With the widespread adoption of low-dose computed tomography (LDCT) and advancements in computed tomography image resolution, the detection rate of pulmonary nodules, especially smaller ones, has ...significantly improved. The risk of developing malignant tumors increases with the pulmonary nodule diameter. Video-assisted thoracoscopic surgery (VATS) stands out as the preferred surgical method. The accurate localization of pulmonary nodules is crucial for the success of VATS and remains a significant challenge for thoracic surgeons. Currently, commonly employed localization methods include CT-guided percutaneous positioning, bronchoscope-guided positioning, intraoperative ultrasound positioning, augmented reality (AR), and 3D print-assisted positioning. This review explores recent research progress, highlights the strengths and weaknesses of various pulmonary nodule localization methods. The aim is to provide valuable insights for clinical applications and guide future developments in this field.
Abstract
Background
Dietary carotenoids have been proven to improve intestinal disorders like inflammatory bowel disease and colon cancer, yet little is known about the link between dietary ...carotenoids and constipation. This study aims to examine the relationship between dietary carotenoids intake and constipation, using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2010.
Methods
A total of 11,722 participants were enrolled. Chronic constipation was defined as type 1 (separate hard lumps, like nuts) and type 2 (sausage-like, but lumpy) in the Bristol stool form scale (BSFS). Carotenoids intake was obtained from the average of two 24-hour dietary recall questionnaires (if only one 24-hour was available, we used it) and divided into quartiles (Q). The prevalence of constipation was calculated across men and women individuals. The relationship between dietary carotenoids intake and constipation in men and women was assessed with weighted logistic regression and smoothed curve fitting after adjusting confounders, with results displayed as weighted odds ratio (OR) with 95% confidence intervals (95% CI). The model was further stratified by age, race, and HEI 2015 scores (with median as cutoff) among men and women.
Results
The total weighted prevalence of chronic constipation in this study was 8.08%, 11.11% in women and 5.18% in men. After multivariable adjustment, compared with the lowest intake, participants with the highest dietary lycopene intake (OR
Q4 vs. Q1=
0.55, 95% CI: 0.36–0.84, p for trend = 0.01) and total lycopene intake (OR
Q4 vs. Q1
= 0.52, 95% CI: 0.34–0.80, p for trend = 0.01) were negatively associated with the risk of chronic constipation in men, whereas increased dietary α-carotene intake reduced the risk of chronic constipation in women (OR
Q4 vs. Q1
= 0.69, 95% CI: 0.48–0.98, p for trend = 0.04). Smoothing curve fitting further supported these results and provided evidence of dose-response effects. No association was found between other types of carotenoids and chronic constipation in men and women.
Conclusions
Increasing lycopene intake may improve bowel function in men while increased α-carotene intake may reduce the risk of chronic constipation in women. Further studies are essential to explore the role that the intake of carotenoids plays in chronic constipation.
► Electrospun cellulose nanofiber/hydroxyapatite composites were synthesized. ► Phosphorylated cellulose nanofibers were highly bioactive in inducing the HAp growth. ► The composites are porous ...materials with micro-, meso-pores and pores in micrometer. ► The composites can be potentially useful in the field of bone tissue engineering.
In biomimicking the formation of collagen fiber/hydroxyapatite (HAp) in natural bone, electrospun cellulose nanofiber (CelluNF)/HAp composites were synthesized in simulated body fluid (SBF). Their morphology and structure were characterized by SEM, TEM, XRD and XPS. CelluNFs showed low bioactivity in inducing the growth of HAp. In order to improve this ability, CelluNFs were slightly phosphorylated with a degree of substitution of phosphate group of 0.28. The modified CelluNFs were highly effective in guiding the HAp growth along the fibers. The HAp crystal size in the composites was ca. 24nm, and the lattice spacing of (211) plane was 2.83Å. It was found that the HAps in the composites were calcium deficient. The CelluNF/HAp composites are highly porous materials with micro-, meso-, and macro-pores. A mechanism for the HAp growth on CelluNFs was presented. Such CelluNF/HAp composites can be potentially useful in the field of bone tissue engineering.
Biochar and sulfur are considered useful amendments for soil cadmium (Cd) contamination remediation. However, there is still a gap in the understanding of how combined biochar and sulfur application ...affects Cd resistance in rice, and the role of the accumulation of iron plaque and the expression of Cd efflux transporter-related genes are still unclear in this type of treatment. In this study, we screened an effective combination of biochar and sulfur (0.75 % biochar, 60 mg/kg sulfur) that significantly reduced the Cd content of rice roots (32.9 %) and shoots (12.3 %); significantly reduced the accumulation of amino acids and their derivatives, organic acids and their derivatives and flavonoids in rice roots; and altered secondary metabolite production and release. This combined biochar and sulfur application alleviated the toxicity of Cd to rice, in which the enhancement of iron plaque (24.8 %) formation and upregulated expression of heavy metal effector genes (NRAMP3, MTP3, ZIP1) were important factors. These findings show that iron plaque and heavy metal transport genes are involved in the detoxification of rice under the combined application of biochar and sulfur, which provides useful information for the combined treatment of soil Cd pollution.
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•Combined application of biochar and sulfur can significantly reduce the accumulation of Cd all parts of the rice plant.•Increased iron plaque accumulation is an important factor in the combined application decreasing the uptake of Cd in rice.•The combined application of biochar and sulfur reduces the stress response of rice under Cd stress.•Combined biochar and sulfur application significantly upregulates the expression of genes encoding efflux proteins.
There are an estimated 800,000 small reservoirs globally with a range of uses. Given the collective importance of these reservoirs to water resource management and wider society, it is essential that ...we can monitor and understand the hydrological dynamics of ungauged reservoirs, particularly in a changing climate. However, unlike large reservoirs, continuous and systematic hydrological observations of small reservoirs are often unavailable. In response, this study has developed a retrieval framework for water levels of small reservoirs using a deep learning algorithm and remotely sensed satellite data. Demonstrated at four reservoirs in California, satellite imagery from both Sentinel-1 and Sentinel-2 along with corresponding water level field measurements was collected. Post-processed images were fed into a water level inversion convolutional neural network model for water level inversion, while different combinations of these satellite images, sampling approaches for training/testing data, and attention modules were used to train the model and evaluated for accuracy. The results show that random sampling of training data coupled with Sentinel-2 satellite imagery was generally the most accurate initially. Performance is improved by incorporating a channel attention mechanism, with the average R2 increasing by 8.6% and the average RMSE and MAE decreasing by 15.5% and 36.4%, respectively. The proposed framework was further validated on three additional reservoirs in different regions. In conclusion, the retrieval framework proposed in this study provides a stable and accurate methodology for water level estimation of small reservoirs and can be a powerful tool for small reservoir monitoring over large spatial scales.
A novel low-alloy ultrahigh-strength steel featuring excellent mechanical properties and comprising a nanolath structure was fabricated in this work using a quenching-partitioning-tempering (Q-P-T) ...process. The Q-P-T process comprised direct quenching and an isothermal bainitic transformation for partitioning after thermo-mechanical control processing (online Q&P) and offline tempering (reheating and tempering). The ultrafine nanolath martensite/bainite mixed structure, combined with residual austenite in the form of a thin film between the nanolaths, was formed, thereby conferring excellent mechanical properties to the steel structures. After the Q-P-T process, the yield and tensile strengths of the steels reached 1450 MPa and 1726 MPa, respectively. Furthermore, the Brinell hardness and elongation rate were 543 HB and 11.5%, respectively, with an average impact energy of 20 J at room temperature.
Blend membranes have attracted great attention because they can combine the advantages of different polymers. To investigate the effect of amphiphilic polymer on the separation performance of blend ...membranes, a series of blend membranes were designed and fabricated by blending an amphiphilic polymer of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) into poly(ether-block-amide) (Pebax) polymer for CO
2
separation. For the as-prepared Pebax/PEDOT:PSS blend membranes, the interconnected CO
2
-philic networks were constructed by hydrophilic anionic chains of PSS
−
for accelerating CO
2
transport. Meanwhile, non-CO
2
-philic networks were constructed by the hydrophobic cationic chains of PEDOT
+
, which distributed around the PSS
−
chains to provide low friction diffusion for CO
2
. Therefore, the amphiphilic polymer of PEDOT:PSS was an excellent material for improving CO
2
separation performance of blend membranes. The results showed that the Pebax/PEDOT:PSS blend membranes were endowed with excellent CO
2
separation performance. Pebax/PEDOT:PSS blend membrane demonstrated the optimal separation performance with a CO
2
permeability of 440.2±3.3 Barrer and a CO
2
/CH
4
separation factor of 28±0.6. This study indicates that introducing the amphiphilic polymer into the blend membranes is an efficient strategy for gas separation.
Strip rotary tillage seeding technology has been widely used in rice–wheat rotation system, benefiting the economy greatly. The purpose of farming is to create a comfortable seedbed environment for ...crop growth. Therefore, it is necessary to consider the effects of tillage methods on wheat root configuration and growth trend in the research of strip tillage, instead of just focusing on optimizing the shape of tillage tools, sowing methods, and soil fragmentation. To clarify the effects of different tillage methods on crop root growth trends, a two-year wheat planting experiment was carried out. Strip tillage (ST1 and ST2) and full width tillage treatment (FT) were designed, 3D models of root structure and soil on the surface of the seedbed wall were established, and four quantitative indexes were proposed: soil surface roughness of seedbed wall (SR), difference coefficient of root soil space occupation (P), difference coefficient of root angle expansion trend (PA), and difference coefficient of root length expansion trend (PL). The results showed that the cultivation method directly affects the growth trend of wheat roots. The wheat roots tended to grow along the inter-specific direction under ST treatment on the 14th day, and the average P, PA, and PL were as high as 38, 43, and 55, respectively. The SR produced by ST1 treatment was 70% lower than that of ST2 treatment, suggesting ST1 treatment had more serious restrictions on root growth. P, PA, and PL in ST1 treatment were 38.5%, 14%, and 43% higher than those in ST2 treatment within 14 days, respectively. This paper briefly explains the effects of tillage methods on the growth trend of wheat roots, provides new methods and technologies for the rapid and effective acquisition of soil surface information, solved the problem of the trend of root expansion being difficult to quantify, and provided a new direction for the optimization of tillage methods.
Robot-assisted surgical systems have been widely applied for minimally invasive needle biopsies thanks to their excellent accuracy and superior stability compared to manual surgical operations, which ...lead to possible fatigue and misoperation due to long procedures. Current needle biopsy robots are normally customed designed for specific application scenarios, and only position-level kinematics are derived, preventing advanced speed control or singularity analysis. As a step forward, this paper aims to design a universal needle biopsy robot platform which features 6 DoF 3-RRRS (Revolute–Revolute–Revolute–Spherical) parallel structure. The analytical solutions to its nonlinear kinematic problems, including forward kinematics, inverse kinematics, and differential kinematics are derived, allowing fast and accurate feedback control calculations. A multibody simulation platform and a first-generation prototype are established next to provide comprehensive verifications for the derived robotic model. Finally, simulated puncture experiments are carried out to illustrate the effectiveness of the proposed method.
The partial substitution of chemical fertilizers with organic manure is an important strategy for improving agricultural sustainability. However, its effect on heavy metal (HM) pollution and its ...potential risk to human health remain unclear. Therefore, a field study was conducted to evaluate the effects of partial organic fertilizer substitution (0, 10%, 20%, 30%, and 40%) on health risks posed by HMs, including Zn, Cu, Ni, Cd, Pb, As, and Cr. The results showed that organic fertilizer substitution significantly increased Cu, Cd, Pb, and As accumulations in the soil. The Zn, Cu, Pb, and As contents were significantly higher in grains grown under organic fertilizer substitution (40%) conditions. The HM contents in the soil and grains were below the safety threshold limits in all treatments. Furthermore, the health risk caused by the exposure to As, Cu, and Zn accounted for 86% of the hazard index (HI) value. The HI value was significantly greater at a substitution ratio of 40% than in the no-nitrogen fertilizer treatment. Ingestion of the wheat grains grown at substitution ratios ≥ 30%) increased the carcinogenic risk of As and the total carcinogenic risk. In conclusion, organic fertilizer substitution at high ratios significantly increased the non-carcinogenic and carcinogenic risks associated with ingesting wheat grain. The optimal organic fertilizer substitution ratio (20%) maintained crop yields and improved soil fertility without increasing the non-carcinogenic or carcinogenic risks to human health. These findings highlight the importance of understanding the impacts of optimal organic fertilizer management in wheat growing systems.
