While he was in Mantua in 1475, the Italian Jewish philosopher Judah Messer Leon (ca. 1425–1498) wrote a wide commentary on Aristotle'sPhysics1–4. As a “Hebrew Schoolman,” he inserted into this work ...a number of explicit and implicit references to Latin Scholastic commentaries on thePhysics. An examination of the Latin sources quoted explicitly has been given elsewhere. Here, two implicit sources are examined: Paul of Venice'sExpositio super octo libros Physicorum necnon super commentum Averrois, and Gaetano de Thiene'sRecollectae super octo libros Physicorum Aristotelis. The former was apparently employed by Judah Messer Leon only for the general structure of his work; the latter, by contrast, was widely employed as the direct source of several long passages, although the Latin author was never mentioned by name. Some of these passages, found in Book 1, Parts 1–2 of the commentary (on Aristotle,Physics184a10–188a8), are listed and examined here. Their close relationship with Gaetano de Thiene's work is shown.
Synthesis, characterization and catalytic activity of a novel tungsten(VI) amino triphenolate complex have been investigated. In particular, a tungsten(VI) amino triphenolate complex has been ...synthesized and tested in the oxidation of sulfides and cyclooctene, using hydrogen peroxide as terminal oxidant. The catalyst has proved to be air and water tolerant, also showing a good efficiency in terms of yields and selectivity. Moreover, an upgrade of our previous ligand synthesis is herein reported. The new developed procedure allows to obtain the triphenolamine in large scale without the use of chromatography for the intermediates purification.
Objetivo: Avaliar a cultura de segurança do paciente sob a ótica de profissionais atuantes em Unidades de Terapia Intensiva. Método: Estudo descritivo-exploratório, transversal, com caráter ...quantitativo. Amostra composta por 72 profissionais: 31 enfermeiros, 21 técnicos de enfermagem, 12 (fisioterapeutas, fonoaudiólogos, terapeuta ocupacional), 5 médicos, 2 psicólogos, 1 auxiliar de enfermagem, atuantes em Unidades de Terapia Intensiva do Sudoeste e Noroeste do Paraná e do Oeste de Santa Catarina. Coleta de dados realizada entre agosto e outubro de 2020, via formulário eletrônico on-line, por meio da plataforma do Google, utilizando-se do questionário adaptado Pesquisa sobre Segurança do Paciente em Hospitais. Os dados foram tabulados no programa Excel e, posteriormente, realizou-se a análise descritiva dos dados, por meio do software Statistical Package for the Social Sciences (SPSS 25.0). Resultados: Duas categorias atingiram mais de 75% de respostas positivas quanto â cultura de segurança nas unidades pesquisadas, sendo elas: quando há muito trabalho a ser feito, os profissionais trabalham em equipe para concluí-lo; e estar ativamente fazendo coisas para melhorar a segurança do paciente. Conclusäo: Na perspectiva dos profissionais, a segurança do paciente ainda näo é efetiva, pois, em alguns aspectos, precisa de melhorias, sendo, ainda, em outros critérios, considerada fragilizada.
A chromatic vectorial strain sensor constituted by hexagonal voids on transparent elastomeric substrate has been successfully fabricated via soft colloidal lithography. Initially a highly ordered 1.6 ...microns polystyrene spheres monolayer colloidal crystal has been realized by wedge-shaped cell method and used as a suitable mold to replicate the periodic structure on a polydimethylsiloxane sheet. The replicated 2D array is characterized by high periodicity and regularity over a large area, as evidenced by morphological and optical properties obtained by means of SEM, absorption and reflectance spectroscopy. In particular, the optical features of the nanostructured elastomer have been investigated in respect to uniaxial deformation up to 10% of its initial length, demonstrating a linear, tunable and reversible response, with a sensitivity of 4.5 ± 0.1 nm/%. Finally, it has been demonstrated that the specific geometrical configuration allows determining simultaneously the vectorial strain-stress information in the x and y directions.
The significance of Born Global firms´ study is increasing due to their early internationalization aspects, innovation and economic growth; however, most of existent studies are focused on developed ...markets. This is the reason why this study is addressed to analyze the internationalization effects on the innovation in a Born Global firm from emerging market. We have used the literature review about innovation, internationalization and Born Global from emerging markets, also an in-depth interview with the founder and the financial/administrative coordinator of a Brazilian Born Global company that have demonstrated a proactive internationalization behavior moving to the United States. The result shows that, the internationalization to a country with stable institutions affects positively the innovation of the firm, providing the possibility of exploring resources, resulting in financial growth, superior knowledge and capabilities. This research contributes for an improved knowledge of the phenomenon in the context of emerging markets. Also, the perspective of institutions in the host country, which determines the firm´s innovation performance and finally, we explore the case of a firm from an emerging economy that moved to a developed country (South-North) to develop new capabilities and maintain its strategy of innovation.
Estrogen and androgen receptors (ER and AR) play key roles in breast and prostate cancers, respectively, where they regulate the transcription of large arrays of genes. The activities of ER and AR ...are controlled by large networks of protein kinases and transcriptional coregulators, including Ddx5 and its highly related paralog Ddx17. The Ddx5 and Ddx17 RNA helicases are also splicing regulators. Here, we report that Ddx5 and Ddx17 are master regulators of the estrogen- and androgen-signaling pathways by controlling transcription and splicing both upstream and downstream of the receptors. First, Ddx5 and Ddx17 are required downstream of ER and AR for the transcriptional and splicing regulation of a large number of steroid hormone target genes. Second, Ddx5 and Ddx17 act upstream of ER and AR by controlling the expression, at the splicing level, of several key regulators of ER and AR activities. Of particular interest, we demonstrate that Ddx5 and Ddx17 control alternative splicing of the GSK3β kinase, which impacts on both ER and AR protein stability. We also provide a freely available online resource which gives information regarding splicing variants of genes involved in the estrogen- and androgen-signaling pathways.
Delayed maternity and risk at delivery Astolfi, Paola; Zonta, Laura A.
Paediatric and perinatal epidemiology,
01/2002, Letnik:
16, Številka:
1
Journal Article
Recenzirano
Summary
We evaluated the effect of the mother’s age on the risk of unfavourable pregnancy outcome. The study considered 1348 190 first‐born and 957 689 second‐born babies born in Italy in 1990–94. ...The risk of stillbirth, preterm birth in liveborns, and low birthweight in liveborns at term, was first evaluated separately and then globally as a function of maternal age, education and parity. Older (≥ 35 years) mothers were found to run an increased risk, both on single and on global evaluation, with respect to their younger counterparts. Primiparae ≥ 35 years of age, of low education, ran a global risk threefold higher (3.14 3.02, 3.26) than the young highly educated secondiparae who were the lowest risk (4.64% of babies at risk). From 26 years the global risk rose with each advancing year of maternal age, but parity and education modified the age effect. Linear fitting of the proportion of mothers ≥ 35 since 1984 indicates that by the year 2025 about 25% of the mothers may face late child bearing.
No-tillage (NT) has been adopted in organic agriculture as an alternative to conventional tillage (CT) for improving soil conservation. Cover crops (CC) play a vital role in this process by providing ...straw and releasing nutrients into the soil. Therefore, in this study, we aimed to evaluate the effects of NT and CT management on the chemical properties and bacterial diversity of soil following the cultivation of diverse CC in an organic system. The experiment was conducted using a randomized block design with subdivided plots, wherein the plots represented CT and NT, and the subplots represented the diverse CC tested, including pearl millet, sunn hemp, jack bean, seed mixes 1 and 2 (containing 100 % and 50 % of the recommended seeding rates for each crop), and spontaneous plants. The evaluations were conducted one year after the experiment was conducted. The results demonstrated that NT promoted increases in soil magnesium, phosphorus, and organic carbon contents, including increased bacterial richness. Moreover, NT resulted in a higher abundance of Bacteroidetes, GAL15, and Myxococcota. Conversely, CT favored a greater relative abundance of Actinobacteria, in addition to the members of Bacteroidetes. Regarding the influence of CC, no significant differences were observed in the diversity and structure of the bacterial communities, except for subgroup 17, which was more abundant in spontaneously grown plants. NT proved to be more effective than CT in improving soil chemical properties and bacterial diversity, implying its potential to contribute to sustainable agricultural systems.
Connexins are plasma membrane proteins that associate in hexameric complexes to form channels named connexons. Two connexons in neighboring cells may dock to form a "gap junction" channel, i.e. an ...intercellular conduit that permits the direct exchange of solutes between the cytoplasm of adjacent cells and thus mediate cell-cell ion and metabolic signaling. The lack of high resolution data for connexon structures has hampered so far the study of the structure-function relationships that link molecular effects of disease-causing mutations with their observed phenotypes. Here we present a combination of modeling techniques and molecular dynamics (MD) to infer side chain positions starting from low resolution structures containing only C alpha atoms. We validated this procedure on the structure of the KcsA potassium channel, which is solved at atomic resolution. We then produced a fully atomistic model of a homotypic Cx32 connexon starting from a published model of the C alpha carbons arrangement for the connexin transmembrane helices, to which we added extracellular and cytoplasmic loops. To achieve structural relaxation within a realistic environment, we used MD simulations inserted in an explicit solvent-membrane context and we subsequently checked predictions of putative side chain positions and interactions in the Cx32 connexon against a vast body of experimental reports. Our results provide new mechanistic insights into the effects of numerous spontaneous mutations and their implication in connexin-related pathologies. This model constitutes a step forward towards a structurally detailed description of the gap junction architecture and provides a structural platform to plan new biochemical and biophysical experiments aimed at elucidating the structure of connexin channels and hemichannels.
Abstract
The efficient catalytic oxidation of secondary amines to nitrones using hydrogen peroxide as primary oxidant is described. The titanium(IV) complex
2
bearing a
C
3
‐symmetrical triphenolate ...amino ligand has proved to be an air‐ and water‐tolerant complex that efficiently catalyzes secondary amine oxidations at 60 °C without previous activation catalyst loading as low as 0.01%, yields up to 99%, turnover numbers (TONs) up to 8000 and turnover frequencies (TOFs) up to 11000 h
−1
).
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