► A new high-strength refractory alloy, Ta20Nb20Hf20Zr20Ti20. ► The alloy has a BCC crystal structure. The lattice parameter
a
=
340.4
pm. ► The alloy density and Vickers microhardness are 9.94
g/cm
...3 and 3826
MPa. ► The compression yield stress
σ
0.2
=
929
MPa and ductility
ɛ
>
50%. ► The alloy shows considerable strain hardening and homogeneous deformation. ► A model of solid-solution strengthening is proposed to explain the behavior.
A new refractory alloy, Ta
20Nb
20Hf
20Zr
20Ti
20, produced by vacuum arc-melting followed by hot isostatic pressing (HIPing) at
T
=
1473
K and
P
=
207
MPa for 3
h has predominantly a single-phase body-centered cubic (BCC) structure with the lattice parameter
a
=
340.4
pm. The alloy density and Vickers microhardness are
ρ
=
9.94
g/cm
3 and
H
v
=
3826
MPa. The alloy has high compression yield strength (
σ
0.2
=
929
MPa) and ductility (
ɛ
>
50%). The alloy shows considerable strain hardening and homogeneous deformation. A simple model of solid-solution strengthening is proposed to explain the behavior.
Compression properties of a refractory multi-component alloy, Ta
20
Nb
20
Hf
20
Zr
20
Ti
20
, were determined in the temperature range of 296–1473 K and strain rate range of 10
−1
–10
−5
s
−1
. The ...properties were correlated with the microstructure developed during compression testing. The alloy was produced by vacuum arc melting, and it was hot isostatically pressed (HIPd) and homogenized at 1473 K for 24 h prior to testing. It had a single-phase body-centered cubic structure with the lattice parameter
a
= 340.4 pm. The grain size was in the range of 100–200 μm. During compression at a strain rate of έ = 10
−3
s
−1
, the alloy had the yield strength of 929 MPa at 296 K, 790 MPa at 673 K, 675 MPa at 873 K, 535 MPa at 1073 K, 295 MPa at 1273 K and 92 MPa at 1473 K. Continuous strain hardening and good ductility (ε ≥ 50%) were observed in the temperature range from 296 to 873 K. Deformation at
T
= 1073 K and έ ≥ 10
−3
s
−1
was accompanied by intergranular cracking and cavitation, which was explained by insufficient dislocation and diffusion mobility to accommodate grain boundary sliding activated at this temperature. The intergranular cracking and cavitation disappeared with an increase in the deformation temperature to 1273 and 1473 K or a decrease in the strain rate to ~10
−5
s
−1
. At these high temperatures and/or low-strain rates the alloy deformed homogeneously and showed steady-state flow at a nearly constant flow stress. Partial dynamic recrystallization, leading to formation of fine equiaxed grains near grain boundaries, was observed in the specimens deformed at 1073 and 1273 K and completed dynamic recrystallization was observed at 1473 K.
Subtypes defined by hormonal receptor (HR) and HER2 status have not been well studied in inflammatory breast cancer (IBC). We characterized clinical parameters and long-term outcomes, and compared ...pathological complete response (pCR) rates by HR/HER2 subtype in a large IBC patient population. We also compared disease-free survival (DFS) and overall survival (OS) between IBC patients who received targeted therapies (anti-hormonal, anti-HER2) and those who did not.
We retrospectively reviewed the records of patients diagnosed with IBC and treated at MD Anderson Cancer Center from January 1989 to January 2011. Of those, 527 patients had received neoadjuvant chemotherapy and had available information on estrogen receptor (ER), progesterone receptor (PR), and HER2 status. HR status was considered positive if either ER or PR status was positive. Using the Kaplan–Meier method, we estimated median DFS and OS durations from the time of definitive surgery. Using the Cox proportional hazards regression model, we determined the effect of prognostic factors on DFS and OS. Results were compared by subtype.
The overall pCR rate in stage III IBC was 15.2%, with the HR-positive/HER2-negative subtype showing the lowest rate (7.5%) and the HR-negative/HER2-positive subtype, the highest (30.6%). The HR-negative, HER2-negative subtype (triple-negative breast cancer, TNBC) had the worst survival rate. HR-positive disease, irrespective of HER2 status, had poor prognosis that did not differ from that of the HR-negative/HER2-positive subtype with regard to OS or DFS. Achieving pCR, no evidence of vascular invasion, non-TNBC, adjuvant hormonal therapy, and radiotherapy were associated with longer DFS and OS.
Hormone receptor and HER2 molecular subtypes had limited predictive and prognostic power in our IBC population. All molecular subtypes of IBC had a poor prognosis. HR-positive status did not necessarily confer a good prognosis. For all IBC subtypes, novel, specific treatment strategies are needed in the neoadjuvant and adjuvant settings.
Since its discovery in 2008, the Andromeda galaxy nova M31N 2008-12a has been observed in eruption every single year. This unprecedented frequency indicates an extreme object, with a massive white ...dwarf and a high accretion rate, which is the most promising candidate for the single-degenerate progenitor of a Type Ia supernova known to date. The previous three eruptions of M31N 2008-12a have displayed remarkably homogeneous multiwavelength properties: (i) from a faint peak, the optical light curve declined rapidly by two magnitudes in less than two days, (ii) early spectra showed initial high velocities that slowed down significantly within days and displayed clear He/N lines throughout, and (iii) the supersoft X-ray source (SSS) phase of the nova began extremely early, six days after eruption, and only lasted for about two weeks. In contrast, the peculiar 2016 eruption was clearly different. Here we report (i) the considerable delay in the 2016 eruption date, (ii) the significantly shorter SSS phase, and (iii) the brighter optical peak magnitude (with a hitherto unobserved cusp shape). Early theoretical models suggest that these three different effects can be consistently understood as caused by a lower quiescence mass accretion rate. The corresponding higher ignition mass caused a brighter peak in the free-free emission model. The less massive accretion disk experienced greater disruption, consequently delaying the re-establishment of effective accretion. Without the early refueling, the SSS phase was shortened. Observing the next few eruptions will determine whether the properties of the 2016 outburst make it a genuine outlier in the evolution of M31N 2008-12a.
Recommendations based on the level of evidence are presented and graded as: A: requires at least one randomised controlled trial of good quality addressing the topic of recommendation (evidence ...categories Ia and Ib); B: requires the availability of clinical studies without randomisation on the topic of recommendation (evidence categories IIa, IIb and III); and C: requires evidence from expert committee reports or opinions or clinical experience of respected authorities in the absence of directly applicable clinical studies of good quality (evidence category IV). Table 7 Current indications for referral of adults to an intestinal transplantation centre in the UK Complications of parenteral nutrition * Liver disease (portal hypertension, bridging hepatic fibrosis, or cirrhosis) due to parenteral nutrition-irreversible despite referral and management by an established parenteral nutrition centre. * Progressively compromised vascular access for parenteral feeding-loss of all but two major venous access points (one of which should be above the diaphragm). * Recurrent or life threatening central line sepsis (including fungal sepsis). * Inadequate maintenance on parenteral nutrition for any other reason-for instance, inability to manage hydration/nutrition status despite parenteral nutrition.
The recurrent nova (RN) V3890 Sgr was observed during the seventh day after the onset of its most recent outburst, with the Chandra ACIS-S camera and High Energy Transmission Gratings. A rich ...emission line spectrum was detected, due to transitions of Fe-L and K-shell ions ranging from neon to iron. The measured absorbed flux is 10−10 erg cm−2 s−1 in the 1.4-15 range (0.77-8.86 keV). The line profiles are asymmetric, blueshifted, and skewed toward the blue side, as if the ejecta moving toward us are less absorbed than the receding ejecta. The full width at half-maximum of most emission lines is 1000-1200 km s−1, with some extended blue wings. The spectrum is thermal and consistent with a plasma in collisional ionization equilibrium with column density 1.3 × 1022 cm−2 and at least two components at temperatures of about 1 and 4 keV, possibly a forward and a reverse shock, or regions with differently mixed ejecta and a red giant wind. The spectrum is remarkably similar to the symbiotic RNe V745 Sco and RS Oph, but we cannot distinguish whether the shocks occurred at a distance of a few au from the red giant, or near the giant's photosphere, in a high-density medium containing only a low mass. The ratios of the flux in lines of aluminum, magnesium, and neon relative to the flux in lines of silicon and iron probably indicate a carbon-oxygen white dwarf.
Body size in ecological networks Woodward, Guy; Ebenman, Bo; Emmerson, Mark ...
Trends in ecology & evolution (Amsterdam),
07/2005, Letnik:
20, Številka:
7
Journal Article
Recenzirano
Odprti dostop
Body size determines a host of species traits that can affect the structure and dynamics of food webs, and other ecological networks, across multiple scales of organization. Measuring body size ...provides a relatively simple means of encapsulating and condensing a large amount of the biological information embedded within an ecological network. Recently, important advances have been made by incorporating body size into theoretical models that explore food web stability, the patterning of energy fluxes, and responses to perturbations. Because metabolic constraints underpin body-size scaling relationships, metabolic theory offers a potentially useful new framework within which to develop novel models to describe the structure and functioning of ecological networks and to assess the probable consequences of biodiversity change.
ABSTRACT
On 2021 August 8, the recurrent nova RS Ophiuchi (RS Oph) erupted again, after an interval of 15.5 yr. Regular monitoring by the Neil Gehrels Swift Observatory began promptly, on August 9.9 ...(0.37 d after the optical peak), and continued until the source passed behind the Sun at the start of November, 86 d later. Observations then restarted on day 197, once RS Oph emerged from the Sun constraint. This makes RS Oph the first Galactic recurrent nova to have been monitored by Swift throughout two eruptions. Here we investigate the extensive X-ray data sets between 2006 and 2021, as well as the more limited data collected by the European X-ray Observatory Satellite (EXOSAT) in 1985. The hard X-rays arising from shock interactions between the nova ejecta and red giant wind are similar following the last two eruptions. In contrast, the early supersoft source (SSS) in 2021 was both less variable and significantly fainter than in 2006. However, 0.3–1 keV light curves from 2021 reveal a 35 s quasi-periodic oscillation consistent in frequency with the 2006 data. The Swift X-ray spectra from 2021 are featureless, with the soft emission typically being well parametrized by a simple blackbody, while the 2006 spectra showed much stronger evidence for superimposed ionized absorption edges. Considering the data after day 60 following each eruption, during the supersoft phase the 2021 spectra are hotter, with smaller effective radii and lower wind absorption, leading to an apparently reduced bolometric luminosity. We explore possible explanations for the gross differences in observed SSS behaviour between the 2006 and 2021 outbursts.
We describe the HadGEM2 family of climate configurations of the Met Office Unified Model, MetUM. The concept of a model "family" comprises a range of specific model configurations incorporating ...different levels of complexity but with a common physical framework. The HadGEM2 family of configurations includes atmosphere and ocean components, with and without a vertical extension to include a well-resolved stratosphere, and an Earth-System (ES) component which includes dynamic vegetation, ocean biology and atmospheric chemistry. The HadGEM2 physical model includes improvements designed to address specific systematic errors encountered in the previous climate configuration, HadGEM1, namely Northern Hemisphere continental temperature biases and tropical sea surface temperature biases and poor variability. Targeting these biases was crucial in order that the ES configuration could represent important biogeochemical climate feedbacks. Detailed descriptions and evaluations of particular HadGEM2 family members are included in a number of other publications, and the discussion here is limited to a summary of the overall performance using a set of model metrics which compare the way in which the various configurations simulate present-day climate and its variability.
Summary
Background
The majority of deleterious health consequences of coeliac disease (CD) are most likely to be secondary to intestinal inflammation; hence, mucosal recovery is a desirable goal of ...therapy. Follow‐up in CD is controversial and serological response is often used as a surrogate for histological recovery.
Aims
To inform the clinical management of CD using comparative serological and histological data from a biopsy‐driven pathway of care.
Methods
A retrospective analysis of the Cambridge Coeliac Clinic database of 595 patients routinely followed up by biopsy and serology.
Results
Paired biopsy results were available for 391 patients (15% seronegative). Persisting villous atrophy (VA) occurred in 182 patients (47%). The sensitivity of anti‐tissue transglutaminase (TTG) antibody for ongoing VA was only 43.6%. Information on dietetic management and further biopsy to assess response was available for 94 initially unresponsive patients, in whom targeted dietetic intervention by removal of identified gluten sources or avoidance of trace amounts of gluten led to resolution of persistent VA in 50%. The effects of institution of a formal care pathway are analysed in 298 patients. Discharge to primary care and clinical management was facilitated by the information derived from repeat biopsy.
Conclusions
Serology appears to be a poor surrogate marker for mucosal recovery on a gluten‐free diet; dietary assessment fails to identify a potential gluten source in many patients with ongoing villous atrophy. The benefits of re‐biopsy on diet include stratification of patients with coeliac disease suitable for early discharge from secondary care or those requiring more intensive clinical management.
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