We presented and demonstrated a new type of vertical nanowire (NW) and nanosheet (NS) field-effect transistors (FETs), named vertical sandwich gate-all-around FETs or VSAFETs, which were formed with ...the process compatible in the main stream industry. The VSAFETs with self-aligned high-<inline-formula> <tex-math notation="LaTeX">{k} </tex-math></inline-formula> metal gates (HKMGs) were fabricated with epitaxy of Si/SiGe/Si sandwich structure, an isotropic quasi-atomic-layer-etch (qALE) process, and gate replacement process. The gate-length of VSAFETs is mainly determined by the thickness of SiGe film grown by epitaxy. The NW diameter and NS thickness could be obtained by the isotropic qALE method, which can be used to the Si-selective etching of SiGe. As a result, p-type NS and NW VSAFETs with good device characteristics were fabricated. Device performance and the influence of silicide, Ge fraction, Si cap, and high thermal process were investigated; threshold voltage tuning and reliability were also discussed.
An organic Rankine cycle (ORC) can be used to harness the wasted heat from an internal combustion engine. In this paper, the characteristics of a novel system combining a gasoline engine with a dual ...loop ORC which recovers the waste heat from both the exhaust and coolant systems is analyzed. A high temperature loop recovers the exhaust heat while a low temperature loop recovers both the residual high temperature loop heat and the coolant heat. The performance map of a gasoline engine is measured on an engine test bench and the heat quantities wasted by the exhaust and coolant systems are calculated and compared within the engine’s entire operating region. Based on this data, the working parameters of a dual loop ORC are defined, and the performance of a combined engine-ORC system is evaluated across this entire region. The results show that the net power of the low temperature loop is higher than that of the high temperature loop, and the relative output power improves by from 14 to 16% in the peak effective thermal efficiency region to 50% in the small load region, and the absolute effective thermal efficiency increases by 3–6% throughout the engine’s operating region.
► The waste heat characteristics for exhaust and coolant systems of a gasoline engine are analyzed. ► A dual loop ORC system is designed to simultaneously recover waste heat from the exhaust and coolant. ► Performance map of the combine engine-ORC system is evaluated over the engine’s entire operating region.
. Huang C‐N, Huang S‐P, Pao J‐B, Hour T‐C, Chang T‐Y, Lan Y‐H, Lu T‐L, Lee H‐Z, Juang S‐H, Wu P‐P, Huang C‐Y, Hsieh C‐J, Bao B‐Y (Kaohsiung Medical University Hospital, Kaohsiung; Kaohsiung Medical ...University, Kaohsiung; Taipei City Hospital, Taipei; Kaohsiung Medical University, Kaohsiung; China Medical University, Taichung; National Taiwan University Hospital; Oriental Institute of Technology; National Taiwan University, Taipei; China Medical University Hospital, Taichung, Taiwan). Genetic polymorphisms in oestrogen receptor‐binding sites affect clinical outcomes in patients with prostate cancer receiving androgen‐deprivation therapy. J Intern Med 2012; 271: 499–509.
Background. Accumulating evidence indicates that oestrogens have significant direct effects on normal prostate development and carcinogenesis. The majority of the biological activities of oestrogens are mediated through the oestrogen receptor (ER), which functions as a hormone‐inducible transcription factor to regulate target gene expression by binding to oestrogen response elements (EREs) in the regulatory regions of target genes. Sequence variants in EREs might affect the ER–ERE interaction and subsequent physiological activities. Therefore, we tested whether common single‐nucleotide polymorphisms (SNPs) inside EREs are related to the clinical outcomes of androgen‐deprivation therapy (ADT) in men with prostate cancer.
Methods. We systematically evaluated 49 ERE SNPs predicted using a genome‐wide database in a cohort of 601 men with advanced prostate cancer treated with ADT. The prognostic significance of these SNPs on disease progression, prostate cancer‐specific mortality (PCSM) and all‐cause mortality (ACM) after ADT was assessed using Kaplan–Meier analysis and a Cox regression model.
Results. Based on multiple hypothesis testing, BNC2 rs16934641 was found to be associated with disease progression; in addition, TACC2 rs3763763 was associated with PCSM, and ALPK1 rs2051778 and TACC2 rs3763763 were associated with ACM. These SNPs remained significant in multivariate analyses that included known clinicopathological predictors. Moreover, a combined genotype effect on ACM was observed when ALPK1 rs2051778 and TACC2 rs3763763 were analysed in combination. Patients with a greater number of unfavourable genotypes had a shorter time to ACM during ADT (P for trend <0.001).
Conclusion. The incorporation of ERE SNPs into models with known predictors might improve outcome prediction in patients with prostate cancer receiving ADT.
This is the second installment for the Large Sky Area Multi-Object Fibre Spectroscopic Telescope (LAMOST) Quasar Survey, which includes quasars observed from 2013 September to 2015 June. There are ...9024 confirmed quasars in DR2 and 10911 in DR3. After cross-match with the Sloan Digital Sky Survey (SDSS) quasar catalogs and NED, 12126 quasars are discovered independently. Among them, 2225 quasars were released by SDSS DR12 QSO catalog in 2014 after we finalized the survey candidates. 1801 sources were identified by SDSS DR14 as QSOs. The remaining 8100 quasars are considered as newly founded, and among them, 6887 quasars can be given reliable emission line measurements and the estimated black hole masses. Quasars found in LAMOST are mostly located at low-to-moderate redshifts, with a mean value of 1.5. The highest redshift observed in DR2 and DR3 is 5. We applied emission line measurements to H , Hβ, Mg ii, and C iv. We deduced the monochromatic continuum luminosities using photometry data, and estimated the virial black hole masses for the newly discovered quasars. Results are compiled into a quasar catalog, which will be available online.
ABSTRACT
We report on the Insight-HXMT observations of the new black hole X-ray binary MAXI J1820+070 during its 2018 outburst. Detailed spectral analysis via the continuum fitting method shows an ...evolution of the inferred spin during its high soft sate. Moreover, the hardness ratio, the non-thermal luminosity and the reflection fraction also undergo an evolution, exactly coincident to the period when the inferred spin transition takes place. The unphysical evolution of the spin is attributed to the evolution of the inner disc, which is caused by the collapse of a hot corona due to condensation mechanism or may be related to the deceleration of a jet-like corona. The studies of the inner disc radius and the relation between the disc luminosity and the inner disc radius suggest that, only at a particular epoch, did the inner edge of the disc reach the innermost stable circular orbit and the spin measurement is reliable. We then constrain the spin of MAXI J1820 + 070 to be $a_*=0.2^{+0.2}_{-0.3}$. Such a slowly spinning black hole possessing a strong jet suggests that its jet activity is driven mainly by the accretion disc rather than by the black hole spin.
Reorganization of the actin cytoskeleton is essential for cell motility and chemotaxis. Actin‐binding proteins (ABPs) and membrane lipids, especially phosphoinositides PI(4,5)P2 and PI(3,4,5)P3 are ...involved in the regulation of this reorganization. At least 15 ABPs have been reported to interact with, or regulated by phosphoinositides (PIPs) whose synthesis is regulated by extracellular signals. Recent studies have uncovered several parallel intracellular signalling pathways that crosstalk in chemotaxing cells. Here, we review the roles of ABPs and phosphoinositides in chemotaxis and cell migration.
Linked Articles
This article is part of a themed section on Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing and Related Topics. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐24
Agriculture is very sensitive to climate change, and correct forecasting of climate change is a great help to accurate allocation of irrigation water. The use of irrigation water is influenced by ...crop water demand and precipitation. Potential evapotranspiration (ET0) is a measure of the ability of the atmosphere to remove water from the surface through the processes of evaporation and transpiration, assuming no control on water supply. It plays an important role in assessing crop water requirements, regional dry–wet conditions, and other factors of water resource management. This study analyzed the spatial and temporal evolution processes and characteristics of major meteorological parameters at 10 stations in the Loess Plateau of northern Shaanxi (LPNS). By using the Mann–Kendall trend test with trend–free pre–whitening and the ArcGIS platform, the potential evapotranspiration of each station was quantified by using the Penman–Monteith equation, and the effects of climatic factors on potential evapotranspiration were assessed by analyzing the contribution rate and sensitivity of the climatic factors. The results showed that the climate in LPNS has become warmer and drier. In terms of the sensitivity of ET0 to the variation of each climatic factor in LPNS, relative humidity (0.65) had the highest sensitivity, followed by daily maximum temperature, wind speed, sunshine hours, and daily minimum temperature (−0.05). In terms of the contribution rate of each factor to ET0, daily maximum temperature (5.16%) had the highest value, followed by daily minimum temperature, sunshine hours, relative humidity, and wind speed (1.14%). This study provides a reference for the management of agricultural water resources and for countermeasures to climate change. According to the climate change and the characteristics of the study area, farmers in the region should increase irrigation to guarantee crop water demand.
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•The Loess Plateau of northern Shaanxi (LPNS) experienced a warmer and drier period.•Sensitivity and contribution rate analysis were used to explore the driving factor of ET0.•ET0 showed a significant upward trend in the northern part of LPNS.•ET0 was most sensitive to the variation of relative humidity in LPNS。•Maximum temperature had a higher contribution rate to the variation of ET0 in LPNS
To further the technique of indirect measurement, the contact-point response of a moving test vehicle is adopted for the damage detection of bridges. First, the contact-point response of the vehicle ...moving over the bridge is derived both analytically and in central difference form (for field use). Then, the instantaneous amplitude squared (IAS) of the driving component of the contact-point response is calculated by the Hilbert transform, making use of its narrow-band feature. The IAS peaks serve as the key parameter for damage detection. In the numerical simulation, a damage (crack) is modeled by a hinge-spring unit. The feasibility of the proposed method to detect the location and severity of a damage or multi damages of the bridge is verified. Also, the effects of surface roughness, vehicle speed, measurement noise and random traffic are studied. In the presence of ongoing traffic, the damages of the bridge are identified from the repeated or invariant IAS peaks generated for different traffic flows by the same test vehicle over the bridge.
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•Use vehicle's contact point with the bridge to identify bridge modal properties and damages.•Performance: Contact-point response > vehicle-body response > bridge response.•Use the instantaneous amplitude squared (IAS) to identify the location and severity of damage(s).•Effects studied: surface roughness, vehicle speed, measurement noise, random traffic.•Identify the damages of a bridge under repeated traffic flows from repeated IAS peaks.
This study presents an effective procedure for extracting the first few bridge frequencies using the data collected by a moving test vehicle. Previously, the effectiveness of the vehicle scanning ...method for bridge frequencies was hampered by factors such as vehicle frequency and road surface roughness. To this end, the
contact-point response
of the vehicle with the bridge that is
free of the vehicle frequency
is adopted in the analysis. To enhance the visibility of the first few bridge frequencies for extraction, the
variational mode decomposition with band-pass filter
(VMD-BPF) is proposed herein. The VMD is neater and more elegant than the empirical mode decomposition (EMD) in that less decompositions are needed, while there exists no mode-coupling problem, and the BPF serves to remove the undesired roughness frequencies. To verify the feasibility of the proposed procedure, both the vehicle and contact-point responses generated either numerically or by the field test are analyzed. It is demonstrated that the VMD-BPF is an effective method for extracting the bridge frequencies using the contact-point response for the scenarios considered.
Of the two isoforms of Liver X receptor (LXR), LXRβ has been shown to have major effects in the central nervous system (CNS) and on the regulation of aquaporins while LXRα has its most marked effects ...on cholesterol homeostasis. Both receptors have immunomodulatory functions. In LXRαβ knockout (ko) mice, the CNS phenotype is much more severe than in the LXRβ ko mice, suggesting a contribution of LXRα in CNS functions. One of the most striking abnormalities in the brains of LXRαβ ko mice is the occlusion of the lateral ventricles with age. In the present study, we have found by immunohistochemical staining that both LXRα and LXRβ are expressed in the cell nuclei of the epithelium of the choroid plexus and in the ependymal cells surrounding the lateral ventricles. The two receptors regulate several genes and can compensate for each other on expression of genes involved in structural integrity (E-cadherin, P-cadherin and β-catenin) and function (aquaporin 1 and carbonic anhydrase IX). Aquaporin 4 (AQ4) is not expressed in the choroid plexus but is expressed in the astrocytic end feet and ependymal cells. AQP4 expression was increased in white matter around lateral ventricles but not in neurons of LXRαβ ko mice. The data show that LXR is a regulator of cerebrospinal fluid (CSF) both at the choroid plexus and at the astrocytic end feet and defects in the synthesis of cerebrospinal fluid may be targeted by LXR agonists to facilitate CSF production, turnover and clearance in CNS diseases.
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