Pluronic polymers (pluronics) are a unique class of synthetic triblock copolymers containing hydrophobic polypropylene oxide (PPO) and hydrophilic polyethylene oxide (PEO) arranged in the PEO-PPO-PEO ...manner. Due to their excellent biocompatibility and amphiphilic properties, pluronics are an ideal and promising biological material, which is widely used in drug delivery, disease diagnosis, and treatment, among other applications. Through self-assembly or in combination with other materials, pluronics can form nano carriers with different morphologies, representing a kind of multifunctional pharmaceutical excipients. In recent years, the utilization of pluronic-based multi-functional drug carriers in tumor treatment has become widespread, and various responsive drug carriers are designed according to the characteristics of the tumor microenvironment, resulting in major progress in tumor therapy. This review introduces the specific role of pluronic-based polymer drug delivery systems in tumor therapy, focusing on their physical and chemical properties as well as the design aspects of pluronic polymers. Finally, using newer literature reports, this review provides insights into the future potential and challenges posed by different pluronic-based polymer drug delivery systems in tumor therapy.
Surface modification is an important technique in fields, such as, self‐cleaning, surface patterning, sensing, and detection. The diselenide bond was shown to be a dynamic covalent bond that can ...undergo a diselenide metathesis reaction simply under visible light irradiation. Herein we develop this diselenide dynamic chemistry into a versatile surface modification method with a fast response and reversibility. The diselenide bond could be modified onto various substrates, such as, PDMS, quartz, and ITO conductive film glass. Different functional diselenide molecules could then be immobilized onto the surface via diselenide metathesis reaction. We demonstrated that by using this modification method we could achieve liquid motion in a capillary tube under light illumination. We also show that this approach has the potential to serve as an efficient modification method for surface bioconjugation, which has practical applications in clinical usage.
Se‐ing and doing: Diselenide dynamic chemistry gives a versatile, reversible, surface modification method with fast response (30 s). Different functional diselenide molecules can then be immobilized onto the surface via diselenide metathesis reactions under visible light irradiation. This approach gives liquid motion in a capillary tube under light illumination and is an efficient tool for surface bioconjugation.
A new colorimetric and NIR fluorescent chemosensor (1) for Cu(2+) based on BODIPY is reported, displaying a highly sensitive and selective fluorescent enhancement with Cu(2+) among various metal ...ions, upon excitation at 620 nm in CH(3)CN.
Transfer request: A self‐assembled supramolecular charge‐transfer complex of 1‐(11‐oxo‐11‐pyren‐1‐ylmethoxy)undecyl)pyridinium bromide (PYR) and ethane‐1,2‐diyl bis(3,5‐dinitrobenzoate) (DNB) is ...shown to form vesicular aggregates in aqueous solution, in contrast to the tubular aggregates of pure PYR (see picture). A curvature‐dependent mechanism for this change is proposed.
Cancer has become a common disease that seriously endangers human health and life. Up to now, the essential treatment method has been drug therapy, and drug delivery plays an important role in cancer ...therapy. To improve the efficiency of drug therapy, researchers are committed to improving drug delivery methods to enhance drug pharmacokinetics and cancer accumulation. Supramolecular coordination complexes (SCCs) with well-defined shapes and sizes are formed through the coordination between diverse functional organic ligands and metal ions, and they have emerged as potential components in drug delivery and cancer therapy. In particular, micelles or vesicles with the required biocompatibility and stability are synthesized using SCC-containing polymeric systems to develop novel carriers for drug delivery that possess combined properties and extended system tunability. In this study, the research status of SCC-containing polymeric systems as drug carriers and adjuvants for cancer treatment is reviewed, and a special focus is given to their design and preparation.
Conjugated polymers generally contain conjugated backbone structures with benzene, heterocycle, double bond, or triple bond, so that they have properties similar to semiconductors and even ...conductors. Their energy band gap is very small and can be adjusted via chemical doping, allowing for excellent photoelectric properties. To obtain prominent conjugated materials, numerous well-designed polymer backbones have been reported, such as polyphenylenevinylene, polyphenylene acetylene, polycarbazole, and polyfluorene. 4,4'-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based conjugated polymers have also been prepared owing to its conjugated structure and intriguing optical properties, including high absorption coefficients, excellent thermal/photochemical stability, and high quantum yield. Most importantly, the properties of BODIPYs can be easily tuned by chemical modification on the dipyrromethene core, which endows the conjugated polymers with multiple functionalities. In this paper, BODIPY-based conjugated polymers are reviewed, focusing on their structures and applications. The forms of BODIPY-based conjugated polymers include linear, coiled, and porous structures, and their structure-property relationship is explored. Also, typical applications in optoelectronic materials, sensors, gas/energy storage, biotherapy, and bioimaging are presented and discussed in detail. Finally, the review provides an insight into the challenges in the development of BODIPY-based conjugated polymers.
Supramolecular polymers based on supramolecular coordination complexes (SCCs) have received extensive attention because of their good stimulus responsiveness, processability and other properties. ...Herein, we report metallacycle-crosslinked supramolecular polymers via amino–yne click reaction, which were employed as well-performing elastomer materials. The supramolecular polymers cross-linked by the metallacycle not only maintained the aggregation induced emission (AIE) properties of the metallacycle, which were used to detect nitroaromatic explosives, but also had enhanced mechanical strength and toughness and exhibited elastomeric properties. This study provides a feasible strategy for the preparation of metallacycle-based supramolecular polymers with better mechanical properties.
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Inspired by the vast array of assemblies present in nature, supramolecular chemistry has attracted significant attention on account of its diverse supra-structures, which include micelles, vesicles, ...and fibers, in addition to its extensive applications in luminescent materials, sensors, bioimaging, and drug delivery over the past decades. Supramolecular polymers, which represent a combination of supramolecular chemistry and polymer science, are constructed by non-covalent interactions, such as host-guest interactions, hydrogen bonding, hydrophobic or hydrophilic interactions, metal-ligand interactions, π-π stacking, and electrostatic interactions. To date, numerous host-guest recognition systems have been reported, including crown ethers, cyclodextrins, calixarenes, cucurbituril, pillararenes, and other macrocyclic hosts. Among them, crown ethers, as the first generation of macrocyclic hosts, provide a promising and facile alternative route to supramolecular polymers. In addition, the incorporation of fluorophores into supramolecular polymers could endow them with multiple properties and functions, thereby presenting potential advantages in the context of smart materials. Thus, this review focuses on the fabrication strategies, interesting properties, and potential applications of fluorescent supramolecular polymers based on crown ethers. Typical examples are presented and discussed in terms of three different types of building blocks, namely covalently bonded low-molecular-weight compounds, polymers modified by hosts or guests, and supramolecular coordination complexes.
Supramolecular polymer networks have attracted considerable attention not only due to their topological importance but also because they can show some fantastic properties such as ...stimuli‐responsiveness and self‐healing. Although various supramolecular networks are constructed by supramolecular chemists based on different non‐covalent interactions, supramolecular polymer networks based on multiple orthogonal interactions are still rare. Here, a supramolecular polymer network is presented on the basis of the host–guest interactions between dibenzo‐24‐crown‐8 (DB24C8) and dibenzylammonium salts (DBAS), the metal–ligand coordination interactions between terpyridine and Zn(OTf)2, and between 1,2,3‐triazole and PdCl2(PhCN)2. The topology of the networks can be easily tuned from monomer to main‐chain supramolecular polymer and then to the supramolecular networks. This process is well studied by various characterization methods such as 1H NMR, UV–vis, DOSY, viscosity, and rheological measurements. More importantly, a supramolecular gel is obtained at high concentrations of the supramolecular networks, which demonstrates both stimuli‐responsiveness and self‐healing properties.
A supramolecular polymer gel network is constructed by three orthogonal non‐covalent interactions: the host–guest interactions between dibenzo‐24‐crown‐8 and dibenzylammonium salts, the metal–ligand coordination interactions between terpyridine and Zn(OTf)2, and between 1,2,3‐triazole and PdCl2(PhCN)2. The topology of the gel networks can be easily tuned from monomer to main‐chain supramolecular polymer and then to supramolecular networks. The gel shows both multiple stimuli‐responsiveness and self‐healing properties.
Two new acceptor-donor-acceptor small molecules DINDTS and DINCNDTS, with dithienosilole as a core unit and 1,3-indanedione (IN) or malononitrile derivative 1,3-indanedione (INCN) units as end-capped ...groups, respectively, have been designed and synthesized for solution-processable bulk-heterojunction (BHJ) solar cells. The impact of these two end-capped groups on their optical, electrochemical properties and photovoltaic performance was systematically studied. The optimal DINDTS:PC71BM based solar cells showed a short-circuit current density (Jsc) of 13.50 mA cm−2 and power conversion efficiency (PCE) of 6.60%. However, DINCNDTS:PC71BM based devices exhibited a poor PCE of 0.58% with a very low Jsc of 1.82 mA cm−2, which are mainly due to its poor morphology of active layers.
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•Two new small molecules with DTS as a core unit and different end-capped groups were reported.•DINDTS and DINCNDTS show broad absorption in the visible and near infrared region with absorption edges reaching 754 and 894 nm, respectively.•The optimized DINDTS-based device achieved a PCE of 6.60%. However, the DINCNDTS-based device achieved a low PCE of 0.58%.
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