Many freshwater fish species are considered vulnerable to stream temperature warming associated with climate change because they are ectothermic, yet there are surprisingly few studies documenting ...changes in distributions. Streams and rivers in the U.S. Rocky Mountains have been warming for several decades. At the same time these systems have been experiencing an increase in the severity and frequency of wildfires, which often results in habitat changes including increased water temperatures. We resampled 74 sites across a Rocky Mountain watershed 17 to 20 years after initial samples to determine whether there were trends in bull trout occurrence associated with temperature, wildfire, or other habitat variables. We found that site abandonment probabilities (0.36) were significantly higher than colonization probabilities (0.13), which indicated a reduction in the number of occupied sites. Site abandonment probabilities were greater at low elevations with warm temperatures. Other covariates, such as the presence of wildfire, nonnative brook trout, proximity to areas with many adults, and various stream habitat descriptors, were not associated with changes in probability of occupancy. Higher abandonment probabilities at low elevation for bull trout provide initial evidence validating the predictions made by bioclimatic models that bull trout populations will retreat to higher, cooler thermal refuges as water temperatures increase. The geographic breadth of these declines across the region is unknown but the approach of revisiting historical sites using an occupancy framework provides a useful template for additional assessments.
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between ...typically developing (TD) and ASD individuals, though it remains unclear whether the microbiome contributes to symptoms. We transplanted gut microbiota from human donors with ASD or TD controls into germ-free mice and reveal that colonization with ASD microbiota is sufficient to induce hallmark autistic behaviors. The brains of mice colonized with ASD microbiota display alternative splicing of ASD-relevant genes. Microbiome and metabolome profiles of mice harboring human microbiota predict that specific bacterial taxa and their metabolites modulate ASD behaviors. Indeed, treatment of an ASD mouse model with candidate microbial metabolites improves behavioral abnormalities and modulates neuronal excitability in the brain. We propose that the gut microbiota regulates behaviors in mice via production of neuroactive metabolites, suggesting that gut-brain connections contribute to the pathophysiology of ASD.
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•Mice harboring human ASD, but not TD, microbiomes exhibit ASD-like behaviors•ASD and TD microbiota produce differential metabolome profiles in mice•Extensive alternative splicing of risk genes in brains of mice with ASD microbiota•BTBR mice treated with 5AV or taurine improved repetitive and social behaviors
Repetitive and social behavioral abnormalities in mice with microbiomes from patients with autism spectrum disorder can be corrected by the administration of specific metabolites.
We study the volume-limited and nearly mass-selected (stellar mass M
stars 6 × 109 M) ATLAS3D sample of 260 early-type galaxies (ETGs, ellipticals Es and lenticulars S0s). We construct detailed ...axisymmetric dynamical models (Jeans Anisotropic MGE), which allow for orbital anisotropy, include a dark matter halo and reproduce in detail both the galaxy images and the high-quality integral-field stellar kinematics out to about 1R
e, the projected half-light radius. We derive accurate total mass-to-light ratios (M/L)
e
and dark matter fractions f
DM, within a sphere of radius
centred on the galaxies. We also measure the stellar (M/L)stars and derive a median dark matter fraction f
DM = 13 per cent in our sample. We infer masses M
JAM ≡ L × (M/L)
e
2 × M
1/2, where M
1/2 is the total mass within a sphere enclosing half of the galaxy light. We find that the thin two-dimensional subset spanned by galaxies in the
coordinates system, which we call the Mass Plane (MP) has an observed rms scatter of 19 per cent, which implies an intrinsic one of 11 per cent. Here,
is the major axis of an isophote enclosing half of the observed galaxy light, while σ
e
is measured within that isophote. The MP satisfies the scalar virial relation
within our tight errors. This show that the larger scatter in the Fundamental Plane (FP) (L, σ
e
, R
e) is due to stellar population effects including trends in the stellar initial mass function (IMF). It confirms that the FP deviation from the virial exponents is due to a genuine (M/L)
e
variation. However, the details of how both R
e and σ
e
are determined are critical in defining the precise deviation from the virial exponents. The main uncertainty in masses or M/L estimates using the scalar virial relation is in the measurement of R
e. This problem is already relevant for nearby galaxies and may cause significant biases in virial mass and size determinations at high redshift. Dynamical models can eliminate these problems. We revisit the (M/L)
e
-σ
e
relation, which describes most of the deviations between the MP and the FP. The best-fitting relation is
(r band). It provides an upper limit to any systematic increase of the IMF mass normalization with σ
e
. The correlation is more shallow and has smaller scatter for slow rotating systems or for galaxies in Virgo. For the latter, when using the best distance estimates, we observe a scatter in (M/L)
e
of 11 per cent, and infer an intrinsic one of 8 per cent. We perform an accurate empirical study of the link between σ
e
and the galaxies circular velocity V
circ within 1R
e (where stars dominate) and find the relation max (V
circ) 1.76 × σ
e
, which has an observed scatter of 7 per cent. The accurate parameters described in this paper are used in the companion Paper XX (Cappellari et al.) of this series to explore the variation of global galaxy properties, including the IMF, on the projections of the MP.
Micronutrient deficiencies compromise immune systems, hinder child growth and development, and affect human potential worldwide. Yet, to our knowledge, the only existing estimate of the global ...prevalence of micronutrient deficiencies is from over 30 years ago and is based only on the prevalence of anaemia. We aimed to estimate the global and regional prevalence of deficiency in at least one of three micronutrients among preschool-aged children (aged 6–59 months) and non-pregnant women of reproductive age (aged 15–49 years).
In this pooled analysis, we reanalysed individual-level biomarker data for micronutrient status from nationally representative, population-based surveys. We used Bayesian hierarchical logistic regression to estimate the prevalence of deficiency in at least one of three micronutrients for preschool-aged children (iron, zinc, and vitamin A) and for non-pregnant women of reproductive age (iron, zinc, and folate), globally and in seven regions using 24 nationally representative surveys done between 2003 and 2019.
We estimated the global prevalence of deficiency in at least one of three micronutrients to be 56% (95% uncertainty interval UI 48–64) among preschool-aged children, and 69% (59–78) among non-pregnant women of reproductive age, equivalent to 372 million (95% UI 319–425) preschool-aged children and 1·2 billion (1·0–1·4) non-pregnant women of reproductive age. Regionally, three-quarters of preschool-aged children with micronutrient deficiencies live in south Asia (99 million, 95% UI 80–118), sub-Saharan Africa (98 million, 83–113), or east Asia and the Pacific (85 million, 61–110). Over half (57%) of non-pregnant women of reproductive age with micronutrient deficiencies live in east Asia and the Pacific (384 million, 279–470) or south Asia (307 million, 255–351).
We estimate that over half of preschool-aged children and two-thirds of non-pregnant women of reproductive age worldwide have micronutrient deficiencies. However, estimates are uncertain due to the scarcity of population-based micronutrient deficiency data.
US Agency for International Development.
One-quarter to one-third of ischemic strokes have no established mechanism after standard diagnostic evaluation and are classified as embolic stroke of undetermined source (ESUS). Failure of ...randomized trials to demonstrate a benefit of direct oral anticoagulants over aspirin for the treatment of ESUS as a single homogeneous entity has led to renewed interest by stroke experts to divide ESUS into subgroups. Emerging data suggest that active cancer, which is present in 5% to 10% of patients with ESUS, is a distinct and important subgroup of ESUS with unique clinical characteristics, underlying pathophysiologies, and treatment and prognostic considerations. Furthermore, the prevalence of cancer-related ESUS is expected to increase as patients with cancer, even those with distant metastases, survive longer due to improvements in cancer treatments. In this topical review, we examine the epidemiological link between ESUS and cancer, the clinical features and potential mechanistic underpinnings of ESUS with cancer (with a focus on novel biomarkers and their relationship to recurrent stroke and other thromboembolic events), and the potential treatment strategies for cancer-related ESUS. We include a critical appraisal of existing data and ongoing or planned clinical trials of different antithrombotic approaches. As cancer-related ESUS is a dynamic disease with variable course, we recommend close collaboration between neurologists and oncologists to develop individualized management plans.
SPIRE Spectroscopy of Early-type Galaxies Lapham, Ryen Carl; Young, Lisa M.
Astrophysical journal/The Astrophysical journal,
04/2019, Letnik:
875, Številka:
1
Journal Article
Recenzirano
Odprti dostop
We present Spectral and Photometric Imaging Receiver (SPIRE) spectroscopy for nine early-type galaxies (ETGs) representing the most CO-rich and far-infrared (FIR) bright galaxies of the ...volume-limited Atlas3D sample. Our data include detections of mid- to high-J CO transitions (J = 4-3 to J = 13-12) and the C i (1-0) and (2-1) emission lines. CO spectral line energy distributions (SLEDs) for our ETGs indicate low gas excitation, barring NGC 1266. We use the C i emission lines to determine the excitation temperature of the neutral gas, as well as estimate the mass of molecular hydrogen. The masses agree well with masses derived from CO, making this technique very promising for high-redshift galaxies. We do not find a trend between the N ii 205 flux and the infrared luminosity, but we do find that the N ii 205/CO(6-5) line ratio is correlated with the 60/100 m Infrared Astronomical Satellite colors. Thus the N ii 205/CO(6-5) ratio can be used to infer a dust temperature and hence the intensity of the interstellar radiation field. Photodissociation region models show that use of C i and CO lines in addition to the typical C ii, O i, and FIR fluxes drive the model solutions to higher densities and lower values of G0. In short, the SPIRE lines indicate that the atomic and molecular gas in the CO-rich ETGs have similar properties to other galaxies. As might be expected from their low levels of star formation activity, the ETGs have rather low excitation CO SLEDs, low temperatures inferred from the C i lines, and modestly lower C i/CO ratios.
ABSTRACT In this letter we construct a large sample of early-type galaxies (ETGs) with measured gas-phase metallicities from the Sloan Digital Sky Survey and Galaxy Zoo in order to investigate the ...origin of the gas that fuels their residual star formation. We use this sample to show that star-forming elliptical galaxies have a substantially different gas-phase metallicity distribution from spiral galaxies, with ≈7.4 per cent having a very low gas-phase metallicity for their mass. These systems typically have fewer metals in the gas phase than they do in their stellar photospheres, which strongly suggests that the material fuelling their recent star formation was accreted from an external source. We use a chemical evolution model to show that the enrichment time-scale for low-metallicity gas is very short, and thus that cosmological accretion and minor mergers are likely to supply the gas in ≳ 37 per cent of star-forming ETGs, in good agreement with estimates derived from other independent techniques.
Galactic archaeology based on star counts is instrumental to reconstruct the past mass assembly of Local Group galaxies. The development of new observing techniques and data reduction, coupled with ...the use of sensitive large field of view cameras, now allows us to pursue this technique in more distant galaxies exploiting their diffuse low surface brightness (LSB) light. As part of the ATLAS3D project, we have obtained with the MegaCam camera at the Canada–France–Hawaii Telescope extremely deep, multiband images of nearby early-type galaxies (ETGs). We present here a catalogue of 92 galaxies from the ATLAS3D sample, which are located in low- to medium-density environments. The observing strategy and data reduction pipeline, which achieve a gain of several magnitudes in the limiting surface brightness with respect to classical imaging surveys, are presented. The size and depth of the survey are compared to other recent deep imaging projects. The paper highlights the capability of LSB-optimized surveys at detecting new prominent structures that change the apparent morphology of galaxies. The intrinsic limitations of deep imaging observations are also discussed, among those, the contamination of the stellar haloes of galaxies by extended ghost reflections, and the cirrus emission from Galactic dust. The detection and systematic census of fine structures that trace the present and past mass assembly of ETGs are one of the prime goals of the project. We provide specific examples of each type of observed structures – tidal tails, stellar streams and shells – and explain how they were identified and classified. We give an overview of the initial results. The detailed statistical analysis will be presented in future papers.
Here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one ...formalin-fixed paraffin-embedded tissue section. To validate this platform, we used tissue microarrays containing 38 archival head and neck squamous cell carcinomas and revealed differential immune profiles based on lymphoid and myeloid cell densities, correlating with human papilloma virus status and prognosis. Based on these results, we investigated 24 pancreatic ductal adenocarcinomas from patients who received neoadjuvant GVAX vaccination and revealed that response to therapy correlated with degree of mono-myelocytic cell density and percentages of CD8+ T cells expressing T cell exhaustion markers. These data highlight the utility of in situ immune monitoring for patient stratification and provide digital image processing pipelines to the community for examining immune complexity in precious tissue sections, where phenotype and tissue architecture are preserved to improve biomarker discovery and assessment.
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•Multiplex IHC and computational image analysis phenotypes tumor-immune complexity•In situ leukocyte density correlates with subclassification and prognosis in HNSCC•Immune complexity stratifies response to vaccination therapy in PDAC•CD8+ T cell and PD-L1 status correlate with outcomes of vaccinated PDAC patients
Tsujikawa et al. develop a multiplex immunohistochemistry and image cytometry platform to reveal immune-based metrics for patient stratification and response monitoring. In HNSCC and PDAC, prognosis correlates with mono-myelocytic cell density. In PDAC, percentages of PD-1, Eomes, Ki67, and granzyme B in CD8+ T cells correlate with response to vaccine therapy.
Pregnant and lactating women were excluded from initial coronavirus disease 2019 vaccine trials; thus, data to guide vaccine decision making are lacking.
This study aimed to evaluate the ...immunogenicity and reactogenicity of coronavirus disease 2019 messenger RNA vaccination in pregnant and lactating women compared with: (1) nonpregnant controls and (2) natural coronavirus disease 2019 infection in pregnancy.
A total of 131 reproductive-age vaccine recipients (84 pregnant, 31 lactating, and 16 nonpregnant women) were enrolled in a prospective cohort study at 2 academic medical centers. Titers of severe acute respiratory syndrome coronavirus 2 spike and receptor-binding domain immunoglobulin G, immunoglobulin A, and immunoglobulin M were quantified in participant sera (n=131) and breastmilk (n=31) at baseline, at the second vaccine dose, at 2 to 6 weeks after the second vaccine, and at delivery by Luminex. Umbilical cord sera (n=10) titers were assessed at delivery. Titers were compared with those of pregnant women 4 to 12 weeks from the natural infection (n=37) by enzyme-linked immunosorbent assay. A pseudovirus neutralization assay was used to quantify neutralizing antibody titers for the subset of women who delivered during the study period. Postvaccination symptoms were assessed via questionnaire. Kruskal-Wallis tests and a mixed-effects model, with correction for multiple comparisons, were used to assess differences among groups.
Vaccine-induced antibody titers were equivalent in pregnant and lactating compared with nonpregnant women (pregnant, median, 5.59; interquartile range, 4.68–5.89; lactating, median, 5.74; interquartile range, 5.06–6.22; nonpregnant, median, 5.62; interquartile range, 4.77–5.98, P=.24). All titers were significantly higher than those induced by severe acute respiratory syndrome coronavirus 2 infection during pregnancy (P<.0001). Vaccine-generated antibodies were present in all umbilical cord blood and breastmilk samples. Neutralizing antibody titers were lower in umbilical cord than maternal sera, although this finding did not achieve statistical significance (maternal sera, median, 104.7; interquartile range, 61.2–188.2; cord sera, median, 52.3; interquartile range, 11.7–69.6; P=.05). The second vaccine dose (boost dose) increased severe acute respiratory syndrome coronavirus 2–specific immunoglobulin G, but not immunoglobulin A, in maternal blood and breastmilk. No differences were noted in reactogenicity across the groups.
Coronavirus disease 2019 messenger RNA vaccines generated robust humoral immunity in pregnant and lactating women, with immunogenicity and reactogenicity similar to that observed in nonpregnant women. Vaccine-induced immune responses were statistically significantly greater than the response to natural infection. Immune transfer to neonates occurred via placenta and breastmilk.
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