The applicability of the Pipe Model Theory in trees of Scots pine of Poland Jelonek, T.,University of Life Sciences, Poznan (Poland). Dept. of Forest Utilisation; Pazdrowski, W.,University of Life Sciences, Poznan (Poland). Dept. of Forest Utilisation; Arasimowicz, M.,Adam Mickiewicz Univ., Poznan (Poland). Dept. of Plant Ecophysiology ...
Journal of forest science (Praha),
(Nov 2008), Letnik:
54, Številka:
11
Journal Article
Recenzirano
Odprti dostop
In order to test the application importance of the Pipe Model Theory and to develop models for the share of sapwood in tree stems, a total of 114 Scots pines were felled within the natural range of ...this species in three natural positions located in northern and western Poland. The analyses were conducted on wood coming from trees from the main layer of the stand, i.e. the first three classes according to the classification developed by Kraft. Dependences were analyzed between the biometric characteristics of model trees, e.g. tree height, diameter at breast height, crown length, crown basal area and the area and volume of sapwood in the stem. All the analyzed characteristics, both biometric traits and sapwood characteristics, were found to be correlated significantly positively. The analyses indicate that the postulates proposed in the Pipe Model Theory and Profile Theory require certain modifications and regression models developed for each social class of tree position in the stand for dependences of sapwood area and volume on the above mentioned biometric variables indirectly include changes occurring in time.
Performance of the NA62 trigger system Cortina Gil, E.; Kleimenova, A.; Minucci, E. ...
The journal of high energy physics,
03/2023, Letnik:
2023, Številka:
3
Journal Article
Recenzirano
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A
bstract
The NA62 experiment at CERN targets the measurement of the ultra-rare
K
+
→
π
+
ν
ν
¯
decay, and carries out a broad physics programme that includes probes for symmetry violations and ...searches for exotic particles. Data were collected in 2016–2018 using a multi-level trigger system, which is described highlighting performance studies based on 2018 data.
Measurement of the K+ → π+γγ decay Kleimenova, A.; Padolski, S.; Petrov, Y. ...
Physics letters. B,
March 2024, 2024-03-00, 2024-03-01, Letnik:
850
Journal Article
Recenzirano
Odprti dostop
A sample of 3984 candidates of the K+→π+γγ decay, with an estimated background of 291±14 events, was collected by the NA62 experiment at CERN during 2017–2018. In order to describe the observed ...di-photon mass spectrum, the next-to-leading order contribution in chiral perturbation theory was found to be necessary. The decay branching ratio in the full kinematic range is measured to be (9.61±0.17)×10−7. The first search for production and prompt decay of an axion-like particle with gluon coupling in the process K+→π+a, a→γγ is also reported.
A search for the K+→μ−νe+e+ decay, forbidden within the Standard Model by either lepton number or lepton flavour conservation depending on the flavour of the emitted neutrino, has been performed ...using the dataset collected by the NA62 experiment at CERN in 2016–2018. An upper limit of 8.1×10−11 is obtained for the decay branching fraction at 90% CL, improving by a factor of 250 over the previous search.
A
bstract
Measurement of the ultra-rare
K
+
→
π
+
ν
ν
¯
decay at the NA62 experiment at CERN requires high-performance particle identification to distinguish muons from pions. Calorimetric ...identification currently in use, based on a boosted decision tree algorithm, achieves a muon misidentification probability of 1
.
2 × 10
−
5
for a pion identification efficiency of 75% in the momentum range of 15–40 GeV/
c
. In this work, calorimetric identification performance is improved by developing an algorithm based on a convolutional neural network classifier augmented by a filter. Muon misidentification probability is reduced by a factor of six with respect to the current value for a fixed pion-identification efficiency of 75%. Alternatively, pion identification efficiency is improved from 72% to 91% for a fixed muon misidentification probability of 10
−
5
.
Anaplastic thyroid cancer (ATC) is one of the most lethal solid tumors, yet there are no effective, long-lasting treatments for ATC patients. Most tumors, including tumors of the endocrine system, ...exhibit an increased consumption of glucose to fuel cancer progression, and some cancers meet this high glucose requirement by metabolizing glycogen. Our goal was to determine whether ATC cells metabolize glycogen and if this could be exploited for treatment. We detected glycogen synthase and glycogen phosphorylase (PYG) isoforms in normal thyroid and thyroid cancer cell lines and patient-derived biopsy samples. Inhibition of PYG using CP-91,149 induced apoptosis in ATC cells but not normal thyroid cells. CP-91,149 decreased NADPH levels and induced reactive oxygen species accumulation. CP-91,149 severely blunted ATC tumor growth in vivo. Our work establishes glycogen metabolism as a novel metabolic process in thyroid cells, which presents a unique, oncogenic target that could offer an improved clinical outcome. Key Words: anaplastic thyroid cancer, glycogen, reactive oxygen species, CP-91,149, cancer metabolism, sorafenib Abbreviations: 2-DG, 2-deoxyglucose; 3-BP, 3-bromopyruvic acid; 6-AN, 6-aminonicotinamide; ATC, anaplastic thyroid cancer; BSA, bovine serum albumin; CDI, coefficient of drug interaction; CP, CP-91,149; CTM, complete thyroid media; ECAR, extracellular acidifcation rate; FTC, follicular thyroid cancer; G6P, glucose-6-phosphate; G6PDH, glucose-6-phosphate dehydrogenase; GYS1, glycogen synthase 1; PAS, periodic acid--Schiff (stain); PCR, polymerase chain reaction; PPP, pentose phosphate pathway; PTC, papillary thyroid cancer; PYG, glycogen phosphorylase; PYGB, glycogen phosphorylase brain isoform; PYGL, glycogen phosphorylase liver isoform; RAI, radioactive iodine; ROS, reactive oxygen species; SRB, sulforhodamine B; TBS, Tris-buffered saline.
NAA, marker of neurons integrity and viability, is one of the most important brain metabolites visible in 1H MRS. In most studies of schizophrenia, the decrease of NAA level was observed in the ...temporal, frontal lobes and in the thalamus. This finding was observed more often among chronic patients, what suggests the influence of disease duration or the effect of neuroleptic treatment. The aim of the present study was the comparison of NAA levels in brain of schizophrenic patients taking typical and atypical neuroleptics.
We analyzed the NAA levels in selected brain areas in 58 schizophrenic patients and 21 healthy controls. 10 patients were treated with typical neuroleptics, 10 patients with clozapine, 17 received olanzapine and 21 - risperidone. 1H MRS was performed on a 1,5 MR scanner with PRESS sequence. Voxels of 2x2x2 cm were localized in the left frontal, left temporal lobe and left thalamus.
There were no differences in NAA levels between patients on typical and atypical medications analyzed together and separately (olanzapine, clozapine and risperidone groups). We also did not find any differences between patients taking selected atypical neuroleptics and controls. The NAA level in the thalamus in the group of patients receiving typical antipsychotics was the lowest among all groups and differed significantly from healthy controls.
The results of our study suggest that atypical neuroleptics may have favorable effect on NAA concentration in brain of schizophrenic patients. Decrease in NAA level in patients taking typical medication may be caused by the progression of the disease or by the direct action of these drugs.
The Observations of Redshift Evolution in Large Scale Environments (ORELSE) survey is an ongoing imaging and spectroscopic campaign initially designed to study the effects of environment on galaxy ...evolution in high-redshift (\(z\sim1\)) large-scale structures. We use its rich data in combination with a powerful new technique, Voronoi tessellation Monte-Carlo (VMC) mapping, to search for serendipitous galaxy overdensities at \(0.55 < z < 1.37\) within 15 ORELSE fields, a combined spectroscopic footprint of \(\sim\)1.4 square degrees. Through extensive tests with both observational data and our own mock galaxy catalogs, we optimize the method's many free parameters to maximize its efficacy for general overdensity searches. Our overdensity search yielded 402 new overdensity candidates with precisely measured redshifts and an unprecedented sensitivity down to low total overdensity masses (\(\mathcal{M}_{tot} \gtrsim 5\times 10^{13} M_{\odot}\)). Using the mock catalogs, we estimated the purity and completeness of our overdensity catalog as a function of redshift, total mass, and spectroscopic redshift fraction, finding impressive levels of both 0.92/0.83 and 0.60/0.49 for purity/completeness at \(z=0.8\) and \(z=1.2\), respectively, for all overdensity masses at spectroscopic fractions of \(\sim\)20%. With VMC mapping, we are able to measure precise systemic redshifts, provide an estimate of the total gravitating mass, and maintain high levels of purity and completeness at \(z\sim1\) even with only moderate levels of spectroscopy. Other methods (e.g., red-sequence overdensities and hot medium reliant detections) begin to fail at similar redshifts, which attests to VMC mapping's potential to be a powerful tool for current and future wide-field galaxy evolution surveys at \(z\sim1\) and beyond.
Here we present new red sequence overdensity measurements for 77 fields in the high-\(z\) Clusters Occupied by Bent Radio AGN (COBRA) survey, based on \(r\)- and \(i\)-band imaging taken with Lowell ...Observatory's Discovery Channel Telescope. We observe 38 COBRA fields in \(r\)-band and 90 COBRA fields in \(i\)-band. By combining the \(r\)- and \(i\)-band photometry with our 3.6\(\mu\)m and 4.5\(\mu\)m \(Spitzer\) IRAC observations, we identify 39 red sequence cluster candidates that host a strong overdensity of galaxies when measuring the excess of red sequence galaxies relative to a background field. We initially treat the radio host as the cluster center and then determine a new cluster center based on the surface density of red sequence sources. Using our color selection, we identify which COBRA cluster candidates have strong red sequence populations. By removing foreground and background contaminants, we more securely determine which fields include cluster candidates with a higher significance than our single-band observations. Additionally, of the 77 fields we analyze with a redshift estimate, 26 include newly estimated photometric redshifts.
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