This study discusses a historical patient series and is designed to describe clinical and epidemiological characteristics of human sporotrichosis in the state of Espírito Santo, Brazil. Data were ...derived from patients treated at the Infectious Diseases service of Cassiano Antônio Moraes University Hospital in Vitória, the state capital, from July 1982 to June 2012. A total of 171 patients were diagnosed with sporotrichosis, mostly men (80.7%) with a median age of 33 years and 5 months. We can presume an approximate average incidence rate of 4.9 cases per 100,000 inhabitants during the studied period. All the patients were involved in occupational or leisure activities with direct contact with soil or plants. Most cases were recorded in the mountainous region of the state during the hot and rainy periods. The average time elapsed from lesion progression to diagnosis was 3 months, with the lymphocutaneous form being the most common (70.2%), followed by the fixed cutaneous form (28.6%). Diagnosis was confirmed in 93.6% of the cases by culturing
spp. in Sabouraud dextrose agar, and from the clinical features in the remaining cases. Aspiration of cutaneous nodule secretions was the best method for the collection of clinical specimens for disease diagnosis. A 25% saturated solution of potassium iodide (SSKI) was provided to almost all patients (98.8%), with therapeutic success. In conclusion, in this retrospective study in the state of Espírito Santo, we found that sporotrichosis affects primarily the ≥ 10-year-old population, and the most common presentation is the lymphocutaneous form affecting the lower and upper limbs, and the infection appeared to be acquired predominantly through occupational activities. Treatment with SSKI was safe and effective.
This paper presents the non-linear investigations carried out on a scaled model of a two-span masonry arch bridge. The model has been built in order to study the effect of the central pile settlement ...due to riverbank erosion. Progressive damage was induced in several steps by applying increasing settlements at the central pier. For each settlement step, harmonic shaker tests were conducted under different excitation levels, this allowing for the non-linear identification of the progressively damaged system. The shaker tests have been performed at resonance with the modal frequency of the structure, which were determined from a previous linear identification. Estimated non-linearity parameters, which result from the systematic application of restoring force based identification algorithms, can corroborate models to be used in the reassessment of existing structures. The method used for non-linear identification allows monitoring the evolution of non-linear parameters or indicators which can be used in damage and safety assessment.
The improvement of performance-based seismic design techniques requires the understanding of the overall behaviour of a structure up to collapse. Therefore, both experimental data and analytical ...models are needed. In a greater detail, material and geometrical nonlinearities, strength degradation and stiffness deterioration should be identified. Also in view of probabilistic-based simulations, hysteretic models, i.e. models able to describe with accuracy the hysteretic and degrading nature of the dynamic response of structures, have to be striven for. At higher level of excitation or under seismic loading, civil structures can exhibit slip effects. This paper presents a technique for the identification of non-linear in framed systems. A new a model for simulating slip effects is also introduced, which demonstrated to be suitable for identification purposes.
Animal models of sepsis Zanotti-Cavazzoni, Sergio L; Goldfarb, Roy D
Critical care clinics,
10/2009, Letnik:
25, Številka:
4
Journal Article
Recenzirano
In this review, we start with a general discussion of relevant factors that can determine the validity of a sepsis animal model. We briefly review some of the currently used animal models of sepsis ...(small animal models and large animal models). We discuss the clinical relevance of animal models in sepsis research today and address potential reasons for the apparent underperformance of animal models in predicting therapeutic success of novel drugs in clinical trials.
Several materials are under investigations for flat panel x‐ray detector applications. Among them, PbO shows interesting properties, i.e. high sensitivity, large stopping power and high resistivity ...at room temperature. However, the exploitation of PbO is limited by the difficulty to obtain good quality films constituted by a single phase. In this paper, we describe a new approach for the vapour phase growth of orthorhombic PbO films. The grown layers show a single phase, good crystallinity, and preferential orientation along the c axis. Optical characterization evidenced the presence of a broad defect band. Gold contacted films showed very high electrical resistivity and appreciable response to X‐ray radiation.
Oriented orthorhombic lead oxide films have been grown by vapour phase deposition. Films show high resistivity and appreciable response to X‐ray irradiation.
Nodular Lymphangitis Syndrome Faccini-Martínez, Álvaro A; Zanotti, Raphael L; Moraes, Maithê S ...
The American journal of tropical medicine and hygiene,
11/2017, Letnik:
97, Številka:
5
Journal Article
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