The C
16C
28 ketone
3, containing the CD-spiroacetal of spongistatin 1 (
1), was prepared in 17 steps from aldehyde
9. Both thermodynamic and kinetic conditions were explored for controlling the ...CD-acetal configuration.
Graphic
Francis Bacon succinctly described a number of methods of communication and he alluded to others. He also characterized his method of scientific investigation (the New Induction). Hence it is ...possible to state Bacon's underlying conception of method. It is a conception far less rigid than that held by contemporaneous logicians, classical or Ramean, and it allowed him to specify more methods of dispositio than the rhetoricians recognized. Furthermore, Bacon applied his notion of method deliberately by naming the method or using the language of method in over a score of his communications in a variety of cirstances, in works major and minor, including the 1597 essays.
Rhetorical invention should focus on topoi which allow learners and users to acquire knowledge and categorize experience for communication and to facilitate the recurrence of experience in ...communication. Special problems: (1) maintaining a balance between the philosophical and the practical; (2) pinning down . the relationships between mental processes typical of rhetorical activity (explaining and arguing) and of poetic activity (imagining) and (3) distinguishing between topics intended primarily to prompt recall and those intended to prompt originality of utterance and argument. Perelman's New Rhetoric is offered as an example of (1) the author presents his topical scheme in illustration of (3).
