Abstract
We examine the effects of an impending cluster merger on galaxies in the large-scale structure (LSS) RX J0910 at z =1.105. Using multiwavelength data, including 102 spectral members drawn ...from the Observations of Redshift Evolution in Large Scale Environments (ORELSE) survey and precise photometric redshifts, we calculate star formation rates and map the specific star formation rate density of the LSS galaxies. These analyses along with an investigation of the colour–magnitude properties of LSS galaxies indicate lower levels of star formation activity in the region between the merging clusters relative to the outskirts of the system. We suggest that gravitational tidal forces due to the potential of the merging haloes may be the physical mechanism responsible for the observed suppression of star formation in galaxies caught between the merging clusters.
In order to reproduce the high-mass end of the galaxy mass distribution, some process must be responsible for the suppression of star formation in the most massive of galaxies. Commonly active ...galactic nuclei (AGN) are invoked to fulfil this role, but the exact means by which they do so is still the topic of much debate, with studies finding evidence for both the suppression and enhancement of star formation in AGN hosts. Using the ZFOURGE (FourStar Galaxy Evolution) and NMBS (Newfirm Medium Band Survey) galaxy surveys, we investigate the host galaxy properties of a mass-limited (M greater than or equal to 10... M...), high-luminosity (L... > 10... W Hz...) sample of radio-loud AGN to a redshift of z = 2.25. In contrast to low-redshift studies, which associate radio-AGN activity with quiescent hosts, we find that the majority of z > 1.5 radio-AGN are hosted by star-forming galaxies. Indeed, the stellar populations of radio-AGN are found to evolve with redshift in a manner that is consistent with the non-AGN mass-similar galaxy population. Interestingly, we find that the radio-AGN fraction is constant across a redshift range of 0.25 less than or equal to z < 2.25, perhaps indicating that the radio-AGN duty cycle has little dependence on redshift or galaxy type. We do however see a strong relation between the radio-AGN fraction and stellar mass, with radio-AGN becoming rare below ~10... M... or a halo mass of 10... M... This halo-mass threshold is in good agreement with simulations that initiate radio-AGN feedback at this mass limit. Despite this, we find that radio-AGN host star formation rates are consistent with the non-AGN mass-similar galaxy sample, suggesting that while radio-AGN are in the right place to suppress star formation in massive galaxies they are not necessarily responsible for doing so. (ProQuest: ... denotes formulae/symbols omitted.)
Utilizing spectroscopic observations taken for the VIMOS Ultra-Deep Survey (VUDS), new observations from Keck/DEIMOS, and publicly available observations of large samples of star-forming galaxies, we ...report here on the relationship between the star-formation rate (SFR) and the local environment (
δ
gal
) of galaxies in the early universe (2 <
z
< 5). Unlike what is observed at lower redshifts (
z
≲ 2), we observe a definite, nearly monotonic increase in the average SFR with increasing galaxy overdensity over more than an order of magnitude in
δ
gal
. The robustness of this trend is quantified by accounting for both uncertainties in our measurements and galaxy populations that are either underrepresented or not present in our sample (e.g., extremely dusty star-forming and quiescent galaxies), and we find that the trend remains significant under all circumstances. This trend appears to be primarily driven by the fractional increase of galaxies in high-density environments that are more massive in their stellar content and are forming stars at a higher rate than their less massive counterparts. We find that, even after stellar mass effects are accounted for, there remains a weak but significant SFR–
δ
gal
trend in our sample implying that additional environmentally related processes are helping to drive this trend. We also find clear evidence that the average SFR of galaxies in the densest environments increases with increasing redshift. These results lend themselves to a picture in which massive gas-rich galaxies coalesce into proto-cluster environments at
z
≳ 3, interact with other galaxies or with a forming large-scale medium, subsequently using or losing most of their gas in the process, and begin to seed the nascent red sequence that is present in clusters at slightly lower redshifts.
We studied active galactic nucleus (AGN) activity in 12 large-scale structures (LSSs) in the Observations of Redshift Evolution in Large-Scale Environments (ORELSE) survey, at 0.65 < z < 1.28, using ...a combination of Chandra observations, optical and NIR imaging and spectroscopy. We located a total of 61 AGNs that were successfully matched to optical counterparts in the LSSs. We found that AGN populations across our sample had more recently had starburst events compared to the overall galaxy populations. We find no relation between AGN activity and location within the LSSs, suggesting triggering mechanisms that depend on global environment are at most sub-dominant. To focus on differences between our AGNs, we grouped them into four sub-samples based on the spectral properties of their parents LSSs. We found one of the sub-samples, SG0023 & SC1604, stood out from the others. AGNs in this sample were disproportionately luminous. These AGNs had the most recent starburst events, in contrast to their parent populations. Additionally, both the AGNs and the overall galaxy population in SG0023 & SC1604 had the largest fraction of close kinematic pairs, which indicates a higher rate of galaxy mergers and interactions. These results suggest that major mergers are driving AGN activity in SG0023 & SC1604, while other processes are likely triggering less luminous AGNs in the rest of our sample. Additionally, minor mergers are unlikely to play a significant role, since the same conditions that lead to more major mergers should also lead to more minor mergers, which is not observed in SG0023 & SC1604.
Abstract
Anaplastic thyroid cancer (ATC) is one of the most lethal solid tumors, yet there are no effective, long-lasting treatments for ATC patients. Most tumors, including tumors of the endocrine ...system, exhibit an increased consumption of glucose to fuel cancer progression, and some cancers meet this high glucose requirement by metabolizing glycogen. Our goal was to determine whether ATC cells metabolize glycogen and if this could be exploited for treatment. We detected glycogen synthase and glycogen phosphorylase (PYG) isoforms in normal thyroid and thyroid cancer cell lines and patient-derived biopsy samples. Inhibition of PYG using CP-91,149 induced apoptosis in ATC cells but not normal thyroid cells. CP-91,149 decreased NADPH levels and induced reactive oxygen species accumulation. CP-91,149 severely blunted ATC tumor growth in vivo. Our work establishes glycogen metabolism as a novel metabolic process in thyroid cells, which presents a unique, oncogenic target that could offer an improved clinical outcome.
This article investigates the rise of populism in Poland, applying an interdisciplinary method, with political, social, and economic factors as the compound reason for the turn from liberalism ...towards populism. The methodology of the study is the exploratory analysis of research, historical materials on Poland's transition to capitalism, and calculation of the selected empirical data of household incomes, linked to election results, in the regional cross-section. The household economic condition was validated by a report on deprivation and the presented growth of households’ disposable income, exposing regional differences between the selected voivodeships. The populist party Law and Justice (PiS) won the two last elections, with the majority of votes in low-income regions, which proved the hypothesis that economic inequality, amplified by globalisation and transition disparities were the main reasons for populism's prevalence. The democratic backsliding has not changed party-political scenery for very long, which revealed that for the majority of Polish voters, economic upgrading counted more, despite the violation of democracy. Therefore, the advance of knowledge about measures to reduce the in-country socioeconomic disparities between regions has become more important.
Aims. Star formation in massive galaxies is quenched at some point during hierarchical mass assembly. To understand where and when the quenching processes takes place, we study the evolution of the ...total star formation rate per unit total halo mass (Σ(SFR)/M) in three different mass scales: low mass halos (field galaxies), groups, and clusters, up to a redshift z ≈ 1.6. Methods. We use deep far-infrared PACS data at 100 and 160 μm to accurately estimate the total star formation rate of the luminous infrared galaxy population of 9 clusters with mass ~1015 M⊙, and 9 groups/poor clusters with mass ~5 × 1013 M⊙. Estimates of the field Σ(SFR)/M are derived from the literature, by dividing the star formation rate density by the mean comoving matter density of the universe. Results. The field Σ(SFR)/M increases with redshift up to z ~ 1 and it is constant thereafter. The evolution of the Σ(SFR)/M – z relation in galaxy systems is much faster than in the field. Up to redshift z ~ 0.2, the field has a higher Σ(SFR)/M than galaxy groups and galaxy clusters. At higher redshifts, galaxy groups and the field have similar Σ(SFR)/M, while massive clusters have significantly lower Σ(SFR)/M than both groups and the field. There is a hint of a reversal of the SFR activity vs. environment at z ~ 1.6, where the group Σ(SFR)/M lies above the field Σ(SFR)/M − z relation. We discuss possible interpretations of our results in terms of the processes of downsizing, and star-formation quenching.
The antioxidant properties of extract from berries of Aronia melanocarpa (chokeberry) containing: anthocyanidines, phenolic acids and quercetine glycosides on oxidative/nitrative stress induced by ...peroxynitrite (ONOO(-), a powerful physiological oxidant, nitrating species and inflammatory mediator) in human blood platelets were studied in vitro. The extract from A. melanocarpa (5 - 50 microg/mL) significantly inhibited platelet protein carbonylation (measured by ELISA method) and thiol oxidation estimated with 5,5'-dithio-bis(2-nitro-benzoic acid) (DTNB) induced by peroxynitrite (0.1 mM) (IC(50)--35 microg/mL for protein carbonylation, and IC(50)--33 microg/mL for protein thiol oxidation). The tested extract only slightly reduced platelet protein nitration (measured by C- ELISA method). The extract also caused a distinct reduction of platelet lipid peroxidation induced by peroxynitrite. Moreover, in our preliminary experiments we observed that the extract (50 microg/mL) reduced oxidative/nitrative stress in blood platelets from patients with breast cancer. The obtained results indicate that in vitro the extract from A. melanocarpa has the protective effects against peroxynitrite-induced oxidative/nitrative damage to the human platelet proteins and lipids. The extract from A. melanocarpa seems to be also useful as an antioxidant in patients with breast cancer.
Abstract
Transcriptional regulation in response to thyroid hormone (3,5,3′-triiodo-l-thyronine, T3) is a dynamic and cell-type specific process that maintains cellular homeostasis and identity in all ...tissues. However, our understanding of the mechanisms of thyroid hormone receptor (TR) actions at the molecular level are actively being refined. We used an integrated genomics approach to profile and characterize the cistrome of TRβ, map changes in chromatin accessibility, and capture the transcriptomic changes in response to T3 in normal human thyroid cells. There are significant shifts in TRβ genomic occupancy in response to T3, which are associated with differential chromatin accessibility, and differential recruitment of SWI/SNF chromatin remodelers. We further demonstrate selective recruitment of BAF and PBAF SWI/SNF complexes to TRβ binding sites, revealing novel differential functions in regulating chromatin accessibility and gene expression. Our findings highlight three distinct modes of TRβ interaction with chromatin and coordination of coregulator activity.
The thyroid hormone receptor beta (TRβ), a key regulator of cellular growth and differentiation, is frequently dysregulated in cancers. Diminished expression of TRβ is noted in thyroid, breast, and ...other solid tumors and is correlated with more aggressive disease. Restoration of TRβ levels decreased tumor growth supporting the concept that TRβ could function as a tumor suppressor. Yet, the TRβ tumor suppression transcriptome is not well delineated and the impact of TRβ is unknown in aggressive anaplastic thyroid cancer (ATC). Here, we establish that restoration of TRβ expression in the human ATC cell line SW1736 (SW-TRβ) reduces the aggressive phenotype, decreases cancer stem cell populations and induces cell death in a T
-dependent manner. Transcriptomic analysis of SW-TRβ cells via RNA sequencing revealed distinctive expression patterns induced by ligand-bound TRβ and revealed novel molecular signaling pathways. Of note, liganded TRβ repressed multiple nodes in the PI3K/AKT pathway, induced expression of thyroid differentiation markers, and promoted proapoptotic pathways. Our results further revealed the JAK1-STAT1 pathway as a novel, T
-mediated, antitumorigenic pathway that can be activated in additional ATC lines. These findings elucidate a TRβ-driven tumor suppression transcriptomic signature, highlight unexplored therapeutic options for ATC, and support TRβ activation as a promising therapeutic option in cancers. IMPLICATIONS: TRβ-T
induced a less aggressive phenotype and tumor suppression program in anaplastic thyroid cancer cells revealing new potential therapeutic targets.
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