Parasites exert a major impact on the eco‐evolutionary dynamics of their hosts and the associated biotic environment. Migration constitutes an effective means for long‐distance invasions of ...vector‐borne parasites and promotes their rapid spread. Yet, ecological and spatial information on population‐specific host–parasite connectivity is essentially lacking. Here, we address this question in a system consisting of a transcontinental migrant species, the European barn swallow (Hirundo rustica) which serves as a vector for avian endoparasites in the genera Plasmodium, Haemoproteus and Leucocytozoon. Using feather stable isotope ratios as geographically informative markers, we first assessed migratory connectivity in the host: Northern European breeding populations predominantly overwintered in dry, savannah‐like habitats in Southern Africa, whereas Southern European populations were associated with wetland habitats in Western Central Africa. Wintering areas of swallows breeding in Central Europe indicated a migratory divide with both migratory programmes occurring within the same breeding population. Subsequent genetic screens of parasites in the breeding populations revealed a link between the host's migratory programme and its parasitic repertoire: controlling for effects of local breeding location, prevalence of Africa‐transmitted Plasmodium lineages was significantly higher in individuals overwintering in the moist habitats of Western Central Africa, even among sympatrically breeding individuals with different overwintering locations. For the rarer Haemoproteus parasites, prevalence was best explained by breeding location alone, whereas no clear pattern emerged for the least abundant parasite Leucocytozoon. These results have implications for our understanding of spatio‐temporal host–parasite dynamics in migratory species and the spread of avian borne diseases.
Evaporation (E) and transpiration (T) respond differently
to ongoing changes in climate, atmospheric composition, and land use. It is
difficult to partition ecosystem-scale evapotranspiration (ET) ...measurements
into E and T, which makes it difficult to validate satellite data and land
surface models. Here, we review current progress in partitioning E and T and
provide a prospectus for how to improve theory and observations going
forward. Recent advancements in analytical techniques create new
opportunities for partitioning E and T at the ecosystem scale, but their
assumptions have yet to be fully tested. For example, many approaches to
partition E and T rely on the notion that plant canopy conductance and
ecosystem water use efficiency exhibit optimal responses to atmospheric
vapor pressure deficit (D). We use observations from 240 eddy covariance flux
towers to demonstrate that optimal ecosystem response to D is a reasonable
assumption, in agreement with recent studies, but more analysis is necessary
to determine the conditions for which this assumption holds. Another
critical assumption for many partitioning approaches is that ET can be
approximated as T during ideal transpiring conditions, which has been
challenged by observational studies. We demonstrate that T can exceed 95 %
of ET from certain ecosystems, but other ecosystems do not appear to reach
this value, which suggests that this assumption is ecosystem-dependent with
implications for partitioning. It is important to further improve approaches
for partitioning E and T, yet few multi-method comparisons have been
undertaken to date. Advances in our understanding of carbon–water coupling
at the stomatal, leaf, and canopy level open new perspectives on how to
quantify T via its strong coupling with photosynthesis. Photosynthesis can be
constrained at the ecosystem and global scales with emerging data sources
including solar-induced fluorescence, carbonyl sulfide flux measurements,
thermography, and more. Such comparisons would improve our mechanistic
understanding of ecosystem water fluxes and provide the observations
necessary to validate remote sensing algorithms and land surface models to
understand the changing global water cycle.
Tumor ablation is often employed for unresectable colorectal liver metastases. However, no survival benefit has ever been demonstrated in prospective randomized studies. Here, we investigate the ...long-term benefits of such an aggressive approach.
In this randomized phase II trial, 119 patients with unresectable colorectal liver metastases (n < 10 and no extrahepatic disease) received systemic treatment alone or systemic treatment plus aggressive local treatment by radiofrequency ablation ± resection. Previously, we reported that the primary end point (30-month overall survival OS > 38%) was met. We now report on long-term OS results. All statistical tests were two-sided. The analyses were according to intention to treat.
At a median follow up of 9.7 years, 92 of 119 (77.3%) patients had died: 39 of 60 (65.0%) in the combined modality arm and 53 of 59 (89.8%) in the systemic treatment arm. Almost all patients died of progressive disease (35 patients in the combined modality arm, 49 patients in the systemic treatment arm). There was a statistically significant difference in OS in favor of the combined modality arm (hazard ratio HR = 0.58, 95% confidence interval CI = 0.38 to 0.88, P = .01). Three-, five-, and eight-year OS were 56.9% (95% CI = 43.3% to 68.5%), 43.1% (95% CI = 30.3% to 55.3%), 35.9% (95% CI = 23.8% to 48.2%), respectively, in the combined modality arm and 55.2% (95% CI = 41.6% to 66.9%), 30.3% (95% CI = 19.0% to 42.4%), 8.9% (95% CI = 3.3% to 18.1%), respectively, in the systemic treatment arm. Median OS was 45.6 months (95% CI = 30.3 to 67.8 months) in the combined modality arm vs 40.5 months (95% CI = 27.5 to 47.7 months) in the systemic treatment arm.
This phase II trial is the first randomized study demonstrating that aggressive local treatment can prolong OS in patients with unresectable colorectal liver metastases.
Context.
High-redshift quasars signpost the early accretion history of the Universe. The penetrating nature of X-rays enables a less absorption-biased census of the population of these luminous and ...persistent sources compared to optical/near-infrared colour selection. The ongoing SRG/eROSITA X-ray all-sky survey offers a unique opportunity to uncover the bright end of the high-
z
quasar population and probe new regions of colour parameter space.
Aims.
We searched for high-
z
quasars within the X-ray source population detected in the contiguous ~140 deg
2
field observed by eROSITA during the performance verification phase. With the purpose of demonstrating the unique survey science capabilities of eROSITA, this field was observed at the depth of the final all-sky survey. The blind X-ray selection of high-redshift sources in a large contiguous, near-uniform survey with a well-understood selection function can be directly translated into constraints on the X-ray luminosity function (XLF), which encodes the luminosity-dependent evolution of accretion through cosmic time.
Methods.
We collected the available spectroscopic information in the eFEDS field, including the sample of all currently known optically selected
z
> 5.5 quasars and cross-matched secure Legacy DR8 counterparts of eROSITA-detected X-ray point-like sources with this spectroscopic sample.
Results.
We report the X-ray detection of eFEDSU J083644.0+005459, an eROSITA source securely matched to the well-known quasar SDSS J083643.85+005453.3 (
z
= 5.81). The soft X-ray flux of the source derived from eROSITA is consistent with previous
Chandra
observations. The detection of SDSS J083643.85+005453.3 allows us to place the first constraints on the XLF at
z
> 5.5 based on a secure spectroscopic redshift. Compared to extrapolations from lower-redshift observations, this favours a relatively flat slope for the XLF at
z
~ 6 beyond
L
*
, the knee in the luminosity function. In addition, we report the detection of the quasar with LOFAR at 145 MHz and ASKAP at 888 MHz. The reported flux densities confirm a spectral flattening at lower frequencies in the emission of the radio core, indicating that SDSS J083643.85+005453.3 could be a (sub-) gigahertz peaked spectrum source. The inferred spectral shape and the parsec-scale radio morphology of SDSS J083643.85+005453.3 indicate that it is in an early stage of its evolution into a large-scale radio source or confined in a dense environment. We find no indications for a strong jet contribution to the X-ray emission of the quasar, which is therefore likely to be linked to accretion processes.
Conclusions.
Our results indicate that the population of X-ray luminous AGNs at high redshift may be larger than previously thought. From our XLF constraints, we make the conservative prediction that eROSITA will detect ~90 X-ray luminous AGNs at redshifts 5.7 <
z
< 6.4 in the full-sky survey (De+RU). While subject to different jet physics, both high-redshift quasars detected by eROSITA so far are radio-loud; a hint at the great potential of combined X-ray and radio surveys for the search of luminous high-redshift quasars.
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