Since livestock product consumption could have a significant effect on tackling climate change, in the few last years, there has been an increasing consumer demand for non-dairy alternatives. Despite ...plant-based beverages being considered crucial to foster the transition towards sustainable diet models, no studies have yet compared the level of emissions of plant-based beverages with animal-based ones. The present study aims at computing the carbon footprint of cow milk and that of soy drink and evaluating the carbon footprint results in the light of the substitutability of cow's milk with soy drink, analyzing the potential environmental, economic and nutritional trade-offs between the two products.
Results highlight that, considering the environmental perspective, soy drink could be a valid substitute of cow milk: its production has a lower carbon footprint, allowing for the achievement of food security objectives. However, focusing on the economic and nutritional perspectives, the high average consumer price of soy drink is associated with an overall lower nutritional level. In order to reach the same nutritional value as 1 L of cow milk in terms of protein intake, the consumption of soy drink should be increased by 13%. Furthermore, soy drink consumption implies paying 66% more than for cow milk, when considering the same protein content.
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•Carbon Footprint Assessment support the transition of diets towards sustainability.•From an environmental perspective, soy drink could be a valid substitute of cow milk.•Soy drink has a higher average consumer price and a lower nutritional level.
The recent COVID-19 emergency has shaped economic performance across all sectors, and the fisheries and aquaculture sector did not come out unscathed. The need to protect against risks has always ...been primary for economic operators, but COVID-19 has accentuated the need to obtain coverage for health risks. In this regard, the European Union has moved quickly with an amendment art. 35 of European Maritime and Fisheries Fund (Regulation EU No. 508/2014), including "public health crises" among the causes considered valid for compensation in mutual funds. In this paper, we analyze the evolution of Regulation 508, focusing on Article 35 and its most recent amendments, to understand if the new reform is adherent to the needs of the fisheries sector in Italy, one of the only two States that have documented in their Operational Plans the intention to implement mutual funds. The work involved an empirical analysis through the use of multivariate statistics carried out on 61 Italian stakeholders. Several company profiles were identified and then the likelihood of subscribing to a mutual fund was estimated based on their focus on health crises. The work underlines that the amendments meet the demands of the sector for improved mutual fund clauses, but it’s not yet an attractive tool for the Italian market.
Aquaculture is now a viable alternative to help depleted wild fish stocks and encourage the production of alternative animal protein sources. However, studies have shown that farmed fish has a less ...positive image in consumers than wild fish. The present study investigates the aspects that most influence the consumption choices of some of the most farmed species in the Mediterranean, sea bass and sea bream. The objective is to analyse the habits and preferences of consumers of these products in Mediterranean countries to identify homogeneous and transversal behaviours in the four countries under analysis in order to recognise common marketing actions and levers. To achieve it, a direct survey was conducted on a representative sample of 6117 consumers from France, Spain, Greece and Italy. The cluster analysis carried out for the four countries revealed 11 well-defined consumer profiles. They showed that different socio-economic characteristics, purchasing habits and product attributes explain a significant part of consumption choices and offer key information for exploring food consumer attitudes. In addition, the role of labelling in consumer behaviour is important to understand which aspects consumers pay more attention to when making their choices, representing a discriminating factor in segmenting respondents' profiles. Understanding these preferences, and the importance of certain information, can be useful to intercept and respond to market demands and to improve consumer confidence in farmed fish products.
•Analysis conducted on 4 Mediterranean countries has identified both specific and cross-cutting consumption dynamics.•Understanding these preferences may be useful to improve consumer confidence in farmed fish products and their demand.•Aquaculture could be an alternative to support the increase in fish consumption and avoid the depletion of marine stocks.
The efficiency of electrocoagulation (spot or zonal) and ligation for the control of bleeding was compared in 376 patients with tonsillectomy. Electrocoagulation and ligation was used in the same ...number of patients (188) in each group. A notable reduction in operative time (40%) was seen in cases in which spot or zonal electrocoagulation was employed. More morbidity was found in cases treated with zonal electrocoagulation. Both techniques were concluded to be equally effective in the control of bleeding following tonsillectomy.
Abstract The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. ...Studies have suggested that accumulation of dopamine in the cytosol can trigger oxidative stress and neurotoxicity. Previously, ectopic expression of the dopamine transporter was shown to cause damage in non-dopaminergic neurons due to their inability to handle cytosolic dopamine. However, it is unknown whether increasing dopamine transporter activity will be detrimental to dopamine neurons that are inherently capable of storing and degrading dopamine. To address this issue, we characterized transgenic mice that over-express the dopamine transporter selectively in dopamine neurons. We report that dopamine transporter over-expressing (DAT-tg) mice display spontaneous loss of midbrain dopamine neurons that is accompanied by increases in oxidative stress markers, 5-S-cysteinyl-dopamine and 5-S-cysteinyl-DOPAC. In addition, metabolite-to-dopamine ratios are increased and VMAT2 protein expression is decreased in the striatum of these animals. Furthermore, DAT-tg mice also show fine motor deficits on challenging beam traversal that are reversed with l -DOPA treatment. Collectively, our findings demonstrate that even in neurons that routinely handle dopamine, increased uptake of this neurotransmitter through the dopamine transporter results in oxidative damage, neuronal loss and l -DOPA reversible motor deficits. In addition, DAT over-expressing animals are highly sensitive to MPTP-induced neurotoxicity. The effects of increased dopamine uptake in these transgenic mice could shed light on the unique vulnerability of dopamine neurons in Parkinson's disease.
•There are a variety of technologies valuable for exploring human brain connectivity.•The main aspects of anatomical, functional and effective connectivity are described.•A multimodality approach can ...be useful to evaluate the human brain connectome.
The goal of this paper is to examine existing methods to study the “Human Brain Connectome” with a specific focus on the neurophysiological ones. In recent years, a new approach has been developed to evaluate the anatomical and functional organization of the human brain: the aim of this promising multimodality effort is to identify and classify neuronal networks with a number of neurobiologically meaningful and easily computable measures to create its connectome. By defining anatomical and functional connections of brain regions on the same map through an integrated approach, comprising both modern neurophysiological and neuroimaging (i.e. flow/metabolic) brain-mapping techniques, network analysis becomes a powerful tool for exploring structural–functional connectivity mechanisms and for revealing etiological relationships that link connectivity abnormalities to neuropsychiatric disorders. Following a recent IFCN-endorsed meeting, a panel of international experts was selected to produce this current state-of-art document, which covers the available knowledge on anatomical and functional connectivity, including the most commonly used structural and functional MRI, EEG, MEG and non-invasive brain stimulation techniques and measures of local and global brain connectivity.
Hard X-ray (≥10 keV) observations of active galactic nuclei (AGNs) can shed light on some of the most obscured episodes of accretion onto supermassive black holes. The 70-month Swift/BAT all-sky ...survey, which probes the 14-195 keV energy range, has currently detected 838 AGNs. We report here on the broadband X-ray (0.3-150 keV) characteristics of these AGNs, obtained by combining XMM-Newton, Swift/XRT, ASCA, Chandra, and Suzaku observations in the soft X-ray band ( keV) with 70-month averaged Swift/BAT data. The nonblazar AGNs of our sample are almost equally divided into unobscured ( ) and obscured ( ) AGNs, and their Swift/BAT continuum is systematically steeper than the 0.3-10 keV emission, which suggests that the presence of a high-energy cutoff is almost ubiquitous. We discuss the main X-ray spectral parameters obtained, such as the photon index, the reflection parameter, the energy of the cutoff, neutral and ionized absorbers, and the soft excess for both obscured and unobscured AGNs.
Non-invasive scoring systems (NSS) are used to identify patients with non-alcoholic fatty liver disease (NAFLD) who are at risk of advanced fibrosis, but their reliability in predicting long-term ...outcomes for hepatic/extrahepatic complications or death and their concordance in cross-sectional and longitudinal risk stratification remain uncertain.
The most common NSS (NFS, FIB-4, BARD, APRI) and the Hepamet fibrosis score (HFS) were assessed in 1,173 European patients with NAFLD from tertiary centres. Performance for fibrosis risk stratification and for the prediction of long-term hepatic/extrahepatic events, hepatocarcinoma (HCC) and overall mortality were evaluated in terms of AUC and Harrell’s c-index. For longitudinal data, NSS-based Cox proportional hazard models were trained on the whole cohort with repeated 5-fold cross-validation, sampling for testing from the 607 patients with all NSS available.
Cross-sectional analysis revealed HFS as the best performer for the identification of significant (F0-1 vs. F2-4, AUC = 0.758) and advanced (F0-2 vs. F3-4, AUC = 0.805) fibrosis, while NFS and FIB-4 showed the best performance for detecting histological cirrhosis (range AUCs 0.85-0.88). Considering longitudinal data (follow-up between 62 and 110 months), NFS and FIB-4 were the best at predicting liver-related events (c-indices>0.7), NFS for HCC (c-index = 0.9 on average), and FIB-4 and HFS for overall mortality (c-indices >0.8). All NSS showed limited performance (c-indices <0.7) for extrahepatic events.
Overall, NFS, HFS and FIB-4 outperformed APRI and BARD for both cross-sectional identification of fibrosis and prediction of long-term outcomes, confirming that they are useful tools for the clinical management of patients with NAFLD at increased risk of fibrosis and liver-related complications or death.
Non-invasive scoring systems are increasingly being used in patients with non-alcoholic fatty liver disease to identify those at risk of advanced fibrosis and hence clinical complications. Herein, we compared various non-invasive scoring systems and identified those that were best at identifying risk, as well as those that were best for the prediction of long-term outcomes, such as liver-related events, liver cancer and death.
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•Different non-invasive scoring systems (NSS) have been proposed to stratify patients according to the risk of advanced fibrosis.•In the cross-sectional analysis, HFS showed the best performance for the identification of advanced fibrosis.•NFS and FIB-4 showed the best performance for the detection of histological cirrhosis.•After a median follow-up of ~7 years, NFS, HFS and FIB-4 performed similarly well for the prediction of HCC and overall mortality.•All NSS had limited performance for extrahepatic events, although those incorporating diabetes performed slightly better.
Motoneurons of neonatal rodents show synchronous activity that modulates the development of the neuromuscular system. However, the characteristics of the activity of human neonatal motoneurons are ...largely unknown. Using a noninvasive neural interface, we identified the discharge timings of individual spinal motoneurons in human newborns. We found highly synchronized activities of motoneurons of the tibialis anterior muscle, which were associated with fast leg movements. Although neonates' motor units exhibited discharge rates similar to those of adults, their synchronization was significantly greater than in adults. Moreover, neonatal motor units showed coherent oscillations in the delta band, which is directly translated into force generation. These results suggest that motoneuron synchronization in human neonates might be an important mechanism for controlling fast limb movements, such as those of primitive reflexes. In addition to help revealing mechanisms of development, the proposed neural interface might monitor children at risk of developing motor disorders.
In many applications, polymer materials undergo a large variety of mechanical loading conditions, wherein the influences of temperature and strain rate are of prime importance. Mahieux and Reifsnider ...Mahieux CA, Reifsnider KL. Polymer 2001;42:3281. 19 have proposed a statistical model to describe the stiffness variation of polymers over a wide range of temperatures. However, this model does not consider any frequency/strain rate dependence of the stiffness modulus. Starting from this consideration, we propose here to transform this latter model into a robust physically based model for the prediction of the stiffness modulus for a wide range of temperatures and frequencies/strain rates. This new formulation has been successfully validated for two amorphous polymers, polymethylmethacrylate (PMMA) and polycarbonate (PC), using dynamic mechanical analysis and uniaxial compression testing. Good agreement has been found between theory and experiment for the non-linear behavior of the initial Young's modulus, at the very high strain rates.
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