Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which can result in cardiac hypertrophy and subsequent heart failure, associated with pyroptosis, the ...pro-inflammatory programmed cell death. MicroRNAs (miRNAs), small endogenous non-coding RNAs, have been shown to be involved in diabetic cardiomyopathy. However, whether miRNAs regulate pyroptosis in diabetic cardiomyopathy remains unknown. Our study revealed that mir-30d expression was substantially increased in streptozotocin (STZ)-induced diabetic rats and in high-glucose-treated cardiomyocytes as well. Upregulation of mir-30d promoted cardiomyocyte pyroptosis in diabetic cardiomyopathy; conversely, knockdown of mir-30d attenuated it. In an effort to understand the signaling mechanisms underlying the pro-pyroptotic property of mir-30d, we found that forced expression of mir-30d upregulated caspase-1 and pro-inflammatory cytokines IL-1β and IL-18. Moreover, mir-30d directly repressed foxo3a expression and its downstream protein, apoptosis repressor with caspase recruitment domain (ARC). Furthermore, silencing ARC by siRNA mimicked the action of mir-30d: upregulating caspase-1 and inducing pyroptosis. These findings promoted us to propose a new signaling pathway leading to cardiomyocyte pyroptosis under hyperglycemic conditions: mir-30d↑→foxo3a↓→ ARC↓→caspase-1↑→IL-1β, IL-18↑→pyroptosis↑. Therefore, mir-30d may be a promising therapeutic target for the management of diabetic cardiomyopathy.
Summary
The aim of this study was to investigate the association between the single‐nucleotide polymorphisms (SNPs) of the interleukin 22 (IL‐22) gene and systemic lupus erythematosus (SLE) in a ...Chinese population. Three IL‐22 SNPs (rs2227485, rs2227513 and rs2227491) were genotyped using SNaPshot SNP genotyping assays and identified by sequencing in 314 SLE patients and 411 healthy controls. The IL‐22 level of serum was assessed by enzyme‐linked immunosorbent assay (ELISA) kits. Data were analysed by spss version 17.0 software. We found that rs2227513 was associated with an increased risk of SLE AG versus AA: adjusted odds ratio (aOR) = 2·24, 95% confidence interval (CI) = 1·22–4·12, P = 0·010; G versus· A: adjusted OR = 2·18, 95% CI = 1·20‐3·97, P = 0·011. Further analysis in patients with SLE showed that the AG genotype and G allele were associated with an increased risk of renal disorder in SLE (G versus A: aOR = 3·09, 95% CI = 1·30–7·33, P = 0·011; AG versus· AA: aOR = 3·25, 95% CI = 1·35–7·85, P = 0·009). In addition, the concentration of IL‐22 was significantly lower in the rs2227513 AG genotype compared with AA genotype (P = 0·028). These results suggest that rs2227513 polymorphism might contribute to SLE susceptibility, probably by decreasing the expression of IL‐22.
rs2227513 AG genotype is a risk factor for SLE, probably by decreasing the level of IL‐22. G allele in rs2227513 is associated with increased risk of SLE. AG genotype and G allele in rs2227513 are associated with increased risks of renal disorder in SLE.
Cross-linked magnetic chitosan-isatin Schiff's base resin (CSIS) was prepared for adsorption of metal ions. CSIS obtained was investigated by means of FTIR,
1H NMR, wide-angle X-ray diffraction ...(WAXRD), magnetic properties and thermogravimetric analysis (TGA). The adsorption properties of cross-linked magnetic CSIS resin toward Cu
2+, Co
2+ and Ni
2+ ions were evaluated. Various factors affecting the uptake behavior such as contact time, temperature, pH and initial concentration of the metal ions were investigated. The kinetic parameters were evaluated utilizing the pseudo-first-order and pseudo-second-order. The equilibrium data were analyzed using the Langmuir, Freundlich, and Tempkin isotherm models. The adsorption kinetics followed the mechanism of the pseudo-second-order equation for all systems studied, evidencing chemical sorption as the rate-limiting step of adsorption mechanism and not involving a mass transfer in solution. The best interpretation for the equilibrium data was given by Langmuir isotherm, and the maximum adsorption capacities were 103.16, 53.51, and 40.15
mg/g for Cu
2+, Co
2+ and Ni
2+ ions, respectively. Cross-linked magnetic CSIS displayed higher adsorption capacity for Cu
2+ in all pH ranges studied. The adsorption capacity of the metal ions decreased with increasing temperature. The metal ion-loaded cross-linked magnetic CSIS were regenerated with an efficiency of greater than 88% using 0.01–0.1
M ethylendiamine tetraacetic acid (EDTA).
Abstract
Assisted by the Magnetospheric Multiscale mission capturing unprecedented high-resolution data in the terrestrial magnetotail, we apply a local streamline-topology classification methodology ...to investigate the categorization of the magnetic field topological structures at kinetic scales in the turbulent reconnection outflow. It is found that strong correlations exist between the straining and rotational part of the velocity gradient tensor as well as the magnetic field gradient tensor. Strong energy dissipation prefers to occur at regions with high magnetic stress or current density, which is contributed mainly by O-type topologies. These results indicate that the kinetic structures with O-type topology play a more important role in energy dissipation in turbulent reconnection outflow.
Electron vortices are usually embedded within different magnetic structures in space plasmas. The effects, including the nonideal electric field, energy dissipation and magnetic field, of electron ...vortices on these magnetic structures are still unclear. Utilizing the unprecedented high‐resolution data from the Magnetospheric Multiscale mission in the terrestrial magnetosheath, we statistically investigate these effects on magnetic structures. Both nonideal electric fields and energy dissipation have no obvious correlations with the scales of electron vortices. However, compared to the scales, stronger correlations are found between the vorticities of electron vortices and nonideal electric fields, and energy dissipation, respectively. Most of electron vortices have positive contributions to magnetic fields of magnetic structures, such as strengthening the decrease (or increase) of Bt for current sheets and magnetic holes (or flux ropes and magnetic peaks). Our results reveal that the electron vortices play an important role in the evolution of magnetic structures.
Plain Language Summary
The magnetosheath exhibits various dynamical features such as heating and compression of the plasma, kinetic instabilities, particle beams and kinetic structures due to the highly dynamical environment in near‐Earth space. The electron vortices as the structure that manifests the in suit observations, including bipolar variations of electron velocity and large electron vorticity, have been revealed widely in the magnetosheath. However, the specific effects of electron vortices embedded within the magnetic structures on these magnetic structures are still unknown, especially in a statistical view. Thanks to the unprecedented high‐time resolution data of the Magnetospheric Multiscale mission in the magnetosheath, we investigated the effects, including the nonideal electric fields, energy dissipation and magnetic fields, of electron vortices on these magnetic structures. We find that the nonideal electric fields, energy dissipation inside the electron vortices is more significant than outside for most of magnetic structures, and more than half of electron vortices have positive effects on generating the measured magnetic field of these magnetic structures, which is helpful for understanding the subsequent evolution and interaction between them.
Key Points
The effects of nonideal electric field, energy dissipation and magnetic field of electron vortices on magnetic structures have been studied
The nonideal electric fields and energy dissipation are more correlated with the vorticities of electron vortices compared to their scales
Most of electron vortices have positive contributions to magnetic fields of magnetic structures
Background
Physical functioning indexed multimorbidity is strongly associated with long‐term mortality, but its role in poor mental health has not been quantified.
Methods
A total of 252 002 ...community‐dwelling adults in the Nurses’ Health Study (NHS), NHS II, and Health Professionals Follow‐up Study (HPFS) prospective cohorts reported physician‐diagnosed diseases and the Short Form‐36 over 8 years and had 24‐year follow‐up for suicide mortality. We quantified multimorbidity using a multimorbidity‐weighted index (MWI). We used multivariable‐adjusted proportional hazards models with competing risks for suicide mortality and mixed‐effects models to estimate mental health‐related quality of life (HRQOL).
Results
Multimorbidity was associated with an increased risk of suicide mortality in an approximately linear manner, with roughly two‐ to threefold higher risk in adults with the highest vs lowest quartile MWI in adjusted models: NHS hazard ratio (HR) = 3.01 (95% confidence interval CI = 1.48‐6.11); NHS II HR = 3.04 (95% CI = 1.82‐5.09); HPFS HR = 1.74 (95% CI = 1.08‐2.81). Greater MWI was associated with worse mental HRQOL 8 years later across all scales and the mental component summary (MCS) in a dose‐response manner. This association was attenuated but persisted after adjustment for baseline mental HRQOL and other covariates. Adults with the highest quartile MWI had lower MCS in adjusted models compared with those with the lowest quartile MWI: NHS ß = −0.61 (95% CI = −0.78 to −0.44); NHS II ß = −1.25 (95% CI = −1.44 to −1.06).
Conclusion
Multimorbidity is associated with substantially higher suicide mortality risk and worse mental HRQOL across all available scales, even when indexed to physical functioning. These results highlight the substantial mental health burden imposed by multimorbidity at all ages and sexes. J Am Geriatr Soc 67:511–519, 2019.
Abstract
Without a global dipole magnetic field, Mars has magnetic anomalies, i.e., crustal fields, in the southern hemisphere and interesting flexible magnetic fields in the magnetotail. The ...magnetic field topology is complex and flexible in the Martian magnetotail, especially over regions of strong crustal fields. However, the answer to how the magnetic field topology within crustal field regions transitions is elusive. Here we report the first case of interchange reconnection between open and closed crustal fields in the near-Mars magnetotail, using Mars Atmosphere and Volatile Evolution (MAVEN) observations. While MAVEN crossed from a region of closed crustal field to one of open crustal field, several characteristics of reconnection, such as the Hall magnetic field and plasma outflow, were observed. And plasmas are exchanged in the reconnection region. Our observations demonstrate that interchange reconnection can occur between open and closed crustal fields in the Martian near-magnetotail. Interchange reconnection occurring on the nightside changes the magnetic field topology within the crustal field regions and contributes to the escape of heavy ions.
MIT's (magnetic induction tomography) low-cost and noninvasive features can offer great excitement and potential to address many challenging problems that exist in the current industrial/medical ...applications. The foundation development of MIT has been made in the past ten years. Many more advancements can be expected in the next decade, including the first commercialized MIT system for industrial or medical application. It will certainly contribute some impact to the current imaging technology.
Omega-3 fatty acid supplements containing both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to reduce triglycerides but also increase low-density lipoprotein (LDL). ...Whether EPA or DHA given as monotherapy has differential effects on serum lipoproteins has not been systematically evaluated. We performed a meta-analysis of randomized placebo-controlled trials of monotherapy with EPA (
n
= 10), DHA (
n
= 17), or EPA versus DHA (
n
= 6). Compared with placebo, DHA raised LDL 7.23 mg/dL (95% CI, 3.98–10.5) whereas EPA non-significantly reduced LDL. In direct comparison studies, DHA raised LDL 4.63 mg/dL (95% CI, 2.15–7.10) more than EPA. Both EPA and DHA reduced triglycerides, with a greater reduction by DHA in direct comparison studies. DHA also raised high-density lipoprotein (4.49 mg/dL; 95% CI, 3.50–5.48) compared with placebo, whereas EPA did not. Although EPA and DHA both reduce triglycerides, they have divergent effects on LDL and high-density lipoprotein. Further research is needed to elucidate the mechanisms and significance of these differences.
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