The near-threshold photo-productions of heavy quarkonia are important ways to test the QCD-inspired models and to constrain the gluon distribution of nucleon in the large x region. Investigating the ...various models, we choose a photon–gluon fusion model and a pomeron exchange model for
J
/
Ψ
photo-production near threshold, emphasising on the explanation of the recent experimental measurement by GlueX at JLab. We find that these two models are not only valid in a wide range of the center-of-mass energy of
γ
and proton, but also can be generalized to describe the
Υ
(1S)
photo-production. Using these two models, we predict the electro-production cross-sections of
Υ
(1S)
at EicC to be 48 fb to 85 fb at the center-of-mass energy of 16.75 GeV.
This work explored the use of porous carbon (PC) materials converted from waste lignin as raw materials for the removal of chloramphenicol (CAP) in water. The PC with controllable pores was prepared ...through a facile, cost-effective one-step method. The physical and chemical properties of the material were characterized by BET, SEM, FT-IR, and XRD, and the best conditions for preparation were selected based on the results of adsorption experiments. The PC, which was prepared at reaction temperature of 800 °C and the K
2
CO
3
/sodium lignosulfonate mass ratio of 4, namely PC-800-4, had a high specific surface area (1305.5 m
2
g
−1
) and pore volume (0.758 cm
3
g
−1
). At a lower initial concentration of CAP (
C
0
= 120 mg L
−1
), the maximum adsorption capacity of this adsorbent was 534.0 mg g
−1
at 303 K. In addition, PC-800-4 maintained good adsorption performance in a wide pH range and strongly resisted the interference of ions and humic acid. The results showed that the adsorption removal CAP was based on physical adsorption and chemical adsorption as a process supplement. The advantages of wide sources, high efficiency and speed, wide application, and rich oxygen-containing functional groups made the adsorbent have great application potential for removal chloramphenicol from water.
To investigate the effects of a structured moderate-intensity resistance exercise program on blood glucose levels and other health-related indicators in patients with GDM.
A total of 99 patients with ...GDM in a tertiary class A general hospital were randomly divided into an experimental group and a control group. GDM patients in the control group received routine prenatal care, online education, and a personalized diabetes diet intervention. The experimental group was treated in the same way as the control group with the addition of a moderate intensity resistance exercise program.
The blood glucose levels in both groups were lower after the intervention compared with before intervention (P < 0.05). After intervention, the average fasting blood glucose, the 2 h postprandial blood glucose, the utilization rate of insulin, the amount of insulin, gestational weight gain and blood pressure (P < 0.05) in the experimental group were lower than the control group. In addition, there was no statistical significance in the incidence of adverse pregnancy outcomes between the two groups after intervention (P > 0.05).
Moderate intensity resistance exercise was helpful for improvement of blood glucose control and insulin use, gestational weight gain and blood pressure in patients with GDM. In the future, long-term follow-up of both maternal and newborn infants should be performed to assess the long-term effects of exercise intervention on maternal and child health. The impact on the risk of obesity and diabetes may need to be further clarified.
The trial was approved by the registration of the Chinese Clinical Trial Registry, and registration number: ChiCTR1900027929.
•GDM, a metabolic disorder with high incidence, can affect the normal pregnancy and delivery process and increase the risk of adverse pregnancy outcomes for mother and child.•Currently, there are very limited studies on the effect of resistance exercise intervention on blood glucose levels and other health aspects in patients with GDM, and the conclusions are inconsistent.•A structured, supervised, planned, moderate-intensity, resistance exercise program improved blood glucose control, insulin use, gestational weight gain and blood pressure in patients with GDM, and was a safe non-pharmacological intervention strategy for this population.
Since the outbreak of the coronavirus disease 2019 (COVID-19), countries around the world have suffered heavy losses of life and property. The global pandemic poses a challenge to the global public ...health system, and public health organizations around the world are actively looking for ways to quickly and efficiently screen for viruses. Point-of-care testing (POCT), as a fast, portable, and instant detection method, is of great significance in infectious disease detection, disease screening, pre-disease prevention, postoperative treatment, and other fields. Microfluidic technology is a comprehensive technology that involves various interdisciplinary disciplines. It is also known as a lab-on-a-chip (LOC), and can concentrate biological and chemical experiments in traditional laboratories on a chip of several square centimeters with high integration. Therefore, microfluidic devices have become the primary implementation platform of POCT technology. POCT devices based on microfluidic technology combine the advantages of both POCT and microfluids, and are expected to shine in the biomedical field. This review introduces microfluidic technology and its applications in combination with other technologies.
•The key technologies involved in microfluidic technology are introduced.•Applications of paper-based microfluidic chips and biosensors in point-of-care testing field are introduced.•The microfluidic technology and its applications in combination with other technologies in biomedical fields are described.
The tumor microenvironment plays an important role in various processes, including tumorigenesis, cancer progression, and metastasis. Immune signatures have been identified and verified for use in ...diagnosis and prognosis prediction. We used single-sample Gene Set Enrichment Analysis to evaluate tumor immune cell infiltration score (TIICs) and verify their prognostic significance in both training and validation cohorts and using this information to build a prognostic model. A total of 1281 samples were obtained for further evaluation of the immune enrichment scores of 28 immune cells, showing that Th17 cell contributed most significantly to survival. Using the median TIICs as a cutoff to divide the samples into two groups, we found that the high-TIICs group was associated with favorable outcomes in both the training and validation sets. We then constructed a prognostic model to predict the 6, 8, and 10-year survival outcomes. Further analysis showed that immune score and tumor purity were higher in the high-TIICs group, while the matrix score was lower in this group. Forty-two differentially expressed genes were identified between the two groups. This new prognostic model based on immune cell infiltration indicates the potential for TIICs in predicting prognosis and as targets for treatment.
The major challenge to promote the commercialization of SnO2 anode materials is to construct unique structures and/or composites that could alleviate the volume effect and extend the lifespan. This ...study develops an efficient synthetic solution for the preparation of mesoporous SnO2 nanosheets, which involves an evaporation-induced selfassembly process and the following thermal treatment. Surfactant F127 is used as the soft template to form abundant cores. The as-prepared sample intrinsically inherits flexible sheet-like structure and porous features, as characterized with XRD, SEM, TEM and BET techniques. Based on these combining structural benefits, the sample is utilized as anode materials for lithium-ion batteries and exhibits excellent Li+ storage performance such as large and stable reversible capacity, good rate capability, and especially the outstanding durable cycling life of over 1000 cycles, which meets the demands of practical applications. The structural changes of SnO2 nanosheets are observed from the decomposed electrodes after different electrochemical cycles. Moreover, this synthesis strategy may offer an alternative and universal approach for synthesis of other transitional metal oxides or their binary composites as high-performance anode materials for lithium-ion batteries.
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•Mesoporous SnO2 NSs are synthesized via EISA followed by calcination.•Large surface area and high pore volume of SnO2 NSs are induced by porous features.•SnO2 NSs exhibit excellent capacity retention ability with high reversible capacity.•Cycle life of pure SnO2 NSs has been extended as long as 1000 cycles.•Stable 2D sheet-like structure is the major reason for its outstanding durability.
The bamboo shoot of
(Keng) Keng f. is a medicinal and edible plant product in China. In this study, the chemical composition of the total alkaloids from bamboo shoots and bamboo shoot shells of
...(Keng) Keng f. (ABSP and ABSSP, respectively) were separated and investigated by UHPLC/QTOF-MS/MS. The results showed that a total of 32 alkaloids were extracted, with 15 common to both ABSP and ABSSP and 10 and 7 alkaloids distinct to ABSP and ABSSP, respectively. ABSP and ABSSP both decreased the lipopolysaccharide (LPS, 0.5 μg/mL)-induced nitric oxide (NO) production in RAW264.7 murine macrophages with half maximal inhibitory concentration (IC
) values of 78 and 55 μg/mL, respectively. We also found that ABSP and ABSSP (100 μg/mL) could decrease the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at both mRNA and protein levels in LPS-exposed RAW264.7 cells. Moreover, 100 μg/mL of ABSP and ABSSP also significantly inhibited LPS-induced mRNA expression of interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α). Additionally, ABSP and ABSSP (100 μg/mL) decreased the phosphorylation of extracellular regulated protein kinase (ERK) in LPS-stimulated RAW264.7 cells. Collectively, the total alkaloids from the bamboo shoots and shells of
exhibit anti-inflammatory effects in LPS-activated RAW264.7 cells through the inhibition of ERK signaling. This result can provide support for the medicinal use and further study of
.
•1D porous Fe2O3@TiO2 core–shell composites are synthesized as high-performance photocatalyst.•Core–shell heterostructures result in the efficient electron–hole separation process.•Porous features ...and 1D core–shell structures are beneficial for the photocatalytic reaction.•The composites show excellent photocatalytic performance under UV and visible light irradiation.•Good thermal stability endows the composites with outstanding photocatalytic durability.
An ideal photocatalyst for degradation of organic pollutants should combine the features of efficient visible light response, fast electron transport, high electron–hole separation efficiency, and large specific surface area. However, these requirements usually cannot be achieved simultaneously in the present state-of-the-art research. In this work, we develop a rational synthesis strategy for the preparation of one-dimensional (1D) mesoporous Fe2O3@TiO2 core–shell composites. In this strategy, FeOOH nanorods are firstly coated by TiO2 shell, followed by a calcination process. The as-prepared composites are thoroughly investigated with X-ray powder diffraction, scanning electron microscope, energy dispersive spectroscopy, transmission electron microscope, N2 adsorption–desorption isotherms, UV–visible diffuse-reflectance spectra, and photoluminescence spectra. Endowed with the advantages of its composition and specific structural features, the presented sample possesses the combined advantages mentioned above, thus delivering evidently enhanced photocatalytic activity for the degradation of methyl orange under UV light irradiation and Rhodamine B under visible light irradiation. And the possible mechanism of the enhanced photocatalytic performance is proposed.
Tick-borne encephalitis virus (TBEV) is the most prevalent arbovirus, with a tentative estimate of 10,000 to 10,500 infections occurring in Europe and Asia every year. Endemic in Northeast China, ...tick-borne encephalitis (TBE) is emerging as a major threat to public health, local economies and tourism. The complicated array of host physiological changes has hampered elucidation of the molecular mechanisms underlying the pathogenesis of this disease.
System-level characterization of the serum metabolome and lipidome of adult TBEV patients and a healthy control group was performed using liquid chromatography tandem mass spectrometry. By tracking metabolic and lipid changes during disease progression, crucial physiological changes that coincided with disease stages could be identified. Twenty-eight metabolites were significantly altered in the sera of TBE patients in our metabolomic analysis, and 14 lipids were significantly altered in our lipidomics study. Among these metabolites, alpha-linolenic acid, azelaic acid, D-glutamine, glucose-1-phosphate, L-glutamic acid, and mannose-6-phosphate were altered compared to the control group, and PC(38:7), PC(28:3;1), TAG(52:6), etc. were altered based on lipidomics. Major perturbed metabolic pathways included amino acid metabolism, lipid and oxidative stress metabolism (lipoprotein biosynthesis, arachidonic acid biosynthesis, leukotriene biosynthesis and sphingolipid metabolism), phospholipid metabolism and triglyceride metabolism. These metabolites were significantly perturbed during disease progression, implying their latent utility as prognostic markers.
TBEV infection causes distinct temporal changes in the serum metabolome and lipidome, and many metabolites are potentially involved in the acute inflammatory response and immune regulation. Our global analysis revealed anti- and pro-inflammatory processes in the host and changes to the entire metabolic profile. Relationships between metabolites and pathologies were established. This study provides important insight into the pathology of TBE, including its pathology, and lays the foundation for further research into putative markers of TBE disease.
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