G4CMP: Condensed matter physics simulation using the Geant4 toolkit Kelsey, M.H.; Agnese, R.; Alam, Y.F. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
October 2023, 2023-10-00, Letnik:
1055
Journal Article
Recenzirano
G4CMP simulates phonon and charge transport in cryogenic semiconductor crystals using the Geant4 toolkit. The transport code is capable of simulating the propagation of acoustic phonons as well as ...electron and hole charge carriers. Processes for anisotropic phonon propagation, oblique charge-carrier propagation, and phonon emission by accelerated charge carriers are included. The simulation reproduces theoretical predictions and experimental observations such as phonon caustics, heat-pulse propagation times, and mean charge-carrier drift velocities. In addition to presenting the physics and features supported by G4CMP, this report outlines example applications from the dark matter and quantum information science communities. These communities are applying G4CMP to model and design devices for which the energy transported by phonons and charge carriers is germane to the performance of superconducting instruments and circuits placed on silicon and germanium substrates. The G4CMP package is available to download from GitHub: github.com/kelseymh/G4CMP.
The Gerda experiment searches for the neutrinoless double beta (0νββ) decay in 76Ge in order to probe whether the neutrino is a Majorana particle and to shed light on the neutrino mass ordering. For ...investigating such a rare decay it is necessary to minimize the background of the experiment. In Phase II of the Gerda experiment the scintillation light of liquid argon (LAr) is used as an additional background veto. In order to estimate the efficiency of such a LAr veto it has to be known how far the scintillation light, which peaks at 128 nm, can travel within the LAr. A dedicated setup was built to measure the attenuation length of the scintillation light in the LAr in-situ within the cryostat of Gerda. The setup is composed of a stainless steel housing with a photomultiplier tube (PMT) at one side and a moveable 90Sr source at the other side to measure the light intensity at different distances between source and PMT. Furthermore, a sophisticated simulation was developed in order to determine the solid angle correction as well as the background for this measurement. The analysis results in an absorption length of 15.8±0.7(stat)−3.2+1.5(syst)cm under the assumption of a scattering length of 70 cm at 128 nm. The obtained value of the absorption length is specific for the LAr in GERDA at the time of the measurement.
Purpose
Over-activation of the renin-angiotensin axis and worsening of vascular function are critical contributors to the development of hypertension. Therefore, inhibition of angiotensin-converting ...enzyme (ACE), a key factor of the renin-angiotensin axis, is a first line treatment of hypertension. Besides pharmaceutical ACE inhibitors, some natural peptides have been shown to exert ACE-inhibiting properties with antihypertensive effects and potentially beneficial effects on vascular function. In this study, the ACE-inhibiting potential and effects on vascular function of tryptophan-containing peptides were evaluated.
Methods
The ACE inhibitory action and stability of tryptophan-containing peptides was tested in endothelial cells—a major source of whole body ACE activity. Furthermore, the efficacy of peptides on vascular ACE activity, as well as vessel tone was assessed both ex vivo and in vivo.
Results
In human umbilical vein endothelial cells (HUVEC), isoleucine-tryptophan (IW) had the highest ACE inhibitory efficacy, followed by glutamic acid-tryptophan (EW) and tryptophan-leucine (WL). Whereas none of the peptides affected basal vessel tone (rat aorta), angiotensin I-induced vasoconstriction was blocked. IW effectively inhibited aortic ACE activity ex vivo taken from SHRs after 14-weeks of oral treatment with IW. Furthermore, IW treated SHRs showed better endothelium-dependent vessel relaxation compared to placebo.
Conclusion
This study shows strong ACE-inhibiting effects of IW, EW and WL in HUVECs and aorta. The peptides effectively counteract angiotensin-induced vasoconstriction and preserve endothelium-dependent vessel relaxation. Thus, tryptophan-containing peptides and particularly IW may serve as innovative food additives with the goal of protection from angiotensin II-induced worsening of vascular function.
Modeling of GERDA Phase II data Agostini, M.; Bakalyarov, A. M.; Balata, M. ...
The journal of high energy physics,
03/2020, Letnik:
2020, Številka:
3
Journal Article
Recenzirano
Odprti dostop
A
bstract
The GERmanium Detector Array (Gerda) experiment at the Gran Sasso underground laboratory (LNGS) of INFN is searching for neutrinoless double-beta (0
νββ
) decay of
76
Ge. The technological ...challenge of Gerda is to operate in a “background-free” regime in the region of interest (ROI) after analysis cuts for the full 100 kg
·
yr target exposure of the experiment. A careful modeling and decomposition of the full-range energy spectrum is essential to predict the shape and composition of events in the ROI around
Q
ββ
for the 0
νββ
search, to extract a precise measurement of the half-life of the double-beta decay mode with neutrinos (2
νββ
) and in order to identify the location of residual impurities. The latter will permit future experiments to build strategies in order to further lower the background and achieve even better sensitivities. In this article the background decomposition prior to analysis cuts is presented for Gerda Phase II. The background model fit yields a flat spectrum in the ROI with a background index (BI) of
16.04
−
0.85
+
0.78
·
10
−
3
cts/(keV
·
kg
·
yr) for the enriched BEGe data set and
14.68
−
0.52
+
0.47
·
10
−
3
cts/(keV
·
kg
·
yr) for the enriched coaxial data set. These values are similar to the one of Phase I despite a much larger number of detectors and hence radioactive hardware components.
Pulse shape analysis in Gerda Phase II Agostini, M.; Araujo, G.; Bakalyarov, A. M. ...
The European physical journal. C, Particles and fields,
04/2022, Letnik:
82, Številka:
4
Journal Article
Recenzirano
Odprti dostop
The GERmanium Detector Array (
Gerda
) collaboration searched for neutrinoless double-
β
decay in
76
Ge using isotopically enriched high purity germanium detectors at the Laboratori Nazionali del ...Gran Sasso of INFN. After Phase I (2011–2013), the experiment benefited from several upgrades, including an additional active veto based on LAr instrumentation and a significant increase of mass by point-contact germanium detectors that improved the half-life sensitivity of Phase II (2015–2019) by an order of magnitude. At the core of the background mitigation strategy, the analysis of the time profile of individual pulses provides a powerful topological discrimination of signal-like and background-like events. Data from regular
228
Th calibrations and physics data were both considered in the evaluation of the pulse shape discrimination performance. In this work, we describe the various methods applied to the data collected in
Gerda
Phase II corresponding to an exposure of 103.7 kg year. These methods suppress the background by a factor of about 5 in the region of interest around
Q
β
β
=
2039
keV, while preserving
(
81
±
3
)
% of the signal. In addition, an exhaustive list of parameters is provided which were used in the final data analysis.
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