In order to achieve the goal of low-emission management in regional energy industry, this paper provides a new method of quantitatively managed process and optimized process to explore the ...development mode of energy industrial clusters by integer programming. After analyzing the relationship of the cost and benefit of the regional energy industry for green and low-carbon transformation, this paper brings the control mechanism of carbon footprint into the energy industry as a new dimension of optimization and reorganization of the industrial chain. Then, this paper establishes a new optimization model of the regional energy industry structure and uses the simulation instance in Hebei province to verify the real value of the new optimization model.
After the analysis of the problems of the relationship between the life cycle of energy industry development and the regional ecological environment, the paper quantitatively studies the interests of ...all parties and key policy variables of the reform process of the energy industry system based on the microeconomic theory of carbon tax and carbon trading cost. At the same time, the paper regards the mechanism of the development in the new energy industry as the object of empirical study in Hebei province, China, and establishes the model of profit distribution in the regional energy industrial cluster. The research will provide a strong theoretical support for the development of new energy industry cluster in some region.
Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the ...embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b high monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80 bright macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia— cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.
Energy supply and environmental capacity are important material foundations for social and economic development and constraints for scientific and sustainable development, and with achieving the ...strategic goals of carbon peak and carbon neutral at an early date, too. Therefore, the international community generally regards energy-economic- environment (3E) as a necessary research direction. This paper studies the relationship among effective energy utilization, economic growth protection and ecological environment protection by establishing the contribution rate model of energy consumption factors to economic GDP growth. At the same time, this paper puts forward the government needs to use carbon trading market, carbon tax, such as low carbon management mechanism based on the Pareto Optimality of carbon trading market, prompts the excess money of the country or the region back to actively invest in low-carbon production, lets more energy companies to clean energy and low carbon production transformation, and helps to achieve the goal of regional energy industry carbon neutral.
Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are responsible for the balanced output of multiple short-lived blood cell lineages in steady-state and in response ...to different challenges. However, feedback mechanisms by which HSCs, through their niches, sense acute losses of specific blood cell lineages remain to be established. While all HSCs replenish platelets, previous studies have shown that a large fraction of HSCs are molecularly primed for the megakaryocyte-platelet lineage and are rapidly recruited into proliferation upon platelet depletion. Platelets normally turnover in an activation-dependent manner, herein mimicked by antibodies inducing platelet activation and depletion. Antibody-mediated platelet activation upregulates expression of Interleukin-1 (IL-1) in platelets, and in bone marrow extracellular fluid in vivo. Genetic experiments demonstrate that rather than IL-1 directly activating HSCs, activation of bone marrow Lepr
perivascular niche cells expressing IL-1 receptor is critical for the optimal activation of quiescent HSCs upon platelet activation and depletion. These findings identify a feedback mechanism by which activation-induced depletion of a mature blood cell lineage leads to a niche-dependent activation of HSCs to reinstate its homeostasis.
•Endothelial KIT ligand deletion reduces systemic KIT ligand, precluding conclusions on role of endothelial niche expression of KIT ligand.•HSC homeostasis is regulated primarily by soluble rather ...than membrane KIT ligand expression in endothelial cells.
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A critical regulatory role of hematopoietic stem cell (HSC) vascular niches in the bone marrow has been implicated to occur through endothelial niche cell expression of KIT ligand. However, endothelial-derived KIT ligand is expressed in both a soluble and membrane-bound form and not unique to bone marrow niches, and it is also systemically distributed through the circulatory system. Here, we confirm that upon deletion of both the soluble and membrane-bound forms of endothelial-derived KIT ligand, HSCs are reduced in mouse bone marrow. However, the deletion of endothelial-derived KIT ligand was also accompanied by reduced soluble KIT ligand levels in the blood, precluding any conclusion as to whether the reduction in HSC numbers reflects reduced endothelial expression of KIT ligand within HSC niches, elsewhere in the bone marrow, and/or systemic soluble KIT ligand produced by endothelial cells outside of the bone marrow. Notably, endothelial deletion, specifically of the membrane-bound form of KIT ligand, also reduced systemic levels of soluble KIT ligand, although with no effect on stem cell numbers, implicating an HSC regulatory role primarily of soluble rather than membrane KIT ligand expression in endothelial cells. In support of a role of systemic rather than local niche expression of soluble KIT ligand, HSCs were unaffected in KIT ligand deleted bones implanted into mice with normal systemic levels of soluble KIT ligand. Our findings highlight the need for more specific tools to unravel niche-specific roles of regulatory cues expressed in hematopoietic niche cells in the bone marrow.
Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-mutation-driven clonal evolution and subsequent transformation is a crucial step toward the design of rational ...therapeutic strategies. Here we carry out allelic resolution single-cell multi-omic analysis of hematopoietic stem/progenitor cells (HSPCs) from patients with a myeloproliferative neoplasm who transform to TP53-mutant secondary acute myeloid leukemia (sAML). All patients showed dominant TP53 'multihit' HSPC clones at transformation, with a leukemia stem cell transcriptional signature strongly predictive of adverse outcomes in independent cohorts, across both TP53-mutant and wild-type (WT) AML. Through analysis of serial samples, antecedent TP53-heterozygous clones and in vivo perturbations, we demonstrate a hitherto unrecognized effect of chronic inflammation, which suppressed TP53 WT HSPCs while enhancing the fitness advantage of TP53-mutant cells and promoted genetic evolution. Our findings will facilitate the development of risk-stratification, early detection and treatment strategies for TP53-mutant leukemia, and are of broad relevance to other cancer types.
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