In the context of global aging, to explore the design needs of elderly with dementia in museum environments, to establish a user cognitive psychological model based on immersion theory, and to ...enhance the satisfaction of cognitively impaired dementia with the museum service experience. Using literature research, surveys, questionnaires, interviews, and focus groups, we analyze the experience design from the psychological demands of elderly with dementia, build a method of mining user needs by combining the KANO model with the analytic hierarchy process (AHP) method, and establish a model for evaluating the excellence of the experience of the museum environment. The conclusion shows that displaying museum virtual scenes or old objects can effectively increase the subjective well-being of people suffering from various health conditions. The method can accurately tap the attributes of the needs of elderly with dementia, break through the drawbacks of the traditional museum experience design which is dominated by the designer's subjective consciousness, and allow the audience to better experience the museum immersive experience, which provides a new idea and method for the effectiveness of cognitive interventions for elderly with cognitive disorders.
In maternity rooms, breastfeeding chairs are crucial pieces of equipment that greatly influence the breastfeeding experience. However, an abundance of data indicates that there are still issues with ...breastfeeding chairs, including inadequate support for breastfeeding, poor body type adaptability, and failure to adequately analyse the requirements of mothers and baby users. This study used an innovative research approach to breastfeeding chair design from the standpoint of user requirements to improve breastfeeding willingness and user experience. We propose a user requirement assessment design approach that integrates the Kano model, analytic hierarchy process (AHP), and quality function development (QFD) based on the requirements of mother and baby groups. This approach was intended to build a user experience evaluation model for mother- and baby-friendly products. Following this approach to breastfeeding chair design, a fuzzy comprehensive evaluation (FCE) was used to assess the chair. Compared to the original breastfeeding chairs, the designs of breastfeeding chairs that met important requirements for mothers and infants, such as safety, hygiene, and breastfeeding support, resulted in an approximately 23 % increase in user satisfaction. This effectively improved the user experience of both mothers and infants. This approach is centred on the basic requirements of mothers and babies. It evaluates the essential requirements that impact the breastfeeding experiences of mothers and babies and provides multifaceted data regarding the attributes of the different requirements of mothers and babies. This results in theoretical research references for ensuing user-driven design products that cater to the requirements of mothers and their infants and play a pivotal role in formulating design guidelines for mother- and baby-friendly products.
The world today is undergoing profound changes unseen in a century. The need to build a community with a shared future for humanity and a more open, inclusive and equal social order is all the more ...urgent. The women’s issue is not just the rights of individual women, but the collective development of society. The upsurge of “She economy” is steadily increasing, but behind it is the diversification trend of social and economic forms and the diversification trend of female cultural psychology. This paper studies the social psychological changes of female groups from the perspective of “she economy”, points out the misunderstanding of the single value of modern women, and constructs multiple levels of female self-consciousness awakening, which has positive significance for promoting the correction of female independence and awakening consciousness, constructing the socialist ideology of gender equality, and thus developing the socialist harmonious society.
Organophosphate esters (OPEs) have been frequently detected in crops. However, few studies have focused on the uptake and translocation of OPEs in plants following foliar exposure. Herein, to ...investigate the foliar uptake, accumulation and translocation mechanisms of OPEs in plant, the cucumber (Cucumis sativus) was selected as a model plant for OPEs exposure via foliar application under control conditions. The results showed that the content of OPEs in the leaf cuticle was higher than that in the mesophyll on exposed leaf. Significant positive correlations were observed between the content of OPEs in the leaf cuticle and their log Kow and log Kcw values (P < 0.01), suggesting that OPEs with high hydrophobicity could not easily move from the cuticle to the mesophyll. The moderately hydrophobic OPEs, such as tris (2-chloroisopropyl) phosphate (TCPP, log Kow = 2.59), were more likely to move not only from the cuticle to the mesophyll but also from the mesophyll to the phloem. The majority of the transported OPEs accumulated in younger leaves (32–45 %), indicating that younger tissue was the primary target organ for OPEs accumulation after foliar exposure. Compared to chlorinated OPEs (except TCPP) and aryl OPEs, alkyl OPEs exhibited the strongest transport capacity in cucumber seedling due to their high hydrophilicity. Interestingly, tri-p-cresyl phosphate was found to be more prone to translocation compared to tri-m-cresyl phosphate and tri-o-cresyl phosphate, despite having same molecular weight and similar log Kow value. These results can contribute to our understanding of foliar uptake and translocation mechanism of OPEs by plant.
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•Hydrophobic OPEs are mainly accumulated in leaf cuticle.•Moderate hydrophilic OPEs cross leaf cuticle to reach mesophyll/phloem easily.•Hydrophilic OPEs are easily transported from exposed leaves to other plant tissues.•Young tissue was the target organ for accumulation of OPEs after foliar exposure.
Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 595 million people worldwide. Nanomaterials possess superior physicochemical properties and can influence ...pathological processes due to their unique structural features, such as size, surface interface, and photoelectromagnetic thermal effects. Unlike traditional OA treatments, which suffer from short half-life, low stability, poor bioavailability, and high systemic toxicity, nanotherapeutic strategies for OA offer longer half-life, enhanced targeting, improved bioavailability, and reduced systemic toxicity. These advantages effectively address the limitations of traditional therapies. This review aims to inspire researchers to develop more multifunctional nanomaterials and promote their practical application in OA treatment.Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 595 million people worldwide. Nanomaterials possess superior physicochemical properties and can influence pathological processes due to their unique structural features, such as size, surface interface, and photoelectromagnetic thermal effects. Unlike traditional OA treatments, which suffer from short half-life, low stability, poor bioavailability, and high systemic toxicity, nanotherapeutic strategies for OA offer longer half-life, enhanced targeting, improved bioavailability, and reduced systemic toxicity. These advantages effectively address the limitations of traditional therapies. This review aims to inspire researchers to develop more multifunctional nanomaterials and promote their practical application in OA treatment.
Germline copy number variation （CNV） is considered to be an important form of human genetic poly- morphisms. Previous studies have identified amounts of CNVs in human genome by advanced technologies, ...such as comparative genomic hybridization, single nucleotide genotyping, and high-throughput sequencing. CNV is speculated to be derived from multiple mechanisms, such as nonallelic homologous recombination （NAHR） and nonhomologous end-joining （NHEJ）. CNVs cover a much larger genome scale than single nucleotide polymorphisms （SNPs）, and may alter gene expression levels by means of gene dosage, gene fusion, gene disruption, and long-range regulation effects, thus affecting individual phenotypes and playing crucial roles in human pathogenesis. The number of studies linking CNVs with common complex diseases has increased dramatically in recent years. Here, we provide a comprehensive review of the current understanding ofgermline CNVs, and summarize the association of germline CNVs with the susceptibility to a wide variety of human diseases that were identified in recent years. We also propose potential issues that should be addressed in future studies.
This work presented the results of tungstic precipitation from Na2WO4-Na2SO4-H20 system at 293.15 K, with which the Pitzer parameters of β（0）Na2wo4 and β（1）Na2wo4 were determined from Pitzer equation ...by regression. Thus the mean ionic activity coeffi- cients of sodium tungstate were calculated. The obtained β（0）Na2wo4 and β（1）Na2wo4 were substituted as fixed values in extraction modeling from Na2WO4-H2SO4-H20 system by primary amine （N1923） in toluene as diluent. Meanwhile the activity coeffi- cient expressions in organic phase were varied based on Pitzer theory that the interaction term for the solvent should not be in- cluded. The Pitzer parameters for organic phase were re-regressed in order to make the model more accurate. The average ab- solute relative deviation （AARD） for calculated and experimental molality of WO42 in aqueous phase was 5.24%. The results showed that the model can not only correlate but also predict the liquid-liquid equilibrium （LLE） data.
Several elastic scattering angular distributions of 12C from target nuclei of A≥ 39 are analyzed to extract the Woods-Saxon poten- tial parameters with the fixed imaginary potential and Coulomb ...radius parameters. Using the best fitted diffuseness parameters, the correlations of the real part parameters with A1/3 1 ＋ A1/3 2and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction. The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by 12C, but also many elastic scattering angular distributions induced by the projectiles other than 12C, thus providing important inputs for the study of nuclear reactions of heavy-ion systems.
