In this paper, the fuzzy control problem for uncertain time-delay active steering systems with actuator fault is investigated. Due to the variation of vehicle mass, Takagi-Sugeno fuzzy model is ...introduced to describe the uncertainties by employing the sector nonlinearity method. In the process of signal transmission, the network-induced delay and packet dropouts are unavoidable. To handle this problem, a robust
H
∞
controller is designed to regulate the vehicle lateral motion. A fault-tolerant controller is designed to reduce the impact of actuator fault on the vehicle active steering systems. Based on the Lyapunov stability theory, sufficient conditions are established to ensure that the resulting closed-loop system is asymptotically stable with the prescribed
H
∞
performance. Simulation results are provided to confirm the effectiveness and applicability of the proposed control scheme.
Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains ...unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. Chromatin immunoprecipitation (ChIP) sequencing revealed that, although Stag2 and Stag1 bind a shared set of genomic loci, a component of Stag2 binding sites is unoccupied by Stag1, even in Stag2-deficient HSPCs. Although concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell lineage. Our data illustrate a role for Stag2 in transformation and transcriptional dysregulation distinct from its shared role with Stag1 in chromosomal segregation.
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•Hematopoietic Stag2 loss enhances stem cell self-renewal and impairs differentiation•Stag1 can maintain TAD boundary integrity in the absence of Stag2•Stag2 is required for intra-TAD interactions at lineage genes (e.g., PU.1 targets)•Stag2 target expression, but not PU.1 overexpression, restores B cell differentiation
In murine hematopoietic Stag2 deletion, Stag1 rescues topologically associated domains in the absence of Stag2 but cannot restore the chromatin architecture required for hematopoietic lineage commitment. PU.1 target genes lose accessibility and expression. Induced target gene expression, but not PU.1 overexpression, is sufficient to restore differentiation in the altered chromatin state.
In order to retrieve similar trademarks from large-scale trademark databases, combining the characteristics of trademark images, this paper presents a trademark image retrieval method based on ...regional and border feature fusion. Based on the target image extraction, the proposed approach describes the target region and border features. The region feature description is mainly based on the concept of partition block statistics. The region is divided into equal-area unit using concentric circles, and feature extraction is performed in each small block unit. For the border feature description, this study first detect corners, and then construct a Delaunay graph and extract features by combining the corner detected and the Delaunay triangulation reconstruction. In the search process, the method also incorporates information such as the trademark's color characteristics, trademark classification, and trademark keywords. The present study carried out image retrieval experiment on CE-SHAPE-1 database containing 1400 MPEG-7 core experimental shape, a classification trademark database containing 2000 images, and a national trademark database containing approximately 4.89 million images. The experimental results show that the proposed approach combines the advantages of region and border feature description, and can choose the best among various local optimizations, which makes the retrieval result more effective, more in line with human visual perception, and improves the retrieval accuracy.
Plasmacytoid dendritic cells (pDCs) are the principal natural type I interferon-producing dendritic cells. Neoplastic expansion of pDCs and pDC precursors leads to blastic plasmacytoid dendritic cell ...neoplasm (BPDCN), and clonal expansion of mature pDCs has been described in chronic myelomonocytic leukemia. The role of pDC expansion in acute myeloid leukemia (AML) is poorly studied. Here, we characterize patients with AML with pDC expansion (pDC-AML), which we observe in ∼5% of AML cases. pDC-AMLs often possess cross-lineage antigen expression and have adverse risk stratification with poor outcome. RUNX1 mutations are the most common somatic alterations in pDC-AML (>70%) and are much more common than in AML without pDC expansion and BPDCN. We demonstrate that pDCs are clonally related to, as well as originate from, leukemic blasts in pDC-AML. We further demonstrate that leukemic blasts from RUNX1-mutated AML upregulate a pDC transcriptional program, poising the cells toward pDC differentiation and expansion. Finally, tagraxofusp, a targeted therapy directed to CD123, reduces leukemic burden and eliminates pDCs in a patient-derived xenograft model. In conclusion, pDC-AML is characterized by a high frequency of RUNX1 mutations and increased expression of a pDC transcriptional program. CD123 targeting represents a potential treatment approach for pDC-AML.
The parabolic approximation has been used extensively for underwater acoustic propagation and is attractive because it is computationally efficient. Widely used parabolic equation (PE) model programs ...such as the range-dependent acoustic model (RAM) are discretized by the finite difference method. Based on the idea of the Pad
e
´
series expansion of the depth operator, a new discrete PE model using the Chebyshev collocation method (CCM) is derived, and the code (CCMPE) is developed. Taking the problems of four ideal fluid waveguides as experiments, the correctness of the discrete PE model using the CCM to solve a simple underwater acoustic propagation problem is verified. The test results show that the CCMPE developed in this article achieves higher accuracy in the calculation of underwater acoustic propagation in a simple marine environment and requires fewer discrete grid points than the finite difference discrete PE model. Furthermore, although the running time of the proposed method is longer than that of the finite difference discrete PE program (RAM), it is shorter than that of the Chebyshev–Tau spectral method.
This paper focuses on the leader-following consensus control problem for nonlinear multiagent systems subject to deferred asymmetric time-varying state constraints. A distributed event-triggered ...adaptive neural control approach is advanced. By virtue of a distributed sliding-mode estimator, the leader-following consensus control problem is converted into multiple simplified tracking control problems. Afterwards, a shifting function is utilized to transform the error variables such that the initial tracking condition can be totally unknown and the state constraints can be imposed at a specified time instant. Meanwhile, the deferred asymmetric time-varying full state constraints are addressed by a class of asymmetric barrier Lyapunov function. In order to reduce the burden of communication, a relative threshold event-triggered mechanism is incorporated into controller and Zeno behavior is excluded. Based on Lyapunov stability theorem, all closed-loop signals are proved to be semi-globally uniformly ultimately bounded. Finally, a practical simulation example is given to verify the presented control scheme.
The normal mode model is important in computational atmospheric acoustics. It is often used to compute the atmospheric acoustic field under a time-independent single-frequency sound source. Its ...solution consists of a set of discrete modes radiating into the upper atmosphere, usually related to the continuous spectrum. In this article, we present two spectral methods, the Chebyshev-Tau and Chebyshev-Collocation methods, to solve for the atmospheric acoustic normal modes, and corresponding programs are developed. The two spectral methods successfully transform the problem of searching for the modal wavenumbers in the complex plane into a simple dense matrix eigenvalue problem by projecting the governing equation onto a set of orthogonal bases, which can be easily solved through linear algebra methods. After the eigenvalues and eigenvectors are obtained, the horizontal wavenumbers and their corresponding modes can be obtained with simple processing. Numerical experiments were examined for both downwind and upwind conditions to verify the effectiveness of the methods. The running time data indicated that both spectral methods proposed in this article are faster than the Legendre-Galerkin spectral method proposed previously.
Summary Hodgkin/Reed-Sternberg (HRS) cells in the setting of chronic lymphocytic leukemia (CLL) exist in 2 forms: type I with isolated HRS cells in a CLL background (Hodgkin-like lesion) and type II ...with typical classic Hodgkin lymphoma, a variant of Richter transformation (CHL-RT). The clinical significance of the 2 morphological patterns is unclear, and their biological features have not been compared. We retrospectively reviewed 77 cases: 26 of type I and 51 of type II CHL-RT; 3 cases progressed from type I to type II. We examined clinical features, Epstein-Barr virus (EBV) status, and clonal relatedness after microdissection. Median age for type I was 62 years versus 73 years for type II ( P = .01); 27% (type I) versus 73% (type II) had a history of CLL. HRS cells were positive for EBV in 71% (55/77), similar in types I and II. Clonality analysis was performed in 33 cases (type I and type II combined): HRS cells were clonally related to the underlying CLL in 14 and unrelated in 19. ZAP-70 expression of the CLL cells but not EBV status or morphological pattern was correlated with clonal relatedness: all 14 clonally related cases were ZAP-70 negative, whereas 74% (14/19) of clonally unrelated cases were ZAP-70 positive. Overall median survival (types I and II) after diagnosis was 44 months. Advanced age was an adverse risk factor for survival, but not histologic pattern, type I versus type II. HRS-like cells in a background of CLL carries a similar clinical risk to that of CHL-RT and may progress to classic Hodgkin lymphoma in some cases.
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