earthquake. The region where the Nazca ridge subducts appears to be mostly creeping aseismically in the interseismic period (low ISC) and seems to act as a permanent barrier as no large earthquake ruptured through it in the last 500 years. In southern Peru, ISC is relatively high and the deficit of moment accumulated since the Mw∼8.8 earthquake of 1868 is equivalent to a magnitude Mw∼8.4 earthquake. Two asperities separated by a subtle aseismic creeping patch are revealed there. This aseismic patch may arrest some rupture as happened during the 2001 Arequipa earthquake, but the larger earthquakes of 1604 and 1868 were able to rupture through it. In northern Chile, ISC is very high and the rupture of the 2007 Tocopilla earthquake has released only 4% of the elastic strain that has accumulated since 1877. The deficit of moment which has accumulated there is equivalent to a magnitude Mw∼8.7 earthquake. This study thus provides elements to assess the location, size and magnitude of future large megathurst earthquakes in the Central Andes subduction zone. Caveats of this study are that interseismic strain of the forearc is assumed time invariant and entirely elastic. Also a major source of uncertainty is due to fact that the available data place very little constraints on interseismic coupling at shallow depth near the trench, except offshore Lima where sea bottom geodetic measurements have been collected suggesting strong coupling.
Key Points
High seismic potential on the subduction offshore Lima, S. Peru and N. Chile
Barriers are persistent features of the megathrust
Asperities are non‐persistent feature
Slip on a subduction megathrust can be seismic or aseismic, with the two modes of slip complementing each other in time and space to accommodate the long-term plate motions. Although slip is almost ...purely aseismic at depths greater than about 40 km, heterogeneous surface strain suggests that both modes of slip occur at shallower depths, with aseismic slip resulting from steady or transient creep in the interseismic and postseismic periods. Thus, active faults seem to comprise areas that slip mostly during earthquakes, and areas that mostly slip aseismically. The size, location and frequency of earthquakes that a megathrust can generate thus depend on where and when aseismic creep is taking place, and what fraction of the long-term slip rate it accounts for. Here we address this issue by focusing on the central Peru megathrust. We show that the Pisco earthquake, with moment magnitude Mw = 8.0, ruptured two asperities within a patch that had remained locked in the interseismic period, and triggered aseismic frictional afterslip on two adjacent patches. The most prominent patch of afterslip coincides with the subducting Nazca ridge, an area also characterized by low interseismic coupling, which seems to have repeatedly acted as a barrier to seismic rupture propagation in the past. The seismogenic portion of the megathrust thus appears to be composed of interfingering rate-weakening and rate-strengthening patches. The rate-strengthening patches contribute to a high proportion of aseismic slip, and determine the extent and frequency of large interplate earthquakes. Aseismic slip accounts for as much as 50-70% of the slip budget on the seismogenic portion of the megathrust in central Peru, and the return period of earthquakes with Mw = 8.0 in the Pisco area is estimated to be 250 years.
This paper presents an analysis and simulation of the mathematical model associated to the DC/DC Boost converter–full-bridge Buck inverter system to regulate the voltage output of the DC/DC Boost ...converter allowing bipolar voltages higher than the input voltage via the full-bridge Buck inverter. To validate the model, the differential flatness property is applied via the flat outputs of the system (energy for the DC/DC Boost converter and the voltage of the full-bridge Buck inverter) considering the complete dynamics, in conjunction with fixed and time-variant trajectory planning. In the simulation results, it is observed that the error signals of the states versus the reference trajectories are acceptable. Regarding the validation of the model, this is performed with open-loop simulations at the circuit level using the SimPowerSystems Toolbox of Matlab-Simulink. The simulation results validate the good performance of the system under study. In this way, the main contribution of this work is that for the first time in the literature, the analysis of a complete dynamics for a conversion system from DC to AC without the use of a transformer and taking advantage of differential flatness is reported; thus, the system analyzed could be represented as an alternative in applications of renewable energies that require conversion from DC to AC.
Numerous chemical compounds isolated from medicinal plants have anti-tumor properties, the effects of which on human cancer cells are currently under study. Here, the chemical transformation of ...glaucolide B were performed to produce a hirsutinolide. The antiproliferative and cytotoxic activity of 5β-hydroxy-hirsutinolide and its ability to induce apoptosis in tumor and non-tumor cells (lymphocyte cultures and the normal HaCaT cell line) (1a) are reported. We ascertained that compound 1a exerts an inhibitory effect on the proliferation of SK-Lu-1, MDA-MB-231 and CaSki cells in a dose-dependent manner at IC50 values of 15, 18 and 30 μg/ml, respectively. The proliferation of lymphocyte cells treated with 1a was inhibited at a range from 14 to 28%, but the HaCaT cell line was not affected, suggesting that compound 1a has a selective action. Cytotoxic activity was evaluated by detecting the lactate dehydrogenase enzyme in supernatants from tumor and non-tumor cells. The 1a compound exhibited low or null cytotoxic activity in both cell types. The presence of apoptotic bodies and active caspase-3 in tumor cell lines treated with compound 1a are suggestive of apoptotic cell death. Notably, flow cytometry evaluation did not detect the presence of active caspase-3 on lymphocytes treated with this compound. Our results suggest that 5β-hydroxy-hirsutinolide is a molecule with antiproliferative activity and low cytotoxic activity in tumor and non-tumor cells; this induces apoptotic cell death in tumor cell lines through selective action. Hence, this lactone could be considered a molecule worthy of study as an anti-tumor agent with therapeutic potential.
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En este trabajo se estudió el comportamiento tribológico, la rigidez y dureza, de la superficie de la aleación Ti6Al4V ELI después de llevar a cabo un tratamiento de nitruración por descarga intensa ...de plasma a temperaturas de 450, 480 y 520 °C. El par tribológico empleado fue metal-metal (pin de Ti6Al4V ELI - disco de Ti6Al4V ELI con tratamiento) para el respectivo cálculo del coeficiente de fricción. Los ensayos de nanoindentación se realizaron con una punta de ultra alta dureza de módulo de rigidez conocido, que permitió obtener la dureza promedio y el módulo de Young en GPa, de acuerdo con las normas ISO 14577 y ASTM G99-95 respectivamente. Para la caracterización del sustrato, se empleó microscopia electrónica de barrido, microscopia de fuerza atómica y difracción de rayos X, obteniendo así características importantes del comportamiento elástico-plástico, antes y después de aplicarse la nitruración a la aleación por descarga intensa de plasma
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