The phenomenal growth of mobile data demand has brought about increasing scarcity in available radio spectrum. Meanwhile, mobile customers pay more attention to their own experience, especially in ...communication reliability and service continuity on the move. To address these issues, LTE-Unlicensed, or LTEU, is considered one of the latest groundbreaking innovations to provide high performance and seamless user experience under a unified radio technology by extending LTE to the readily available unlicensed spectrum. In this article, we offer a comprehensive overview of the LTEU technology from both operator and user perspectives, and examine its impact on the incumbent unlicensed systems. Specifically, we first introduce the implementation regulations, principles, and typical deployment scenarios of LTE-U. Potential benefits for both operators and users are then discussed. We further identify three key challenges in bringing LTE-U into reality together with related research directions. In particular, the most critical issue of LTE-U is coexistence with other unlicensed systems, such as widely deployed WiFi. The LTE/WiFi coexistence mechanisms are elaborated in time, frequency, and power aspects, respectively. Simulation results demonstrate that LTE-U can provide better user experience to LTE users while well protecting the incumbent WiFi users' performance compared to two existing advanced technologies: cellular/WiFi interworking and licensed-only heterogeneous networks (Het-Nets).
How much information can be carried over a wireless network with a multiplicity of nodes, and how should the nodes cooperate to transfer information? To study these questions, we formulate a model of ...wireless networks that particularly takes into account the distances between nodes, and the resulting attenuation of radio signals, and study a performance measure that weights information by the distance over which it is transported. Consider a network with the following features. I) n nodes located on a plane, with minimum separation distance /spl rho//sub min/>0. II) A simplistic model of signal attenuation e/sup -/spl gamma//spl rho///spl rho//sup /spl delta// over a distance /spl rho/, where /spl gamma//spl ges/0 is the absorption constant (usually positive, unless over a vacuum), and /spl delta/>0 is the path loss exponent. III) All receptions subject to additive Gaussian noise of variance /spl sigma//sup 2/. The performance measure we mainly, but not exclusively, study is the transport capacity C/sub T/:=sup/spl Sigma/on/sub /spl lscr/=1//sup m/R/sub /spl lscr///spl middot//spl rho//sub /spl lscr//, where the supremum is taken over m, and vectors (R/sub 1/,R/sub 2/,...,R/sub m/) of feasible rates for m source-destination pairs, and /spl rho//sub /spl lscr// is the distance between the /spl lscr/th source and its destination. It is the supremum distance-weighted sum of rates that the wireless network can deliver. We show that there is a dichotomy between the cases of relatively high and relatively low attenuation. When /spl gamma/>0 or /spl delta/>3, the relatively high attenuation case, the transport capacity is bounded by a constant multiple of the sum of the transmit powers of the nodes in the network. However, when /spl gamma/=0 and /spl delta/<3/2, the low-attenuation case, we show that there exist networks that can provide unbounded transport capacity for fixed total power, yielding zero energy priced communication. Examples show that nodes can profitably cooperate over large distances using coherence and multiuser estimation when the attenuation is low. These results are established by developing a coding scheme and an achievable rate for Gaussian multiple-relay channels, a result that may be of interest in its own right.
We consider the discrete memoryless symmetric primitive relay channel, where, a source X wants to send information to a destination Y with the help of a relay Z and the relay can communicate to the ...destination via an error-free digital link of rate R 0 , while Y and Z are conditionally independent and identically distributed given X. We develop two new upper bounds on the capacity of this channel that are tighter than existing bounds, including the celebrated cut-set bound. Our approach significantly deviates from the standard information-theoretic approach for proving upper bounds on the capacity of multi-user channels. We build on the blowing-up lemma to analyze the probabilistic geometric relations between the typical sets of the n-letter random variables associated with a reliable code for communicating over this channel. These relations translate to new entropy inequalities between the n-letter random variables involved. As an application of our bounds, we study an open question posed by (Cover, 1987), namely, what is the minimum rate R 0 * needed for the Z-Y link in order for the capacity of the relay channel to be equal to that of the broadcast cut. We consider the special case when the X-Y and X-Z links are both binary symmetric channels. Our tighter bounds on the capacity of the relay channel immediately translate to tighter lower bounds for R 0 *. More interestingly, we show that when p → 1/2, R 0 * ≥ 0.1803; even though the broadcast channel becomes completely noisy as p → 1/2 and its capacity, and therefore the capacity of the relay channel, goes to zero, a strictly positive rate R 0 is required for the relay channel capacity to be equal to the broadcast bound. Existing upper bounds on the capacity of the relay channel, and the cut-set bound in particular, would rather imply R 0 * → 0, while achievability schemes require R 0 * → 1. We conjecture that R 0 * → 1 as p → 1/2.
Xiyanping (XYP) is a Chinese herbal medicine used in the clinic to treat respiratory infection and pneumonia. Recent evidence identified XYP as a potential inhibitor of severe acute respiratory ...syndrome coronavirus 2, implying XYP as a possible treatment for the coronavirus disease 2019 (COVID‐19). Here, we conducted a prospective, multicenter, open‐label and randomized controlled trial to evaluate the safety and effectiveness of XYP injection in patients with mild to moderate COVID‐19. We consecutively recruited 130 COVID‐19 patients with mild to moderate symptoms from five study sites, and randomized them in 1:1 ratio to receive XYP injection in combination with standard therapy or receive standard supportive therapy alone. We found that XYP injection significantly reduced the time to cough relief, fever resolution and virus clearance. Less patients receiving XYP injection experienced disease progression to the severe stage during the treatment process. No severe adverse events were reported during the study. Taken together, XYP injection is safe and effective in improving the recovery of patients with mild to moderate COVID‐19. However, further studies are warranted to evaluate the efficacy of XYP in an expanded cohort comprising COVID‐19 patients at different disease stages.
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and ...play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties via interaction with immune cells in both innate and adaptive immune systems, leading to immunosuppression of various effector functions. Numerous bioactive molecules secreted by MSCs, particularly cytokines, growth factors, and chemokines, exert autocrine/paracrine effects that modulate the physiological processes of MSCs. These invaluable virtues of MSCs provide new insight into potential treatments for tissue damage and inflammation. In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. Though immunotherapy of MSCs remains controversial, these clinical trials pave the way for their widespread therapeutic application in immune-based diseases. In this review, we will summarize and update the latest research findings and clinical trials on MSC-based immunomodulation.
As an emerging technology to support scalable content-based image retrieval (CBIR), hashing has recently received great attention and became a very active research domain. In this study, we propose a ...novel unsupervised visual hashing approach called semantic-assisted visual hashing (SAVH). Distinguished from semi-supervised and supervised visual hashing, its core idea is to effectively extract the rich semantics latently embedded in auxiliary texts of images to boost the effectiveness of visual hashing without any explicit semantic labels. To achieve the target, a unified unsupervised framework is developed to learn hash codes by simultaneously preserving visual similarities of images, integrating the semantic assistance from auxiliary texts on modeling high-order relationships of inter-images, and characterizing the correlations between images and shared topics. Our performance study on three publicly available image collections: Wiki, MIR Flickr, and NUS-WIDE indicates that SAVH can achieve superior performance over several state-of-the-art techniques.
What makes biological systems different from man-made systems? One distinction is explored in this paper: Biological systems achieve reliable functions through randomness, i.e., by both mitigating ...and exploiting the effects of randomness. The fundamental reason for biological systems to take such a random approach is the randomness of the microscopic world, which is dramatically different from the macroscopic world we are familiar with. To substantiate the idea, bacterial chemotaxis is used as an example.
For the multiple-level relay channel, an achievable rate formula, and a simple coding scheme to achieve it, are presented. Generally, higher rates can be achieved with this coding scheme in the ...multiple-level relay case than previously known. For a class of degraded channels, this achievable rate is shown to be the exact capacity. An application of the coding scheme to the allcast problem is also discussed.
This paper investigates quality of service (QoS) provisioning for Internet of Things (IoT) in long-term evolution advanced (LTE-A) heterogeneous networks (HetNets) with partial spectrum usage (PSU). ...In HetNets, the IoT users with ubiquitous mobility support or low-rate services requirement can connect with macrocells (MCells), while femtocells (FCells) with PSU mechanism can be deployed to serve the IoT users requiring high-data-rate transmissions within small coverage. Despite the great potentials of HetNets in supporting various IoT applications, the following challenges exist: 1) how to depict the unplanned random behaviors of the IoT-oriented FCells and cope with the randomness in user QoS provisioning and 2) how to model the interplay of resource allocation (RA) between MCells and FCells under PSU mechanism. In this work, the stochastic geometry (SG) theory is first exploited to statistically analyze how the unplanned random behaviors of the IoT-oriented FCells impact the user performance, considering the user QoS requirements and FCell PSU policy. Particularly, to satisfy the QoS requirements of different IoT user types, the concept of effective bandwidth (EB) is leveraged to provide the users with probabilistic QoS guarantee, and a heuristic algorithm named QA-EB algorithm is proposed to make the EB determination tractable. Then, the interplay of RA between the MCells and FCells is formulated into a two-level Stackelberg game, where the two parties try to maximize their own utilities through optimizing the macro-controlled interference price and the femto-controlled PSU policy. A backward induction method is proposed to achieve the Stackelberg equilibrium. Finally, extensive simulations are conducted to corroborate the derived SINR and ergodic throughput performance of different user types and demonstrate the Stackelberg equilibrium under varying user QoS requirements and spectrum aggregation capabilities.
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