Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely ...limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. On the bandage, an alternating discrete electric field is generated by a wearable nanogenerator by converting mechanical displacement from skin movements into electricity. Rat studies demonstrated rapid closure of a full-thickness rectangular skin wound within 3 days as compared to 12 days of usual contraction-based healing processes in rodents. From in vitro studies, the accelerated skin wound healing was attributed to electric field-facilitated fibroblast migration, proliferation, and transdifferentiation. This self-powered electric-dressing modality could lead to a facile therapeutic strategy for nonhealing skin wound treatment.
Nanomechanical resonators (NMRs), as the quantum mechanical sensing probers, have played the important roles for various high-precision quantum measurements. Differing from the previous emission ...spectral probes (i.e., the NMR modified the atomic emission), in this paper we propose an alternative approach, i.e., by probing the scattering spectra of the quantum mechanical prober coupled to the driving microwaves, to characterize the physical features of the NMR embedded in a rf-SQUID based superconducting qubit. It is shown that, from the observed specifical frequency points in the spectra, i.e., either the dips or the peaks, the vibrational features (i.e., they are classical vibration or quantum mechanical one) and the physical parameters (typically such as the vibrational frequency and displacements) of the NMR can be determined effectively. The proposal is feasible with the current technique and should be useful to design the desired NMRs for various quantum metrological applications.
Abstract
The HH 24 complex harbors five collimated jets emanating from a small protostellar multiple system. We have carried out a multiwavelength study of the jets, their driving sources, and the ...cloud core hosting the embedded stellar system, based on data from the Hubble Space Telescope, Gemini, Subaru, Apache Point Observatory 3.5 m, Karl G. Jansky Very Large Array, and Atacama Large Millimeter/submillimeter Array (ALMA) telescopes. The data show that the multiple system, SSV 63, contains at least 7 sources, ranging in mass from the hydrogen-burning limit to proto-Herbig Ae stars. The stars are in an unstable nonhierarchical configuration, and one member, a borderline brown dwarf, is moving away from the protostellar system with 25 km s
−1
, after being ejected ∼5800 yr ago as an orphaned protostar. Five of the embedded sources are surrounded by small, possibly truncated, disks resolved at 1.3 mm with ALMA. Proper motions and radial velocities imply jet speeds of 200–300 km s
−1
. The two main HH 24 jets, E and C, form a bipolar jet system that traces the innermost portions of parsec-scale chains of Herbig–Haro and H
2
shocks with a total extent of at least 3 pc. H
2
CO and C
18
O observations show that the core has been churned and continuously fed by an infalling streamer.
13
CO and
12
CO trace compact, low-velocity, cavity walls carved by the jets and an ultracompact molecular outflow from the most embedded object. Chaotic
N
-body dynamics likely will eject several more of these objects. The ejection of stars from their feeding zones sets their masses. Dynamical decay of nonhierarchical systems can thus be a major contributor to establishing the initial mass function.
As one of the typical quantum coherence phenomena, electromagnetically induced transparency (EIT) has been extensively applied to implement various quantum coherent manipulations, typically, e.g., ...optical quantum memories, photonic switches, and optical quantum computations, etc. By applying the input-output theory to the photonic transports through two cavities dispersively coupled by an artificial two-level atomic ensemble, we show here that the EIT-like effects could be observed. Particularly, the transparency windows and phase shift spectra of the transmitting photons could be engineered by manipulating the atomic levels in the ensemble to adjust the effective coupling strength between the cavities. As a consequence, the group delays of the transmitting photons can be manipulated by using the EIT-like effects. The proposal is demonstrated specifically with the experimental superconducting coplanar waveguide resonators coupled by the voltage-biased electrons on liquid Helium.
Relational cognition-the ability to infer relationships that generalize to novel combinations of objects-is fundamental to human and animal intelligence. Despite this importance, it remains unclear ...how relational cognition is implemented in the brain due in part to a lack of hypotheses and predictions at the levels of collective neural activity and behavior. Here we discovered, analyzed, and experimentally tested neural networks (NNs) that perform transitive inference (TI), a classic relational task (if A > B and B > C, then A > C). We found NNs that (i) generalized perfectly, despite lacking overt transitive structure prior to training, (ii) generalized when the task required working memory (WM), a capacity thought to be essential to inference in the brain, (iii) emergently expressed behaviors long observed in living subjects, in addition to a novel order-dependent behavior, and (iv) expressed different task solutions yielding alternative behavioral and neural predictions. Further, in a large-scale experiment, we found that human subjects performing WM-based TI showed behavior inconsistent with a class of NNs that characteristically expressed an intuitive task solution. These findings provide neural insights into a classical relational ability, with wider implications for how the brain realizes relational cognition.
A Josephson radiation threshold detector (JRTD) that is based on the threshold behaviour of a current bias Josephson junction (CBJJ) is designed and fabricated for infrared radiation (IR@1550nm) ...detection at low temperatures. To achieve the optimal performance, we develop a binary hypothesis detection method to calibrate Josephson threshold behaviours (i.e. the switching current distributions of the CBJJ with the Al/AlO
/Al junction) in the absence and presence of radiation. In the absence of IR radiation, the junction transitioned with a measurable voltage drop across the junction, and this signal was treated as the events of hypothesis H
. The events of junction transition observed in the presence of the IR radiation served as hypothesis H
. Considering the usual Gaussian noise and based on statistical decision theory, the accumulated data of the measured switching current distributions are processed, and the threshold sensitivity of the demonstrated JRTD device is estimated. The minimum detectable IR radiation power of the proposed detector is approximately 0.74 pW, which corresponds to the photon rate of 5.692 × 10
photons/second. Further optimisation of JRTDs to implement the desired binary detection of a single photon is still a subject of argument, at least theoretically.
Mitochondrial homeostasis depends on mitophagy, the programmed degradation of mitochondria. Only a few proteins are known to participate in mitophagy. Here we develop a multidimensional CRISPR-Cas9 ...genetic screen, using multiple mitophagy reporter systems and pro-mitophagy triggers, and identify numerous components of parkin-dependent mitophagy
. Unexpectedly, we find that the adenine nucleotide translocator (ANT) complex is required for mitophagy in several cell types. Whereas pharmacological inhibition of ANT-mediated ADP/ATP exchange promotes mitophagy, genetic ablation of ANT paradoxically suppresses mitophagy. Notably, ANT promotes mitophagy independently of its nucleotide translocase catalytic activity. Instead, the ANT complex is required for inhibition of the presequence translocase TIM23, which leads to stabilization of PINK1, in response to bioenergetic collapse. ANT modulates TIM23 indirectly via interaction with TIM44, which regulates peptide import through TIM23
. Mice that lack ANT1 show blunted mitophagy and consequent profound accumulation of aberrant mitochondria. Disease-causing human mutations in ANT1 abrogate binding to TIM44 and TIM23 and inhibit mitophagy. Together, our findings show that ANT is an essential and fundamental mediator of mitophagy in health and disease.
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