We propose a design of an ultra-broadband absorber based on a thin metamaterial nanostructure composed of a periodic array of titanium-silica (Ti-SiO
) cubes and an aluminum (Al) bottom film. The ...proposed structure can achieve nearly perfect absorption with an average absorbance of 97% spanning a broad range from visible to near-infrared (i.e., from 354 nm to 1066 nm), showing a 90% absorption bandwidth over 712 nm, and the peak absorption is up to 99.8%. The excitation of superior surface plasmon resonance combined with the resonance induced by the metal-insulator-metal Fabry-Perot (FP) cavity leads to this broadband perfect absorption. The polarization and angle insensitivity is demonstrated by analyzing the absorption performance with oblique incidences for both TE- and TM-polarized waves. In addition, we discuss the impact of various metal materials and geometry structure on absorption performance in detail. The proposed broadband metamaterial absorber shows a promising prospect in applications such as solar cell, infrared detection, and imaging. Moreover, the use of a thin titanium cap and an aluminum film instead of noble metals has the potential to reduce production cost in applications.
Assessments of climate change impacts on streamflow and sediment processes are essential for developing science‐based sustainable watershed management plans. We assessed climate change impacts on ...streamflow and sediment load in the upstream of the Mekong River Basin, as a case study. Future climate scenarios including an ensemble‐mean climate scenario (EnM scenario) were generated based on 20 GCMs in CMIP5, using a stochastic weather generator (LARS‐WG) coupled with a distribution‐free shuffle procedure. The SWAT model was applied to simulate changes in streamflow and sediment load for the future period 2071–2100 under RCP8.5 with respect to the baseline period 1971–2000. Results show that mean monthly maximum and minimum temperature were projected to increase by all the 20 GCMs, with an ensemble‐mean increase of 4.6–5.7°C and 4.2–5.8°C across the 12 months, respectively. An increase in mean annual precipitation (3.4–55.8%) and streamflow (1.0–72.7%) was also projected by all GCMs. However, projected changes in sediment load were not consistent. One half of the GCMs projected an increase (5.2–53.2%) in annual sediment load while the other half projected a decrease (5.1%–43.2%). In each month, at least three‐quarters of the GCMs projected an increase in monthly streamflow. For monthly sediment load, an increase in May to July was projected by over half of the GCMs, while a decrease was projected by a majority of the GCMs for other months. Our results indicate large uncertainties in streamflow and sediment projections under climate change, demonstrating the need to use multi‐model ensembles in climate change impact studies. Moreover, it was found that the streamflow and sediment loads simulated using the EnM scenario were often close to the ensemble means simulated using the 20 GCMs, which implies that the single EnM scenario has the potential of effectively and efficiently estimating the ensemble means of projections in a multi‐model ensemble.
Future temperature, precipitation and streamflow are projected to increase but uncertainties are large. Projected changes in sediment load are not consistent and more uncertain than streamflow. A single ensemble‐mean climate scenario generated using a stochastic approach has the potential of effectively estimating ensemble means of the simulated streamflow and sediment load in a multi‐GCM ensemble.
In the context of the “Internet Plus” era, the reform of children’s literature curriculum content is fundamental. This study explores the impact of such reform on the quality of children’s ...psychological aesthetic education, aiming to provide theoretical guidance for future educational practice. The research method uses quantitative and qualitative methods, constructs word lists and word lists for teaching children’s literature courses by analyzing the texts in language textbooks at the compulsory stage, and explores the data using multiple regression models. The results show that the reform of teaching children’s literature significantly improves students’ psycho-aesthetic qualities, among which the improvement of teaching methods has the most significant impact on psycho-aesthetic education, with a path coefficient of 0.2906 (P<0.0001). The teaching reform of children’s literature curriculum positively impacts the quality of children’s psychological aesthetic education, especially in the innovation of teaching methods.
To examine the association between blood urea nitrogen (BUN) and risk of type 2 diabetes (T2DM) among Chinese adults, we performed an ongoing cohort study of 38578 Chinese adults (56.3% males; ...average age, 41.6 y) who underwent repeated health check-up examinations between 2009 and 2016 and without T2DM at baseline. During follow-up, incident T2DM cases were identified based on self-report, medication use, measurements of fasting plasma glucose, 2 h post oral glucose, or haemoglobinA1c. 2009 (5.2%) cases confirmed with incident T2DM were identified during median follow-up of 3.1 years. With increasing quartiles of BUN levels, the incidences of T2DM gradually increased with 0.69%, 1.11%, 1.53%, and 1.87% for quartile 1 to quartile 4 (p trend <0.001). Compared with quartile 1, the multivariate-adjusted hazard ratios (HRs) and its 95% confidence intervals (95% CIs) for T2DM risk were 1.16 (0.97–1.38) for quartile 2, 1.28 (1.07–1.51) for quartile 3, and 1.28 (1.08–1.52) for quartile 4 (p trend = 0.005). HR for per each standard deviation increase in BUN level was 1.10 (1.04–1.16) (p trend <0.001). This association tended to be more pronounced in those with a lower body mass index at baseline (p-interaction <0.001). Our results suggested that BUN levels were positively associated with incident T2DM risk among Chinese adults. Future prospective investigations in other populations are necessary to confirm our findings.
Six flavonoids, namely, three undescribed biflavonoids, one undescribed 8-aryl flavonoid, and two known compounds, were isolated from Selaginella tamariscina (P.Beauv.) Spring. The structures and ...absolute configurations of those undescribed compounds were established by NMR spectroscopy data, HRESIMS analyses and electronic circular dichroism (ECD) analyses. In addition, all the isolates were evaluated for their hypoglycemic activity in HepG2 cells. Involvenflavone H, I, and J significantly increased glucose consumption in both normal and insulin-resistant HepG2 cells. Interestingly, these three compounds can effectively upregulate the protein expression of glucokinase (GCK) and adenylate cyclases (ADCYs). These results suggested that involvenflavone H, I, and J (especially involvenflavone J) may have potent hypoglycemic activity, which also provided promising molecular targets for the treatment of diabetes.
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•Four undescribed flavonoids were isolated from Selaginella tamariscina (P.Beauv.) Spring.•Involvenflavone H, I, and J significantly increased the glucose consumption in insulin-resistant HepG2 cells.•Involvenflavone J up-regulated the protein expression of glucokinase and adenylate cyclases effectively.
The consensus recommendations in 2018 from The Chinese Society of Hematology (CSH) on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation ...(allo-HSCT) facilitated the standardization of clinical practices of allo-HSCT in China and progressive integration with the world. There have been new developments since the initial publication. To integrate recent developments and further improve the consensus, a panel of experts from the CSH recently updated the consensus recommendations, which are summarized as follows: (1) there is a new algorithm for selecting appropriate donors for allo-HSCT candidates. Haploidentical donors (HIDs) are the preferred donor choice over matched sibling donors (MSDs) for patients with high-risk leukemia or elderly patients with young offspring donors in experienced centers. This replaces the previous algorithm for donor selection, which favored MSDs over HIDs. (2) Patients with refractory/relapsed lymphoblastic malignancies are now encouraged to undergo salvage treatment with novel immunotherapies prior to HSCT. (3) The consensus has been updated to reflect additional evidence for the application of allo-HSCT in specific groups of patients with hematological malignancies (intermediate-risk acute myeloid leukemia (AML), favorable-risk AML with positive minimal residual disease, and standard-risk acute lymphoblastic leukemia). (4) The consensus has been updated to reflect additional evidence for the application of HSCT in patients with nonmalignant diseases, such as severe aplastic anemia and inherited diseases. (5) The consensus has been updated to reflect additional evidence for the administration of anti-thymocyte globulin, granulocyte colony-stimulating factors and post-transplantation cyclophosphamide in HID-HSCT.
Wave numbers about the three types of waves in saturated soils are firstly given in this paper. The lengths of the pipe piles are much larger than their diameters, so the isolation problem about SV ...waves by discontinuous barriers composed of a row of pipe piles can be simplified as a two-dimensional scattering problem. The expansion method of wave functions is adopted, the stresses and displacements at the boundaries between the pipe piles and adjacent soils are considered as continuous and the inner sides of the pipe piles are free, and then the theoretical solutions are obtained about this two-dimensional scattering problem. Normalized displacements are introduced, which are the displacements behind the barriers caused by both the incident and scattered waves to those only by the incident SV waves, contours and curves of the normalized displacements are drawn, and the influences of wall thickness of pipe piles, modulus ratio of pipe piles to soils, spacing distance between the pipe piles and pipe pile numbers on the isolation effectiveness are analyzed.
In field conditions, crops are adversely affected by a wide range of abiotic stresses including drought, cold, salt, and heat, as well as biotic stresses including pests and pathogens. These stresses ...can have a marked effect on crop yield. The present and future effects of climate change necessitate the improvement of crop stress tolerance. Plants have evolved sophisticated stress response strategies, and genes that encode transcription factors (TFs) that are master regulators of stress-responsive genes are excellent candidates for crop improvement. Related examples in recent studies include TF gene modulation and overexpression approaches in crop species to enhance stress tolerance. However, much remains to be discovered about the diverse plant TFs. Of the >80 TF families, only a few, such as NAC, MYB, WRKY, bZIP, and ERF/DREB, with vital roles in abiotic and biotic stress responses have been intensively studied. Moreover, although significant progress has been made in deciphering the roles of TFs in important cereal crops, fewer TF genes have been elucidated in sorghum. As a model drought-tolerant crop, sorghum research warrants further focus. This review summarizes recent progress on major TF families associated with abiotic and biotic stress tolerance and their potential for crop improvement, particularly in sorghum. Other TF families and non-coding RNAs that regulate gene expression are discussed briefly. Despite the emphasis on sorghum, numerous examples from wheat, rice, maize, and barley are included. Collectively, the aim of this review is to illustrate the potential application of TF genes for stress tolerance improvement and the engineering of resistant crops, with an emphasis on sorghum.
Background Metastasis was the major cause of the high mortality in ovarian cancer. Although some mechanisms of metastasis in ovarian cancer were proposed, few have been targeted in the clinical ...practice. In the study, we aimed to identify novel genes contributing to metastasis and poor clinical outcome in ovarian cancer from bioinformatics databases. Methods Studies collecting matched primary tumors and metastases from ovarian cancer patients were searched in the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened by software R language. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the DEGs were implemented by Metascape. Venn diagram was plotted to present overlapping DEGs. The associations between the overlapping DEGs and prognosis were tested by Cox proportional hazard regression model using a cohort of ovarian cancer patients from the TCGA database. Genes affecting patients' outcomes significantly were served as hub genes. The mechanisms of the hub genes in promoting ovarian cancer metastasis were then predicted by R software. Results Two gene expression profiles (GSE30587 and GSE73168) met the inclusion criteria and were finally analyzed. A total of 259 genes were significantly differentially expressed in GSE30587, whereas 712 genes were in GSE73168. In GSE30587, DEGs were mainly involved in extracellular matrix (ECM) organization; For GSE73168, most of DEGs showed ion trans-membrane transport activity. There were 9 overlapping genes between the two datasets (RUNX2, FABP4, CLDN20, SVEP1, FAM169A, PGM5, ZFHX4, DCN and TAS2R50). ZFHX4 was proved to be an independent adverse prognostic factor for ovarian cancer patients (HR = 1.44, 95%CI: 1.13-1.83, p = 0.003). Mechanistically, ZFHX4 was positively significantly correlated with epithelial-mesenchymal transition (EMT) markers (r = 0.54, p = 2.59 x 10.sup.-29) and ECM-related genes (r = 0.52, p = 2.86 x 10.sup.-27). Conclusions ZFHX4 might promote metastasis in ovarian cancer by regulating EMT and reprogramming ECM. For clinical applications, ZFHX4 was expected to be a prognostic biomarker for ovarian cancer metastasis. Keywords: ZFHX4, Ovarian cancer, Metastasis, Epithelial-mesenchymal transition, Extracellular matrix
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