The thesis deals with the study of the compressibility and properties of tablets from Prosolv® ODT G2. This substance was tested in combination with two lubricants - magnesium stearate and sodium ...stearyl fumarate, for this purpose two concentrations were used 0.5 % and 1 %. Combination with model drugs was also included. Prosolv ® ODT G2 was also compared with Prosolv® SMCC 50 in the studied properties. The compressibility was evaluated by energy profile of compression process. Tensile strength and disintegration time were tested properties of tablets. The total energy values of tableting materials with Prosolv® ODT G2 were not enough affected by lubricants, though acetylsalicylic acid increased total energy. In the case of Prosolv® SMCC 50 the values of total energy were increased. Plasticity decreased in the case of Prosolv® ODT G2 under the influence of lubricants and drugs. Plasticity values for Prosolv® SMCC 50 were higher and more balanced. Lubricants in the mixtures with Prosolv® ODT G2 caused higher strength, however ascorbic acid decreased tensile strength of tablets. Tablets from the Prosolv® SMCC 50 mixture were significantly stronger, but lubricants decreased tensile strength of tablets. The disintegration time of tablets with Prosolv® ODT G2 was very short. It was proved that...
The effect of four pyrazine derivatives on the content of phenolic compounds in Urtica dioica L. and rutin in Fagopyrum esculentum Moench was studied. Pyrazine derivatives H1 and H2 were used on U. ...dioica, and derivatives S1 and S2 on F. esculentum, both separately and in combination with urea. The content of phenolic compounds in the stems of U. dioica after treatment with H2 at a concentration of 10−3 M significantly increased compared with the control and to a lower concentration of the same pyrazine derivative. In the case of S1 and S2 for F. esculentum, rutin content also increased in stems, mainly after treatment together with urea. By contrast, rutin and phenolics contents in the leaves did not change in comparison with controls after application of H1, H2, S1 and S2. Treatment with H1 and H2 in two chosen concentrations resulted in a significant increase in the net photosynthetic rate, transpiration rate and stomatal conductance. A slight increase in the rate of photosynthesis was observed also after application of variants of S1 and S1 with urea. Pyrazine derivatives did not show any effect on either the relative content of chlorophyll or chlorophyll fluorescence. A slight weight reduction of above ground biomass was shown only after application of S1 and S2. Dark necrosis on the edges and center of the leaves was observed in all treated plants after pyrazine application. The results suggest that all the pyrazine derivatives possess herbicidal effects.
Vitamin D during cancer treatment Tomíška, M; Novotná, Š; Klvačová, L ...
Klinická onkologie,
2015, Letnik:
28, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Recent knowledge on vitamin D has shown that its active form not only regulates calcium and phosphate metabolism but also has significant antimitotic and cell differentiation effects. It can inhibit ...proliferation, angiogenesis and metastatic potential in cancer tissue. Insufficient vitamin D plasma levels are found in 20- 60% of cancer patients at dia-gnosis. By many authors, vitamin D deficiency is associated with higher aggressivity of tumor and shorter survival of patients. Even in the absence of clinical studies showing benefit of supplementation on outcome, clear recommendations are currently available for treatment of vitamin D deficiency. Owing to the high prevalence of vitamin D insufficiency in cancer patients and significant risks of its further decrease after antitumor therapy, it should become standard of care to examine 25- hydroxyvitamin D serum levels and correct vitamin D insufficiency in cancer patients.
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