C-reactive protein, cystatin C, myoglobin, and D-dimer represent the inflammatory or thromboembolic status of the patient and play important roles in early diagnostics of acute myocardial infarction. ...Each protein can indicate some health problems, but their simultaneous detection can be crucial for differential diagnostics. The express analysis of these proteins in a small drop of plasma was developed using magnetic beads. The suggested method is based on immunomagnetic extraction of the target analyte from plasma samples and its simultaneous labelling by fluorescent dye. Reaction time was optimized for quantification of cardiac biomarkers in the spike solutions and human plasma samples. In this paper, we developed a one-protein detection technique for each cardiac biomarker and united it to a four-protein facility using an automatic platform. The proposed technique requires only 17 μL of the human plasma and takes 14 min for four-protein measuring. The suggested technique covers concentration difference by more than two orders of magnitude and demonstrates analytical applicability by measurements of human plasma samples of 16 volunteers.
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•The technique allows cardiac biomarkers quantification for less than 15 min.•The covered concentration range is more than two orders of magnitude.•Automatization allows multiplex detection due to carrying out several parallel processes.•The technique was validated on healthy donor's plasma using reference method.•The technique requires 17 μL of the plasma and takes 14 min for four-protein measuring.
Factors affecting the stability of gadolinium- and neodymium-loaded liquid organic scintillators intended for use in large-scale experimental facilities for neutrino physics and astrophysics are ...examined. The effect of composition (type and structural formula of gadolinium and neodymium compounds) on the optical properties of such scintillators is analyzed. It is shown that the oxidation of alkylbenzenes is one of the reasons for the degradation (decrease in transparency) of the scintillators. Gadolinium and neodymium compounds may be catalysts for the oxidation processes.
We consider the problem of minimizing the risk taken on by investors in a two-tier (banking) system of lending and a system of peer-to-peer lending, assuming the incoming risks to be constant. It is ...shown that with the introduction of a special (nonsystematic) risk, the peer-to-peer lending model turns out to be optimal.
For the work with polynomials such data representations as lists of terms, geobuckets, and heaps are usually used. In this paper, an attempt to give a new look on the representation of polynomials ...for computing involutive and Gröbner bases of systems of nonlinear polynomial equations is made. The proposed approach makes it possible to execute a part of this computational task on the GPU, which opens prospects for solving more complicated problems.
A representation of the Ising model in a longitudinal magnetic field on a quantum computer is introduced. The ansatz of the wave function of the model for a quantum approximation optimization ...algorithm is constructed. The scheme and the result of its operation for a lattice of size 2 × 2 are presented.
We consider the process of tokenization of credits in the peer-to-peer lending model. The investor risk is formulated in terms of reliability theory. This allows us to write restrictions on the ...parameters of the token package that provide a given risk and profitability for the known parameters of the loan portfolio.
Synthine and T-6 propellant are studied as new basic solvents for creating liquid organic scintillators. The light attenuation length in these solvents (both those obtained from the manufacturer and ...those subjected to chromatographic purification on Al
O
) was measured along with the relative light yield of scintillators based on them. The chemical composition of synthine was determined by the method of chromato-mass spectrometry and UV spectrophotometry. A Nd-loaded scintillator (
9 g/L) based on a synthine–pseudocumene mixture was created, and its light yield (LY 60
) was measured with respect to a scintillator based on linear alkyl benzene (LAB).
Ideas of use the particle channeling in bent crystals for steer the beams have been checked up and advanced in many experiments. However, until now, this method of beam formation has limitations in ...application, since the channeling process involves beam particles with low angular divergence, limited by the angle of Lindhard. Here we describe the focusing crystals, which expand the boundaries of application of bent crystals at accelerators.
Annotation. The use of channeling in crystals is quite effective for controlling the primary proton beam, but to manipulate secondary beams π, K, etc., it is necessary not only to deflect them, but ...also to focus them, since here the beam divergences are much higher. Focusing devices created to date are suitable for applications at TeV-class accelerators because they have small transverse dimensions. To increase the angular acceptance, a device consisting of several crystals assembled into an array is proposed. In this case, two problems are solved: a large bending angle and acceptable angular acceptance of the device are ensured, which makes it possible to use it at a beam energy of 50 GeV on the domestic U-70 accelerator. The paper presents the results of testing a new device on the U-70 beam.
A modification of the LENS (Low Energy Neutrino Spectroscopy) project for spectroscopy of solar neutrinos with energies above about 715 keV on the basis of new technologies and solutions is examined. ...The respective detector employs
In nuclei as a target for neutrinos. The creation of a detector containing about 200 t of a scintillator loaded with 10 t of indium will make it possible to measure, within five years, the energy spectra of solar neutrinos from
Be, neutrinos from the CNO cycle, and
neutrinos with small systematic errors. The detector was simulated in the form of a set of cells of a liquid scintillator doped with indium (about 10
in weight). Necessary technical conditions for detector cells are formulated, and the possible counting rate for events induced by internal and external backgrounds and characterized by an energy release of 600 to 1600 keV is estimated. It is shown that such a detector is implementable, in principle.
