The Timepix Telescope for high performance particle tracking Akiba, K.; Ronning, P.; van Beuzekom, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
09/2013, Letnik:
723
Journal Article
Recenzirano
Odprti dostop
The Timepix particle tracking telescope has been developed as part of the LHCb VELO Upgrade project, supported by the Medipix Collaboration and the AIDA framework. It is a primary piece of ...infrastructure for the VELO Upgrade project and is being used for the development of new sensors and front end technologies for several upcoming LHC trackers and vertexing systems. The telescope is designed around the dual capability of the Timepix ASICs to provide information about either the deposited charge or the timing information from tracks traversing the 14×14mm matrix of 55×55μm pixels. The rate of reconstructed tracks available is optimised by taking advantage of the shutter driver readout architecture of the Timepix chip, operated with existing readout systems. Results of tests conducted in the SPS North Area beam facility at CERN show that the telescope typically provides reconstructed track rates during the beam spills of between 3.5 and 7.5kHz, depending on beam conditions. The tracks are time stamped with 1ns resolution with an efficiency of above 98% and provide a pointing resolution at the centre of the telescope of ∼1.6μm. By dropping the time stamping requirement the rate can be increased to ∼15kHz, at the expense of a small increase in background. The telescope infrastructure provides CO2 cooling and a flexible mechanical interface to the device under test, and has been used for a wide range of measurements during the 2011–2012 data taking campaigns.
•We provide a technical description of the Timepix Telescope for particle tracking applications.•We demonstrate the spatial and timing resolution to be 2μm and 1ns respectively.•The maximum particle rate is 7.5kHz with highly resolved timing and spacing.•The maximum particle rate is 15kHz with only highly resolved spacing.•We briefly describe the software and tracking algorithms used to achieve this.
Probing active-edge silicon sensors using a high precision telescope Akiba, K.; Artuso, M.; van Beveren, V. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
03/2015, Letnik:
777
Journal Article
Recenzirano
Odprti dostop
The performance of prototype active-edge VTT sensors bump-bonded to the Timepix ASIC is presented. Non-irradiated sensors of thicknesses 100–200μm and pixel-to-edge distances of 50μm and 100μm were ...probed with a beam of charged hadrons with sub-pixel precision using the Timepix telescope assembled at the SPS at CERN. The sensors are shown to be highly efficient up to a few micrometers from the physical edge of the sensor. The distortion of the electric field lines at the edge of the sensors is studied by reconstructing the streamlines of the electric field using two-pixel clusters. These results are supported by TCAD simulations. The reconstructed streamlines are used to study the field distortion as a function of the bias voltage and to apply corrections to the cluster positions at the edge.
Previous reports have identified interleukin-2 (IL-2), quantified in the supernatants of QuantiFERON®-TB Gold In-tube (QFT) after 72 h of incubation, as a potential biomarker for distinguishing ...between latent and active tuberculosis (TB). However, its validity has not been tested in an appropriate clinical cohort.
A multicentre study of 161 consecutive adult patients undergoing evaluation for active TB at eight TB Units in Spain. Interferon-γ (IFN-γ) and IL-2 were assessed in the supernatant of QFT after 16–24 h and 72 h of incubation. The accuracy of IL-2 for indicating latent TB infection (LTBI) was assessed by receiving operating characteristic curves. .
Twenty-eight participants were not infected, 43 had LTBI, 69 had TB, and 21 were not classifiable. Median (interquartile range) IL-2 concentrations after 72 h of incubation were 0.0 pg/mL (0.0–0.0) in uninfected individuals, 261.0 pg/mL (81.0–853.0) in LTBI individuals, 166.5 pg/mL (33.5–551.5) in patients with extrapulmonary TB, 95.0 pg/mL (26.0–283.0) in patients with smear-negative pulmonary TB, and 38.5 pg/mL (7.5–178.0) in patients with smear-positive pulmonary TB (p <0.0001). The area under the curve of the receiving operating characteristic curve (95% CI) of IL-2 after 72 h of incubation for the diagnosis of LTBI was 0.63 (0.53–0.74) when all TB cases were considered as a single group, ranging from 0.59 (0.47–0.71) to 0.72 (0.58–0.85) when only extrapulmonary and smear-positive pulmonary TB cases respectively were considered.
Quantification of IL-2 in the supernatant of QFT after a prolonged incubation is not useful to distinguish between LTBI and active disease in clinical practice.
The production of the
η
c
(
1
S
)
state in proton-proton collisions is probed via its decay to the
p
p
¯
final state with the LHCb detector, in the rapidity range
2.0
<
y
<
4.5
and in the meson ...transverse-momentum range
p
T
>
6.5
GeV
/
c
. The cross-section for prompt production of
η
c
(
1
S
)
mesons relative to the prompt
J
/
ψ
cross-section is measured, for the first time, to be
σ
η
c
(
1
S
)
/
σ
J
/
ψ
=
1.74
±
0.29
±
0.28
±
0
.
18
B
at a centre-of-mass energy
s
=
7
TeV
using data corresponding to an integrated luminosity of 0.7 fb
-
1
, and
σ
η
c
(
1
S
)
/
σ
J
/
ψ
=
1.60
±
0.29
±
0.25
±
0
.
17
B
at
s
=
8
TeV
using 2.0 fb
-
1
. The uncertainties quoted are, in order, statistical, systematic, and that on the ratio of branching fractions of the
η
c
(
1
S
)
and
J
/
ψ
decays to the
p
p
¯
final state. In addition, the inclusive branching fraction of
b
-hadron decays into
η
c
(
1
S
)
mesons is measured, for the first time, to be
B
(
b
→
η
c
X
)
=
(
4.88
±
0.64
±
0.29
±
0
.
67
B
)
×
10
-
3
, where the third uncertainty includes also the uncertainty on the
J
/
ψ
inclusive branching fraction from
b
-hadron decays. The difference between the
J
/
ψ
and
η
c
(
1
S
)
meson masses is determined to be
114.7
±
1.5
±
0.1
MeV
/
c
2
.
HIV-2 is a neglected virus despite estimates of 1-2 million people being infected worldwide. The virus is naturally resistant to some antiretrovirals used to treat HIV-1 and therapeutic options are ...limited for patients with HIV-2.
In this retrospective observational study, we analysed all HIV-2-infected individuals treated with integrase strand transfer inhibitors (INSTIs) recorded in the Spanish HIV-2 cohort. Demographics, treatment modalities, laboratory values, quantitative HIV-2 RNA and CD4 counts as well as drug resistance were analysed.
From a total of 354 HIV-2-infected patients recruited by the Spanish HIV-2 cohort as of December 2017, INSTIs had been given to 44, in 18 as first-line therapy and in 26 after failing other antiretroviral regimens. After a median follow-up of 13 months of INSTI-based therapy, undetectable viraemia for HIV-2 was achieved in 89% of treatment-naive and in 65.4% of treatment-experienced patients. In parallel, CD4 gains were 82 and 126 cells/mm3, respectively. Treatment failure occurred in 15 patients, 2 being treatment-naive and 13 treatment-experienced. INSTI resistance changes were recognized in 12 patients: N155H (5), Q148H/R (3), Y143C/G (3) and R263K (1).
Combinations based on INSTIs are effective and safe treatment options for HIV-2-infected individuals. However, resistance mutations to INSTIs are selected frequently in failing patients, reducing the already limited treatment options.
The production of J/ψ mesons in proton–proton collisions at √s = 7 TeV is studied with the LHCb detector at the LHC. The differential cross-section for prompt J/ψ production is measured as a function ...of the J/ψ transverse
momentum pT and rapidity y in the fiducial region pT ∈ 0; 14 GeV/c and y ∈ 2.0; 4.5. The differential cross-section and fraction of J/ψ from b-hadron decays are also measured in the same pT and y ranges. The analysis is based on a data sample corresponding to an integrated luminosity of 5.2 pb−1. The measured cross-sections integrated over the fiducial region are 10.52 ± 0.04 ± 1.40+1.64 −2.20 µb for prompt J/ψ production and 1.14 ± 0.01 ± 0.16 µb for J/ψ from b-hadron decays, where the first uncertainty is statistical and the second systematic. The prompt J/ψ production cross-section is obtained assuming no J/ψ polarisation and the third error indicates the acceptance uncertainty due to this assumption.
The angular distribution and differential branching fraction of the decay $B^{0} \to K^{*0} \mu^{+}\mu^{-}$ are studied using a data sample, collected by the LHCb experiment in $pp$ collisions at ...$\sqrt{s}=7\,{\rm TeV}$, corresponding to an integrated luminosity of $1.0\,{\rm fb}^{-1}$. Several angular observables are measured in bins of the dimuon invariant mass squared, $q^{2}$. A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be $q_{0}^{2} = 4.9 \pm 0.9 \,{\rm GeV}^{2}/c^{4}$, where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions.
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