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zadetkov: 58
1.
  • Distinction of lymphoid and... Distinction of lymphoid and myeloid clonal hematopoiesis
    Niroula, Abhishek; Sekar, Aswin; Murakami, Mark A ... Nature medicine, 11/2021, Letnik: 27, Številka: 11
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    Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. Somatic gene mutations associated with hematologic malignancies detected in ...
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  • Premature Menopause, Clonal... Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women
    Honigberg, Michael C; Zekavat, Seyedeh M; Niroula, Abhishek ... Circulation, 02/2021, Letnik: 143, Številka: 5
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    Premature menopause is an independent risk factor for cardiovascular disease in women, but mechanisms underlying this association remain unclear. Clonal hematopoiesis of indeterminate potential ...
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  • ANGPTL3 Deficiency and Prot... ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
    Stitziel, Nathan O., MD, PhD; Khera, Amit V., MD; Wang, Xiao, PhD ... Journal of the American College of Cardiology, 04/2017, Letnik: 69, Številka: 16
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    Abstract Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene ...
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4.
  • Whole-Genome Sequencing to ... Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction
    Khera, Amit V; Chaffin, Mark; Zekavat, Seyedeh M ... Circulation, 03/2019, Letnik: 139, Številka: 13
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    The relative prevalence and clinical importance of monogenic mutations related to familial hypercholesterolemia and of high polygenic score (cumulative impact of many common variants) pathways for ...
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5.
  • Genetic Association of Wais... Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease
    Emdin, Connor A; Khera, Amit V; Natarajan, Pradeep ... JAMA, 02/2017, Letnik: 317, Številka: 6
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    In observational studies, abdominal adiposity has been associated with type 2 diabetes and coronary heart disease (CHD). Whether these associations represent causal relationships remains uncertain. ...
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6.
  • Cardiovascular and Kidney O... Cardiovascular and Kidney Outcomes Across the Glycemic Spectrum: Insights From the UK Biobank
    Honigberg, Michael C; Zekavat, Seyedeh M; Pirruccello, James P ... Journal of the American College of Cardiology, 08/2021, Letnik: 78, Številka: 5
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    Treatment guidelines for prediabetes primarily focus on glycemic control and lifestyle management. Few evidence-based cardiovascular and kidney risk-reduction strategies are available in this ...
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8.
  • Genetics of smoking and ris... Genetics of smoking and risk of clonal hematopoiesis
    Levin, Michael G; Nakao, Tetsushi; Zekavat, Seyedeh M ... Scientific reports, 05/2022, Letnik: 12, Številka: 1
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    Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing expanded somatic mutations have been ...
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  • A Genetic Variant Associate... A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression
    Gupta, Rajat M.; Hadaya, Joseph; Trehan, Aditi ... Cell, 07/2017, Letnik: 170, Številka: 3
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    Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine headache, cervical artery dissection, ...
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