Cells and the extracellular matrix of the loose connective tissue as well as the macrophage system were studied in experimental crush-syndrome in 50 rats using histological, histochemical and ...electron microscopical methods. The results of the investigation have shown that the components of the loose connective tissue and the macrophage system actively responded to 1-hour-long hindlimb compression. Severe structural and functional injury of the cells and extracellular matrix of the subcutaneous loose connective tissue and of the stroma of different organs (lung, heart, kidney) was detected on dayl, was especially pronounced on day 7 and partly regressed by day 30 after the decompression. These changes included the structural damage of fibroblasts, changes in the number and degranulation of the mast cells, inhibition of RNA synthesis in plasmoblasts and lymphoblasts and the destruction of the collagen, elastic and reticular fibers. The number of macrophages in the liver, lungs, spleen, lymph nodes was reduced on days 1 and 7 after the decompression, in some organs this effect persisted until day 20. The activity of acid phosphatase was reduced in the macrophages in crush-syndrome.
Trimetazidine is a new metabolic antiischemic agent, which increases the tolerance of cardiomyocytes to ischemia. The aim of the study was to evaluate the effect of additional trimatazidine therapy ...in patients with ischemic cardiomyopathy (ICMP) in comparison with standard therapy of cardiac insufficiency. According to the results of the study, trimetazidine improves the clinical status, functional class of cardiac insufficiency, left ventricular ejection fraction, in ICMP patients. Trimetazidine increases physical exercise tolerance according to the results of six-minute walking test. Thus, the optimization of myocardial energetic metabolism may be a promising perspective in the treatment of coronary heart disease with systolic dysfunction.
Autoimmunization in systemic blood diseases Torgomian, T L; Nersesian, V M; Enlian, L N ...
Zhurnal eksperimental'noi i klinicheskoi meditsiny,
1969, Letnik:
9, Številka:
4
Journal Article
