ABSTRACT We present a new model for the distribution of free electrons in the Galaxy, the Magellanic Clouds, and the intergalactic medium (IGM) that can be used to estimate distances to real or ...simulated pulsars and fast radio bursts (FRBs) based on their dispersion measure (DM). The Galactic model has an extended thick disk representing the so-called warm interstellar medium, a thin disk representing the Galactic molecular ring, spiral arms based on a recent fit to Galactic H ii regions, a Galactic Center disk, and seven local features including the Gum Nebula, Galactic Loop I, and the Local Bubble. An offset of the Sun from the Galactic plane and a warp of the outer Galactic disk are included in the model. Parameters of the Galactic model are determined by fitting to 189 pulsars with independently determined distances and DMs. Simple models are used for the Magellanic Clouds and the IGM. Galactic model distances are within the uncertainty range for 86 of the 189 independently determined distances and within 20% of the nearest limit for a further 38 pulsars. We estimate that 95% of predicted Galactic pulsar distances will have a relative error of less than a factor of 0.9. The predictions of YMW16 are compared to those of the TC93 and NE2001 models showing that YMW16 performs significantly better on all measures. Timescales for pulse broadening due to interstellar scattering are estimated for (real or simulated) Galactic and Magellanic Cloud pulsars and FRBs.
Atherosclerosis is one of the most common vascular disorders. Endothelial cell (EC) dysfunction and vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis. ...Long non-coding RNAs (lncRNAs) have been implicated in several biological processes and human diseases. Here we show that lncRNA-RNCR3 is expressed in ECs and VSMCs. RNCR3 expression is significantly upregulated in mouse and human aortic atherosclerotic lesions, and cultured ECs and VSMCs upon ox-LDL treatment in vitro. RNCR3 knockdown accelerates the development of atherosclerosis, aggravates hypercholesterolemia and inflammatory factor releases, and decreases EC and VSMC proliferation in vivo. RNCR3 knockdown also reduces the proliferation and migration, and accelerates apoptosis development of EC and VSMC in vitro. RNCR3 acts as a ceRNA, and forms a feedback loop with Kruppel-like factor 2 and miR-185-5p to regulate cell function. This study reveals that RNCR3 has an atheroprotective role in atherosclerosis, and its intervention is a promising strategy for treating atherosclerosis-related vascular dysfunction.
Our review provides a comprehensive overview on the latest progress in pulsed-laser deposition (PLD) of 2D layered materials (2DLMs), and its application in photoelectric detection. We begin with a ...retrospective overview on various 2DLMs and their development in photoelectric detection. Then we present the fundamentals of PLD and its unique advantages compared with the traditional growth methods. Subsequently, the PLD growth of 2DLMs and the influence of various parameters are discussed. After this, we describe the current metal-semiconductor-metal and vertical heterojunction photodetectors that incorporate the PLD-grown 2DLMs. This leads into a summary of the strategies used to improve the photosensitivity and in-depth insights into the working mechanism. We then present the PLD-fabricated transparent and flexible 2DLM photodetectors. Finally, we highlight the unresolved issues and propose the future directions in this emerging research field.
The present paper is divided into two parts. In the first part, we introduce implicit and explicit iterative schemes for finding the fixed point of a nonexpansive mapping defined on the closed convex ...subset of a real Hilbert space. We establish results on the strong convergence of the sequences generated by the proposed schemes to a fixed point of a nonexpansive mapping. Such a fixed point is also a solution of a variational inequality defined on the set of fixed points. In the second part, we propose implicit and explicit iterative schemes for finding the approximate minimizer of a constrained convex minimization problem and prove that the sequences generated by our schemes converge strongly to a solution of the constrained convex minimization problem. Such a solution is also a solution of a variational inequality defined over the set of fixed points of a nonexpansive mapping. The results of this paper extend and improve several results presented in the literature in the recent past.
Long noncoding RNAs (lncRNAs) have important roles in diverse biological processes. Our previous study has revealed that lncRNA-MALAT1 deregulation is implicated in the pathogenesis of ...diabetes-related microvascular disease, diabetic retinopathy (DR). However, the role of MALAT1 in retinal vasculature remodeling still remains elusive. Here we show that MALAT1 expression is significantly upregulated in the retinas of STZ-induced diabetic rats and db/db mice. MALAT1 knockdown could obviously ameliorate DR in vivo, as shown by pericyte loss, capillary degeneration, microvascular leakage, and retinal inflammation. Moreover, MALAT1 knockdown could regulate retinal endothelial cell proliferation, migration, and tube formation in vitro. The crosstalk between MALAT1 and p38 MAPK signaling pathway is involved in the regulation of endothelial cell function. MALAT1 upregulation represents a critical pathogenic mechanism for diabetes-induced microvascular dysfunction. Inhibition of MALAT1 may serve as a potential target for anti-angiogenic therapy for diabetes-related microvascular complications.
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