This paper presents the radiation testing of a commercial-off-the-shelf SRAM-based field-programmable gate arrays (FPGAs) with heavy ions. Test experiments have been conducted to identify and to ...classify the single-event upsets (SEUs) in the configuration memory that induce single-event functional interrupt for the user-implemented circuit. Moreover the paper presents a new approach for assessing the effects of SEUs based on the combination of radiation testing and simulation-based fault injection tool. First experimental results show the FPGA look-up table (LUT) resources (used to implement combinatorial logic) are the most sensitive to SEUs, whereas interconnect resources are the most critical for the device cross section because they use the largest number of configuration bits. The analysis of experimental data underlines that the most probable error affecting interconnections is the shorting of two nets. This observation indicates that new fault models should be considered along with the classic stuck-at one model designing fault-tolerant architectures, which are intended for implementation in FPGA devices.
A stigmatic spectrometer for the 2.5–40
nm extreme-ultraviolet (EUV) region has been realized. The design consists of a grazing-incidence spherical varied-line-spaced grating with flat-field ...properties and of a spherical mirror mounted in the Kirkpatrick–Baez configuration that compensates for the astigmatism. The spectrum is acquired on a fluorescent screen and intensified CCD detector that can be moved along the spectral focal curve to select the spectral region to be acquired. This stigmatic design has also spectral and spatial resolution capability for extended sources. The spectral and spatial resolution of the system has been characterized by using the emission from a hollow-cathode lamp or a laser-produced plasma. At present, the instrument is installed at the vacuum–ultraviolet free-electron-laser (VUV FEL) at DESY for the spectral monitoring of the FEL beam in the 20–40
nm region.
Many scientific disciplines ranging from physics, chemistry and biology to material sciences, geophysics and medical diagnostics need a powerful X-ray source with pulse lengths in the femtosecond ...range 1-4. This would allow, for example, time-resolved observation of chemical reactions with atomic resolution. Such radiation of extreme intensity, and tunable over a wide range of wavelengths, can be accomplished using high-gain free-electron lasers (FEL) 5-10. Here we present results of the first successful operation of an FEL at a wavelength of 32 nm, with ultra-short pulses (25 fs FWHM), a peak power at the Gigawatt level, and a high degree of transverse and longitudinal coherence. The experimental data are in full agreement with theory. This is the shortest wavelength achieved with an FEL to date and an important milestone towards a user facility designed for wavelengths down to 6 nm. With a peak brilliance exceeding the state-of-the-art of synchrotron radiation sources 4 by seven orders of magnitude, this device opens a new field of experiments, and it paves the way towards sources with even shorter wavelengths, such as the Linac Coherent Light Source 3 at Stanford, USA, and the European X-ray Free Electron Laser Facility 4 in Hamburg, Germany.
Blood flow occlusion (BFO) has been previously used to investigate physiological responses to muscle ischemia, showing increased perceptual effort (RPE) and pain along with impaired neuromuscular ...performance. However, at present, it is unclear how BFO alters corticomuscular activities when either applied to the exercising or nonexercising musculature. The present study therefore set out to assess the corticomuscular response to these distinct BFO paradigms during an isometric contraction precision task. In a repeated measures design, fifteen participants (age = 27.00 ± 5.77) completed 15 isometric contractions across three experimental conditions; no occlusion (CNTRL), occlusion of the contralateral (i.e., nonexercising) limb (CON‐OCC), and occlusion of the ipsilateral (i.e., exercising) limb (IPS‐OCC). Measures of force, electroencephalographic (EEG), and electromyographic (EMG) were recorded during contractions. We observed that IPS‐OCC broadly impaired force steadiness, elevated EMG of the vastus lateralis, and heightened RPE and pain. IPSI‐OCC also significantly decreased corticomuscular coherence during the early phase of contraction and decreased EEG alpha activity across the sensorimotor and temporoparietal regions during the middle and late phases of contraction compared with CNTRL. By contrast, CON‐OCC increased perceived levels of pain (but not RPE) and decreased EEG alpha activity across the prefrontal cortex during the middle and late phases of contraction, with no changes observed for EMG and force steadiness. Together, these findings highlight distinctive psychophysiological responses to experimental pain via BFO showing altered cortical activities (CON‐OCC) and altered cortical, corticomuscular, and neuromuscular activities (IPS‐OCC) when applied to the lower limbs during an isometric force precision task.
Blood flow occlusion is a common experimental model to induce pain and fatigue during exercise. However, the corticomuscular mechanisms underlying this model remain poorly understood. In this study, we show that blood flow occlusion of non‐exercising musculature elicits a suppression of electromyographic (EEG) alpha activity across the prefrontal cortex. By contrast, occlusion of exercising musculature elicits a suppression of EEG alpha activity across central and posterior cortical regions and impairs both brain‐muscle communication and neuromuscular activation.
In penile cancer the therapeutic benefits of early inguinal lymphadenectomy must be counterbalanced by the high rates of morbidity, postoperative complications and mortality. A relevant aim is ...optimizing the selection of the patients who could really have the highest survival advantage from inguinal lymphadenectomy, limiting the cases in which this surgery might be considered over treatment with a risk of severe complications. We generated a nomogram estimating the risk of pathological inguinal lymph node involvement according to clinical lymph node stage and pathological findings of the primary tumor.
We retrospectively collected the clinical and pathological data of 175 patients who had undergone surgical therapy for squamous cell carcinoma of the penis from 1980 to 2002 at 11 urological centers in northeastern Italy. A logistic regression model was used to construct the nomogram.
The presence of palpable groin lymph nodes and the histological findings of vascular and/or lymphatic embolization were important predictors of metastatic inguinal lymph node involvement. The nomogram predicting the risk of metastatic lymph node involvement showed a good concordance index (0.876) and good calibration.
The clinical stage of groin lymph nodes and pathological findings of penectomy specimens allowed us to generate a nomogram to predict the probability of metastatic lymph node involvement in patients with squamous cell carcinoma of the penis. The statistical model showed an excellent ability to identify the patients with lymph node metastases and good calibration.
Aims: To compare the pathological stage and surgical margin status in patients undergoing either immediate radical prostatectomy or 12 and 24 weeks of neoadjuvant hormonal treatment (NHT) in a ...prospective, randomised study. Methods: Whole mount sections of 393 radical prostatectomy specimens were evaluated: 128 patients had immediate surgery, 143 were treated for 12 weeks and 122 for 24 weeks with complete androgen blockade. Results: Histopathology revealed organ confined tumours in 40.4% of patients with clinical stage B disease in the immediate surgery group, whereas 12 and 24 weeks of NHT increased the number of organ confined tumours to 54.6% and 64.8%, respectively. Among patients with clinical stage C tumours, pathological staging found organ confined disease in 10.4%, 31.4%, and 61.2% in the immediate surgery, 12 weeks of NHT, and 24 weeks of NHT groups, respectively. Preoperative NHT caused a significant decrease in positive margins both in patients with clinical stage B and C disease. The extent of margin involvement was not influenced by preoperative treatment. Conclusions: Neoadjuvant androgenic suppression is effective in reducing both the pathological stage and the positive margin rate in patients with stage B and C prostatic cancer undergoing radical surgery. Some beneficial effects are evident in those patients treated for 24 weeks, and it is reasonable to assume that the optimal duration of NHT is longer than three months.
We report our indications and experience in the use of intraprostatic endoprosthesis. We report also our preliminary experience in the use of a new intraprostatic endoprosthesis which has been ...developed at our institute. This prosthesis can be easily positioned, shows little invasiveness and does not require ultrasonic, radiological or endoscopical guidance.
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