Phthalates are a series of widely used chemicals that demonstrate to be endocrine disruptors and are detrimental to human health. Phthalates can be found in most products that have contact with ...plastics during producing, packaging, or delivering. Despite the short half-lives in tissues, chronic exposure to phthalates will adversely influence the endocrine system and functioning of multiple organs, which has negative long-term impacts on the success of pregnancy, child growth and development, and reproductive systems in both young children and adolescents. Several countries have established restrictions and regulations on some types of phthalates; however, we think that more countries should establish constraints or substitute measures for phthalates to reduce health risks. This article aims to summarize the adverse impacts of phthalates on human health, analyze the toxicity mechanism, assess the risks, and finally provide feasible strategies to reduce exposure of the public to phthalates.
In recent years, with the popularity of the Internet, more and more people like to comment on movies they have watched on the film platform after watching them. These reviews hide the reviewers' ...feedback on films. Mining the emotional orientation information in these reviews can provide consumers with shopping references and help businesses optimize film works and improve business strategies. Therefore, the emotional classification of film reviews has high research value because few emotion dictionaries and analysis tools are available for reference and use in film reviews. The accuracy of emotion classification still needs to be improved. This study introduces the attention mechanism and dual channel long short term memory (DC-LSTM) while building the emotion dictionary in the field of Chinese film review. It classifies Chinese film reviews in terms of topic-based fine-grained emotion. First, the emotion vector is constructed using the constructed movie review emotion lexicon. The semantic vector obtained by the Word2vector tool is input to LSTM to encode the comment text. Then, the topic attention module is used to decode. Finally, the final emotion classification result is obtained through the softmax function of the entire link layer and the output layer. The thematic attention modules constructed in this study are independent of each other for attention parameter adjustment and learning. One attention module corresponds to one film theme. In this study, eight themes, including "plot," "special effects," "original work," "music," "thought," "theme," "acting skills," and "joke," were extracted, and each theme was classified into three types of emotions: "positive," "neutral," and "negative." The experimental results on the crawled Chinese film review dataset show that the proposed algorithm is superior to some existing algorithms and models in accuracy, precision, recall and F1 measure. The DCLSTM based on the thematic attention mechanism (DCLSTM-TAM) model constructed in this study introduces the emotion vector into the network and adds the theme attention mechanism. It can not only classify the emotion for different topics of a film review but also effectively deal with film reviews with fuzzy emotional tendencies. It realizes the fine-grained emotion classification of film topics and improves the accuracy of emotion classification of film reviews. The emotion classification method and model proposed in this study have good transferability, and the change of training corpus is also applicable to other short text fields.
Porous yet densely packed carbon electrodes with high ion-accessible surface area and low ion transport resistance are crucial to the realization of high-density electrochemical capacitive energy ...storage but have proved to be very challenging to produce. Taking advantage of chemically converted graphene's intrinsic microcorrugated two-dimensional configuration and self-assembly behavior, we show that such materials can be readily formed by capillary compression of adaptive graphene gel films in the presence of a nonvolatile liquid electrolyte. This simple soft approach enables subnanometer scale integration of graphene sheets with electrolytes to form highly compact carbon electrodes with a continuous ion transport network. Electrochemical capacitors based on the resulting films can obtain volumetric energy densities approaching 60 watt-hours per liter.
With the global climate anomalies and the destruction of ecological balance, the water shortage has become a serious ecological problem facing all mankind, and drought has become a key factor ...restricting the development of agricultural production. Therefore, it is essential to study the drought tolerance of crops. Based on previous studies, we reviewed the effects of drought stress on plant morphology and physiology, including the changes of external morphology and internal structure of root, stem, and leaf, the effects of drought stress on osmotic regulation substances, drought-induced proteins, and active oxygen metabolism of plants. In this paper, the main drought stress signals and signal transduction pathways in plants are described, and the functional genes and regulatory genes related to drought stress are listed, respectively. We summarize the above aspects to provide valuable background knowledge and theoretical basis for future agriculture, forestry breeding, and cultivation.
Endostar, an anti-angiogenic drug, has been approved for treating non-small cell lung cancer (NSCLC). At present, endostar combined with radiotherapy or chemotherapy has achieved ideal results in the ...treatment of some tumors, but there is a lack of application and study in NSCLC. This study investigated the therapeutic effect and potential mechanism of endostar combined with cisplatin (EC) in NSCLC.
HE staining, TUNEL staining, immunofluorescence, colony formation ability, and cell migration ability were used to evaluate the anti-tumor activity of EC. The expressions of FMOD, VEGF, FGF-2, and PDGF-B were detected by western blotting and qPCR. The target of combination therapy was analyzed by m6A sequencing and RNA sequencing. METTL3 knockdown and overexpressed A549 cells were constructed and co-cultured with HUVECs to further evaluate the effect of METLL3 on combination therapy.
Combination therapy significantly reduced the colony formation and migration ability of NSCLC cells, induced cell apoptosis, and inhibited the tube formation ability of HUVECs. The results of m6A sequencing and RNA sequencing showed that the EC could down-regulate the expression level of FMOD in tumor tissues, which might be related to the reduction of its m6A methylation modification regulatory enzyme METTL3. Restricting FMOD expression could reduce the expression of FGF2, TGF-β1, VEGF and PDGF-B. Moreover, overexpression of METTLE almost abolished the anti-tumor effect of EC and promoted angiogenesis.
Endostar combined with cisplatin might exert anti-tumor effects by down-regulating the expression of METTL3 and FMOD.
The photodegradation of seven micropollutants commonly found in municipal wastewater, namely caffeine, carbamazepine, diuron, simazine, sulfamethoxazole, triclosan and 2,4-D, was investigated in pure ...water and secondary effluent to understand the direct and indirect photolysis of these compounds under natural sunlight irradiation. Sulfamethoxazole and triclosan were readily photodegraded with half-lives of 5.8 and 1.8 h, respectively, whilst the others were relatively resistant towards sunlight irradiation. Enhanced degradation was observed in secondary effluent compared with in the pure water matrix for all compounds, except for triclosan. It was confirmed that hydroxyl radicals played an important role in the photodegradation of the micropollutants while singlet oxygen may also play a role. The contribution of hydroxyl radical to the overall degradation of the five compounds that were resistant to direct sunlight accounted for 32%–70%. The impact of humic acid and nitrate, two known photosensitisers and wastewater components, on the photodegradation of the seven micropollutants in pure water was investigated under simulated solar radiation. The presence of nitrate promoted the photochemical loss of all seven micropollutants, however, humic acid caused promotion or inhibition, depending on the characteristics of the micropollutant. Humic acid enhanced the photolytic degradation of caffeine, sulfamethoxazole and diuron, while it hindered the photodegradation of the other four compounds by absorbing the available irradiation energy and/or reforming the parent compound. Furthermore, it was shown that there was only a small increase (up to 15%) in photodegradation of the compounds at 25 °C compared with that at 10 °C in the simulated system.
•CAF, CBZ, DUR, SMZ and 2,4-D primarily degraded via indirect photolysis.•Hydroxyl radicals had important role in the indirect photolysis of five compounds.•SMX and TCS primarily degraded via direct photolysis.•Nitrate promoted the photolysis of all compounds while affected TCS & SMX slightly.•Humic acid had differing effects on the photodegradation of the selected compounds.
As a basic structural unit of the city, the community plays a crucial role in decreasing carbon emissions and creating a low carbon city. This paper selects a classic and official low carbon ...community named Min'an Community in Beijing as a case to illustrate the governance mechanism of the low carbon community in China from the perspective of polycentric governance. The paper summarizes the government mechanism, market mechanism, and public participation mechanism in Min'an Community and analyzes the provision, monitoring, and enforcement of each mechanism. We find that unlike the low carbon governance at the city or industry park levels, China's low carbon governance at the community level lacks a dominant mechanism. Even though it involves community-wide governance, the public participation mechanism is also inadequate. For improving low carbon governance at the community level, the government should broaden finance channels to strengthen the incentive mechanisms, make active use of new technologies, such as mobile Internet, encourage innovation of public participation mechanism, and employ various publicity and education measures to cultivate the low carbon culture.
External stimuli-responsive nanomedicine with desirable repetitive on-demand drug release character is postulated to greatly accommodate patients' flexible medication regime. To this object, ...light-activatable liposomes (Pt/Ce6-LP) integrated with both a Ce6 photodynamic component and a tetravalent platinum prodrug (Pt(IV)) chemotherapeutic component are engineered. This multifunctional system was rationally designed using unsaturated phospholipid to achieve repetitive on-demand drug release under discontinuous light irradiation, thus performing chemo-photodynamic therapy effect and immunopotentiation in hypoxic tumor. Furthermore, glutathione (GSH) consumption during transformation from Pt(IV) prodrug to Pt(II) can avoid depletion of reactive oxygen species (ROS) in photodynamic therapy (PDT). Note this positive feedback loop appears to remodel the redox balance of H2O2 and GSH in tumors, alleviating the hypoxic tumor microenvironment. The alleviated hypoxia is found to be critical to the enhancement of PDT efficacy, reversal of cisplatin resistance in tumors, and polarization of tumor-associated macrophages (TAMs) to the immunocompetent M1-phynotype. Pt/Ce6-LP with light radiation demonstrates significant antitumor effect and persistent post-medication inhibition in patient-derived tumor xenograft model of hepatocellular carcinoma.
A light-activatable liposome (Pt/Ce6-LP) was constructed to realize repetitive on-demand drug release and intensified PDT/chemotherapy on patient-derived tumor xenograft model of hepatocellular carcinoma. Pt/Ce6-LP with light irradiation overcame hypoxia-relative therapeutic resistance via a positive feedback loop and increased M1-TAMs populations to potentiate immune activity for hypoxic tumor treatment. Display omitted
Nanoscale electrochemical mapping techniques,
, scanning electrochemical cell microscopy (SECCM), have been increasingly used to study the local electrochemistry in electrocatalysis. Its capability ...for local electrochemistry mapping helps to reveal the heterogeneity in the electrode kinetics and mechanisms, which are otherwise averaged out in ensemble measurements. Accurate determination of the electrode kinetics requires the careful assessment of the ohmic potential drop in the solution,
, the
drop. Herein, the
drop in SECCM experiments is assessed. We showed that the
drop in single-barrel SECCM can be estimated using the solution conductivity and pipette geometry, or the mass transfer limiting current without the assumption of pipette geometry. For dual-barrel SECCM, we developed a method of measuring the solution resistance directly, which can be used to compensate for the
drop and the potential shift in the experiments. These methods offer a convenient way to estimate and compensate for the
drop in SECCM, allowing the more accurate measurement of local electrode kinetics for the determination of local mechanisms in electrocatalysis.