Mesenchymal stem cells (MSC) represent a promising therapeutic approach in many diseases in view of their potent immunomodulatory properties, which are only partially understood. Here, we show that ...the endothelium is a specific and key target of MSC during immunity and inflammation. In mice, MSC inhibit activation and proliferation of endothelial cells in remote inflamed lymph nodes (LNs), affect elongation and arborization of high endothelial venules (HEVs) and inhibit T-cell homing. The proteomic analysis of the MSC secretome identified the tissue inhibitor of metalloproteinase-1 (TIMP-1) as a potential effector molecule responsible for the anti-angiogenic properties of MSC. Both in vitro and in vivo, TIMP-1 activity is responsible for the anti-angiogenic effects of MSC, and increasing TIMP-1 concentrations delivered by an Adeno Associated Virus (AAV) vector recapitulates the effects of MSC transplantation on draining LNs. Thus, this study discovers a new and highly efficient general mechanism through which MSC tune down immunity and inflammation, identifies TIMP-1 as a novel biomarker of MSC-based therapy and opens the gate to new therapeutic approaches of inflammatory diseases.
Neutrinoless double-beta (0vββ) decay is a hypothesized lepton-number-violating process that offers the only known means of asserting the possible Majorana nature of neutrino mass. The Cryogenic ...Underground Observatory for Rare Events (CUORE) is an upcoming experiment designed to search for 0vββ decay of sup.130Te using an array of 988 TeO.sub.2 crystal bolometers operated at 10 mK. The detector will contain 206 kg of sup.130Te and have an average energy resolution of 5 keV; the projected 0vββ decay half-life sensitivity after five years of livetime is 1.6 x 10.sup.26 γ at 1σ (9.5 x 10.sup.25 γ at the 90% confidence level), which corresponds to an upper limit on the effective Majorana mass in the range 40-100 meV (50-130 meV). In this paper, we review the experimental techniques used in CUORE as well as its current status and anticipated physics reach.
The work focuses on the structural design and performances of a unique optical test system (OTS) used for measuring metre-scale optical surfaces. The investigation was carried out through a modal ...analysis. Two sets of results are presented. Both modal analysis of the entire OTS and transmissibility function related to its use as an optical system are carried out and analysed. The OTS is used for the measurements of the form accuracy at nanometre level of metre-scale concave surfaces. The OTS is a four and half-metre-tall mechanical structure made of bolted aluminium profiles, two structural platens, two dedicated precision positioning supports, a test piece, and a state-of-the-art laser interferometer. The OTS was numerically modelled and fully instrumented with triaxial accelerometers. The results of the modal analysis highlight the natural modes of the entire OTS. Both numerical and experimental methods are designed. The investigation methods are iterative. Indeed, a preliminary numerical model is created using finite element analysis (FEA). FEA results enable the determination of the dynamic range and suitable locations of accelerometers that are mounted onto the OTS for the experimental validation of the FEA model and further to carry out the transmissibility study. Natural frequencies, damping ratios, and mode shape values are obtained and scrutinized. These results are used for refining the FEA model. In fact, the lack of symmetry and the use of feet are identified as the key design feature that affects the OTS. The correlation between experimental and numerical results is within five percent for the first four modes. The results of the transmissibility study highlight the specific natural modes that influence the OTS measurement capability. Overall, the study enables to guide engineers and researchers towards a robust design using a validated and methodical approach.
The MOSCAB experiment (Materia OSCura A Bolle) uses the “geyser technique”, a variant of the superheated liquid technique of extreme simplicity. Operating principles of the new dark matter detector ...and technical solutions of the device are reported in detail. First results obtained in a series of test runs taken in laboratory demonstrate that we have successfully built and tested a geyser-concept bubble chamber that can be used in particle physics, especially in dark matter searches, and that we are ready to move underground for extensive data taking.
This work describes a novel method for measuring the damping, the elastic modulus and the non-linear behavior of high strength low damping fiber materials such as para-aramids, silicon carbide (SiC) ...and carbon. The method is based on resonant response characterization of a spring-mass system excited by a sine-wave forcing term which is applied as a vertical force to the suspended mass. The damping is obtained from the measured resonance quality factor
Q
, the elasticity modulus is calculated from the resonance frequency, and the non-linear coefficient is obtained with the backbone approach from resonance profile variations as a function of the forcing term amplitude. It is argued that the method is very sensitive, to the point that a maximum excitation amplitude of the order of a few percent of resistance is sufficient to obtain an estimate of the non-linear coefficient. This claim is supported by experimental results. A testing machine is also discussed, which provides the necessary sensitivity at such small excitation amplitudes and the capability of evaluating very small damping values, as expected in high strength low damping fiber materials. The sensitivity is guaranteed by an optical position sensor with sub-micron resolution. To evaluate small damping values, particular care has been taken to ensure that energy dispersions in the generator are much smaller than energy dispersions in the fibers themselves. Examples of dynamic characterization are shown for para-aramid, silicon carbide, and carbon fibers.
Defects in SnO2 nanowires have been studied by cathodoluminescence, and the obtained spectra have been compared with those measured on SnO2 nanocrystals of different sizes in order to reveal ...information about point defects not determined by other characterization techniques. Dependence of the luminescence bands on the thermal treatment temperatures and pre-treatment conditions have been determined pointing out their possible relation, due to the used treatment conditions, with the oxygen vacancy concentration. To explain these cathodoluminescence spectra and their behavior, a model based on first-principles calculations of the surface oxygen vacancies in the different crystallographic directions is proposed for corroborating the existence of surface state bands localized at energy values compatible with the found cathodoluminescence bands and with the gas sensing mechanisms. CL bands centered at 1*90 and 2*20eV are attributed to the surface oxygen vacancies 100 deg coordinated with tin atoms, whereas CL bands centered at 2*37 and 2*75eV are related to the surface oxygen vacancies 130 deg coordinated. This combined process of cathodoluminescence and ab initio calculations is shown to be a powerful tool for nanowire defect analysis.
We report the complete GNO solar neutrino results for the measuring periods GNO III, GNO II, and GNO I. The result for GNO III (last 15 solar runs) is 54.3−9.3+9.9(stat)±2.3(syst)SNU(1σ) or ...54.3−9.6+10.2(incl. syst) SNU (1σ) with errors combined. The GNO experiment is now terminated after altogether 58 solar exposure runs that were performed between 20 May 1998 and 9 April 2003. The combined result for GNO (I+II+III) is 62.9−5.3+5.5(stat)±2.5(syst) SNU (1σ) or 62.9−5.9+6.0 SNU (1σ) with errors combined in quadrature. Overall, gallium based solar observations at LNGS (first in GALLEX, later in GNO) lasted from 14 May 1991 through 9 April 2003. The joint result from 123 runs in GNO and GALLEX is 69.3±5.5(incl. syst) SNU (1σ). The distribution of the individual run results is consistent with the hypothesis of a neutrino flux that is constant in time. Implications from the data in particle- and astrophysics are reiterated.
Semiconducting oxides nanobelts of tin oxide have been obtained by vapour phase deposition, using SnO as source material. In this work, we present the results obtained using tin oxide nanobelts as ...conductometric gas sensors. Electrical characterization showed that the nanobelts were sensitive to oxygen and environmental polluting species, like CO and NO
2 as well as ethanol for breath analyzers and food control applications. The sensor response, defined as the relative variation in conductance or resistance due to the introduction of the gas, is 200% for 30
ppm of CO at 350
°C, 900% for 200
ppb NO
2 at 300
°C, and 2500% for 10
ppm of ethanol at 350
°C. It has been studied the variation of the response as a function of the density of the nanobelts. The results demonstrate the potential of fabricating nanosize sensors using the integrity of a single nanobelt with sensitivity at the level of a few ppb and the necessity to control nanobelts density to optimize the sensing performances.
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