We present Atacama Large Millimeter/submillimeter Array and Multi-Unit Spectroscopic Explorer observations of the brightest cluster galaxy in Abell 2597, a nearby (z = 0.0821) cool core cluster of ...galaxies. The data map the kinematics of a three billion solar mass filamentary nebula that spans the innermost 30 kpc of the galaxy's core. Its warm ionized and cold molecular components are both cospatial and comoving, consistent with the hypothesis that the optical nebula traces the warm envelopes of many cold molecular clouds that drift in the velocity field of the hot X-ray atmosphere. The clouds are not in dynamical equilibrium, and instead show evidence for inflow toward the central supermassive black hole, outflow along the jets it launches, and uplift by the buoyant hot bubbles those jets inflate. The entire scenario is therefore consistent with a galaxy-spanning "fountain," wherein cold gas clouds drain into the black hole accretion reservoir, powering jets and bubbles that uplift a cooling plume of low-entropy multiphase gas, which may stimulate additional cooling and accretion as part of a self-regulating feedback loop. All velocities are below the escape speed from the galaxy, and so these clouds should rain back toward the galaxy center from which they came, keeping the fountain long lived. The data are consistent with major predictions of chaotic cold accretion, precipitation, and stimulated feedback models, and may trace processes fundamental to galaxy evolution at effectively all mass scales.
•Mapping the neural circuitry of RRB is in its early stages.•MRI provides needed translational studies of the network connectivity mediating RRB.•MRI findings implicate cortico-basal ganglia and ...cerebellar circuits in RRB.•MRI studies of animal models of RRB are lacking and sorely needed.•Advanced MRI with in vitro neuroscience methods are needed to confirm RRB circuitry.
Restricted, repetitive behaviors (RRBs) are patterns of behavior that exhibit little variation in form and have no obvious function. RRBs although transdiagonstic are a particularly prominent feature of certain neurodevelopmental disorders, yet relatively little is known about the neural circuitry of RRBs. Past work in this area has focused on isolated brain regions and neurotransmitter systems, but implementing a neural circuit approach has the potential to greatly improve understanding of RRBs. Magnetic resonance imaging (MRI) is well-suited to studying the structural and functional connectivity of the nervous system, and is a highly translational research tool. In this review, we synthesize MRI research from both neurodevelopmental disorders and relevant animal models that informs the neural circuitry of RRB. Together, these studies implicate distributed neural circuits between the cortex, basal ganglia, and cerebellum. Despite progress in neuroimaging of RRB, there are many opportunities for conceptual and methodological improvement. We conclude by suggesting future directions for MRI research in RRB, and how such studies can benefit from complementary approaches in neuroscience.
We present a measure of the hard (2-8 keV) X-ray luminosity function (XLF) of AGNs up to image. At high redshifts, the wide area coverage of the Chandra Multiwavength Project is crucial to detect ...rare and luminous AGNs. The inclusion of samples from deeper published surveys, such as the Chandra Deep Fields, allows us to span the lower L sub(X) range of the XLF. Our sample is selected from both the hard and soft energy band detections. Within our optical magnitude limits, we achieve an adequate level of completeness (>50%) regarding X-ray source identification (i.e., redshift). We find that the luminosity function is similar to that found in previous X- ray surveys up to image with an evolution dependent on both luminosity and redshift. At image, there is a significant decline in the numbers of AGNs with an evolution rate similar to that found by studies of optically selected QSOs. Based on our XLF, we assess the resolved fraction of the cosmic X-ray background, the cumulative mass density of SMBHs, and the comparison of the mean accretion rate onto SMBHs and the star formation history of galaxies as a function of redshift. A coevolution scenario up to image is plausible, although at higher redshifts the accretion rate onto SMBHs drops more rapidly. Finally, we highlight the need for better statistics of high- redshift AGNs at image, which is achievable with the upcoming Chandra surveys.
Dystonia is a neurological movement disorder characterized by repetitive, unintentional movements and disabling postures that result from sustained or intermittent muscle contractions. The basal ...ganglia and cerebellum have received substantial focus in studying DYT1 dystonia. It remains unclear how cell-specific ∆GAG mutation of torsinA within specific cells of the basal ganglia or cerebellum affects motor performance, somatosensory network connectivity, and microstructure. In order to achieve this goal, we generated two genetically modified mouse models: in model 1 we performed Dyt1 ∆GAG conditional knock-in (KI) in neurons that express dopamine-2 receptors (D2-KI), and in model 2 we performed Dyt1 ∆GAG conditional KI in Purkinje cells of the cerebellum (Pcp2-KI). In both of these models, we used functional magnetic resonance imaging (fMRI) to assess sensory-evoked brain activation and resting-state functional connectivity, and diffusion MRI to assess brain microstructure. We found that D2-KI mutant mice had motor deficits, abnormal sensory-evoked brain activation in the somatosensory cortex, as well as increased functional connectivity of the anterior medulla with cortex. In contrast, we found that Pcp2-KI mice had improved motor performance, reduced sensory-evoked brain activation in the striatum and midbrain, as well as reduced functional connectivity of the striatum with the anterior medulla. These findings suggest that (1) D2 cell-specific Dyt1 ∆GAG mediated torsinA dysfunction in the basal ganglia results in detrimental effects on the sensorimotor network and motor output, and (2) Purkinje cell-specific Dyt1 ∆GAG mediated torsinA dysfunction in the cerebellum results in compensatory changes in the sensorimotor network that protect against dystonia-like motor deficits.
•Dyt1 ∆GAG knock-in has differential effects in the basal ganglia and cerebellum•Dopamine-2 receptor specific Dyt1 knock-in mice display motor deficits•Purkinje neuron specific Dyt1 knock-in mice have improved motor performance•D2-KI and Pcp2-KI mice have unique sensorimotor activation and network connectivity
DYT1 dystonia is a debilitating movement disorder characterized by repetitive, unintentional movements and postures. The disorder has been linked to mutation of the TOR1A/DYT1 gene encoding torsinA. ...Convergent evidence from studies in humans and animal models suggest that striatal medium spiny neurons and cholinergic neurons are important in DYT1 dystonia. What is not known is how torsinA dysfunction in these specific cell types contributes to the pathophysiology of DYT1 dystonia. In this study we sought to determine whether torsinA dysfunction in cholinergic neurons alone is sufficient to generate the sensorimotor dysfunction and brain changes associated with dystonia, or if torsinA dysfunction in a broader subset of cell types is needed. We generated two genetically modified mouse models, one with selective Dyt1 knock-out from dopamine-2 receptor expressing neurons (D2KO) and one where only cholinergic neurons are impacted (Ch2KO). We assessed motor deficits and performed in vivo 11.1 T functional MRI to assess sensory-evoked brain activation and connectivity, along with diffusion MRI to assess brain microstructure. We found that D2KO mice showed greater impairment than Ch2KO mice, including reduced sensory-evoked brain activity in key regions of the sensorimotor network, and altered functional connectivity of the striatum that correlated with motor deficits. These findings suggest that (1) the added impact of torsinA dysfunction in medium spiny and dopaminergic neurons of the basal ganglia generate more profound deficits than the dysfunction of cholinergic neurons alone, and (2) that sensory network impairments are linked to motor deficits in DYT1 dystonia.
•Cell-specific effects of Dyt1 knock-out are important for understanding Dystonia.•Dopamine-2 receptor specific Dyt1 knock-out mice displayed motor deficits.•Cholinergic Dyt1 knock-out mice in this study did not display motor deficits.•More sensory-network impairment in Dopamine-2 receptor specific Dyt1 knock-out mice.•Sensory-network impairment was correlated with motor performance.
ABSTRACT As part of our program to build a complete radio and X-ray database of all Third Cambridge catalog extragalactic radio sources, we present an analysis of 93 sources for which Chandra ...archival data are available. Most of these sources have already been published. Here we provide a uniform re-analysis and present nuclear X-ray fluxes and X-ray emission associated with radio jet knots and hotspots using both publicly available radio images and new radio images that have been constructed from data available in the Very Large Array archive. For about 1/3 of the sources in the selected sample, a comparison between the Chandra and radio observations was not reported in the literature: we find X-ray detections of 2 new radio jet knots and 17 hotspots. We also report the X-ray detection of extended emission from the intergalactic medium for 15 galaxy clusters.
This paper presents the analysis of Chandra X-ray snapshot observations of a subsample of the extragalactic sources listed in the revised Third Cambridge radio catalog (3CR), previously lacking X-ray ...observations and thus observed during Chandra Cycle 15. This data set extends the current Chandra coverage of the 3CR extragalactic catalog up to redshift z = 1.0. Our sample includes 22 sources consisting of 1 compact steep spectrum source, 3 quasars (QSOs), and 18 FR II radio galaxies. As in our previous analyses, here we report the X-ray detections of radio cores and extended structures (i.e., knots, hotspots, and lobes) for all sources in the selected sample. We measured their X-ray intensities in three energy ranges, soft (0.5-1 keV), medium (1-2 keV), and hard (2-7 keV), and we also performed standard X-ray spectral analysis for brighter nuclei. All radio nuclei in our sample have an X-ray counterpart. We also discovered X-ray emission associated with the eastern knot of 3CR 154, with radio hotspots in 3CR 41, 3CR 54, and 3CR 225B, and with the southern lobe of 3CR 107. Extended X-ray radiation around the nuclei 3CR 293.1 and 3CR 323 on a scale of few tens of kiloparsecs was also found. X-ray extended emission, potentially arising from the hot gas in the intergalactic medium and/or due to the high-energy counterpart of lobes, is detected for 3CR 93, 3CR 154, 3CR 292, and 3CR 323 over a scale of a few hundred kiloparsecs. Finally, this work also presents an update on the state-of-the-art of Chandra and XMM-Newton observations for the entire 3CR sample.
The aim of this paper is to present an analysis of newly acquired X-ray observations of 16 extragalactic radio sources listed in the Third Cambridge Revised (3CR) catalog and not previously observed ...by Chandra. Observations were performed during Chandra Cycle 17, extending X-ray coverage for the 3CR extragalactic catalog up to z = 1.5. Among the 16 targets, two lie at z < 0.5 (3CR 27 at z = 0.184 and 3CR 69 at z = 0.458); all of the remaining 14 have redshifts between 1.0 and 1.5. In the current sample, there are three compact steep spectrum (CSS) sources, three quasars, and an FR I radio galaxy, while the other nine are FR II radio galaxies. All radio sources have an X-ray counterpart. We measured nuclear X-ray fluxes as well as X-ray emission associated with radio jet knots, hotspots, or lobes in three energy bands: soft (0.5-1 keV), medium (1-2 keV), and hard (2-7 keV). We also performed standard X-ray spectral analysis for the four brightest nuclei. We discovered X-ray emission associated with the radio lobe of 3CR 124, a hotspot of the quasar 3CR 220.2, another hotspot of the radio galaxy 3CR 238, and the jet knot of 3CR 297. We also detected extended X-ray emission around the nuclear region of 3CR 124 and 3CR 297 on scales of several tens of kiloparsecs. Finally, we present an update on the X-ray observations performed with Chandra and XMM-Newton on the entire 3CR extragalactic catalog.
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